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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Olfactory ecto-mesenchymal stem cell-derived exosomes ameliorate murine Sjögren’s syndrome by modulating the function of myeloid-derived suppressor cells显示文摘Sjögren’s syndrome(SS)is a systemic autoimmune disease characterized by progressive inflammation and tissue damage in salivary glands and lacrimal glands.Our previous studies showed that myeloid-derived suppressor cells(MDSCs)exhibited impaired immunosuppressive function during disease progression in patients with SS and mice with experimental Sjögren’s syndrome(ESS),but it remains unclear whether restoring the function of MDSCs can effectively ameliorate the development of ESS.In this study,we found that murine olfactory ecto-mesenchymal stem cell-derived exosomes(OE-MSC-Exos)significantly enhanced the suppressive function of MDSCs by upregulating arginase expression and increasing ROS and NO levels.Moreover,treatment with OE-MSC-Exos via intravenous injection markedly attenuated disease progression and restored MDSC function in ESS mice.Mechanistically,OE-MSC-Exo-secreted IL-6 activated the Jak2/Stat3 pathway in MDSCs.In addition,the abundant S100A4 in OE-MSC-Exos acted as a key factor in mediating the endogenous production of IL-6 by MDSCs via TLR4 signaling,indicating an autocrine pathway of MDSC functional modulation by IL-6.Taken together,our results demonstrated that OE-MSC-Exos possess therapeutic potential to attenuate ESS progression by enhancing the immunosuppressive function of MDSCs,possibly constituting a new strategy for the treatment of Sjögren’s syndrome and other autoimmune diseases. | Ke Rui Yue Hong Qiugang Zhu Xiaofei Shi Fan Xiao Hailong Fu Qing Yin Yida Xing Xinfeng Wu Xiaodan Kong Huaxi Xu Jie Tian Shengjun Wang Liwei Lu | 2021 | Cellular & Molecular Immunology2021，18，2： | 12 |
| 3 | Homeostasis of Brassinosteroids Regulated by DRL1, a Putative Acyltransferase in Arabidopsis显示文摘在调整工厂生长和开发并且在对多样的环境暗示作出回应的各种各样的方面的 Brassinosteroids (BR ) 戏必需品角色,和他们的新陈代谢是在工厂调整他们的动态平衡的一个重要方法。这里,我们识别了主导的异种,矮子和圆 leaf-1 (drl1-D ) ,它展出弱 BR 缺乏或 BR 感觉迟钝的变异的显型,包括短、圆的叶子,延长老朽,相形见绌的形状,和 BR 应答的基因的改变的表示层次。胚轴长度和根抑制试金建议 drl1-D 异种通常对 BR 作出回应,但是减少了 BR 发信号产量。几 BR,包括的 typhasterol (TY ) , 6-deoxotyphasterol (6-deoxoTY ) ,和 6-deoxocastasterone (6-deoxoCS ) 的内长的层次,比在在 drl1-D 异种是显著地更低的野类型。DRL1 基因编码 acyltransferase 并且是广泛地在叶子,根,花,和 siliques 表示了。没有 DRL1 和它的相当或相同的事物的植物是更大的,提高的 BR 发信号。DRL1 的表示被 eBL 导致并且由骆驼毛的织物禁止了。DRL1 被通过酯化作用催化 BR 变化形式多半涉及 BR 新陈代谢,它在调整 BR 动态平衡并且在 Arabidopsis 对不能生活的压力作出回应起重要作用。 | Wenjiao Zhu Haijiao Wang Shozo Fujioka Tao Zhou Hailong Tian Weisheng Tian Xuelu Wang | 2013 | Molecular Plant2013，6，2： | 7 |
| 4 | Studies on Lung Cancer Angiogenesis-Application of Interventional Therapy (A Report of 56 Cases)显示文摘OBJECTIVE To investigate the significance of angiogenesis of lung cancer, in order to provide a scientific basis for interventional therapy. METHODS Double-phase enhancementscanning spiral CT and DSA were performed in 56 pathologically confi rmed lung cancer cases, in order to evaluate angiogenesis of the tumors. The patients included 36 males and 20 females, with ages ranging from 33 to 76 years (average of 53). Assessments and indexes for SCT and DSA examinations were as follows: a) Peak value (PV) of the cancerous focus was the difference between the maximum CT value after enhancement and the CT value of a plain scan; b) The abnormally distorted and expanded new vessels of the cancerous focus which could be macroscopically discriminated; c) DSA staining of the focus of cancer was sparse, grid-like and dense. Chemotherapy and embolotherapy via the bronchial artery (interventional therapy) were conducted. Radiotherapy was added for some of the solid tumors with a diameter exceeding 4 cm. RESULTS a) There were 25 cases with a central-type lesion, among which 4 were small cell lung cancers (SCLC) and 21 non-small cell lung cancers (NSCLC). The cases with a peripheral location accounted for 31 of the total, with a maximum diameter of 1.5 to 13.5 cm and a median of 4.2 cm, including 5 small cell lung cancers and 26 NSCLC cases. b) The reinforced PVs of the cancerous foci were as follows: The PV ranged