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| 1 | Endoscopic submucosal dissection for premalignant lesions and noninvasive early gastrointestinal cancers显示文摘AIM: To investigate the indication, feasibility, safety, and clinical utility of endoscopic submucosal dissection (ESD) in the management of various gastrointestinal pathologies. METHODS: The medical records of 60 consecutive patients (34 female, 26 male) who underwent ESD at the gastroenterology department of Kocaeli University from 2006-2010 were examined. Patients selected for ESDhad premalignant lesions or non-invasive early cancers of the gastrointestinal tract and had endoscopic and histological diagnoses. Early cancers were considered to be confined to the submucosa, with no lymph node involvement by means of computed tomography and endosonography. RESULTS: Sixty ESD procedures were performed. The indications were epithelial lesions (n = 39) (33/39 adenoma with high grade dysplasia, 6/39 adenoma with low grade dysplasia), neuroendocrine tumor (n = 7), cancer (n = 7) (5/7 early colorectal cancer, 2/7 early gastric cancer), granular cell tumor (n = 3), gastrointestinal stromal tumor (n = 2), and leiomyoma (n = 2). En bloc and piecemeal resection rates were 91.6% (55/60) and 8.3% (5/60), respectively. Complete and incomplete resection rates were 96.6% (58/60) and 3.3% (2/60), respectively. Complications were major bleeding [n = 3 (5%)] and perforations [n = 5 (8.3%)] (4 colon, 1 stomach). Two patients with colonic perforations and two patients with submucosal lymphatic and microvasculature invasion (1 gastric carcinoid tumor, 1 colonic adenocarcinoma) were referred to surgery. During a mean follow-up of 12 mo, 1 patient with adenoma with high grade dysplasia underwent a second ESD procedure to resect a local recurrence. CONCLUSION: ESD is a feasible and safe method for treatment of premalignant lesions and early malignant gastrointestinal epithelial and subepithelial lesions. Successful en bloc and complete resection of lesions yield high cure rates with low recurrence. | Sadettin Hulagu Omer Senturk Cem Aygun Orhan Kocaman Altay Celebi Tolga Konduk Deniz Koc Goktug Sirin Ugur Korkmaz Ali Erkan Duman Neslihan Bozkurt Gokhan Dindar Tan Attila Yesim Gurbuz Orhan TarcinDivision of Gastroenterology Derince State Hospital Kocaeli 41900 Turkey Cem Kalayci | 2011 | World Journal of Gastroenterology2011，17，13： | 23 |
| 2 | Clinicopathologic and immunohistochemical profile of ovarian metastases from colorectal carcinoma显示文摘Metastasis of colorectal adenocarcinoma of the ovary is not an uncommon occurrence and ovarian metastases from colorectal carcinoma frequently mimic endometrioid and mucinous primary ovarian carcinoma.The clinical and pathologic features of metastatic colorectal adenocarcinoma involving the ovary is reviewed with particular focus on the diagnostic challenge of distinguishing these secondary ovarian tumors from primary ovarian neoplasm.Immunohistochemical stains that may be useful in the differential diagnosis of metastatic colorectal tumors to the ovary and primary ovarian tumors are detailed. | Gozde Kir Ayse Gurbuz Ates Karateke Mustafa Kir | 2010 | World Journal of Gastrointestinal Surgery2010，2，4： | 11 |
