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| 1 | Single-cell transcriptomics reveals regulators underlying immune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma显示文摘Nasopharyngeal carcinoma(NPC)is an aggressive malignancy with extremely skewed ethnic and geographic distributions.Increasing evidence indicates that targeting the tumor microenvironment(TME)represents a promising therapeutic approach in NPC,highlighting an urgent need to deepen the understanding of the complex NPC TME.Here,we generated single-cell transcriptome profiles for 7581 malignant cells and 40,285 immune cells from fifteen primary NPC tumors and one normal sample.We revealed malignant signatures capturing intratumoral transcriptional heterogeneity and predicting aggressiveness of malignant cells.Diverse immune cell subtypes were identified,including novel subtypes such as CLEC9A^+dendritic cells(DCs).We further revealed transcriptional regulators underlying immune cell diversity,and cell–cell interaction analyses highlighted promising immunotherapeutic targets in NPC.Moreover,we established the immune subtype-specific signatures,and demonstrated that the signatures of macrophages,plasmacytoid dendritic cells(pDCs),CLEC9A^+DCs,natural killer(NK)cells,and plasma cells were significantly associated with improved survival outcomes in NPC.Taken together,our findings represent a unique resource providing in-depth insights into the cellular heterogeneity of NPC TME and highlight potential biomarkers for anticancer treatment and risk stratification,laying a new foundation for precision therapies in NPC. | Yu-Pei Chen Jian-Hua Yin Wen-Fei Li Han-Jie Li Dong-Ping Chen Cui-Juan Zhang Jia-Wei Lv Ya-Qin Wang Xiao-Min Li Jun-Yan Li Pan-Pan Zhang Ying-Qin Li Qing-Mei He Xiao-Jing Yang Yuan Lei Ling-Long Tang Guan-Qun Zhou Yan-Ping Mao Chen Wei Ke-Xu Xiong Hong-Bo Zhang Shi-Da Zhu Yong Hou Ying Sun Michael Dean Ido Amit Kui Wu Dong-Ming Kuang Gui-Bo Li Na Liu Jun Ma | 2020 | Cell Research2020，30，11： | 19 |
| 2 | Clinical study on the changes of the tumor target volume and organs at risk in helical tomotherapy for nasopharyngeal carcinoma显示文摘背景螺旋状的 tomotherapy ( HT )是学习是在螺旋状的 tomotherapy.Methods 期间与鼻咽的癌( NPC )在病人的风险(浆)在目标体积和机关评估变化的这的一个新指导图象的调制紧张的放射治疗( IMRT ) .The 目的有 NPC 的 43 个病人并且经由 HT 对待从2008年3月是考察 retrospectively.Repeated CT 扫描到2010年1月,计划改编在 radiotherapy.The 期间在 第20 部分被进行容量的 | LU Na FENG Lin-chun CAI Bo-ning HOU Jun WANG Yun-lai XIE Chuan-bin | 2012 | Chinese Medical Journal2012，，1： | 18 |
| 3 | Spatiotemporal variability of precipitation during 1961-2014 across the Mongolian Plateau显示文摘Precipitation is the dominant factor that controls vegetation growth and land-use practices in the arid and semiarid Mongolian Plateau(MP), so the spatiotemporal heterogeneity of precipitation change has been an important scientific question in the region. This study investigated the spatiotemporal characteristics of annual and seasonal precipitation across the entire MP based on monthly precipitation data from 136 meteorological stations during 1961–2014 by using a modified Mann–Kendall test, Sen's slope, Morlet Wavelet Transform, and geostatistical methods. Results show the following: 1) Annual precipitation decreased slightly from 1961 to 2014.Stations with positive and negative trends were 41.9%and 58.1%, respectively. Significant positive trends were mainly in the southwestern and northeastern regions of the plateau, whereas significant negative trends were in the northern and southeastern regions.2) Precipitation decreased at rates of-5.65 and-0.41 mm/decade in summer and autumn, respectively, but increased at 1.91 and 0.51 mm/decade in spring and winter. The contribution of spring and winter precipitation to the annual amount increased significantly, but that of summer precipitation decreased significantly. 