from 45 to 70 Hu in 34 cases, 25 to 45 Hu in 19, and 10 to 25 Hu in 3. Sparse DSA staining occurred in 3 cases, there was uneven grid-like staining in 22 and dense staining in 31; c) The interventional therapy via the bronchial artery was con-ducted twice in 5 cases with the SCLC, and three times in 4 SCLC cases. For 3 of the latter cases, a dose of 5,000 to 7,000 cGy radiation therapy was added during the interventional treatment. Complete remissions (CR) were seen in 88.9% of the cases (8/9) and partial remission (PR) in 11.1% (1/9). Interventional therapy was conducted twice in 8 cases with NSCLC and three times in 30 with NSCLC and four times in 9 cases. Among the total cases, 13 received radiotherapy during interventional therapy, with a radiation dose of 5,000-7,000 cGy; The CR rate was 78.7% (37/47), PR was 14.9% (7/47) and the rate of non-remission was 6.4% (3/47). CONCLUSION Using imaging technology, analysis of angiogenesis of lung cancers was employed to accurately detect and quantify angiogenesis. This analysis was combined for interventional therapy, using embolizing agents and large doses of the anti-tumor drugs and angiogenesis inhibitors. The agents were selectively delivered into the tumor vessels to eliminate the primary tumor, in order to depress distant metastases and thus enhance the curative effect of the therapy. | Qiang Zhang Jun Guo Hailong Qian Baoqi Shi Jigang Zhang Chunjing Li Ailing Yang Zhuang Tian Baotou No. 7 Hospital Department of Radiol-ogy, Baotou Cancer Hospital, Baotou 014030, Inner Mongolia Autonomous Region, China. | 2007 | Chinese Journal of Clinical Oncology2007，4，1： | 5 |
| 5 | A review of progress in coupled ocean-atmosphere model developments for ENSO studies in China显示文摘El Nino-Southern Oscillation(ENSO) is the strongest interannual signal that is producedby basinscale processes in the tropical Pacific,with significant effects on weather and climate worldwide.In the past,extensive and intensive international efforts have been devoted to coupled model developments for ENSO studies.A hierarchy of coupled ocean-atmo sphere models has been formulated;in terms of their complexity,they can be categorized into intermediate coupled models(ICMs),hybrid coupled models(HCMs),and fully coupled general circulation models(CGCMs).ENSO modeling has made significant progress over the past decades,reaching a stage where coupled models can now be used to successfully predict ENSO events 6 months to one year in advance.Meanwhile,ENSO exhibits great diversity and complexity as observed in nature,which still cannot be adequately captured by current state-of-the-art coupled models,presenting a challenge to ENSO modeling.We primarily reviewed the long-term efforts in ENSO modeling continually and steadily made at different institutions in China;some selected representative examples are presented here to review the current status of ENSO model developments and applications,which have been actively pursued with noticeable progress being made recently.As ENSO simulations are very sensitive to model formulations and process representations etc.,dedicated efforts have been devoted to ENSO model developments and improvements.Now,different ocean-atmosphere coupled models have been available in China,which exhibit good model performances and have already had a variety of applications to climate modeling,including the Coupled Model Intercomparison Project Phase 6(CMIP6).Nevertheless,large biases and uncertainties still exist in ENSO simulations and predictions,and there are clear rooms for their improvements,which are still an active area of researches and applications.Here,model performances of ENSO simulations are assessed in terms of advantages and disadvantages with these differently formulated coupled models,pinpointing to the areas where they need to be further improved for ENSO studies.These analyses provide valuable guidance for future improvements in ENSO simulations and predictions. | ZHANG Rong-Hua YU Yongqiang SONG Zhenya REN Hong-Li TANG Youmin QIAO Fangli WU Tongwen GAO Chuan HU Junya TIAN Feng ZHU Yuchao CHEN Lin LIU Hailong LIN Pengfei WU Fanghua WANG Lin | 2020 | Journal of Oceanology and Limnology2020，38，4： | 4 |