| 3 | 帕罗西汀与达帕西汀的对比,治疗早泄的新的选择性5-羟色胺再摄取抑制剂显示文摘达帕西汀氢氯化物是一种选择性5-羟色胺再摄取抑制剂,也是第一种被批准可以按需服用治疗早泄的药物。本文目的为研究按需服用达帕西汀(30mg和H60mg)和每日服用帕罗西汀(20mg)对早泄的疗效。研究募集了150名患者进行了长达1个月的研究。患者被分成3组,每组50人。第一组按需服用达帕西汀30mg。第二组按需服用达帕西汀60mg。第三组每日服用帕罗西汀20mg。治疗结束后,我们的结果检测值相对于基准阴道内射精潜伏期(IELT)延长了。与基准IELT相比,帕罗西汀组、30mg达帕西汀组和60mg达帕西汀组的治疗后IELT分别延长了117%(P〈0.01),117%(P〈0.01)和170%(P〈0.01)。30mg达帕西汀组和帕罗西汀组的IELT增幅相同(P〉0.05),而60mg达帕西汀组的IELT增幅明显高于30mg达帕西汀组(P〈0.05和帕罗西汀组P〈0.01)。性交前1~3小时服用达帕西汀60mg是针对早泄的非常有效的治疗方法。然而,与当前普遍使用的帕罗西汀相比,达帕西汀30mg疗效并不显著。 | Abdulmuttalip Simsek Sinan Levent Kirecci Onur Kucuktopcu Faruk Ozgor Mehmet Fatih Akbulut Omer Sarilar Unsal Ozkuvanci Zafer Gokhan Gurbuz | 2014 | Asian Journal of Andrology2014，16，5： | 10 |
| 4 | Effect of acupuncture therapy on fracture healing in rats with femur fractures显示文摘OBJECTIVE: To investigate the effect of acupuncture therapy on fracture healing in rats with femur fractures.METHODS: A total of 10 groups were formed;control group, groups sacrificed on 7 th, 14 th, and 21 st days of fracture formation, groups to which acupuncture was applied for 7, 14, and 21 d, groups to which fracture and acupuncture were applied for 7,14, and 21 d. A transverse fracture line was formed in femurs of rats by using a Gigli saw. The Kirschner wire was driven retrograde down from the fracture line to proximal part of the bone and then, the fracture was fixed towards distal part. Acupuncture was applied to the rats for 7, 14, and 21 d as 4 sessions per week after formation of the fracture.RESULTS: Malondialdehyde(MDA), reduced glutathione(GSH) levels, catalase(CAT), glutathione-Stransferase(GST), superoxide dismutase(SOD), and glucose-6-phosphate dehydrogenase(G6 PD) activities were measured. Despite the increased MDA levels, G6 PD and SOD activities reduced during the fracture healing. There was a statistically significant increase in MDA, GSH levels, and G6 PD activity in fracture groups compared to control group, but CAT, GST, and SOD activities decreased. The use of acupuncture enhanced callus development and bone mineralization during bone healing.CONCLUSION: The acupuncture therapy can affect suppression of the effects of free oxygen radicals and regulation of the antioxidant enzyme activity in fracture healing. Thus, it is suggested that acupuncture treatment would be beneficial for fracture healing in order to eliminate the negative effects induced by oxygen free radicals. | Seval Yilmaz Emre Kaya Erhan Yilmaz Ahmet Kavakli Suleyman Gurbuz Mustafa Ozkaraca | 2020 | Journal of Traditional Chinese Medicine2020，40，2： | 6 |
| 5 | Falls from height: A retrospective analysis显示文摘BACKGROUND: Emergency services manage trauma patients frequently and falls from height comprise the main cause of emergency service admissions. In this study, we aimed to analyse the demographic characteristics of falls from height and their relationship to the mortality.METHODS: A total of 460 patients, who admitted to the Emergency Department of Inonu University between November 2011 and November 2014 with a history of fall from height, were examined retrospectively. Demographic parameters, fall characteristics and their effect to mortality were evaluated statistically. RESULTS: The study comprised of 292(63.5%) men and 168(36.5%) women patients. The mean age of all patients was 27±24.99 years. Twenty-six(5.6%) patients died and the majority of them were in ≥62 years old group. The highest percentage of falls was at 0–5 years age group(28.3%). People fell mainly from 1.1–4 metres(m) level(46.1%). The causes of falls were ordered as unintentional(92.2%), workplace(8.1%) and suicidal(1.7%). Skin and soft tissue injuries(37.4%) were the main traumatic lesions. CONCLUSION: Age, fall height, fall place, linear skull fracture, subarachnoidal hemorrhage, cervical fracture, thoracic vertebra fracture and trauma scores had statistically significant effect on mortality. The casualties died because of subarachnoid hemorrhage mostly. | Kasim Turgut Mehmet Ediz Sarihan Cemil Colak Taner Giiven Ali Gur Sukru Gurbuz | 2018 | World Journal of Emergency Medicine2018，9，1： | 5 |
