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| 1 | Reduction of the incidence and mortality of rectal cancer bypolypectomy:a prospective cohort study in Haining County显示文摘AIM: To reduce the incidence and morlality of rectal cancerand address the hypothesis that colorectal cancer often arisefrom precursor lesion (s), either adenomas or non-alenomatous polyps, by conducting a population-basedmass screening for colorectal cancer in Haining County,Zhejiang, PRCMETHODS: From 1977 to 1980, physicians screened thepopulation of Haining County using 15 cm rigid endoscopy.Of over 240 000 participants, 4076 of them were diagnoselwith Precursor Iesions, eitler alenomas or non-adenomatous polyps, which were then removedl surgically.All individuals with precursor lesionswere followed up andreexamined by endoscopy every two to five years upto 1998.RESULTS: After the initial screening, 953 metactronousadenomas and 417 non-adenomatous polyps ware detected andremoved from the members of this cohort. Further, 27 cases ofcolorectal cancer were detected and treated. Log-rank tuestsshowed that the survival time among those cancer patients whounderwent mass screening increased significantly comparedtothat of other colorectal cancer patients (P < 0.0001). Accordingto the population-based cancer registry in Haining County,age-adjusted incidence and mortality of rectal cancer decreasedby 41% and 29 % from 1977-1981 to 1992-1996, respectively.Observed cumulative 20-year rectal cancer incidence was 31%lower than the expected in the screened group; the mortalitydue to rectal cancer was 18 % lower thah the expected in thescreened group.CONCLUSION: Mass screening for rectal cancer andprecursor lesions with protocoscopy in the generalpopulation and periodical following-up with routineendoscopy for high-risk patients may decrease both theincidence and mortality of rectal cancer. | Shu Zheng Xi-Yong Liu Qi Dong,Cancer Institute,Zhejiang University,88 Jiefang Road,HangZhou 310009,Zhejiang Province,China Ke-feng Ding Lin-Bo Wang Pei-Lin Qiu Su-Zhan Zhang,The 2~(nd)affiliated Hospital,Medical School of Zhejiang University,88 Jiefang Road,HangZhou 310009,Zhejiang Province,China Xin-Feng Ding Yong-Zhou Shen Gao-Fei Shen Oi-Rong Sun Wei-Dong Li,Haining Cancer Institute,Haining 314400,Zhejiang Province,China | 2002 | World Journal of Gastroenterology2002，8，3： | 37 |
| 2 | An efficient bifunctional electrocatalyst derived from layer-by-layer self-assembly of a three-dimensional porous Co-N-C@graphene显示文摘Three-dimensional (3D) porous carbon-based materials with tunable composition and microstructure are of great interest for the development of oxygen involved electrocatalytic reactions. Here, we report the synthesis of 3D porous carbon-based electrocatalyst by self-assembling Co-metal organic frameworks (MOF) building blocks on graphene via a layer-by-layer technique. Precise control of the structure and morphology is achieved by varying the MOF layer to tune the electrocatalytic properties. The as-produced electrocatalyst exhibits an excellent catalytic activity for the oxygen reduction reaction in 0.1molL^-1 KOH, showing a high onset potential of 0.963V vs. reversible hydrogen electrode (RHE) and a low tafel slope of 54mVdec^-1, compared to Pt/C (0.934V and 52mVdec^-1, respectively). Additionally, it shows a slightly lower potential vs. RHE (1.72V) than RuO2 (1.75V) at 10mAcm^-2 in an alkaline electrolyte. A rechargeable Zn-air battery based on the as-produced 3D porous catalyst demonstrates a high peak power density of 119mWcm^-2 at a cell voltage of 0.578V while retaining an excellent stability over 250 charge-discharge cycles. | Shichang Cai Rui Wang William M. Yourey Junsheng Li Haining Zhang Haolin Tang | 2019 | Science Bulletin2019，64，14： | 6 |