3) A large majority of stations(80.2%) showed decreasing trends in summer,whereas 89.7% and 83.1% of stations showed increasing trends in spring and winter. The spatial distribution of trend magnitude in seasonal precipitation amount was strongly heterogeneous. 4)By climatic zones, precipitation increased in humid and arid zones, but decreased in a semiarid zone. On the whole, the MP experienced a drying trend, with significant regional differentiation and seasonal variations. | QIN Fu-ying JIA Gen-suo YANG Jie NA Yin-tai HOU Mei-ting Narenmandula | 2018 | Journal of Mountain Science2018，15，5： | 10 |
| 4 | Characterization and allergic role of IL-33-induced neutrophil polarization显示文摘Neutrophils are involved in the pathogenesis of allergy.However,the contribution of the different functionally polarized neutrophils in allergy needs to be clarified.We sought to define the characteristics of interleukin(IL)-33-induced neutrophils and the involvement of this subset of polarized neutrophils in allergic pathogenesis.Freshly isolated neutrophils were treated with different cytokines and the cytokine expression levels were detected by realtime PCR.The gene expression profile of IL-33-induced neutrophils was determined by microarray assay.Adoptive transfer assay was used to investigate the function of IL-33-induced neutrophils in an ovalbumin(OVA)-induced allergic asthma model.IL-33-treated neutrophils selectively produced IL-4,IL-5,IL-9 and IL-13(referred as to N(IL-33)cells)and displayed a distinctive gene expression profile in sharp contrast to resting and lipopolysaccharide(LPS)-treated neutrophils.IL-33-induced neutrophils expressed high Levels of IL-1R2 on cell surface,whereas resting and LPS-treated neutrophils did not,indicating IL-1R2 might be used as a biomarker for N(IL-33)cells.Importantly,N(IL-33)neutrophils exist in the lungs of OVA-induced allergic asthma mice.Adoptive transfer of N(IL-33)neutrophils significantly promotes the severity of the lung pathogenesis in this model.IL-33 induces neutrophil polarization through c-Jun N-terminal kinase-and nuclear factor-κB-dependent pathways.A previously unappreciated neutrophil polarization driven by IL-33 with unique cell surface markers and cytokine/chemokineproducing gene profile was defined.The newly identified N(IL-33)subpopulation may have significant contribution to IL-33-related pathogenesis. | Bo Sun Linnan Zhu Yaling Tao Hai-Xi Sun Yang Li Peng Wang Yuzhu Hou Yang Zhao Xiaodong Zhang Lianfeng Zhang Ning Na Yong Zhao | 2018 | Cellular & Molecular Immunology2018，15，8： | 9 |
| 5 | Identifying Metabolite and Protein Biomarkers in Unstable Angina In-patients by Feature Selection Based Data Mining Method显示文摘Unstable angina(UA) is the most dangerous type of Coronary Heart Disease(CHD) to cause more and more mortal and morbid world wide. Identification of biomarkers for UA at the level of proteomics and metabolomics is a better avenue to understand the inner mechanism of it. Feature selection based data mining method is better suited to identify biomarkers of UA. In this study, we carried out clinical epidemiology to collect plasmas of UA in-patients and controls. Proteomics and metabolomics data were obtained via two-dimensional difference gel electrophoresis and gas chromatography techniques. We presented a novel computational strategy to select biomarkers as few as possible for UA in the two groups of data. Firstly, decision tree was used to select biomarkers for UA and 3-fold cross validation was used to evaluate computational performances for the three methods. Alternatively, we combined independent t test and classification based data mining method as well as backward elimination technique to select, as few as possible, protein and metabolite biomarkers with best classification performances. By the method, we selected 6 proteins and 5 metabolites for UA. The novel method presented here provides a better insight into the pathology of a disease. | SHI Cheng-he ZHAO Hui-hui HOU Na CHEN Jian-xin SHI Qi XU Xue-gong WANG Juan ZHENG Cheng-long ZHAO Ling-yan YANG Yi WANG Wei | 2011 | Chemical Research in Chinese Universities2011，27，1： | 8 |
