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| 1 | Early Cambrian phosphatized blastula- and gastrula-stage animal fossils from southern Shaanxi显示文摘Marine invertebrate animal embryos and their early developmental products are of great significance to the study of taxonomy and phylogeny of early animals. A great number of phosphatized globular fossils were collected fromthe early Cambrian Kuanchuanpu Member (upper Dengying Formation), southern Shaanxi, and a nearly complete develo-pmental sequence—from a fertilized egg, via blastodisc formation, blastula development, blastodisc enlargement toward gastrulae, to tissue differentiation—can be discerned in this collection. This discovery provides unmatchable material for studies on the origin, taxonomy, radiation, and ontogeny of early metazoans. | HUAHong CHENZhe ZHANGLuyi | 2004 | Chinese Science Bulletin2004，49，5： | 7 |
| 2 | The chromosome-scale genome of Phoebe bournei reveals contrasting fates of terpene synthase (TPS)-a and TPS-b subfamilies显示文摘Terpenoids,including aromatic volatile monoterpenoids and sesquiterpenoids,function in defense against pathogens and herbivores.Phoebe trees are remarkable for their scented wood and decay resistance.Unlike other Lauraceae species investigated to date,Phoebe species predominantly accumulate sesquiterpenoids instead of monoterpenoids.Limited genomic data restrict the elucidation of terpenoid variation and functions.Here,we present a chromosome-scale genome assembly of a Lauraceae tree,Phoebe bournei,and identify 72 full-length terpene synthase(TPS)genes.Genome-level comparison shows pervasive lineage-specific duplication and contraction of TPS subfamilies,which have contributed to the extreme terpenoid variation within Lauraceae species.Although the TPS-a and TPS-b subfamilies were both expanded via tandem duplication in P.bournei,more TPS-a copies were retained and constitutively expressed,whereas more TPS-b copies were lost.The TPS-a genes on chromosome 8 functionally diverged to synthesize eight highly accumulated sesquiterpenes in P.bournei.The essential oil of P.bournei and its main component,b-caryophyllene,exhibited antifungal activities against the three most widespread canker pathogens of trees.The TPS-a and TPS-b subfamilies have experienced contrasting fates over the evolution of P.bournei.The abundant sesquiterpenoids produced by TPS-a proteins contribute to the excellent pathogen resistance of P.bournei trees.Overall,this study sheds light on the evolution and adaptation of terpenoids in Lauraceae and provides valuable resources for boosting plant immunity against pathogens in various trees and crops. | Xiao Han Junhong Zhang Shuang Han Sun Li Chong Guanliang Meng Minyan Song Yang Wang Shengcai Zhou Chengcheng Liu Luhuan Lou Xiongzhen Lou Longjun Cheng Erpei Lin Huahong Huang Qi Yang Zaikang Tong | 2022 | Plant Communications2022，3，6： | 3 |
| 3 | MicroRNA-501 promotes HBV replication by targeting HBXIP显示文摘 | Jiang Jin Shanhong Tang Lin Xia Rui Du Huahong Xie Jiugang Song Rui Fan Qian Bi Zheng Chen Guitao Yang Jie Liu Yongquan Shi Daiming Fan | 2013 | Biochemical and Biophysical Research Communications2013，，： | 2 |
| 4 | Synthesis,characterization and luminescent properties of Eu(Ⅲ) and Tb(Ⅲ) fluorescent chelates used as label in medical immunoassays显示文摘 | Shi Huahong Yang Yansheng | 1994 | Journal of Alloys and Compounds1994，，： | 2 |
| 5 | Association of systemic inflammation and body mass index with survival in patients with resectable gastric or gastroesophageal junction adenocarcinomas显示文摘Objective:The systemic inflammation index and body mass index(BMI)are easily accessible markers that can predict mortality.However,the prognostic value of the combined use of these two markers remains unclear.The goal of this study was therefore to evaluate the association of these markers with outcomes based on a large cohort of patients with gastric cancer.Methods:A total of 2,542 consecutive patients undergoing radical surgery for gastric or gastroesophageal junction adenocarcinoma between 2009 and 2014 were included.Systemic inflammation was quantified by the preoperative neutrophil-to-lymphocyte ratio(NLR).High systemic