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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Regulation of myocardial carbohydrate metabolism under normal and ischaemic conditions:potential for pharmacological interventions 显示文摘 | Stanley WC Lopaschuk GD Hall JK McCormack JG | 1997 | Cardiovsc Res1997，33，： | 1 |
| 3 | Genomic imprinting:rewie and relevance to human diseases显示文摘 | Hall JG | 1990 | Am J Hum genet1990，46，5： | 1 |
| 4 | The unc-5,unc-6,and unc40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C elegans显示文摘 | Hedgecock EM Culotti JG Hall DH | 1990 | Neuron1990，4，： | 1 |
| 5 | Job scope and individual differ-ence as predictors of job involvement : Independent or interaction 显示文摘 | Rabinowitz S Hall DT Goodale JG | 1977 | Acadf Managem J1977，20，2： | 1 |
| 6 | High-dose conformal radiotherapy for treatment of stage Ⅲ A/ⅢB non-small-cell lung cancer :technical issues and results of a phaseⅠ/Ⅱ trial显示文摘 | Rosenman JG Halle JS Socinski MA | 2002 | Int J Radiat Oncol Biol Phys2002，54，： | 1 |
| 7 | Polymorphism identifi- cation and quantitative detection of genomic DNA by invasivecleavage of oligonucleotide probes 显示文摘 | Lyamichev V Mast AL Hall JG | 1999 | Nat Biotechnol1999，17，： | 1 |
| 8 | Differential mortality and transplantation rates among Asians and Pacific Is- landers with ESRD 显示文摘 | Hall YN Sugihara JG Go AS | 2005 | J Am Soc Nephrol2005，16，12： | 1 |
| 9 | Analysis of single nucle- otide polymorphism typing with solid phase in-asi-e clea-age reactions 显示文摘 | Willkins SP Hall JG Lyamiche- V | 2001 | Nucleic Acids Res2001，29，： | 1 |
| 10 | Polymorphism identification and quantitative detection of genomic DNA by invasive cleavage of oligonucleotide probes 显示文摘 | Lyamichev V Mast AL Hall JG | 1999 | Nature Biotechnology1999，17，： | 1 |
| 11 | Identifying acoustic scattering sources in normal renal parenchyma in vivo by varying arterial and urethral pressures 显示文摘 | Insana MF Wood JG Hall TJ | 1992 | Ultrasound Med Biol1992，18，67： | 1 |
| 12 | Dose-escalating conforreal thoracic radiation therapy with induction and concurrent carboplatin/paclitaxel in unresectable stage ⅢA/B no small cell lung carcinoma:a modified phase Ⅰ/Ⅱ trial显示文摘 | Socinski MA Rosenman JG Halle J | 2001 | Cancer2001，92，5： | 1 |
| 13 | The comparative role of activator protein 1 and Smad factors in the regulation of Timp-1 and MMP-1 gene expression by transforming growth factor-beta 1显示文摘 | Hall MC Young DA Waters JG | 2003 | J Biol Chem2003，278，10： | 1 |
| 14 | An inexpensive,rapid and precise affinity chromatography method for the measurement of glycosylated haemoglobins显示文摘 | Hall PM Cook JG Gould BJ | 1983 | Ann Clin Biochem1983，20，3： | 1 |
| 15 | Arthrogryposis multiplex congenita (amyoplasia) : an orthopaedic perspective 显示文摘 | Bevan WP Hall JG Bamshad M | 2007 | J Pediatr Orthop2007，27，5： | 1 |
| 16 | Randomized clinical trial of con- ventional versus cylindrical abdominoperineal resection for locally ad- vanced lower rectal cancer显示文摘 | Hall JG Wang ZJ Wei GH | 2012 | Am J Surg2012，204，3： | 1 |
| 17 | Individualized medicine What the genetic revolution will bring to health care in the 21st century显示文摘 | Hall JG | 2003 | Can Fam Physician2003，49，9： | 1 |
| 18 | Clinical, Genetic, and epidemiological factors in neural tube defects显示文摘 | Hall JG Friedman JM | 1988 | J HUM Genet1988，43，： | 1 |
| 19 | Identifying acoustic scatter- ing sources in normal renal parenchyma in vivo by varying ar- terial and ureteral pressures显示文摘 | Insana MF Wood JG Hall TJ | 1992 | Ultrasound Med Bio!1992，18，67： | 1 |
| 20 | Primary and secondary control in academic development: Gender - specific implications for stress and health in college students显示文摘 | Hall NC Chipperfield JG Perry RP | 2006 | Anxiety Stress and Coping2006，19，： | 1 |
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