| 6 | The aboveground biomass of desert steppe and its spatiotemporal variation in western Inner Mongolia显示文摘A precise understanding of the aboveground biomass of desert steppe and its spatio-temporal variation is important to understand how arid ecosystems respond to climate change and to ensure that scarce grassland resources are used rationally. On the basis of 756 ground survey quadrats sampled in western Inner Mongolia steppe in 2005-2011 and remote sensing data from the Moderate Resolution Imaging Spectroradiometer (MODIS)-the normalized difference vegetation index (NDVI) dataset for the period of 2001-2011-we developed a statistical model to estimate the aboveground biomass of the desert steppe and further explored the relationships between aboveground biomass and climate factors. The conclusions are as follows: (1) the aboveground biomass of the steppe in the research area was 5.27 Tg (1 Tg=1012 g) on average over 11 years; between 2001 and 2011, the aboveground biomass of the western Inner Mongolia steppe exhibited fluctuations, with no significant trend over time; (2) the aboveground biomass of the steppe in the research area exhibits distinct spatial variation and generally decreases gradually from southeast to northwest; and (3) the important factor causing interannual variations in aboveground biomass is precipitation during the period from January to July, but we did not find a significant relationship between the aboveground biomass and the corresponding temperature changes. The precipitation in this period is also an important factor influencing the spatial distribution of aboveground biomass (R2 =0.39, P<0.001), while the temperature might be a minor factor (R2 =0.12, P<0.01). The uncertainties in our estimate are primarily due to uncertainty in converting the fresh grass yield estimates to dry weight, underestimates of the biomass of shrubs, and error in remote sensing dataset. | Tian Gao Bin Xu XiuChun Yang YunXiang Jin HaiLong Ma JinYa Li HaiDa Yu | 2013 | Research in Cold and Arid Regions2013，5，3： | 3 |
| 7 | Managing the immune microenvironment of osteosarcoma:the outlook for osteosarcoma treatment显示文摘Osteosarcoma,with poor survival after metastasis,is considered the most common primary bone cancer in adolescents.Notwithstanding the efforts of researchers,its five-year survival rate has only shown limited improvement,suggesting that existing therapeutic strategies are insufficient to meet clinical needs.Notably,immunotherapy has shown certain advantages over traditional tumor treatments in inhibiting metastasis.Therefore,managing the immune microenvironment in osteosarcoma can provide novel and valuable insight into the multifaceted mechanisms underlying the heterogeneity and progression of the disease.Additionally,given the advances in nanomedicine,there exist many advanced nanoplatforms for enhanced osteosarcoma immunotherapy with satisfactory physiochemical characteristics.Here,we review the classification,characteristics,and functions of the key components of the immune microenvironment in osteosarcoma.This review also emphasizes the application,progress,and prospects of osteosarcoma immunotherapy and discusses several nanomedicine-based options to enhance the efficiency of osteosarcoma treatment.Furthermore,we examine the disadvantages of standard treatments and present future perspectives for osteosarcoma immunotherapy. | Hailong Tian Jiangjun Cao Bowen Li Edouard CNice Haijiao Mao Yi Zhang Canhua Huang | 2023 | Bone Research2023，11，1： | 3 |
| 8 | Weakness Ranking Method for Subsystems of Heavy-Duty Machine Tools Based on FMECA Information显示文摘Heavy-duty machine tools are composed of many subsystems with different functions,and their reliability is governed by the reliabilities of these subsystems.It is important to rank the weaknesses of subsystems and identify the weakest subsystem to optimize products and improve their reliabilities.However,traditional ranking methods based on failure mode effect and critical analysis(FMECA)does not consider the complex maintenance of products.Herein,a weakness ranking method for the subsystems of heavy-duty machine tools is proposed based on generalized FMECA information.In this method,eight