| 6 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 7 | Pneumonia relevant to lung transplantation and pathogen distribution显示文摘 | HE Xuan DAI Hua-ping CHEN Qi-rui MIAO Jin-bai SUN Bing BAO Na HU Bin LI Hui WU An-shi BAN Cheng-jun GE Su-juan WANG Chen HOU Sheng-cai | 2013 | Chinese Medical Journal2013，，17： | 7 |
| 8 | Chemoprophylaxis, diagnosis, treatments, and discharge management of COVID-19: An evidence-based clinical practice guideline(updated version)显示文摘The novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the cause of a rapidly spreading illness,coronavirus disease 2019(COVID-19),affecting more than seventeen million people around the world.Diagnosis and treatment guidelines for clinicians caring for patients are needed.In the early stage,we have issued'A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV)infected pneumonia(standard version)';now there are many direct evidences emerged and may change some of previous recommendations and it is ripe for develop an evidence-based guideline.We formed a working group of clinical experts and methodologists.The steering group members proposed 29 questions that are relevant to the management of COVID-19 covering the following areas:chemoprophylaxis,diagnosis,treatments,and discharge management.We searched the literature for direct evidence on the management of COVID-19,and assessed its certainty generated recommendations using the Grading of Recommendations,Assessment,Development and Evaluation(GRADE)approach.Recommendations were either strong or weak,or in the form of ungraded consensus-based statement.Finally,we issued 34 statements.Among them,6 were strong recommendations for,14 were weak recommendations for,3 were weak recommendations against and 11 were ungraded consensus-based statement.They covered topics of chemoprophylaxis(including agents and Traditional Chinese Medicine(TCM)agents),diagnosis(including clinical manifestations,reverse transcription-polymerase chain reaction(RT-PCR),respiratory tract specimens,IgM and IgG antibody tests,chest computed tomography,chest X-ray,and CT features of asymptomatic infections),treatments(including lopinavirritonavir,umifenovir,favipiravir,interferon,remdesivir,combination of antiviral drugs,hydroxychloroquine/chloroquine,interleukin-6 inhibitors,interleukin-1 inhibitors,glucocorticoid,qingfei paidu decoction,lianhua qingwen granules/capsules,convalescent plasma,lung transplantation,invasive or noninvasive ventilation,and extracorporeal membrane oxygenation(ECMO)),and discharge management(including discharge criteria and management plan in patients whose RT-PCR retesting shows SARS-CoV-2 positive after discharge).We also created two figures of these recommendations for the implementation purpose.We hope these recommendations can help support healthcare workers caring for COVID-19 patients. | Ying-Hui Jin Qing-Yuan Zhan Zhi-Yong Peng Xue-Qun Ren Xun-Tao Yin Lin Cai Yu-Feng Yuan Ji-Rong Yue Xiao-Chun Zhang Qi-Wen Yang Jianguang Ji Jian Xia Yi-Rong Li Fu-Xiang Zhou Ya-Dong Gao Zhui Yu Feng Xu Ming-Li Tu Li-Ming Tan Min Yang Fang Chen Xiao-Ju Zhang Mei Zeng Yu Zhu Xin-Can Liu Jian Yang Dong-Chi Zhao Yu-Feng Ding Ning Hou Fu-Bing Wang Hao Chen Yong-Gang Zhang Wei Li Wen Chen Yue-Xian Shi Xiu-Zhi Yang Xue-Jun Wang Yan-Jun Zhong Ming-Juan Zhao Bing-Hui Li Lin-Lu Ma Hao Zi Na Wang Yun-Yun Wang Shao-Fu Yu Lu-Yao Li Qiao Huang Hong Weng Xiang-Ying Ren Li-Sha Luo Man-Ru Fan Di Huang Hong-Yang Xue Lin-Xin Yu Jin-Ping Gao Tong Deng Xian-Tao Zeng Hong-Jun Li Zhen-Shun Cheng Xiao-Mei Yao Xing-Huan Wang | 2020 | Military Medical Research2020，7，3： | 6 |
