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| 1 | Molecular mechanism about lymphogenous metastasis of hepatocarcinoma cells in mice显示文摘AIM To investigate the correlation between lymphogenous metastasis and matrix metalloproteinases (MMPs) activity and the expression of Fas Iigand of tumor cells in lymph nodes.METHODES Fifty-six inbred 615-mice were equally divided into 2 groups and inoculated with Hca-F and Hca-P cells. Their lymph node metastatic rates were examined.Growth fraction of lymphocytes in host lymph nodes was detected by flow cytometry. The Hca-F and Hca-P cells were cultured with extract of lymph node, liver or spleen.The quantity of MMPs in these supernatants was examined by zymographic analysis. The expression of Fas ligand,PCNA, Bcl-2 protein of Hca-F and Hca-P cells in the mice were examined by immunohistochemistry. The apoptosis signals of macrophages in lymph nodes were observed with in situ DNA fragmentation.RESULTS On the 28th day post-inoculation, the lymph node metastatic rate of Hca-F was 80% (16/20), whereas that of Hca-P was 25% (5/20). The growth fraction of lymphocytes was as follows: in the Hca-F cells, the proliferating peak of lymphocytes appeared on the 14th day post-inoculation and then decreased rapidly, while in HcaP cells, the peak appeared on the 7th day post-inoculation and then kept at a high level. With the extract of lymph node, the quantity of the MMP-9 activity increased (P<0.01) and active MMP-9 and MMP-2 were produced by both Hca-F and Hca-P tumor cells, which did not produce MMPs without the extract of lymph node or with the extracts of the liver and spleen. The expression of Fas Ligand of Hca-F cells was stronger than that of Hca-P cells (P<0.01). The expressions of PCNA and Bcl-2 protein of Hca-F cells in the tumors of inoculated area were the same as that of Hca-P cells. In situ DNA fragmentation showed that the positive signals of macrophages were around HcaF cells.CONCLUSION Secretion of MMPs which was associated with metastatic ability of Hca-F and Hca-P tumor cells depends on the environment of lymph nodes. The increased expression of Fas ligand protein of Hca-F tumor cells with high lymphogenous metastatic potential in lymph nodes may help tumor cells escape from being killed by host lymphocytes. | Li Hou Ying Li Yong-Hua Jia Bo Wang Yi Xin Mao-Ying Ling Shen Lü Department of Pathology,Dalian Medical University,Dalian 116027,Liaoning Province,ChinaDepartment of Biochemistry,Dalian Medical University,Dalian 116027,Liaoning Province,China | 2001 | World Journal of Gastroenterology2001，7，4： | 47 |
| 2 | Bovine lactoferrin improves bone mass and micro-structure in ovariectomized rats via OPG/RANKL/RANK pathway显示文摘目的: Lactoferrin (LF ) , 80-kDa 铁绑定 glycoprotein,一个多种的因素在初乳,牛奶,口水和外分泌腺的上皮的房间被发现。这研究的目的是在 ovariectomized (Ovx ) 在骨头上评估 LF 的效果老鼠并且识别调停的小径骨头上的 LF 的 anabolism 的行动。 | Jian-ming HOU Ying XUE Qing-ming LIN | 2012 | Acta Pharmacologica Sinica2012，33，10： | 27 |
| 3 | Chemerin and apelin are positively correlated with inflammation in obese type 2 diabetic patients显示文摘 | YU Shan ZHANG Ying LI Mei-zhen XU Hua WANG Qian SONG Jun LIN Peng ZHANG Li LIU Qian HUANG Qing-xian WANG Kun HOU Wei-kai | 2012 | Chinese Medical Journal2012，，19： | 27 |
| 4 | Comprehensive Treatment with Chinese Medicine in Patients with Advanced Non-Small Cell Lung Cancer: A Multicenter, Prospective, Cohort Study显示文摘Objective: To determine whether additional Chinese medicine(CM) could prolong survival and improve the quality of life(QOL) in patients with advanced non-small cell lung cancer(NSCLC) compared with Western medicine(WM) alone. Methods: This was a multicenter, prospective cohort study. A total of 474 hospitalized patients with stage Ⅲ–Ⅳ NSCLC were recruited and divided into 2 groups. Patients in the WM group received