reliability indexes,including maintainability and maintenance cost,are considered in the generalized FMECA information.Subsequently,the cognition best worst method is used to calculate the weight of each screened index,and the weaknesses of the subsystems are ranked using a technique for order preference by similarity to an ideal solution.Finally,based on the failure data collected from certain domestic heavy-duty horizontal lathes,the weakness ranking result of the subsystems is obtained to verify the effectiveness of the proposed method.An improved weakness ranking method that can comprehensively analyze and identify weak subsystems is proposed herein for designing and improving the reliability of complex electromechanical products. | Zhaojun Yang Jinyan Guo Hailong Tian Chuanhai Chen Yongfu Zhu Jia Liu | 2021 | Chinese Journal of Mechanical Engineering2021，34，1： | 2 |
| 9 | UPF1 increases amino acid levels and promotes cell proliferation in lung adenocarcinoma via the eIF2α-ATF4 axis显示文摘Up-frameshift 1(UPF1),as the most critical factor in nonsense-mediated messenger RNA(mRNA)decay(NMD),regulates tumor-associated molecular pathways in many cancers.However,the role of UPF1 in lung adenocarcinoma(LUAD)amino acid metabolism remains largely unknown.In this study,we found that UPF1 was significantly correlated with a portion of amino acid metabolic pathways in LUAD by integrating bioinformatics and metabolomics.We further confirmed that UPF1 knockdown inhibited activating transcription factor 4(ATF4)and Ser51 phosphorylation of eukaryotic translation initiation factor 2α(eIF2α),the core proteins in amino acid metabolism reprogramming.In addition,UPF1 promotes cell proliferation by increasing the amino-acid levels of LUAD cells,which depends on the function of ATF4.Clinically,UPF1 mRNA expression is abnormal in LUAD tissues,and higher expression of UPF1 and ATF4 was significantly correlated with poor overall survival(OS)in LUAD patients.Our findings reveal that UPF1 is a potential regulator of tumor-associated amino acid metabolism and may be a therapeutic target for LUAD. | Lei FANG Huan QI Peng WANG Shiqing WANG Tianjiao LI Tian XIA Hailong PIAO Chundong GU | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，10： | 2 |
| 10 | Organocatalytic Stereoselective Synthesis of 3-Alkyl-3-hydroxy-2-oxindoles Catalyzed by Novel Water-compatible Axially Unfixed Biaryl-based Bifunctional Organocatalysts显示文摘In this work,six novel axially unfixed biaryl-based water-compatible bifunctional organocatalysts were de-signed and synthesized for the organocatalytic access to a variety of 3-alkyl-3-hydroxy-2-oxindole derivatives via aldol reactions in water.Organocatalyzed by 5a,the direct aldol reactions of isatins with enolisable ketones under-went readily in water,furnishing the structurally diverse 3-alkyl-3-hydroxy-2-oxindoles in various stereoselectivi-ties(up to>99%dr and>99%ee).Moreover,a plausible transition state of the conducted aldol reactions was hy-pothesized to shed light on the observed stereoselectivities of the obtained 3-alkyl-3-hydroxy-2-oxindoles. | Hongwu Zhao Wei Meng Zhao Yang Ting Tian Zhihui Sheng Hailong Li Xiuqing Song Yutong Zhang Sen Yang Bo Li | 2014 | Chinese Journal of Chemistry2014，32，5： | 1 |
| 11 | Existence of dimerized phases in frustrated spin ladder models显示文摘 | LIU Guanghua WANG Hailong TIAN Guangshan | 2008 | PhysRevB2008，77，21： | 1 |
| 12 | Carbon nanoparticle for highly sensitive and selective fluorescent detection of mercury(II) ion in aqueous solution显示文摘 | Hailong Li Junfeng Zhai Jingqi Tian Yonglan Luo Xuping Sun | 2011 | Biosensors and Bioelectronics2011，，12： | 1 |