| 9 | Two New Oleanene-Type Triterpenoid Saponins from Pueraria peduncularis显示文摘From the radix of Pueraria peduncularis Grab., two new oleanene-type triterpenoid saponins named pedunsaponins B (2) and C (3) were isolated. Their structures were determined as 3-O-(6-O-methyl)-β-D-glucuronopyranosyl -3β.15a-diol-12-oleanene-16-one (2) and 3-O-β- Dglucopyranosyl-(1 -3)-β-D-glucuronopyranosyl-3β. 15a-diol- 12-oleancne- 16-one (3) on the basis of spectroscopic evidence and chemical reactions. | Na Ll~1 Zhi Da MIN~1 Hou Ming WU~2 (1 Department of Natural Products Chemistry, China Pharmaceutical University, Nanjing 210009 2 State Key.Laboratory of Bio-organic and Natural Products Chemistry. Shanghai Institute of Organic Chemistry. Chinese Academy | 2000 | Chinese Chemical Letters2000，11，4： | 5 |
| 10 | Kinetics of serum HBsAg in Chinese patients with chronic HBV infection with long-term adefovir dipivoxil treatment显示文摘 | Li Minran Xi Hongli Wang Qinhuan Hou Fengqin Huo Na Zhang Xiaxia Li Fang Xu Xiaoyuan | 2014 | Chinese Medical Journal2014，，11： | 5 |
| 11 | 铜离子改性的凹凸棒石粘土在预防和治疗由沙门氏菌引起的腹泻中的应用(英文)显示文摘目的:研究开发一种抗生素替代品,应用于动物细菌性腹泻病的治疗。创新点:将凹凸棒石的吸附作用、肠道粘膜保护作用和铜离子的杀菌作用巧妙的结合在一起,能够替代抗生素,在动物细菌性腹泻的预防和治疗中发挥作用。方法:用硝酸铜和凹凸棒石粘土(Pal)制备铜离子改性的凹凸棒石粘土(CM-Pal)。通过比较添加CM-Pal前后沙门氏菌数量的变化检测抗菌活性。体内试验,将70只小鼠分为7组,其中5组感染沙门氏菌后分别给予Pal、CM-Pal、蒙脱石散、庆大霉素和生理盐水;1组在感染沙门氏菌之前给予CM-Pal,作为预防组;1组不感染沙门氏菌,作为未感染组。通过粪便形态、粪便计分、生长性能和肠绒毛高度等指标判断对沙门氏菌引起的小鼠腹泻的预防和治疗效果。结论:体外抑菌试验显示,CM-Pal与沙门氏菌作用2 h后抗菌率达100%。体内试验也显示,CM-Pal组小鼠24 h后腹泻症状消失,所有小鼠恢复正常。但是其他组小鼠(Pal组、蒙脱石散组和庆大霉素组)分别在48、48和96 h后才恢复正常。CM-Pal治疗组小鼠肠绒毛的高度在感染3 d后恢复正常,但是其他组小鼠肠绒毛高度恢复正常至少需要5 d。CM-Pal预防组小鼠增重高于其他组小鼠。本研究表明,CM-Pal在预防和治疗由沙门氏菌引起的腹泻方面能够替代抗生素具有较好的效果。 | Da-wei YAO Ze-zhong YU Na LI Yu-nong HOU Jia-rong XU De-ji YANG | 2017 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2017，18，6： | 4 |
| 12 | Tick-borne Pathogens in Shanxi Province, China显示文摘Ticks are recognized as one of the most important vectors that cause diseases in animals and humans,and have significant public health impacts worldwide[1].They have a wide range of hosts among terrestrial vertebrates,including mammals,birds,amphibians.The numerous zoonotic pathogens transmitted by ticks are the causative agents of Lyme disease,rickettsiosis,ehrlichioses,relapsing fever,Q fever,and tularemia.Cases of tick-borne diseases are increasing around the world and some emerging or re-emerging pathogens are being discovered,which pose great challenges for prevention and control. | YANG Xiao Na YANG Hui Jun ZHANG Lin HOU Xue Xia MIAO Guang Qing CAO Hong Bing HAO Rui E HAO Qin | 2021 | Biomedical and Environmental Sciences2021，34，5： | 4 |
| 13 | The FAST Galactic Plane Pulsar Snapshot survey:I.Project design and pulsar discoveries显示文摘Discovery of pulsars is one of the main goals for large radio telescopes.The Five-hundredmeter Aperture Spherical radio Telescope(FAST),that incorporates an L-band 19-beam receiver with a system temperature of about 20 K,is the most sensitive radio telescope utilized for discovering pulsars.We designed the snapshot observation mode for a FAST key science project,the Galactic Plane Pulsar Snapshot(GPPS)survey,in which every four nearby pointings can observe a cover of a sky patch of 0.1575 square degrees through beam-switching of the L-band 19-beam receiver.The integration time for each pointing is 300 seconds so that the GPPS observations for a cover can be made in 21 minutes.The goal of the GPPS survey is to discover pulsars within the Galactic latitude of±10∘from the Galactic plane,and the highest priority is given to the inner Galaxy within±5∘.Up to