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| 1 | Uncompromised NK cell activation is essential for virus-specific CTL activity during acute influenza virus infection显示文摘Natural killer (NK) cells are indispensable components of both the innate and adaptive immune response. However,their precise roles in the cross-talk between innate and adaptive immunity during influenza virus infection remaincontroversial. By comparing NK cell dynamics and activity under a sub-lethal dose and high dose of influenza virusinfection, we showed that influenza virus PR8 directly infected NK cells during natural infection, which wasconsistent with our previous findings obtained from an in vitro investigation of human NK cells. The impairments incytotoxicity and IFN-γ production by spleen NK cells following high-dose infection were accompanied by decreasedvirus-specific killing mediated by cytotoxic T lymphocytes (CTLs). Importantly, the weakened CTL activity could bereversed by adoptive transfer of spleen NK cells harvested from low-dose-infected mice but not healthy donors.Taken together, our data provide direct evidence supporting the contribution of NK cells to antiviral T-cellresponses. This study also indicates that a novel NK-targeted immune evasion strategy is used by influenza virusto shrink both innate and adaptive immune responses. | Yuan Liu Jian Zheng Yinping Liu Liyan Wen Lei Huang Zheng Xiang Kwok-Tai Lam Aizhen Lv Huawei Mao Yu-Lung Lau Wenwei Tu | 2018 | Cellular & Molecular Immunology2018，15，9： | 6 |
| 2 | Adaptive Service Provisioning for Mobile Edge Cloud显示文摘A mobile edge cloud provides a platform to accommodate the offloaded traffic workload generated by mobile devices.It can significantly reduce the access delay for mobile application users.However,the high user mobility brings significant challenges to the service provisioning for mobile users,especially to delay-sensitive mobile applications.With the objective to maximize a profit,which positively associates with the overall admitted traffic served by the local edge cloud,and negatively associates with the access delay as well as virtual machine migration delay,we study a fundamental problem in this paper:how to update the service provisioning solution for a given group of mobile users.Such a profit-maximization problem is formulated as a nonlinear integer linear programming and linearized by absolute value manipulation techniques.Then,we propose a framework of heuristic algorithms to solve this Nondeterministic Polynomial(NP)-hard problem.The numerical simulation results demonstrate the efficiency of the devised algorithms.Some useful summaries are concluded via the analysis of evaluation results. | HUANG Huawei GUO Song | 2017 | ZTE Communications2017，15，2： | 5 |
| 3 | An Aggregate Signature Scheme with Specified Verifier显示文摘 | WEN Yiling MA Jianfeng HUANG Huawei | 2011 | Chinese Journal of Electronics2011，20，2： | 4 |
| 4 | Surface plasmon polaritons based optical directional coupler显示文摘As a basic optical device, the optical directional coupler (ODC) is basically used as optical splitters, optic switches and so on. A novel ODC employing surface plas- mon polaritons (SPPs) is proposed for high integration. The finite difference time domain (FDTD) method is adopted to simulate and analyze its properties. Results show that the ODC proposed here follows the general regulations of a conventional dielectric ODC, but its transverse size is of nanoscale, which improves the optical integration greatly. For 1550 nm and 1310 nm input wavelengths, when the coupling region length (L) equals half of its coupling length, the Excess Loss is respectively 0.57 dB and 0.56 dB, which is practical in applications. So the research on the present ODC is of some practical importance. | ZHAO HuaWei HUANG XuGuang HUANG JingTang | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，12： | 3 |
| 5 | A new electroplated Ir/Ir(OH)_x pH electrode and its application in the coastal areas of Newport Harbor, California显示文摘Resulting from the rising levels of atmospheric carbon, ocean acidification has become a global problem. It has significant impacts on the development, survival, growth and physiology of marine organisms. Therefore, a highprecision sensor is urgently needed to measure the pH of sea-water. Iridium wire with a diameter of 0.25 mm is used as the substrate, and an Ir/Ir(OH)_x pH electrode is prepared by a one-step electrochemical method in a Li OH solution at the room temperature. A scanning electron microscope(SEM) observation reveals that it is coated with nanoscale particles. In laboratory tests, the electrode exhibits a very promising pH response, with an ideal Nernst slope(56.14–59.52), fast response, good stability and long life-span in tested pH buffer solutions. For a sea trial,four pH electrodes and one Ag/Ag Cl reference electrode are integrated with a self-made chemical sensor, and a profile detection of nearly 70 m is implemented near Newport Harbor, California on August 3, 2015. The results reflect that the pH value measured by the sensor is very close to the data given by Sea-Bird 911 plus CTD, with a difference value ranging from 0.000 075 to 0.064 719. And the sensor shows a better data matching degree in 0–40m water depth. In addition, the high precision and accuracy of the sensor make it possible to use in the ocean observation field. | ZHANG Xiao YE Ying KAN Yating HUANG Yuanfeng JIA Jianjun ZHAO Yue CHEN Chen-Tung Arthur QIN Huawei | 2017 | Acta Oceanologica Sinica2017，36，5： | 2 |