| 6 | 西地那非能改善慢性肾功能衰竭大鼠的勃起功能显示文摘勃起功能障碍(ED)和慢性肾衰竭(CRF)之间的关系已在几个研究中被报道。本研究旨在探讨长期使用西地那非是否能增强CRF诱导大鼠的勃起能力。此外,我们评估了该治疗对某些分子的影响,这些分子被认为在勃起生理学及CRF相关的ED中起关键作用。研究分三组:(1)年龄配对的对照组,(2)CRF诱导的大鼠模型组,(3)CRF诱导大鼠给予西地那非慢性给药组((5 mg /kg口服6周[CRF诱导后6周开始治疗])。 3个月时,所有的动物进行海绵体神经刺激(CNS)来评估勃起功能。在所有大鼠组进行,阴茎组织晚期糖化终产物(AGE的) / 5-羟甲基-2-糠醛,丙二醛(MDA),cGMP(ELISA),诱导型一氧化氮合酶(iNOS)和神经元型NOS(nNOS的)(Western印迹)分析。CRF诱导大鼠与对照组相比,勃起功能有显著降低(P 〈0.05)。CRF诱导大鼠西地那非治疗组(第3组),海绵体内压(ICP)和曲线下面积的
增加量,大于CRF诱导大鼠组(第2组)。此外,西地那非治疗下调了AGE,MDA和iNOS的水平,同时保持了CRF诱导阴茎组织的nNOS和cGMP含量。西地那非治疗组AGE,MDA,iNOS的下降和nNOS,cGMP水平的增加,增加了ICP和海绵体神经刺激(CNS)的总ICP,使得CRF诱导大鼠阴茎勃起功能得到改善。本研究的结果表明慢性西地那非给药对CRF诱导大鼠的勃起功能有治疗效果。 | Nilgun Gurbuz Arif Kol Tumay Ipekci Erhan Ates Asli Baykal Mustafa F Usta | 2015 | Asian Journal of Andrology2015，17，5： | 3 |
| 7 | Hypogonadism and erectile dysfunction: an overview显示文摘在人,雄激素衰落表现为包括减少的性兴趣的一幅临床的图画,减少的可勃起的 capasity,推迟或不在的高潮和减少的性快乐。另外,在心情,是的减少的井,疲劳,消沉和易怒变化也与雄激素不足被联系。在阴茎的发展,生长,和 maintanence 的雄激素的关键角色广泛地被接受了。尽管,可勃起的生理学上的雄激素的准确效果仍然保持未经决定,最近的试验性的研究有关于在雄激素和可勃起的功能之间的关系拓宽我们的理解。现出症状之前的潜的研究证明雄激素剥夺在阴茎的神经结构导致阴茎织物萎缩和改变。而且,雄激素剥夺引起了到包含房间的脂肪的累积并且减少内皮和神经元的氮的氧化物 synthases (eNOS 和 nNOS ) 的蛋白质表示,和磷酸二酯酶 type-5 (PDE-5 ) ,哪个戏在正常的关键角色可勃起的生理学。在最近的文学的光上,我们试图也在阴茎织物和可勃起的生理学的结构,开发和 maintanence 上介绍雄激素的直接效果。Furhermore,根据临床的研究,我们在使人变老结束原因论,病理生理学, prevalance,诊断和性腺机能减退的治疗选择。 | Nilgun Gurbuz Elnur Mammadov Mustafa Faruk Usta | 2008 | Asian Journal of Andrology2008，10，1： | 3 |
| 8 | Growth efficiency,intestinal biology,and nutrient utilization and requirements of black soldier fly(Hermetia illucens)larvae compared to monogastric livestock species:a review显示文摘In recent years,interest in the larvae of black soldier fly(BSF)(Hermetia illucens)as a sustainable protein resource for livestock feed has increased considerably.However,knowledge on the nutritional and physiological aspects of this insect,especially compared to other conventional farmed animals is scarce.This review presents a critical comparison of data on the growth potential and efficiency of the BSF larvae(BSFL)compared to conventional monogastric livestock species.Advantages of BSFL over other monogastric livestock species includes their high growth rate and their ability to convert low-grade organic waste into high-quality protein and fat-rich biomass suitable for use in animal feed.Calculations using literature data suggest that BSFL are more efficient than broilers,pigs and fish in terms of conversion of substrate protein into body mass,but less efficient than broilers and fish in utilization of substrate gross energy to gain body mass.BSFL growth efficiency varies greatly depending on the nutrient quality of their dietary substrates.This might be associated with the function of their gastrointestinal tract,including the activity of digestive enzymes,the substrate particle characteristics,and their intestinal microbial community.The conceived advantage of BSFL having an environmental footprint better