radiotherapy, chemotherapy, and optimal supportive therapy according to the National Comprehensive Cancer Network(NCCN) guidelines. In the integrative medicine(IM) group, individualized CM(Chinese patent medicines and injections) and WM were administered. The primary end point was overall survival, and the secondary end points were time to disease progression, adverse events, and QOL. Follow-up clinical examinations and chest radiography were performed every 2 months. Results: The median survival was 16.60 months in the IM group and 13.13 months in the WM group(P<0.01). The incidences of loss of appetite, nausea, and vomiting in the IM group were significantly lower than those in the WM group(P<0.05). The QOL based on Functional Assessment of Cancer Therapy-Lung in the IM group was markedly higher than that in the WM group at the fourth course(P<0.05). Conclusions: Additional CM may prolong survival and improve the QOL patients with NSCLC. The adverse effects of radio-and chemotherapy may be attenuated as CM is used in combination with conventional treatments. | LIU Jie LIN Hong-sheng HOU Wei HUA Bao-jin ZHANG Pei-tong LI Jie WANG Shen-yu XIE Ying ZHANG Yue XIE Guang-ru ZHANG Mei-ying SHI Wen-guang GUAN Nian-bo GUAN Tian-yu LI Cong-huang LU Li-yuan ZHANG Ying LI Dao-rui LIU Hao | 2017 | Chinese Journal of Integrative Medicine2017，23，10： | 22 |
| 5 | Quality Markers of Traditional Chinese Medicine:Concept,Progress,and Perspective显示文摘As the most important complementary medication against a variety of diseases,traditional Chinese medicines(TCMs)have been extensively applied over thousands of years.Current quality control of herbal medicines,however,is in great dispute.Unlike chemical drugs,which have clear and validated quality standards,the content of only one(or a few)compounds of many herbs and preparations is currently assessed as an indicator of quality,even though the assessed compound(s)is neither closely associated with the efficacy nor representative of the medicine as a whole.Based on the clinical use,compatibility of multiple component prescriptions,and manufacturing process of TCM,the new concept of a TCM quality marker that was proposed in previous work is discussed further here.In addition,practical technological approaches are described for the qualitative analysis and quantification of TCMs including herbs,processed products,and preparations,which lead to the discovery and identification of specific chemicals as quality markers and new quality control patterns.The progress that has been made in TCM quality control is also addressed.This work provides useful information for the quality control of herbal medicines in the future. | Yazhuo Li Ying Xie Yufei He Wenbin Hou Maoliang Liao Changxiao Liu | 2019 | Engineering2019，5，5： | 22 |
| 6 | Blockade of Tim-3 Pathway Ameliorates Interferon-γ Production from Hepatic CD8^+ T Cells in a Mouse Model of Hepatitis B Virus Infection显示文摘T cell immunoglobulin-and mucin-domain-containing molecule-3(Tim-3) has been reported to participate in the pathogenesis of inflammatory diseases. However,whether Tim-3 is involved in hepatitis B virus(HBV) infection remains unknown. Here,we studied the expression and function of Tim-3 in a hydrodynamics-based mouse model of HBV infection. A significant increase of Tim-3 expression on hepatic T lymphocytes,especially on CD8+ T cells,was demonstrated in HBV model mice from day 7 to day 18. After Tim-3 knockdown by specific shRNAs,significantly increased IFN-γ production from hepatic CD8+ T cells in HBV model mice was observed. Very interestingly,we found Tim-3 expression on CD8+ T cells was higher in HBV model mice with higher serum anti-HBs production. Moreover,Tim-3 knockdown influenced anti-HBs production in vivo. Collectively,our data suggested that Tim-3 might act as a potent regulator of antiviral T-cell responses in HBV infection. | Ying Ju Nan Hou Xiaoning Zhang Di Zhao Ying Liu Jinjin Wang Fang Luan Wei Shi Faliang Zhu Wensheng Sun Lining Zhang Chengjiang Gao Lifen Gao Xiaohong Liang Chunhong Ma | 2009 | Cellular & Molecular Immunology2009，6，1： | 19 |