now,the GPPS survey has discovered 201 pulsars,including currently the faintest pulsars which cannot be detected by other telescopes,pulsars with extremely high dispersion measures(DMs)which challenge the currently widely used models for the Galactic electron density distribution,pulsars coincident with supernova remnants,40 millisecond pulsars,16 binary pulsars,some nulling and mode-changing pulsars and rotating radio transients(RRATs).The follow-up observations for confirmation of new pulsars have polarization-signals recorded for polarization profiles of the pulsars.Re-detection of previously known pulsars in the survey data also leads to significant improvements in parameters for 64 pulsars.The GPPS survey discoveries are published and will be updated at http://zmtt.bao.ac.cn/GPPS/. | J.L.Han Chen Wang P.F.Wang Tao Wang D.J.Zhou Jing-Hai Sun Yi Yan Wei-Qi Su Wei-Cong Jing Xue Chen X.Y.Gao Li-Gang Hou Jun Xu K.J.Lee Na Wang Peng Jiang Ren-Xin Xu Jun Yan Heng-Qian Gan Xin Guan Wen-Jun Huang Jin-Chen Jiang Hui Li Yun-Peng Men Chun Sun Bo-Jun Wang H.G.Wang Shuang-Qiang Wang Jin-Tao Xie Heng Xu Rui Yao Xiao-Peng You D.J.Yu Jian-Ping Yuan Rai Yuen Chun-Feng Zhang Yan Zhu | 2021 | Research in Astronomy and Astrophysics2021，21，5： | 4 |
| 14 | Endoplasmic reticulum stress contributed to β1-adrenoceptor autoantibody-induced reduction of autophagy in cardiomyocytes显示文摘Autophagy reduction has been confirm ed as an im portant mechanism in apoptosis induction.Our previous study showed that decreased autophagy induced by Pi-adrenoceptor autoantibodies(Pi-AAs)enhanced cardiom yocyte apoptosis and contributed to heart failure progression.Endoplasmic reticulum stress(ERS)is known to be an im portant mechanism in intracellular homeostasis and is closely related to autophagy.However,ERS in pi-AA-induced autophagy dysfunction of cardiom yocytes remains unclear.In this study,we used an active im m unization rat model and H9c2 cardiom yocytes to study the role of ERS in Pi-AA-induced autophagy.Results showed that prolonged action of Pi-AAs significantly reduced the autophagy of myocardial tissues and H9c2 cardiom yocytes,and ERS and its related apoptotic pathways were significantly activated.Moreover,mRFP-GFP-LC3 double-labeled adenoviruses were used to detect cardiom yocyte autophagic flux to confirm that Pi-AAs caused a significant decrease in autophagic flux in H9c2 cardiom yocytes.The ERS inhibitor,4-phenylbutyrate(4-PBA),partially attenuated the β1-AA-induced reduction of cardiom yocyte autophagy,consistent w ith the effect of the m am m alian target of rapam ycin inh ibito r rapamycin(Rapa).Compared to the pretreatm ent with 4-PBA or Rapa alone,pretreatm ent w ith the com bination of 4-PBA and Rapa had a greater effect on attenuating the pi-AA-induced decrease in autophagy and Pi-AA-induced apoptosis in cardiomyocytes.This study provides an experim ental basis fo r the role of Pi-AAs in the homeostatic maintenance of cardiom yocytes in patients w ith heart failure w ith respect to autophagy and ERS. | Li Wang Na Ning Changtu Wang Xiaohong Hou Yuan Yuan Yanan Ren Cong Sun Zi Yan Xiaohui Wang Huirong Liu | 2019 | Acta Biochimica et Biophysica Sinica2019，51，10： | 3 |
| 15 | Cardiac differentiation and electrophysiology characteristics of bone marrow mesenchymal stem cells显示文摘 | LIU Bo-wu LU An-lin HOU Jing HUANG Wei LI Yao HOU Zhao-lei HOU Hong DA Jing YANG Na Al Shi-yi | 2012 | Chinese Medical Journal2012，，18： | 3 |