inflammation was defined as NLR≥3,and underweight was defined as BMI<18.5 kg/m2.Results:Among 2,542 patients,NLR≥3 and underweight were common[627(25%)and 349(14%),respectively].In the entire cohort,NLR≥3 or underweight independently predicted overall survival(OS)[hazard ratio(HR):1.236,95%confidence interval(95%CI):1.069–1.430;and HR:1.600,95%CI:1.350–1.897,respectively]and recurrence-free survival(RFS)(HR:1.230,95%CI:1.054–1.434;and HR:1.658,95%CI:1.389–1.979,respectively).Patients with both NLR≥3 and underweight(vs.neither)had much worse OS(HR:2.445,95%CI:1.853–3.225)and RFS(HR:2.405,95%CI:1.802–3.209).Furthermore,we observed similar results in subgroup analyses according to pathological stage,age,and postoperative chemotherapy.Conclusions:Our results showed that preoperative elevated NLR and decreased BMI had a significant negative effect on survival.Underweight combined with severe inflammation could enhance prognostication.Taking active therapeutic measures to reduce inflammation and increase nutrition may help improve outcomes. | Xianchun Gao Yanan Pan Weili Han Caie Hu Chenchen Wang Ling Chen Yong Guo Yupeng Shi Yan Pan Huahong Xie Liping Yao Jianjun Yang Jianyong Zheng Xiaohua Li Xiaonan Liu Liu Hong Jipeng Li Mengbin Li Gang Ji Zengshan Li Jielai Xia Qingchuan Zhao Daiming Fan Kaichun Wu Yongzhan Nie | 2021 | Cancer Biology & Medicine2021，18，1： | 2 |
| 6 | Nontrivial periodic solutions for asymptotically linear resonant difference problem显示文摘 | Bin Huahong Yu Jianshe Guo Zhiming | 2006 | J Math Anal Appl2006，，322： | 1 |
| 7 | New immunochemical fecal occult blood teat with two-consecutive stool sample testing is a cost-effective approach for colon cancer screening:Results of a prospective multicenter study in Chinese patients显示文摘 | Shirong L Huahong Wang Jichun Hu | | 0，，02： | 1 |
| 8 | Identification and evaluation of reference genes for normalization in quantitative real-time PCR analysis in the premodel tree Betula luminifera显示文摘Betula luminifera is a commercial tree species that is emerging as a new model system for tree genomics research. A draft genomic sequence is expected to be publicly available in the near future, which means that an explosion of gene expression studies awaits. Thus, the work of selecting appropriate reference genes for q PCR normalization in different tissues or under various experimental conditions is extremely valuable. In this study, ten candidate genes were analyzed in B. luminifera subjected to different abiotic stresses and at various flowering stages.The expression stability of these genes was evaluated using three distinct algorithms implemented using ge Norm,Norm Finder and Best Keeper. The best-ranked reference genes varied across different sample sets, though RPL39,MDH and EF1 a were determined as the most stable by the three programs among all tested samples. RPL39 and EF1 a should be appropriate for normalization in N-starved roots,while the combination of RPL39 and MDH should be appropriate for N-starved stems and EF1 a and MDH should be appropriate in N-starved leaves. In PEG-treated(osmotic) roots, MDH was the most suitable, whereas EF1 a was suitable for PEG-treated stems and leaves. TUA was also stably expressed levels in PEG-treated plants. The combination of RPL39 and TUB should be appropriate for heat-stressed leaves and flowering stage. For reference gene validation, the expression levels of SOD and NFYA-3were investigated. This work will be beneficial to future studies on gene expression under different abiotic stress conditions and flowering status in B. luminifera. | Jun Wu Junhong Zhang Ying Pan Huahong Huang Xiongzhen Lou Zaikang Tong | 2017 | Journal of Forestry Research2017，28，2： | 1 |
| 9 | De novo characterization of the Chinese fir (Cunninghamia lanceolata) transcriptome and analysis of candidate genes involved in cellulose and lignin biosynthesis显示文摘 | Huang Huahong Xu Lili Tong Zaikang | | 0，，01： | 1 |
| 10 | Prediction of sweetpotato starch physiochemical quality and pasting properties by using NIRS显示文摘 | LU Guoquan HANG Huahong ZHANG Dapeng | 2006 | Food Chemistry2006，94，4： | 1 |