| 7 | Single-cell transcriptomics reveals regulators underlying immune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma显示文摘Nasopharyngeal carcinoma(NPC)is an aggressive malignancy with extremely skewed ethnic and geographic distributions.Increasing evidence indicates that targeting the tumor microenvironment(TME)represents a promising therapeutic approach in NPC,highlighting an urgent need to deepen the understanding of the complex NPC TME.Here,we generated single-cell transcriptome profiles for 7581 malignant cells and 40,285 immune cells from fifteen primary NPC tumors and one normal sample.We revealed malignant signatures capturing intratumoral transcriptional heterogeneity and predicting aggressiveness of malignant cells.Diverse immune cell subtypes were identified,including novel subtypes such as CLEC9A^+dendritic cells(DCs).We further revealed transcriptional regulators underlying immune cell diversity,and cell–cell interaction analyses highlighted promising immunotherapeutic targets in NPC.Moreover,we established the immune subtype-specific signatures,and demonstrated that the signatures of macrophages,plasmacytoid dendritic cells(pDCs),CLEC9A^+DCs,natural killer(NK)cells,and plasma cells were significantly associated with improved survival outcomes in NPC.Taken together,our findings represent a unique resource providing in-depth insights into the cellular heterogeneity of NPC TME and highlight potential biomarkers for anticancer treatment and risk stratification,laying a new foundation for precision therapies in NPC. | Yu-Pei Chen Jian-Hua Yin Wen-Fei Li Han-Jie Li Dong-Ping Chen Cui-Juan Zhang Jia-Wei Lv Ya-Qin Wang Xiao-Min Li Jun-Yan Li Pan-Pan Zhang Ying-Qin Li Qing-Mei He Xiao-Jing Yang Yuan Lei Ling-Long Tang Guan-Qun Zhou Yan-Ping Mao Chen Wei Ke-Xu Xiong Hong-Bo Zhang Shi-Da Zhu Yong Hou Ying Sun Michael Dean Ido Amit Kui Wu Dong-Ming Kuang Gui-Bo Li Na Liu Jun Ma | 2020 | Cell Research2020，30，11： | 19 |
| 8 | Agriculture Green Development: a model for China and the world显示文摘Realizing sustainable development has become a global priority.This holds,in particular,for agriculture.Recently,the United Nations launched the Sustainable Development Goals(SDGs),and the Nineteenth National People’s Congress has delivered a national strategy for sustainable development in China—realizing green development.The overall objective of Agriculture Green Development(AGD)is to coordinate'green'with'development'to realize the transformation of current agriculture with high resource consumption and high environmental costs into a green agriculture and countryside with high productivity,high resource use efficiency and low environmental impact.This is a formidable task,requiring joint efforts of government,farmers,industry,educators and researchers.The innovative concept for AGD will focus on reconstructing the whole crop-animal production and food production-consumption system,with the emphasis on high thresholds for environmental standards and food quality as well as enhanced human well-being.This paper addresses the significance,challenges,framework,pathways and potential solutions for realizing AGD in China,and highlights the potential changes that will lead to a more sustainable agriculture in the future.Proposals include interdisciplinary innovations,whole food chain improvement and regional solutions.The implementation of AGD in China will provide important implications for the countries in developmental transition,and contribute to global sustainable development. | Jianbo SHEN Qichao ZHU Xiaoqiang JIAO Hao YING Hongliang WANG Xin WEN Wen XU Tingyu LI Wenfeng CONG Xuejun LIU Yong HOU Zhenling CUI Oene OENEMA William JDAVIES Fusuo ZHANG | 2020 | Frontiers of Agricultural Science and Engineering2020，7，1： | 18 |