| 3 | A Plant Immune Receptor Adopts a Two-Step Recognition Mechanism to Enhance Viral Effector Perception显示文摘Plant intracellular nucleotide binding leucine-rich repeat (NLR) immune receptors play critical roles in pathoge n surveillance. Most plant NLRs characterized so far were found to use a single domain/sensor to recognize pathogen effectors. Here we report that the Sw-5b NLR immune receptor uses two distinct domains to detect the viral movement protein NSm encoded by tospovirus. In addition to its leucine-rich repeat (LRR) domain that has been previously reported, the N-terminal Solanaceae domain (SD) of Sw- 5b also interacts with NSm and a conserved 21-amino-acid region of NSm (NSm^21). The specific interaction between Sw-5b SD and NSm is required for releasing the inhibitory effect of coiled-coil domain on the NBARC- LRR region. Furthermore, we found that the binding of NSm affects the nucleotide binding activity of the NB-ARC-LRR in vitro, while Sw-5b NB-ARC-LRR is activated only when NSm and NSm^21 levels are high. Interestingly, Sw-5b SD could significantly enhanee the ability of the NB-ARC-LRR to detect low levels of NSm effector and facilitate its activation and induction of defense response. An Sw-5b SD mutant that is disrupted in NSm recognition failed to enhance the ability of the NB-ARC-LRR to sense low levels of NSm and NSm^21 . Taken together, our results suggest that Sw-5b SD functions as an extra sensor and the NB-ARC-LRR as an activator, and that Sw-5b NLR adopts a two-step recog nition mechanism to enhance viral effector perception. | Jia Li Haining Huang Min Zhu Shen Huang Wenhua Zhang Savithramma P. Dinesh-Kumar Xiaorong Tao | 2019 | Molecular Plant2019，12，2： | 6 |
| 4 | Emissions of automobiles fueled with alternative fuels based on engine technology:A review显示文摘Diversi?cation of alternative fuels for automobiles is not only an actual situation,but also a development trend.Whether the alternative fuels are clean is an important issue.Emissions of automobiles fueled with natural gas(NG),methanol,ethanol,biodiesel,dimethyl ether(DME)and polyoxymethylene dimethyl ethersare investigated and reviewed based on engine technology and fuel properties.Compared to gasoline,NG/gasoline bi-fuel and NG automobiles have higher brake thermal ef?ciencies(BTE)and produce less HC,CO and PM emissions,while moreCompared to diesel,NG/diesel dual fuel automobiles have lower BTE and emit lower soot andbut higher HC and CO emissions.Methanol and ethanol blending in gasoline can obviously reduce the HC,CO and PM emissions of spark ignition(SI)automobiles.Methanol or ethanol blending in diesel may prolong the ignition delay,shorten the combustion duration and improve the BTE,resulting in lower soot emissions.However,the HC,CO andof methanol or ethanol diesel blend fuels are uncertain due to low cetane number,high latent heat of vaporization.Most biodiesel has higher viscosity,distillation temperature,cetane number and oxygen content than diesel.Soot emission of biodiesel is lower than that of diesel,whileis higher.Both DME andnot contain Ce C bonds and their blend with diesel can prohibit the formation of soot.high cetane number and low viscosity,resulting in better ignitability and spray quality respectively.shortens both the ignition delay and the combustion duration,improves the BTE,and increases the temperature in the diffusion combustion phase,leading to a higher NOx emission. | Yisong Chen Jinqiu Ma Bin Han Peng Zhang Haining Hua Hao Chen Xin Su | 2018 | Journal of Traffic and Transportation Engineering(English Edition)2018，5，4： | 5 |