| 13 | Transient-Spatial Pattern Mining of Eddy Current Pulsed Thermography Using Wavelet Transform显示文摘Eddy current pulsed thermography(ECPT) is an emerging Non-destructive testing and evaluation(NDT & E) technique, which uses hybrid eddy current and thermography NDT & E techniques that enhances the detectability from their compensation. Currently, this technique is limited by the manual selection of proper contrast frames and the issue of improving the efficiency of defect detection of complex structure samples remains a challenge. In order to select a specific frame from transient thermal image sequences to maximize the contrast of thermal variation and defect pattern from complex structure samples, an energy driven approach to compute the coefficient energy of wavelet transform is proposed which has the potential of automatically selecting both optimal transient frame and spatial scale for defect detection using ECPT. According to analysis of the variation of different frequency component and the comparison study of the detection performance of different scale and wavelets, the frame at the end of heating phase is automatically selected as an optimal transient frame for defect detection. In addition, the detection capabilities of the complex structure samples can be enhanced through proper spatial scale and wavelet selection. The proposed method has successfully been applied to low speed impact damage detection of carbon fibre reinforced polymer(CFRP) composite as well as providing the guidance to improve the detectability of ECPT technique. | YANG Hailong GAO Bin TIAN Guiyun REN Wenwei WOO Wai Lok | 2014 | Chinese Journal of Mechanical Engineering2014，27，4： | 1 |
| 14 | Review of David Li Discourse in Search of Members:In Honor of Ron Scollon显示文摘 | Tian Hailong | 2004 | Language in Society2004，2，： | 1 |
| 15 | Influence of cracking on chloride diffusivity and moisture influential depth in concrete sub- jected to simulated environmental conditions 显示文摘 | Ye Hailong Ye Tian Jin Nanguo et aI | 2013 | Construction and Building Materials2013，，47： | 1 |
| 16 | Effect of Curing Temperature on the Morphology and Hydration of MgO Expansive Material in Paste显示文摘The morphologies and hydration properties of MgO expansive material at different curing temperatures were investigated.When the curing temperature varies from 25℃to 50℃,the conductivity of MgO rises from 40 to 80μs/cm,the hydration product of MgO expansive material curing in water for 28 days is from 1.5—2 mm to 2—2.5μm in length through SEM observation,and the expansion of pastes with 5%of the magnesium oxide is from 0.36%up to 1.01%,it is increased by 2.78 times.When the content of cement paste increases to 95%and cured in water for 90 days,the brucite forms as hexaflaggy?shaped crystal,which is less than 0.1μm and tends to aggregates.The effect of curing temperature on the hydration of MgO expansive material is obvious. | ENG Tian Zi WANG Fu PENG Hailong YANG Weibo GAO Peiwei | 2019 | Transactions of Nanjing University of Aeronautics and Astronautics2019，36，4： | 1 |
| 17 | Influence of cracking on chloride diffusivity and moisture influential depth in concrete subjected to simulated environmental conditions显示文摘 | Hailong Ye Ye Tian Nanguo Jin Xianyu Jin Chuanqing Fu | 2013 | Construction and Building Materials2013，，： | 1 |
| 18 | Roles of plasma interleukin-6 and tumor necrosis factor-α and FFA and TG in the development of insulin resistance induced by high-fat diet显示文摘 | Kai Jiao Hailong Liu Jiankang Chen Dengmei Tian Junfeng Hou Alan D. Kaye | 2008 | Cytokine2008，，2： | 1 |
| 19 | Quantum phase transition in quarter-filled nanoclusters of manganite induced by element substitution at B site显示文摘In the present paper,we study the effect of element substitution for quarter-filled nanoclusters of perovskite manganite by introducing Jahn-Teller type of perturbation interaction to the double-exchange Hamiltonian.Using the unrestricted real-space Hartree-Fock approximation method we find that,the Jahn-Teller electron-phonon interaction plays the central role in producing the phase transition from ferromagnetic phase to CE type antiferromagnetic phase.Not only the Jahn-Teller interaction benefits antiferromagnetic correlation,it also increases the charge density order parameter.These theoretical results provide a guidance to predict the properties and modify the composition of particles of perovskite manganite under nano-scale. | WANG HaiLong WANG RongMing WANG YuGang TIAN GuangShan | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，7： | 1 |
| 20 | Luminescence properties of SrIn 2 O 4 :Eu 3+ incorporated with Gd 3+ or Sm 3+ ions显示文摘 | Hailong Wang Lianhua Tian | 2010 | Journal of Alloys and Compounds2010，，： | 1 |
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