| 9 | The critical role of CD133*CD44+/high tumor cells in hematogenous metastasis of liver cancers显示文摘变形 hepatocellular 癌(HCC ) 是世界范围的最致命的癌症之一。然而,为它的转移负责的房间人口仍然保持大部分未知。这里,我们报导了那 CD133 + CD44 +/high 定义为肝癌症的造血的转移负责的肿瘤房间的亚群。人的 HCC 标本的 Immunohistochemical 调查表明 CD133 + 和 CD44 + HCC 房间的数字被增加并且与门静脉侵略被联系。净化的 CD133 + 或 CD44 高 HCC 细胞分别地在 clonogenic 生长和脉管的侵略是优异的。因此, CD133 和 CD44 的联合被用来定义一张新奇 HCC 亚人口。CD133 + CD44 高 , 然而并非 CD133 + CD44 low/− , CD133 − CD44 高 或 CD133 − CD44 low/−在裸体老鼠的 异种皮移植,生产 intrahepatic 或肺转移。由流动 cytometry 的人的 HCC 样品的进一步的分析证明 CD133 + CD44 + 肿瘤房间与门静脉转移被联系。CD133 + CD44 + 和 CD133 + 从变形 HCC 病人孤立的 CD44 − 肿瘤房间表明这些房间拥有不同基因表示侧面的二张不同人口包括了。我们的结果建议那 CD133 + CD44 + 肿瘤房间是为在肝癌症和那的造血的转移负责的一张特别人口这些房间可能是为 HCC 的治疗的目标转移。 | Ying Hou QifeiZou Ruiliang Ge Feng Shen Yizheng Wang | 2012 | Cell Research2012，22，1： | 15 |
| 10 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 11 | Protective effect of hyperoside on cardiac ischemia reperfusion injury through inhibition of ER stress and activation of Nrf2 signaling显示文摘Objective:To study the protective effect of hyperoside(Hyp) on cardiac ischemia reperfusion injury and its potential mechanism.Methods:Rats were divided into two groups for the evaluation,the Hyp(50 uM Hyp;n=8) and the control group(n=8).Rat hearts were isolated and perfused with Krebs-Henseleit buffer(KHB) for 30 min.After being inhibited with cardioplegic solution,they were stored for 4 h in B21 solution at 4℃.Afterwards,rat hearts were perfused with KHB again for 45 min.In this period.Hyp was added into solutions of cardioplegia for storage and KHB.Parameters of cardiac functions,including heart rate,the systolic pressure of the left ventricle,the end-diastolic pressure of the left ventricle,the developed pressure of the left ventricle,the left-ventricular systolic pressure and the peak rise rate of the pressure of the left ventricle were recorded.The levels of adenosine triphosphate(ATP),the content of malondialdehyde and apoptotic cells were determined to evaluate the protective effect of Hyp on hearts suffered from ischemia reperfusion injury.Moreover,cultured cardiac myocytes were subjected to the process simulating ischemia/reperfusion.What were analyzed included the endoplasmic reticulum(ER) stress hallmarks expressions,such as binding immunoglobulin protein and C/EBP homologous protein,using the western blot and real-time PCR.Besides,the NF-E2-related factor 2(Nrf2) expression was measured to explore the potential mechanism.Results:Compared with the control group,the Hyp group had better cardiac functional parameters and higher ATP levels;pretreatment of Hyp greatly relieved the apoptosis of myocyte,decreased oxidative stress as well as ER stress and activated the signaling pathway of anti-oxidative Nrf2 to a further extent.Conclusions:Hyp plays an important role in preserving cardiac function by improving ATP levels of tissue,easing oxidative injury of myocardium and reducing apoptosis following IRI dramatically,while the ER stress inhibition and the downstream Nrf2 signaling activation may contribute to the effects of protection. | Jia-Yin Hou Ying Liu Liang Liu Xin-Ming Li | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，1： | 13 |
| 12 | SM905, an artemisinin derivative, inhibited NO and pro-inflammatory cytokine production by suppressing MAPK and NF-KB pathways in RAW 264.7 macrophages显示文摘 | Jun-xia WANG Li-fei HOU Yang YANG Wei TANG Ying LI Jian-ping ZUO | 2009 | Acta Pharmacologica Sinica2009，30，10： | 12 |