| 11 | Establishment and Characterization of a High Metastatic Potential in the Peritoneum for Human Gastric Cancer by Orthotopic Tumor Cell Implantation显示文摘 | Feihu Bai Xinning Guo Li Yang Jun Wang Yongquan Shi Faming Zhang Huihong Zhai Yuanyuan Lu Huahong Xie Kaichun Wu Daiming Fan | 2007 | Digestive Diseases and Sciences2007，，6： | 1 |
| 12 | Effects of exogenous methyl jasmonate on artemisinin biosynthesis and secondary metabolites in Artemisia annua L 显示文摘 | Huahong W Chenfei M Zhenctiu L | 2010 | Industrial Crops and Products2010，31，： | 1 |
| 13 | Prediction of sweetpotato starch physiochemical quality and pasting properties by using NIRS显示文摘 | Lu Guoquan Hang Huahong Zhang dapeng | 2006 | Food Chemistry2006，94，4： | 1 |
| 14 | New immunochemical fecal occult blood test with two consecutive stool sample testing is a cost effective approach for colon cancer screening:Results of a prospective multicenter study in chinese patients显示文摘 | Shirong L Huahong W Jichun H | 2006 | Int J Can-cer2006，118，2： | 1 |
| 15 | Histological observation on unique phenotypes of malformation induced in Xenopus tropicalis larvae by tributyltin显示文摘Tributyltin(TBT),a biocide used in antifouling paints,has shown strong teratogenic effects on Xenopus tropicalis embryos at environmentally relevant concentrations.X.tropicalis embryos were exposed to 50,100 and 200 ng/L tributyltin chloride for 72 hr.The histological changes were further observed on abnormal eyes,enlarged trunks,enlarged proctodaeums and absence of fins induced by TBT.The lens and the retinal layers of abnormal eyes were slightly or barely differentiated,and that the pigment epithelium was neither continuous nor smooth.The abdomens were full of undifferentiated gut tissue with yolk-rich inclusions in the tadpoles with enlarged trunks.The proctodaeums formed a bump-like or columnar structure.The mass of yolk-rich cells occupied the lumen,blocked the opening and even turned inside out of the proctodaeum.Both the ventral and dorsal fins in trunks and tails became narrow or even disappeared totally.Our results suggest that great changes of histology took place corresponding to the unique phenotypes.The gut tissue was poorly differentiated,which led to the failed elongation of the guts and subsequently the enlarged trunks.The enlarged proctodaeums were due to the undifferentiation of inner layer,the expansion of outer epidermal part and the absence of fins around them.In brief,the histological observations provided insights into the reason of the unique external malformations in some degree. | Junqi Liu Qinzhen Cao Jing Yuan Xiaoli Zhang Lin Yu Huahong Shi | 2012 | Journal of Environmental Sciences2012，24，2： | 1 |
| 16 | Bioaccumulation, depuration and oxidative stress in fish Carassius auratus under phenanthrene exposure显示文摘 | Yuanyuan Sun Hongxia Yu Jingfei Zhang Ying Yin Huahong Shi Xiaorong Wang | 2005 | Chemosphere2005，，8： | 1 |
| 17 | NON-PARAMETRIC LEAST SQUARE ESTIMATION OF DISTRIBUTION FUNCTION显示文摘By using the non parametric least square method, the strong consistent estimations of distribution function and failure function are established,where the distribution function F(x) after logist transformation is assumed to be approximated by a polynomial.The performance of simulation shows that the estimations are highly satisfactory. | ChaiGenxiang HuaHong ShangHanji | 2002 | Applied Mathematics(A Journal of Chinese Universities)2002，17，4： | 1 |
| 18 | TheLantianbiotaAnewwindowontotheoriginandearlyevolutionofmulticellularorganisms显示文摘 | YuanXun-lai(袁训来) HuaHong(华洪) ZhouChuan-ming(周传明) WangWei(王伟) GuanCheng-guo(关成国) WanBin(万斌) XiaoShu-hai(肖书海) ChenZhe(陈哲) | 2012 | 科学通2012，57，34： | 1 |
| 19 | Electron paramagnetic resonance evidence of hydroxyl radical generation and oxidative damage induced by tetrabromobisphenol A in Carassius auratus显示文摘 | Huahong Shi Xiaorong Wang Yi Luo Yan Su | 2005 | Aquatic Toxicology2005，，4： | 1 |
| 20 | New immunochemical fecal occult blood test with two-consecutive stool sample testing is a cost-effective approach for colon cancer screening:Results of a prospective multicenter study in Chinese patients显示文摘 | Shirong L Huahong Wang Jichun Hu | 2006 | Int J Cancer2006，118，2： | 1 |
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