| 16 | Long-term clinical observation of patients with acute and chronic complete spinal cord injury after transplantation of Neuro Regen scaffold显示文摘Spinal cord injury(SCI)often results in an inhibitory environment at the injury site.In our previous studies,transplantation of a scaffold combined with stem cells was proven to induce neural regeneration in animal models of complete SCI.Based on these preclinical studies,collagen scaffolds loaded with the patients’own bone marrow mononuclear cells or human umbilical cord mesenchymal stem cells were transplanted into SCI patients.Fifteen patients with acute complete SCI and 51 patients with chronic complete SCI were enrolled and followed up for 2 to 5 years.No serious adverse events related to functional scaffold transplantation were observed.Among the patients with acute SCI,five patients achieved expansion of their sensory positions and six patients recovered sensation in the bowel or bladder.Additionally,four patients regained voluntary walking ability accompanied by reconnection of neural signal transduction.Among patients with chronic SCI,16 patients achieved expansion of their sensation level and 30 patients experienced enhanced reflexive defecation sensation or increased skin sweating below the injury site.Nearly half of the patients with chronic cervical SCI developed enhanced finger activity.These long-term follow-up results suggest that functional scaffold transplantation may represent a feasible treatment for patients with complete SCI. | Fengwu Tang Jiaguang Tang Yannan Zhao Jiaojiao Zhang Zhifeng Xiao Bing Chen Guang Han Na Yin Xianfeng Jiang Changyu Zhao Shixiang Cheng Ziqiang Wang Yumei Chen Qiaoling Chen Keran Song Zhiwei Zhang Junjie Niu Lingjun Wang Qin Shi Liang Chen Huilin Yang Shuxun Hou Sai Zhang Jianwu Dai | 2022 | Science China(Life Sciences)2022，65，5： | 3 |
| 17 | Novel insight into perirenal adipose tissue: A neglected adipose depot linking cardiovascular and chronic kidney disease显示文摘Obesity is associated with adverse metabolic diseases including cardiovascular disease(CVD) and chronic kidney disease(CKD).These obesity-related diseases are highly associated with excess fat accumulation in adipose tissue.However,emerging evidence indicates that visceral adiposity associates more with metabolic and cardiovascular risk factors.Perirenal adipose tissue,surrounding the kidney,is originally thought to provides only mechanical support for kidney.However,more studies demonstrated perirenal adipose tissue have a closer association with renal disease than other visceral fat deposits in obesity.Additionally,perirenal adipose tissue is also an independent risk factor for CKD and even associated more with CVD.Thus,perirenal adipose tissue may be a connection of CVD with CKD.Here,we will provide an overview of the perirenal adipose tissue,a neglected visceral adipose tissue,and the roles of perirenal adipose tissue linking with CVD and CKD and highlight the perirenal adipose tissue as a potential strategy for future therapeutics against obesity-related disease. | Na Huang En-Wen Mao Ning-Ning Hou Yong-Ping Liu Fang Han Xiao-Dong Sun | 2020 | World Journal of Diabetes2020，11，4： | 3 |
| 18 | Association between Coronary Atherosclerotic Plaque Composition and Cardiovascular Disease Risk显示文摘Objective The objective of this study is to determine whether coronary atherosclerotic plaque composition is associated with cardiovascular disease(CVD) risk in Chinese adults. Methods We performed a cross-sectional analysis in 549 subjects without previous diagnosis or clinical symptoms of CVD in a community cohort of middle-aged Chinese adults. The participants underwent coronary computed tomography(CT) angiography for the evaluation of the presence and composition of coronary plaques. CVD risk was evaluated by the Framingham risk score(FRS) and the 10-year atherosclerotic cardiovascular disease(ASCVD) risk score. Results Among the 549 participants, 267(48.6%) had no coronary plaques, 201(36.6%) had noncalcified coronary plaques, and 81(14.8%) had calcified or mixed coronary plaques. The measures of CVD risk including