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| 1 | Removal of Crystal Violet from aqueous solution using powdered mycelial biomass of Ceriporia lacerata P2显示文摘A biosorbent prepared from powdered mycelial biomass of Ceriporia lacerata (CLB), a basidiomycetous fungus, was applied for the uptake of Crystal Violet from aqueous solution. A batch adsorption experiment was used for the biosorption process, involving effect of experimental factors and biosorption kinetics and equilibrium. Biosorption process showed that the removal of Crystal Violet by CLB was effective over wide pH range, and meanwhile was independent on ionic strength. Biosorption capacities of CLB increased with the initial dye concentration increasing, due to an increase in the driving force of the concentration gradient. The adsorbed Crystal Violet amount per unit biomass weight decreased with increasing biosorbent dosage, due to the splitting effect of flux (concentration gradient) between sorbate and biosorbent. A maximum sorption capacity of 239.25 mg/g was observed. Biosorption kinetics was found to be best represented by the pseudo second-order kinetic model. The equilibrium adsorption data was well described by the Koble-Corrigan model. FT-IR (Fourier Transform Infrared Spetroscopy) spectrum showed the presence of O-H, COOH, C=O, C-N, C-H, -NH2 and P-OH in the surface of CLB as functional groups. This study showed CLB can effectively remove CV from dye wastewater. | Yonghui Lin Xingbing He Guomin Han Qijian Tian Wenyong Hu | 2011 | Journal of Environmental Sciences2011，23，12： | 11 |
| 2 | Insight into the temperature sensitivity of forest litter decomposition and soil enzymes in subtropical forest in China显示文摘Aims With the continuing increase in the impact of human activities on ecosystems,ecologists are increasingly interested in understanding the effects of high temperature on litter decomposition since litter decomposition and the accompanying release of nutrients and carbon dioxide are key processes in ecosystem nutrient cycling and carbon flux.This study was conducted to evaluate the temperature sensitivity of forest litter decomposition and soil enzymes during litter decomposition in subtropical forest in China.Methods Two dominant litter types were chosen from Zijin Mountain in China:Quercus acutissima leaves from a broadleaf forest(BF)and Pinus massoniana needles from a coniferous forest(CF).The litter samples were incubated in soil microcosms at ambient control temperature(20 C)and 10 C warmer.During a 5-month incubation,chemical composition of litter samples,litter mass losses,and related soil enzyme activities were determined.Important Findings Three main results were found:(i)high temperature accelerated decomposition rates of both litter types,and the temperature sensitivities of litter decomposition for BF leaves and that for CF needles are equivalent basically,(ii)high temperature enhanced soil enzyme activities in the two forest types,and the temperature sensitivities of polyphenol oxidase were significantly higher than those of the other soil enzymes and(iii)the temperature sensitivities of nitrate reductase were significantly higher in the CF soil than in the BF soil,while there was no significant difference in the temperature sensitivities of the other soil enzymes between BF and CF.As a long-term consequence,the high-temperature-induced acceleration of litter decomposition rates in these subtropical forests may cause carbon stored belowground to be transferred in the atmosphere,which may alter the balance between carbon uptake and release,and then alter the global carbon cycle in the coming decades. | Congyan Wang Guomin Han Yong Jia Xiaoguang Feng Xingjun Tian | 2012 | Journal of Plant Ecology2012，5，3： | 8 |
| 3 | Galectin-3-centered paracrine network mediates cardiac inflammation and fibrosis upon β-adrenergic insult显示文摘Rapid over-activation of β-adrenergic receptors (β-AR) following acute stress initiates cardiac inflammation and injury by activating interleukin-18 (IL-18),however,the process of inflammation cascades has not been fully illustrated.The present study aimed to determine the mechanisms of cardiac inflammatory amplification following acute sympathetic activation.With bioinformatics analysis,galectin-3 was identified as a potential key downstream effector of β-AR and IL-18 activation.The serum level of galectin-3 was positively correlated with norepinephrine or IL-18 in patients with chest pain.In the heart of mice treated with β-AR agonist isoproterenol (ISO,5 mg kg^(-1)),galectin-3 expression was upregulated