| 6 | Astaxanthine attenuates cisplatin ototoxicity in vitro and protects against cisplatin-induced hearing loss in vivo显示文摘Astaxanthine(AST) has important biological activities including antioxidant and antiinflammatory effects that could alleviate neurological and heart diseases, but its role in the prevention of cisplatin-induced hearing loss(CIHL) is not yet well understood. In our study, a steady interaction between AST and the E3 ligase adapter Kelch-like ECH-associated protein 1, a predominant repressor of nuclear factor erythroid 2-related factor 2(NRF2), was performed and tested via computer molecular docking and dynamics. AST protected against cisplatin-induced ototoxicity via NRF2 mediated pathwayusing quantitative PCR and Western blotting. The levels of reactive oxygen species(ROS) and mitochondrial membrane potential revealed that AST reduced ROS overexpression and mitochondrial dysfunction.Moreover, AST exerted anti-apoptosis effects in mouse cochlear explants using immunofluorescence staining and HEI-OC1 cell lines using quantitative PCR and Western blotting. Finally, AST combined with poloxamer was injected into the middle ear through the tympanum, and the protection against CIHL was evaluated using the acoustic brain stem test and immunofluorescent staining in adult mice. Our results suggest that AST reduced ROS overexpression, mitochondrial dysfunction, and apoptosis via NRF2-mediated pathway in cisplatin-exposed HEI-OC1 cell lines and mouse cochlear explants, finally promoting cell survival. Our study demonstrates that AST is a candidate therapeutic agent for CIHL. | Benyu Nan Zirui Zhao Kanglun Jiang Xi Gu Huawei Li Xinsheng Huang | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 2 |
| 7 | Determining gastric cancer resectability by dynamic MDCT显示文摘 | Zilai Pan Huan Zhang Chao Yan Lianjun Du Bei Ding Qi Song Huawei Ling Baisong Huang Kemin Chen | 2010 | European Radiology2010，，3： | 2 |
| 8 | Changes in Protein Content and Chitinase and β-1,3- glucanase Activities of Rice with Blast Resistance Induced by Ag-antibiotic 702显示文摘[Objective] The paper was to explore the effect of rice blast resistance induced by Ag-antibiotics 702 on protein content and chitinase and β-1,3-glucanase activities in rice. [Method]At the fourth leaf stage of Luliangyou 996,15 μg/m L Ag-antibiotic 702 was sprayed,while Validamycin and distilled water were sprayed as positive control and negative control,respectively. All treatments were inoculated with spore fluid of Magnaporthe grisea at 48 h post spraying,and the rice inoculated with only distilled water was used as blank control. The enzymes activities( endochitinase,exochitinase and β-1,3-glucanase) and total protein content in rice leaves were determined every 24 h within 168 h post spraying. [Result] Compared with the blank control,the rice inoculated with spore fluid of M. grisea could significantly increase the total protein content and the activities of β-1,3-glucanase and chitinase. The induction effect of Ag-antibiotics 702 exceeded that of Validamycin treatment. And the changes in activities of β-1,3-glucanase and chitinase had obvious synchronicity. [Conclusion] Ag-antibiotic 702 can significantly improve the total protein content and the activities of β-1,3-glucanase and chitinase,thus enhancing the resistance to rice blast. | Hu Neng Tu Xiaorong Li Kuntai Ding Hao Li Huan Zhang Huawei Tu Guoquan Huang Lin | 2017 | Plant Diseases and Pests2017，8，4： | 2 |
| 9 | Novel optical directional coupler based on surface plasmon polaritons显示文摘 | Huawei Zhao Xu Guang Guang Jingtang Huang | 2008 | Physica E: Low-dimensional Systems and Nanostructures2008，，10： | 1 |
| 10 | Relation between parity-check matrixes and cycles of associated tanner graphs显示文摘 | Chen Ruwei Huang Huawei Xiao Guozhen | 2007 | IEEE Commun Lett2007，11，8： | 1 |
| 11 | Novel aminopeptidase N inhibitors derived from 1,3,4-thiadiazole scaffold显示文摘 | GuoGang Tu ShaoHua Li HuiMing Huang Gang Li Fang Xiong Xi Mai HuaWei Zhu BinHai Kuang Wen Fang Xu | 2008 | Bioorganic & Medicinal Chemistry2008，，14： | 1 |
| 12 | An electrocatalyst with anti-oxidized capability for overall water splitting显示文摘 | Chang Yu Huawei Huang Si Zhou Xiaotong Han Changtai Zhao Juan Yang Shaofeng Li Wei Guo Bowen An Jijun Zhao Jieshan Qiu | 2018 | Nano Research2018，11，6： | 1 |
| 13 | The effects of information provision and interactivity on etailerwebsites显示文摘 | HUANG MINXUE ZHU HUAWEI ZHOU XUECHUN | 2013 | Online information review2013，37，6： | 1 |