| 5 | In-situ fabrication of dual porous titanium dioxide films as anode for carbon cathode based perovskite solar cell显示文摘We develop a dual porous(DP) TiO_2 film for the electron transporting layer(ETL) in carbon cathode based perovskite solar cells(C-PSCs). The DP TiO_2 film was synthesized via a facile PS-templated method with the thickness being controlled by the spin-coating speed. It was found that there is an optimum DP TiO_2 film thickness for achieving an effective ETL, a suitable perovskite/TiO_2 interface, an efficient light harvester and thus a high performance C-PSC. In particular, such a DP TiO_2 film can act as a scaffold for complete-filling of the pores with perovskite and for forming high-quality perovskite crystals that are seamlessly interfaced with Ti_O2 to enhance interfacial charge injection. Leveraging the unique advantages of DPTiO2 ETL, together with a dense-packed and pinhole-free TiO_2 compact layer, PCE of the C-PSCs has reached 9.81% with good stability. | Xiaoli Zheng Zhanhua Wei Haining Chen Yang Bai Shuang Xiao Teng Zhang Shihe Yang | 2015 | Journal of Energy Chemistry2015，24，6： | 3 |
| 6 | A Flexible Three Clouds 5G Mobile Network Architecture Based on NFV & SDN显示文摘Along with the completion of the development of 4G technologies, the global mobile community starts the study of the next generation technologies, i.e. 5G technologies. This paper proposes a new flexible architecture for 5G mobile networks based on Network Function Virtualization(NFV) and Software Defined Network(SDN) technologies, which is adaptable to use cases and scenarios. Then implementation reference architecture and some typical 5G network deployment cases are discussed. Besides, some key issues for further study are also indicated at the end. | YANG Fengyi WANG Haining MEI Chengli ZHANG Jianmin WANG Min | 2015 | China Communications2015，12，S1： | 3 |
| 7 | Effect of Adsorption of ZrO2 in Catalysts on the Efficiency of Hydrolysis of Cellulose to Sugar in Aqueous System under Microwave Radiation显示文摘Summary of main observation and conclusion Five types of ZrO2 are used to simply establish an effective aqueous catalytic system with sulfuric acid for the hydrolysis of cellulose to sugar,respectively.By adjusting surface roughness and particle size of ZrO2 dfferent adsorption is produced.Accordingy,following the thought to inhibit the self-aggregation nature of cellulose,after the introduction of ZrO2 with adsorption in catalysts,the efficiency of the hydrolysis of cellulose to sugar is improved.The results show different ZrO2 can produce different effects during the hydrolysis of the cellulose with rela-tively low crystallinity.Under the optimal conditions,the conversion of cellulose and TRS yield reaches 95.5%and 93.6%,respectively.Through this re-search,it reveals the critical point to organize a feasible and useful way for the hydrolysis of cellulose to sugar with high efficiency in an aqueous system.An important theoretical and technical support is also provided for the conversion and utiliation of cellulose in the future. | Ying Qiao Lixin Feng Zhongqiu Li Zhenyu Zhang Jing Chen Haining Na Jin Zhu Lai Chen | 2020 | Chinese Journal of Chemistry2020，38，4： | 3 |
| 8 | Research on beamforming method for dual-line array with space mismatch between the two line arrays显示文摘当在双线的数组的二个线数组之间的空格是延期和的 mismatched.The 择向性功能,延期减去 beamforming 被推出,延期和和延期减去 beamforming 的港口/右舷辨别也在理想的地位下面两个都被学习时,双线的数组的港口/右舷辨别的性能将严重被降级并且在双线的数组的二个线数组之间的空格在下面被错配的地位。分析结果证明延期减去 beamforming 有港口 / 右舷辨别的更好的性能。最后,海试用结果表明理论结果。 | WANG Huakui LI Qihu HUANG Haining YE Qinghua LI Shuqiu ZHANG Chunhua | 2008 | Chinese Journal of Acoustics2008，27，1： | 2 |
| 9 | Cep57, a NEDDl-binding pericentriolar material component, is essential for spindle pole integrity显示文摘 | Qixi Wu Runsheng He Haining Zhou Albert CH Yu Bo Zhang Junlin Teng Jianguo Chen | 2012 | Cell Research2012，22，9： | 2 |
