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| 1 | IL-37b suppresses T cell priming by modulating dendritic cell maturation and cytokine production via dampening ERK/NF-κB/S6K signalings显示文摘Interleukin 37b (IL-37b ) 在压制有免疫力的回答起一个关键作用,部分由 modulating 树枝状的房间(DC ) 的功能。然而,精确机制大部分仍然是未知的。这里,我们在回答由 DC 导致了的 DC 成熟和 T 房间上调查了 IL-37b 的效果,并且探索了深奥发信号的小径。它被发现那 IL-37b 下面调整在 vitro 的 DC 上的 co-stimulatory 分子 CD80 和 CD86 的表情。同时,支持 inflammatory cytokines 的表情例如 TNF-6, 和 IL-6,被压制,当时 T 房间的表示禁止的 cytokine TGF- 在 IL-37b-treated DC 被增加。另外, T 房间上的 DC 的激活效果被 IL-37b 损害。我们进一步表明细胞外的调整单人赛的 kinase (英皇家空军之阶级最低之兵) ,原子 factor-B (NF-B ) ,和表明小径的 mTOR-S6K 涉及 IL-37b 导致的 DC 的抑制。这被化学禁止者的同样镇压的效果在 DC 在 IL-6 和 TNF- 的表情上对 NF-B,英皇家空军之阶级最低之兵,和 S6K 证实。在结论,这些结果证明 IL-37b 由在英皇家空军之阶级最低之兵, NF-B,和基于 S6K 的禁止的发信号小径包含在 T 房间 priming 压制了 DC 成熟和 immunostimulatory 能力。 | Wantong Wu Weiqiang Wang Yun Wang Wenwen Li Gang Yu Zhonglong Li Chunmin Fang Yue Shen Zhina Sun Ling Han Juan Yu Lijun Fang Song Chen Kui Dong Zhongchao Han Hanzhi Liu Yuechen Luo Xiaoming Feng | 2015 | Acta Biochimica et Biophysica Sinica2015，47，8： | 8 |
| 2 | A critical epitope in CD147 facilitates memory CD4^(+) T-cell hyper-activation in rheumatoid arthritis显示文摘The abnormal activation of CD4^(+)CD45RO+memory T(Tm)cells plays an important role in the pathogenesis of rheumatoid arthritis(RA).Previous studies have shown that CD147 participates in T-cell activation.However,it remains unclear whether CD147 is involved in abnormal Tm-cell activation in RA patients.In this study,we demonstrated that CD147 was predominantly upregulated in Tm cells derived from RA patients.The anti-CD147 mAb 5A12 specifically inhibited Tm-cell activation and proliferation and further restrained osteoclastogenesis.Using a structural–functional approach,we depicted the interface between 5A12 and CD147.This allowed us to identify two critical residues,Lys63 and Asp65,as potential targets for RA treatment,as the double mutation K63A/D65A inhibited Tm-cell activation,mimicking the neutralization by 5A12.This study provides not only a theoretical basis for a“CD147-Tm/Osteoclast-RA chain”for the potential prevention and treatment of RA or other T-cell-mediated autoimmune diseases but also a new target for related drug design and development. | Na Guo Sheng Ye Kui Zhang Xiaoling Yu Hongyong Cui Xiangmin Yang Peng lin Minghua Lv Jinlin Miao Yang Zhang Qing Han Rongguang Zhang Zhinan Chen Ping Zhu | 2019 | Cellular & Molecular Immunology2019，16，6： | 6 |
| 3 | Epidemiological Characteristics of Echinococcosis in Non-Endemic PLADs—China,2017–2020显示文摘Summary What is already known about this topic?Echinococcosis,also known as hydatid disease,is a zoonotic parasitic disease caused by the larvae of Echinococcus granulosus.Western China has one of the most severe epidemics worldwide.Echinococcosis is endemic in 370 counties of 9 provincial-level administrative divisions(PLADs)including Inner Mongolia,Sichuan,Yunnan,Tibet,Shaanxi,Gansu,Qinghai,Ningxia,Xinjiang and Xinjiang Production and Construction Corps(XPCC). | Yan Kui Baixue Liu Xu Wang Cuizhao Xue Jingbo Xue Yalan Zhang Benguang Zhang Yang Dai Shuai Han Weiping Wu | 2021 | China CDC weekly2021，3，51： | 5 |
| 4 | Unraveling a genetic roadmap for improved taste in the domesticated apple显示文摘Although taste is an important aspect of fruit quality, an understanding of its genetic control remains elusive in apple and other fruit crops. In this study, we conducted genomic sequence analysis of 497 Malus accessions and revealed erosion of genetic diversity caused by apple breeding and possible independent domestication events of dessert and cider apples. Signatures of selection for fruit acidity and size, but not for fruit sugar content, were detected during the processes of both domestication and improvement. Furthermore, we found that single mutations in major genes affecting fruit taste, including Ma1, MdTDT, and MdSOT2, dramatically decrease malate, citrate, and sorbitol accumulation, respectively, and correspond to important domestication events. Interestingly, Ma1 was identified to have pleiotropic effects on both organic acid content and sugar:acid ratio, suggesting that it plays a vital role in determining fruit taste. Fruit taste is unlikely to have been negatively affected by linkage drag associated with selection for larger fruit that resulted from the pyramiding of multiple genes with minor effects on fruit size. Collectively, our study provides new insights into the genetic basis of fruit quality and its evolutionary roadmap during apple domestication, pinpointing several candidate genes for genetic manipulation of fruit taste in apple. | Liao Liao Weihan Zhang Bo Zhang Ting Fang Xiao-Fei Wang Yarning Cai Collins Ogutu Lei Gao Gang Chen Xiaoqing Nie Jinsheng Xu Quanyan Zhang Yiran Ren Jianqiang Yu Chukun Wang Cecilia H.Deng Baiquan Ma Beibei Zheng Chun-Xiang You Da-Gang Hu Richard Espley Kui Lin-Wang Jia-Long Yao Andrew C.Allan Awais Khan Schuyler S.Korban Zhangjun Fei Ray Ming Yu-Jin Hao Li Li Yuepeng Han | 2021 | Molecular Plant2021，14，9： | 5 |