| 14 | Co-seismic fault geometry and slip distribution of the 26 December 2004, giant Sumatra–Andaman earthquake constrained by GPS, coral reef, and remote sensing data显示文摘We analyze co-seismic displacement field of the 26 December 2004, giant Sumatra–Andaman earthquake derived from Global Position System observations,geological vertical measurement of coral head, and pivot line observed through remote sensing. Using the co-seismic displacement field and AK135 spherical layered Earth model, we invert co-seismic slip distribution along the seismic fault. We also search the best fault geometry model to fit the observed data. Assuming that the dip angle linearly increases in downward direction, the postfit residual variation of the inversed geometry model with dip angles linearly changing along fault strike are plotted. The geometry model with local minimum misfits is the one with dip angle linearly increasing along strike from 4.3oin top southernmost patch to 4.5oin top northernmost path and dip angle linearly increased. By using the fault shape and geodetic co-seismic data, we estimate the slip distribution on the curved fault. Our result shows that the earthquake ruptured *200-km width down to a depth of about 60 km.0.5–12.5 m of thrust slip is resolved with the largest slip centered around the central section of the rupture zone78N–108N in latitude. The estimated seismic moment is8.2 9 1022 N m, which is larger than estimation from the centroid moment magnitude(4.0 9 1022 N m), and smaller than estimation from normal-mode oscillation data modeling(1.0 9 1023 N m). | Yongge Wan Zheng-kang Shen Min Wang Yuehua Zeng Jichao Huang Xiang Li Huawei Cui Xiwei Gao | 2015 | Earthquake Science2015，28，3： | 1 |
| 15 | Novel optical directional coupler based on surface plasmon polaritons显示文摘 | Huawei Zhao Xu Guang Guang Jingtang Huang | 2008 | Physica E: Low-dimensional Systems and Nanostructures2008，，10： | 1 |
| 16 | Biomarkers measured by cytokinesis-block micronucleus cytome assay for evaluating genetic damages induced by polycyclic aromatic hydrocarbons显示文摘 | Huawei Duan Shuguang Leng Zufei Pan Yufei Dai Yong Niu Chuanfeng Huang Ping Bin Yadong Wang Qingjun Liu Wen Chen Yuxin Zheng | 2009 | MutRes-Genetic Toxicology and Environmental Mutagenesis2009，，1： | 1 |
| 17 | Ap- plication of an integrated system of coagulation and electrodialysis for treatment of wastewater produced by fracturing显示文摘 | Hao Huawei Huang Xing Gao Congjie | 2015 | Desalin Water Treat2015，55，8： | 1 |
| 18 | Preventing autosomal-dominant hearing loss in Bth mice with CRISPR/CasRx-based RNA editing显示文摘CRISPR/RfxCas13d(CasRx)editing system can specifically and precisely cleave single-strand RNAs,which is a promising treatment for various disorders by downregulation of related gene expression.Here,we tested this RNA-editing approach on Beethoven(Bth)mice,an animal model for human DFNA36 due to a point mutation in Tmc1.We first screened 30 sgRNAs in cell cultures and found that CasRx with sgRNA3 reduced the Tmc1^(Bth)transcript by 90.8%,and the Tmc1 wild type transcript(Tmc1^(+))by 44.3%.We then injected a newly developed AAV vector(AAV-PHP.eB)based CasRx into the inner ears of neonatal Bth mice,and we found that Tmc1^(Bth)was reduced by 70.2%in 2 weeks with few off-target effects in the whole transcriptome.Consistently,we found improved hair cell survival,rescued hair bundle degeneration,and reduced mechanoelectrical transduction current.Importantly,the hearing performance,measured in both ABR and DPOAE thresholds,was improved significantly in all ages over 8 weeks.We,therefore,have validated the CRISPR/CasRx-based RNA editing strategy in treating autosomal-dominant hearing loss,paving way for its further application in many other hereditary diseases in hearing and beyond. | Ziwen Zheng Guo Li Chong Cui Fang Wang Xiaohan Wang Zhijiao Xu Huiping Guo Yuxin Chen Honghai Tang Daqi Wang Mingqian Huang Zheng-Yi Chen Xingxu Huang Huawei Li Geng-Lin Li Xiaoxiang Hu Yilai Shu | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 1 |
| 19 | Audit Industry Specialization, Client Bargaining Power, and Audit Fees : Further Evidence 显示文摘 | HUANG HUAWEI LILIN LIU RAGHUNAINDAN K | 2007 | Auditing : Journal of Theory & Practice2007，26，1： | 1 |
| 20 | Review of studies on target acquisition in virtual reality based on the crossing paradigm显示文摘Crossing is a fundamental paradigm for target selection in human-computer interaction systems.This paradigm was first introduced to virtual reality(VR)interactions by Tu et al.,who investigated its performance in comparison to pointing,and concluded that crossing is generally no less effective than pointing and has unique advantages.However,owing to the characteristics of VR interactions,there are still many factors to consider when applying crossing to a VR environment.Thus,this review summarizes the main techniques for object selection in VR and crossing-related studies.Then,factors that may affect crossing interactions are analyzed from the perspectives of the input space and visual space.The aim of this study is to provide a reference for future studies on target selection based on the crossing paradigm in virtual reality. | Susu HUANG Daqing QI Jiabin YUAN Huawei TU | 2019 | Virtual Reality & Intelligent Hardware2019，1，3： | 1 |
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