markedly later than IL-18 activation,and Nlrp3^(-/-)and Il18^(-/-)mice did not show ISO-induced galectin-3 upregulation.It was further revealed that cardiomyocyte-derived IL-18 induced galectin-3 expression in macrophages following ISO treatment.Moreover,galectin-3deficiency suppressed ISO-induced cardiac inflammation and fibrosis without blocking ISO-induced IL-18 increase.Treatment with a galectin-3 inhibitor,but not a β-blocker,one day after ISO treatment effectively attenuated cardiac inflammation and injury.In conclusion,galectin-3 is upregulated to exaggerate cardiac inflammation and injury following acute β-AR activation,a galectin-3 inhibitor effectively blocks cardiac injury one day after β-AR insult. | Guomin Hu Jimin Wu Huijun Gu Xiangning Deng Wenli Xu Shan Feng Shuaixing Wang Yao Song Zhengda Pang Xiuling Deng Aleksandr E.Vendrov Nageswara R.Madamanchi Marschall S.Runge Xinyu Wang Youyi Zhang Han Xiao Erdan Dong | 2023 | Science China(Life Sciences)2023，66，5： | 3 |
| 4 | Pathological matrix stiffness promotes cardiac fibroblast differentiation through the POU2F1 signaling pathway显示文摘Cardiac fibroblast(CF)differentiation into myofibroblasts is a crucial cause of cardiac fibrosis,which increases in the extracellular matrix(ECM)stiffness.The increased stiffness further promotes CF differentiation and fibrosis.However,the molecular mechanism is still unclear.We used bioinformatics analysis to find new candidates that regulate the genes involved in stiffnessinduced CF differentiation,and found that there were binding sites for the POU-domain transcription factor,POU2F1(also known as Oct-1),in the promoters of 50 differentially expressed genes(DEGs)in CFs on the stiffer substrate.Immunofluorescent staining and Western blotting revealed that pathological stiffness upregulated POU2F1 expression and increased CF differentiation on polyacrylamide hydrogel substrates and in mouse myocardial infarction tissue.A chromatin immunoprecipitation assay showed that POU2F1 bound to the promoters of fibrosis repressors IL1R2,CD69,and TGIF2.The expression of these fibrosis repressors was inhibited on pathological substrate stiffness.Knockdown of POU2F1 upregulated these repressors and attenuated CF differentiation on pathological substrate stiffness(35 kPa).Whereas,overexpression of POU2F1 downregulated these repressors and enhanced CF differentiation.In conclusion,pathological stiffness upregulates the transcription factor POU2F1 to promote CF differentiation by inhibiting fibrosis repressors.Our work elucidated the crosstalk between CF differentiation and the ECM and provided a potential target for cardiac fibrosis treatment. | Mingzhe Li Jimin Wu Guomin Hu Yao Song Jing Shen Junzhou Xin Zijian Li Wei Liu Erdan Dong Ming Xu Youyi Zhang Han Xiao | 2021 | Science China(Life Sciences)2021，64，2： | 3 |
| 5 | Estimation of transpiration coefficient and aboveground biomass in maize using time-series UAV multispectral imagery显示文摘Estimating spatial variation in crop transpiration coefficients(CTc) and aboveground biomass(AGB)rapidly and accurately by remote sensing can facilitate precision irrigation management in semiarid regions. This study developed and assessed a novel machine learning(ML) method for estimating CTc and AGB using time-series unmanned aerial vehicle(UAV)-based multispectral vegetation indices(VIs)of maize under several irrigation treatments at the field scale. Four ML regression methods: multiple linear regression(MLR), support vector regression(SVR), random forest regression(RFR), and adaptive boosting regression(ABR), were used to address the complex relationship between CTcand VIs. AGB was then estimated using exponential, logistic, sigmoid, and linear equations because of their clear mathematical formulations based on the optimal CTcestimation model. The UAV VIs-derived CTcusing the RFR estimation model yielded the highest accuracy(R^(2)= 0.91, RMSE = 0.0526, and n RMSE = 9.07%). The normalized difference red-edge index, transformed chlorophyll absorption in reflectance index, and simple ratio contributed significantly to the RFR-based CTcmodel. The accuracy of AGB estimation using nonlinear methods was higher than that using the linear method. The exponential method yielded the highest accuracy(R^(2)= 0.76, RMSE = 282.8 g m, and n RMSE = 39.24%) in both the 2018 and 2019 growing seasons. The study confirms that AGB estimation models based on cumulative CTcperformed well under several irrigation treatments using high-resolution time-series UAV multispectral VIs and can support irrigation management with high spatial precision at a field scale. | Guomin Shao Wenting Han Huihui Zhang Yi Wang Liyuan Zhang Yaxiao Niu Yu Zhang Pei Cao | 2022 | The Crop Journal2022，10，5： | 2 |