than conventional livestock is only true if BSFL is produced on low-grade organic waste and its protein would directly be used for human consumption.Therefore,their potential role as a new species to better close nutrient cycles in agro-ecological systems needs to be reconsidered,and we conclude that BSFL is a complementary livestock species efficiently utilizing organic waste that cannot be utilized by other livestock.In addition,we provide comparative insight into morpho-functional aspects of the gut,characterization of digestive enzymes,gut microbiota and fiber digestion.Finally,current knowledge on the nutritional utilization and requirements of BSFL in terms of macro-and micronutrients is reviewed and found to be rather limited.In addition,the research methods to determine nutritional requirements of conventional livestock are not applicable for BSFL.Thus,there is a great need for research on the nutrient requirements of BSFL. | Mohammad M.Seyedalmoosavi Manfred Mielenz Teun Veldkamp Gurbuz Das Cornelia C.Metges | 2022 | Journal of Animal Science and Biotechnology2022，13，5： | 2 |
| 9 | Retrograde Intrarenal Surgery for the Treatment of Renal Stones in Patients With a Solitary Kidney显示文摘 | Gokhan Atis Cenk Gurbuz Ozgur Arikan Mert Kilic Sabri Pelit Cengiz Canakci Samet Gungor Turhan Caskurlu | 2013 | Urology2013，，： | 2 |
| 10 | Label-free capacitive biosensor for sensitive detection of multiple biomarkers using gold interdigitated capacitor arrays显示文摘 | Anjum Qureshi Javed H. Niazi Saravan Kallempudi Yasar Gurbuz | 2010 | Biosensors and Bioelectronics2010，，10： | 2 |
| 11 | Protective effect of L-camitine on renal ischaemia - reperfusion injury in the rat 显示文摘 | Sadik G Ozlen TB Gurbuz P | 2005 | Cell Biochem Funct2005，23，3： | 1 |
| 12 | Differentiation of adenomas (lipid rich and lipid poor) from nonadenomas by use of washout characteristics on delayed enhanced CT显示文摘 | Kebapci M Kaya T Gurbuz B | 2003 | Abdominal Imaging2003，28，： | 1 |
| 13 | Coordinated Replenishment Strategies in Inventory/Distribution Systems显示文摘 | Mustafa Cagri Gurbuz Kamran Moinzadeh Yong-Pin Zhou | 2007 | Management Science2007，53，2： | 1 |
| 14 | Wireless model-based predictive networked control system over cooperative wireless network 显示文摘 | Ulusoy A Gurbuz O Onat A | 2011 | IEEE Transactions on Industrial Informatics2011，7，1： | 1 |
| 15 | The elect of c0a second phase particles oll fatigue crack prorton of an Al-Zn-Mg-Cu alloy显示文摘 | Alpay S P Gurbuz R | 1994 | Script Metallursia1994，30，11： | 1 |
| 16 | High local endometrial effect of vaginal progesterone gel显示文摘 | Ficicioglu C Gurbuz B Tasdemir S | 2004 | Gynecol Endocrinol2004，18，5： | 1 |
| 17 | Mixed medullary- papillary carcinoma of the thyroid: Report of two cases and review of the literature 显示文摘 | Gurkan E Gurbuz Y Tarkun I | 2014 | Indian J Pathol Microbi- ol2014，57，4： | 1 |
| 18 | High local endometrial effect of vaginal progesterone gel显示文摘 | Ficicioglu C Gurbuz B Tasdemir S | 2004 | Gynecol Endocrinol2004，18，5： | 1 |
| 19 | Effects of ultrasound on the reaction step of boric acid production process from colemanite显示文摘 | Taylan N Gurbuz H Bulutcu A N | 2007 | Ultrasonics Sonochemistrv2007，14，5： | 1 |
| 20 | An analytical design methodology for microelectromechanical (MEM) filets显示文摘 | Gurbuz Y Parlak M Bechterler T F | 2005 | Sensors and Actuators A2005，119，1： | 1 |
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