| 10 | Prison Term Prediction on Criminal Case Description with Deep Learning显示文摘The task of prison term prediction is to predict the term of penalty based on textual fact description for a certain type of criminal case.Recent advances in deep learning frameworks inspire us to propose a two-step method to address this problem.To obtain a better understanding and more specific representation of the legal texts,we summarize a judgment model according to relevant law articles and then apply it in the extraction of case feature from judgment documents.By formalizing prison term prediction as a regression problem,we adopt the linear regression model and the neural network model to train the prison term predictor.In experiments,we construct a real-world dataset of theft case judgment documents.Experimental results demonstrate that our method can effectively extract judgment-specific case features from textual fact descriptions.The best performance of the proposed predictor is obtained with a mean absolute error of 3.2087 months,and the accuracy of 72.54%and 90.01%at the error upper bounds of three and six months,respectively. | Shang Li Hongli Zhang Lin Ye Shen Su Xiaoding Guo Haining Yu Binxing Fang | 2020 | Computers, Materials & Continua2020，，3： | 2 |
| 11 | Treadmill Exercise Relieves Chronic Restraint Stress-induced Cognitive Impairments in Mice Via Activating Protein Phosphatase 2A显示文摘Dear Editor,Aerobic exercise is well known to improve cognitive functions including hippocampus-dependent spatial memory[1]and object recognition[2].Regarding the molecular mechanisms,the indispensable role of brain-derived neurotrophic factor(BDNF)in governing exercise-induced neural plasticity has been demonstrated for the improvement of learning and memory[3].Our recent study further demonstrated the activation of mechanistic target of rapamycin pathways downstream of BDNF to drive synaptic protein synthesis upon persistent exercise[4],but leaving the effect of exercise on the post-translational modification of proteins largely unknown. | Wenjing Zhang Haining Ou Borui Zhang Meifeng Zheng Lan Yan Yang Chen Kwok-Fai So Li Zhang | 2021 | Neuroscience Bulletin2021，37，10： | 2 |
| 12 | Transarterial chemoembolization in combination with programmed death-1/programmed cell death-ligand 1 immunotherapy for hepatocellular显示文摘Hepatocellular carcinoma(HCC)is one of the most common malignancies worldwide.With the development of systemic therapies,several studies are currently underway,especially those related to the use of programmed death-1/programmed cell death-ligand 1(PD-1/PD-L1)immunotherapy.Moreover,studies on transarterial che-moembolization(TACE)and PD-1/PD-L1 immunotherapy have demonstrated some interesting outcomes.This article reviewed the current clinical evidence on the combination of TACE and PD-1/PD-L1 immunotherapy.Overall,our review summarized that a favorable survival time could be achieved using this combination in most patients.However,complications such as hyperprogression should be taken seriously,and the underlying mechanisms need to be explored. | Jingxin Yan Manjun Deng Shunyu Kong Ting Li Zhenwu Lei Lushun Zhang Yutong Zhuang Xin He Huanwei Wang Haining Fan Yingxing Guo | 2022 | iLIVER2022，1，4： | 2 |
| 13 | Urban structure and the risk of influenza A(H1N1) outbreaks in municipal districts显示文摘Changsha was one of the most affected areas during the 2009 A(H1N1)influenza pandemic in China.Here,we analyze the spatial–temporal dynamics of the 2009 pandemic across Changsha municipal districts,evaluate the relationship between case incidence and the local urban spatial structure and predict high-risk areas of influenza A(H1N1).We obtained epidemiological data on all cases of influenza A(H1N1)reported across municipal districts in Changsha during period May 2009–December 2010 and data on population density and basic geographic