| 6 | Evaluation of a new fungus Ceriporia lacerate strain P2—its ability to decolorize Alizarin Red and Methyl Orange显示文摘 | Liang Xu Yue Zhu Xingbing He Guomin Han Xingjun Tian | | 0，2008，： | 1 |
| 7 | Hippocampal neuron loss is correlated with cognitive deficits in SAMP8 mice显示文摘 | Guomin Li Haiyan Cheng Xuezhu Zhang Xuemei Shang Hui Xie Xin Zhang Jianchun Yu Jingxian Han | 2013 | Neurological Sciences2013，，6： | 1 |
| 8 | Isolation and evaluation of terrestrial fungi with algicidal ability from Zijin Mountain,Nanjing,China显示文摘 | HAN Guomin FENG Xiaoguang JIA Yong | 2011 | The Journal of Microbiology2011，49，4： | 1 |
| 9 | The importance of bacteria in promoting algal growth in eutrophic lakes with limited available phosphorus显示文摘 | Guiying Zhao Jingjing Du Yong Jia Yanna Lv Guomin Han Xingjun Tian | 2012 | Ecological Engineering2012，，： | 1 |
| 10 | Effect of simulated acid rain on the litter decomposition of Quercus acutissima and Pinus massoniana in forest soil microcosms and the relationship with soil enzyme activities 显示文摘 | WANG Congyan GUO Peng HAN Guomin | 2010 | Sci Total Environ2010，408，13： | 1 |
| 11 | Effect of simulated acid rain on the litter decomposition of Quercus acutissima and Pinus massoniana in forest soil microcosms and the relationship with soil enzyme activities 显示文摘 | WANG Congyan GUO Peng HAN Guomin | 2010 | Sci Total Environ2010，408，13： | 1 |
| 12 | Ki67 as a predictor of poor prognosis in patients with triple?negativebreast cancer显示文摘 | Haitao Li Xinghua Han Yingxin Liu Guodong Liu Guomin Dong | 2015 | Oncology Letters2015，，： | 1 |
| 13 | Genetic Architecture of Childhood Kidney and Urological Diseases in China显示文摘Kidney disease is manifested in a wide variety of phenotypes,many of which have an important hereditary component.To delineate the genotypic and phenotypic spectrum of pediatric nephropathy,a multicenter registration system is being imple-mented based on the Chinese Children Genetic Kidney Disease Database(CCGKDD).In this study,all the patients with kidney and urological diseases were recruited from 2014 to 2020.Genetic analysis was conducted using exome sequencing for families with multiple affected individuals with nephropathy or clinical suspicion of a genetic kidney disease owing to early-onset or extrarenal features.The genetic diagnosis was confirmed in 883 of 2256(39.1%)patients from 23 provinces in China.Phenotypic profiles showed that the primary diagnosis included steroid-resistant nephrotic syndrome(SRNS,23.5%),glomerulonephritis(GN,32.2%),congenital anomalies of the kidney and urinary tract(CAKUT,21.2%),cystic renal disease(3.9%),renal calcinosis/stone(3.6%),tubulopathy(9.7%),and chronic kidney disease of unknown etiology(CKDu,5.8%).The pathogenic variants of 105 monogenetic disorders were identified.Ten distinct genomic disorders were identified as pathogenic copy number variants(CNVs)in 11 patients.The diagnostic yield differed by subgroups,and was highest in those with cystic renal disease(66.3%),followed by tubulopathy(58.4%),GN(57.7%),CKDu(43.5%),SRNS(29.2%),renal calcinosis/stone(29.3%)and CAKUT(8.6%).Reverse phenotyping permitted correct identification in 40 cases with clinical reassessment and unexpected genetic conditions.We present the results of the largest cohort of children with kidney disease in China where diagnostic exome sequencing was performed.Our data demonstrate the utility of family-based exome sequencing,and indicate that the combined analysis of genotype and phenotype based on the national patient registry is pivotal to the genetic diagnosis of kidney disease. | Ye Fang Hua Shi Tianchao Xiang Jiaojiao Liu Jialu Liu Xiaoshan Tang Xiaoyan Fang Jing Chen Yihui Zhai Qian Shen Guomin Li Li Sun Yunli Bi Xiang Wang Yanyan Qian Bingbing Wu Huijun Wang Wenhao Zhou Duan Ma Jianhua Mao Xiaoyun Jiang Shuzhen Sun Ying Shen Xiaorong Liu Aihua Zhang Xiaowen Wang Wenyan Huang Qiu Li Mo Wang Xiaojie Gao Yubin Wu Fang Deng Ruifeng Zhang Cuihua Liu Li Yu Jieqiu Zhuang Qing Sun Xiqiang Dang Haitao Bai Ying Zhu Siguang Lu Bili Zhang Xiaoshan Shao Xuemei Liu Mei Han Lijun Zhao Yuling Liu Jian Gao Ying Bao Dongfeng Zhang Qingshan Ma Liping Zhao Zhengkun Xia Biao Lu Yulong Wang Mengzhun Zhao Jianjiang Zhang Shan Jian Guohua He Huifeng Zhang Bo Zhao Xiaohua LI Feiyan Wang Yufeng Li Hongtao Zhu Xinhui Luo Jinghai Li Jia Rao Hong Xu | 2021 | Phenomics2021，1，3： | 0 |
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