| 13 | Assessing Agricultural Sustainable Development Based on the DPSIR Approach: Case Study in Jiangsu, China显示文摘According to the contemporary ecosystem approach, the linkages of human actions with their environment have to be assessed in an integrative manner. The Driver-Pressure-State-Impact-Response (DPSIR) model is applied to identify and describe processes and interactions in human-environmental systems. An example application from a research project dealing with the development of sustainable management strategies for the agriculture in Jiangsu, China, illustrates the potentials and limitations of its sustainable development. The concept and indicators of ecological integrity are used to assess the indicators in the dimensions of DPSIR between 2003 and 2006. The main drivers included population growth which caused increasing demand for food, growing environmental demands, and rapidly decreasing of land and other natural resources. The main environmental problem was water pollution. The results show that in the dimension of driver, total grain output and agricultural land productivity both increased. Labor intensive agriculture has been promoted to increase agricultural land productivity. In the dimension of pressure, on the positive side, infrastructure got greatly improved, the input level such as total power of machinery, and level of fertilizer use increased, and level of pesticides use decreased, but on the negative side, cultivated land per capita and irrigation rate decreased, natural resources keep decreased. Environmental pollution indicators such as industrial wastewater discharge and acid rain rate increased in Jiangsu Province. In the aspect of state, ecosystem state was improved, plant coverage index increased, biological abundance index increased, fertilizer productivity increased, eco-environmental quality index increased, but land degradation index also increased. In the aspect of impact, output level increased, output efficiency enhanced, farmer's social economic benefit improved. In the aspect of response, social support was greatly improved, input for environmental governance increased. To assess the effects of environmental governance, Jiangsu government was successful to increase compliance rate of sulfur dioxide emissions, but not so efficient in compliance rate of industrial wastewater discharge. | ZHOU Shu-dong Felix Mueller Benjamin Burkhard CAO Xing-jin HOU Ying | 2013 | Journal of Integrative Agriculture2013，12，7： | 12 |
| 14 | Association between Chinese Medicine Therapy and Survival Outcomes in Postoperative Patients with NSCLC: A Multicenter, Prospective, Cohort Study显示文摘Objective:To evaluate the association between Chinese medicine(CM)therapy and disease-free survival(DFS)outcomes in postoperative patients with non-small cell lung cancer(NSCLC).Methods:This multiple-center prospective cohort study was conducted in 13 medical centers in China.Patients with stage I,II,or IDA NSCLC who had undergone radical resection and received conventional postoperative treatment according to the National Comprehensive Cancer Network(NCCN)guidelines were recruited.The recruited patients were divided into a CM treatment group and a control group according to their wishes.Patients in the CM treatment group received continuous CM therapy for more than 6 months or until disease progression.Patients in the control group received CM therapy for less than 1 month.Follow-up was 8nducted over 3 years.The primary outcome was DFS,with recurrence/metastasis rates as a secondary outcome.Results:Between May 2013 and August 2016,503 patients were enrolled into the cohort;266 were classified in the CM treatment group and 237 in the control group.Adjusting for covariates,high exposure to CM was associated with better DFS[hazard ratio(HR)=0.417,95%confidential interval(Cl):0.307-0.567)].A longer duration of CM therapy(6-12 months,12-18 months,>24 months)was associated with lower