characteristics for 239 primary schools,97 middle schools,347 universities,96 malls and markets,674 business districts and 121 hospitals.Spatial–temporal K functions,proximity models and logistic regression were used to analyze the spatial distribution pattern of influenza A(H1N1)incidence and the association between influenza A(H1N1)cases and spatial risk factors and predict the infection risks.We found that the 2009 influenza A(H1N1)was driven by a transmission wave from the center of the study area to surrounding areas and reported cases increased significantly after September 2009.We also found that the distribution of influenza A(H1N1)cases was associated with population density and the presence of nearest public places,especially universities(OR=10.166).The final predictive risk map based on the multivariate logistic analysis showed high-risk areas concentrated in the center areas of the study area associated with high population density.Our findings support the identification of spatial risk factors and highrisk areas to guide the prioritization of preventive and mitigation efforts against future influenza pandemics. | Hong Xiao Xiaoling Lin Gerardo Chowell Cunrui Huang Lidong Gao Biyun Chen Zheng Wang Liang Zhou Xinguang He Haining Liu Xixing Zhang Huisuo Yang | 2014 | Chinese Science Bulletin2014，59，5： | 1 |
| 14 | Effects of chronic treatment with honokiol in spontaneously hypertensive rats 显示文摘 | ZHANG Genshui WANG Rujun ZHANG Haining | 2010 | Biol Pharm Bull2010，33，3： | 1 |
| 15 | Survivin, a key component of the Wnt/β?catenin signaling pathway, contributesto traumatic brain injury-induced adult neurogenesis in the mouse dentate gyrus显示文摘 | Lin Zhang Rong Yan Qi Zhang Haining Wang Xiaokui Kang Jia Li Shuyuan Yang Jianning Zhang Zhenlin Liu Xinyu Yang | 2013 | International Journal of Molecular Medicine2013，，4： | 1 |
| 16 | Suppression of endothelin-l-induced cardiac myocyte hypertrophy by PPAR agonists : role of diacylglycerol kinase zeta 显示文摘 | HUANG Yingsu ZHANG Haining SHAO Zongjun | 2011 | Cardiovasc Res2011，90，2： | 1 |
| 17 | Impregnation of amine-tailored titanate nanotubes in polymer electrolyte membranes显示文摘 | Qiong Li Haining Zhang Zhengkai Tu Jun Yu Chuanxi Xiong Mu Pan | 2012 | Journal of Membrane Science2012，，： | 1 |
| 18 | Epitaxial growth and thermal-conductivity limit of singlecrystalline Bi2Se3/In2Se3 superlattices on mica显示文摘在超点阵的热运输被各种各样的散布声子的过程管理。为在 chalcogenide 超点阵提取异种接口的散布声子的贡献,单人赛水晶的双性人 2 Se 3/In2 有最小化的缺点的 Se 3(BS/IS ) 超点阵被分子的横梁取向附生在 fluorophlogopite 云母上准备。BS/IS 超点阵的跨飞机的进行热的性质被表明精确取决于时期厚度和超点阵的成分,在在热传导性的最小显示一条转线路从的地方对在超点阵的像波浪的声子运输像粒子。BS/IS 超点阵的热传导性的最小比内在的 BS 电影的低将近一个数量级。 | Wuyang Ren Handong Li Lei Gao Yong Li Zhongyang Zhang Chengjia Long Haining Ji Xiaobin Niu Yuan Lin Zhiming Wang | 2017 | Nano Research2017，10，1： | 1 |
| 19 | Evidence of mTOR Activation by an AKT-Independent Mechanism Provides Support for the Combined Treatment of PTEN-Deficient Prostate Tumors with mTOR and AKT Inhibitors显示文摘 | Zhang W Haines BB Efferson C | 2012 | Transl Oncol2012，5，6： | 1 |
| 20 | Differential gene expression profiling of human epidermal growth factor receptor 2- overexpressing mammary tumor显示文摘(HER2 ) 人的表皮的生长因素受体 2 高度在约 30% 乳癌病人被表示,并且实质的证据支持在 HER2 overexpression 和差的全面幸存之间的关系。然而, HER2 信号 transduction 小径的生物功能不是完全清楚的。在小径以内调查基因激活,我们屏蔽了差别在 HER2 积极的老鼠的表示基因用减少性的杂交与反向的弄污点的分析相结合的二方向性的抑制的乳房的肿瘤。与 transduction,房间 proliferation/growth/apoptosis 和 secreted/extracellular 矩阵蛋白质有关的四十基因和表示顺序标签是在 HER2 积极的乳房的肿瘤织物表示的差别。在这些之中, 19 已经被报导是在乳房的肿瘤表示的差别, 11 首先被识别是在这研究在乳房的肿瘤表示,但是是的差别已经在另外的肿瘤报导了,并且 10 与另外的癌症相关。这些基因能便于在乳癌发信号的 HER2 的角色的理解。 | Yan Wang Haining Peng Yingli Zhong Daiqiang Li Mi Tang Xiaofeng Ding Jian Zhang | 2008 | Acta Biochimica et Biophysica Sinica2008，40，5： | 1 |
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