FRS and ASCVD risk score and the likelihood of having elevated FRS significantly increased across the groups of participants without coronary plaques, with noncalcified coronary plaques, and with calcified or mixed coronary plaques. However, only calcified or mixed coronary plaques were significantly associated with an elevated ASCVD risk score [odds ratio(OR) 2.41; 95% confidence interval(CI) 1.09-5.32] compared with no coronary plaques, whereas no significant association was found for noncalcified coronary plaques and elevated ASCVD risk score(OR 1.25; 95% CI 0.71-2.21) after multivariable adjustment. Conclusion Calcified or mixed coronary plaques might be more associated with an elevated likelihood of having CVD than noncalcified coronary plaques. | LI Lin WANG Long LIU Shan Shan ZHAO Zhi Yun LI Mian WANG Tian Ge XU Min LU Jie Li CHEN Yu Hong WANG Shuang Yuan DAI Meng HOU Ya Nan WU Xue Yan MA Li Na WANG Wei Qing XU Yu BI Yu Fang | 2019 | Biomedical and Environmental Sciences2019，32，2： | 3 |
| 19 | One inorganic–organic hybrid derived from reduced molybdophosphate and trinuclear cadmium(II) fragment显示文摘One new polyoxometalate(POM)-based inorganic–organic hybrid [CdII3(HPO4)(Hbpp)(H2O)2]{CdII[P4-Mo6O28H3.5(OH)3]2}(H4tpb) 7H2O(1)(bpp = 1,3-bis-(4-pyridyl)propane, tpb = 1,2,4,5-tetra(4-pyridyl)-benzene) constructed from reduced molybdophosphate [P4Mo6O28H3.5(OH)3]5.5(P4Mo6), trinuclear CdII-phosphate-Hbpp fragment and protonated tpb has been hydrothermally synthesized and structurally characterized by IR, elemental analyses and single crystal X-ray diffraction. The complex1 crystallizes in the monoclinic system with the space group P21/c and cell parameters of a = 15.672(12), b = 23.839(19), c = 27.654(2), b = 115.850(10)8, V = 9297.9(12) 3, Z = 4,R1= 0.0534 and wR2= 0.1135. In complex 1, the P4Mo6units are bridged by CdIIions to form the classic sandwich-type [Cd(P4Mo6)2] dimers, which are further connected into a two dimensional network via the trinuclear CdIIsubunits. The tpb is synthesized in situ from the bpp ligands and connects the adjacent 2D layers into a 3D supramolecular framework through hydrogen bonding interactions. The electrochemical and fluorescent properties of complex 1 have been investigated. | Xiu-Li Wang Jing-Jing Cao Ji-Lin Hou Guo-Cheng Liu Dan Zhao Xiao-Jing Liu Na Li Ai-Xiang Tian | 2013 | Chinese Chemical Letters2013，24，10： | 2 |
| 20 | Electrochemical Lithium Storage Performance of Molten Salt Derived V_(2)SnC MAX Phase显示文摘MAX phases are gaining attention as precursors of two-dimensional MXenes that are intensively pursued in applications for electrochemical energy storage.Here,we report the preparation of V_(2)SnC MAX phase by the molten salt method.V_(2)SnC is investigated as a lithium storage anode,showing a high gravimetric capacity of 490 mAh g−1 and volumetric capacity of 570 mAh cm^(−3) as well as superior rate performance of 95 mAh g^(−1)(110 mAh cm^(−3))at 50 C,surpassing the ever-reported performance of MAX phase anodes.Sup-ported by operando X-ray diffraction and density functional theory,a charge storage mechanism with dual redox reaction is proposed with a Sn-Li(de)alloying reaction that occurs at the edge sites of V_(2)SnC particles where Sn atoms are exposed to the electrolyte followed by a redox reaction that occurs at V_(2)C layers with Li.This study offers promise of using MAX phases with M-site and A-site elements that are redox active as high-rate lithium storage materials. | Youbing Li Guoliang Ma Hui Shao Peng Xiao Jun Lu Jin Xu Jinrong Hou Ke Chen Xiao Zhang Mian Li Per OÅPersson Lars Hultman Per Eklund Shiyu Du Zhifang Chai Zhengren Huang Na Jin Jiwei Ma Ying Liu Zifeng Lin Qing Huang | 2021 | Nano-Micro Letters2021，13，10： | 2 |
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