recurrence and metastasis rates(HR=0.225,0.119 and 0.083,respectively).In a subgroup exploratory analysis,CM therapy was also a protective factor of cancer recurrence and metastasis in both stage n-MA(HR=0.50,95%Cl:0.37-0.67)and stage IDA NSCLC postoperative patients(HR=0.48,95%Cl:0.33-0.71),DFS was even longer among CM treatment group patients.Conclusions:Lon ger duration of CM therapy could be 8nsidered a protective factor of cancer recurrence and metastasis.CM treatment is associated with improving survival outcomes of postoperative NSCLC patients in China. | WANG Xue-qian ZHANG Ying HOU Wei WANG Ying-tian ZHENG Jia-bin LI Jie LIN Li-zhu JIANG Yi-lan WANG Shen-yu XIE Ying ZHANG Hong-liang SHU Qi-jin LI Ping WANG Wei YOU Jian-liang LI Ge LIU Jie FAN Hui-ting ZHANG Mei-ying LIN Hong-sheng | 2019 | Chinese Journal of Integrative Medicine2019，25，11： | 12 |
| 15 | Dynamic expression of glucose transporters 1 and 3 in the brain of diabetic rats with cerebral ischemia reperfusion显示文摘d 葡萄糖控制不应该是太严格的,否则服的 ischemic 损害导致的 GLUT1 和 GLUT3 的起来规定可能不能在房间满足精力新陈代谢的需要。 | ZHANG Wen-wen ZHANG Li HOU Wei-kai XU Yu-xin XU Hua LOU Fu-chen ZHANG Ying WANG Qian | 2009 | Chinese Medical Journal2009，，17： | 10 |
| 16 | Transient expression and antigenic characterization of HBsAg of HBV nt551 A to G mutant显示文摘NTRODUCTIONFromthelate80s,therehavebeenincreasingnumberofreportsonhepatitisB(HB)patientswithatypicalHBVserologicalmarkers,so... | FANG De Xing 1, LI Fa Qing 1, TAN Wei Guo 1, CHEN Hua Biao 1, JIN Hui Ying 1, LI Su Qin 1, LIN Hou Ji 2 and ZHOU Zhen Xian 2 | 1999 | World Journal of Gastroenterology1999，5，1： | 10 |
| 17 | Incidence and risk factors of tuberculosis among the elderly population in China:a prospective cohort study显示文摘Background:China is facing challenges of the shifting presentation of tuberculosis(TB)from younger to elderly due to an ageing population,longer life expectancy and reactivation disease.However,the burden of elderly TB and influence factors are not yet clear.To fill the gap,we generated a cohort study to measure the magnitude of TB incidence and associated factors among the elderly population aged 65 years and above in China.Methods:In this cohort established in 2013 through a prevalence survey conducted in selected sites,a total of 34076 elderlies without TB were enrolled into two-year follow-up.We used both active and passive case findings to find out all TB patients among them.The person-year(PY)incidence rates for both bacteriologically positive TB and active TB were calculated.Cox proportional regression model was performed to test effect of risk factors,and the population attributable fraction(PAF)of each risk factor contributing to incident TB among elderlies was calculated.Results:Over the two-year follow-up period,a total of 215 incident active TB were identified,62 of which were bacteriologically positive.The incidence rates for active TB and bacteriologically positive TB were 481.8 per 100000 PY(95%CI:417.4–546.2 per 100000 PY)and 138.9 per 100000 PY(95%CI:104.4–173.5 per 100000 PY),respectively.Incident cases detected by active case finding were significantly higher(P<0.001).Male,non-Han nationality,previously treated TB,ex/current smoker and body mass index(BMI)<18.5 presented as independent predictors for developing TB disease.For developing bacteriologically positive TB,the biggest contribution was from self-reported ex or current smoker(18.06%).And,for developing active TB,the biggest contribution was from non-Han nationality(35.40%),followed by male(26.80%)and age at 75 years and above(10.85%).Conclusions:Ageing population in China had a high TB incidence rate and risk to develop TB disease,implying that National TB Program(NTP)needs to prioritize for elderly.Active case finding should be applied capture more active TB cases among this particular population,especially for male,non-Han nationality,and those with identified risk factors. | Jun Cheng Yan-Ni Sun Can-You Zhang Yan-Ling Yu Li-Hong Tang Hong Peng Ying Peng Yu-Xia Yao Shuang-Yi Hou Jian-Wei Li Jin-Ming Zhao Lan Xia Lin Xu Yin-Yin Xia Fei Zhao Li-Xia Wang Hui Zhang | 2020 | Infectious Diseases of Poverty2020，9，1： | 10 |
| 18 | Adult endothelial progenitor cells from human peripheral blood maintain monocyte/macrophage function throughout in vitro culture显示文摘密度坡度 centrifugation 从外部血孤立的 Mononuclear 房间(MNC ) 是人的 fibronectin 涂的文化盘子上的 plated 并且在 EGM-2 有教养中等。依附塑造锭子的房间,由一些调查者作为 endothelial 祖先房间(EPC ) 报导了,从支持者回合房间伸长了,但是没从以前想了的房间的一个小数字增殖。主要 EPC 的生长曲线证明房间几乎没有很少 proliferative 能力。当他们能也表示 CD14 时,流动 cytometry 分析证明房间能表示一些 endothelial 系标记,它在整个文化被认为单核白血球 / 巨噬细胞系的一个标记。在 endothelial 函数试金,房间比在反向的抄写聚合酶的成熟 endothelial 房间锁住反应并且没显示一个能力在 vitro 在 angiogenesis 试金开发像试管的结构表明了 eNOS 的表示的底层。在这研究,我们由低密度的脂蛋白(Dil-Ac-LDL ) 和印度墨水举起测试的联合标记 Dil 的乙酰 ated 识别了 EPC 的单音的似细胞的功能。所有房间是双的为在天的 Dil-Ac-LDL 和印度墨水举起积极 4 文化, 14 和 28,它意味着 EPC 在整个文化维持了单音的似细胞的功能。因此,尽管从外部 MNC 的成年 EPC 有一些 endothelial 系性质,他们维持典型 monocytic 功能并且几乎没有很少 proliferative 能力。 | Shi Ju Zhang Hao Zhang Ying Jie Wei Wen Jun Su Zhong Kai Liao Mai Hou Jian Ye Zhou Sheng Shou Hu | 2006 | Cell Research2006，16，6： | 9 |
| 19 | Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress显示文摘在细胞的 ubiquitin (Ub ) 的改变动态平衡,作为 Ub 知道强调,展示并且影响处于多重条件的细胞的回答,然而,内在的机制不完全地被理解。这里,我们报导 autophagy 受体 p62/sequestosome-1 与结合酶, UBE2D2 和 UBE2D3 的 E2 Ub 交往。内长的 p62 在 Ub 动态平衡的 upregulation 期间经历 E2 依赖的 ubiquitylation,一个条件作为 Ub + 应力称为,那对由 bortezomib 的 Ub overexpression,热吃惊或延长 proteasomal 抑制内在,化学疗法的药。p62 的 Ubiquitylation 破坏 p62 的 UBA 领域的 dimerization,解放它的能力认出为选择 autophagy 的 polyubiquitylated 货物。我们进一步证明这机制可能为在 Ub + 压力条件之上的 autophagy 激活是批评的。机制的描述和在察觉到 Ub 应力并且控制选择 autophagy 的 p62 的规章的角色能帮助理解并且调制细胞的回答到许多内长、环境的挑战,潜在地对 autophagy 相关的病为治疗学的策略的发展打开一条新大街。 | Hong Peng Jiao Yang Guangyi Li Qing You Wen Han Tianrang Li Darning Gao Xiaoduo Xie Byung-Hoon Lee Juan Du Jian Hou Tao Zhang Hai Rao Ying Huang Qinrun Li Rong Zeng Lijian Hui Hongyan Wang Qin Xia Xuemin Zhang Yongning He Masaaki Komatsu Ivan Dikic Daniel Finley Ronggui Hu | 2017 | Cell Research2017，27，5： | 9 |
| 20 | 30-W supercontinuum generation based on ZBLAN fiber in an all-fiber configuration显示文摘We report an all-fiberized 30-W supercontinuum(SC) generation in a piece of ZrF4-BaF2-LaF3-AlF3-NaF(ZBLAN) fiber. The pump source is a thulium-doped fiber amplifier(TDFA) with broadband output spectrum spanning the 1.9 to 2.6 μm region. The used ZBLAN fiber has a core diameter of 10 μm, and was directly fusion-spliced to the pigtail of the TDFA without using a traditional mode field adapter(MFA) or a piece of transition fiber. Such a low-loss and robust fusion splice joint, together with a robust AlF3-fiber-based endcap,enables efficient and high-power SC generation in the ZBLAN fiber. An SC with an average power up to 30.0 W and a spectral coverage of 1.9–3.35 μm with 20-dB bandwidth of 1.92–3.20 μm was obtained. Moreover, an SC with a broader spectrum was achieved by raising the pump pulse peak power(via reducing the duty ratio of the pump laser pulse). An SC with an output power of 27.4 W and a spectral coverage of 1.9–3.63 μm(with 20-dB bandwidth of 1.92–3.47 μm) was obtained, as well as an SC with output power of 24.8 W and a spectral coverage of 1.9–3.70 μm(with 20-dB bandwidth of 1.93–3.56 μm). The power conversion efficiency was measured as>69%. To the best of the authors’ knowledge, this research demonstrates the record output power of SC lasers based on ZBLAN fibers, paving the way for broadband and efficient multi-tens-of-watts SC generation in softglass fibers. | LINYONG YANG YING LI BIN ZHANG TIANYI WU YIJUN ZHAO JING HOU | 2019 | Photonics Research2019，7，9： | 9 |
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