| 5 | A New Kinetic Model for Residue Hydrotreating Based on Chemical Reaction Sections显示文摘New definition of virtual molecular-group components about CH and CH2 is proposed in the paper.The new reaction,hydrogenation of CH to CH2(HDCH),can be used to represent the change of C and H in RHT.By using the lumping approach,the kinetic models about HDCH,HDS,HDN,HDCCR,HDM,HDNi and HDV reactions were established.They are key components of the new kinetic model for RHT based on reaction sections.During the construction of kinetic model,goodness-to-fit(R^2)between test data and model data was set as the target value,and the model parameters were calculated accurately.In verification test,the predicted content of H,S,N,CCR,M,Ni and V can match well with the test data. | Zhang Kui Dai Lishun Nie Hong Shao Zhicai Liu Tao Deng Zhonghuo Han Wei Jia Yanzi | 2020 | China Petroleum Processing & Petrochemical Technology2020，22，2： | 4 |
| 6 | Therapeutic Efficacy Observation on Combining Herbal Cake-partitioned Moxibustion with Plum- blossom Needle Therapy for Cervical Radiculopathy显示文摘Objective:To observe the clinical effect of combining Herbal cakepartitioned moxibustion with plum-blossom needle therapy for cervical radiculopathy.Methods:A total of 150 cases with cervical radiculopathy were randomly allocated into a treatment group(n=90)and a control group(n=60)at ratio of 3:2.Cases in the treatment group were treated with combining herbal cake-partitioned moxibustion with plum-blossom needle therapy,whereas cases in the control group were treated with combining Dan Shen(Radix Salviae Miltiorrhizae)injection with traction.The therapeutic efficacies were evaluated by the third party after three courses of treatments.Results:The recovery and total effective rates in the treatment group were 51.1%and 97.8%respectively,versus 18.3%and 78.3%in the control group,showing statistically significant differences(both P<0.05).And there was a between-group statistical difference in the number of recovery cases in different courses of treatments(P<0.05).Conclusion:Combining herbal cake-partitioned moxibustion with plum-blossom needle therapy was more effective than combining Dan Shen(Radix Salviae Miltiorrhizae)injection with traction for cervical radiculopathy,and it took effect more quickly.It is worth further popularization in clinic. | Liu Min-juan Wang Kui Han Chou-ping | 2013 | Journal of Acupuncture and Tuina Science2013，11，6： | 3 |
| 7 | Shape-controlled growth of SrTiOz polyhedral submicro/ nanocrystals显示文摘 | Lingqing Dong Hui Shi Kui Cheng Qi Wang Wenjian Weng Weiqiang Han | 2014 | Nano Research2014，7，9： | 3 |
| 8 | Deterministic Secure Quantum Communication with Cluster State and Bell-Basis Measurements显示文摘We present a novel protocol for deterministic secure quantum communication by using the four-qubit clusterstate as quantum channel.It is shown that two legitimate users can directly transmit the secret messages based on Bell-basis measurements and classical communication.The present protocol makes use of the ideas of block transmission anddecoy particle checking technique.It has a high capacity as each cluster state can carry two bits of information,and hasa high intrinsic efficiency because almost all the instances except the decoy checking particles (its number is negligible)are useful.Furthermore,this protocol is feasible with present-day technique. | YUAN Hao HE Qin HU Xiao-Yuan HOU Kui HAN Lian-Fang SHI Shou-Hua | 2008 | Communications in Theoretical Physics2008，50，11： | 3 |
| 9 | Study on Effect of Gd (III) Speciation on Ca (II) Speciationin Human Blood Plasma by Computer Simulation显示文摘Ca (II) speciation and effect of Gd (III) speciation on Ca (II) speciation in human blood plasma were studied by computer simulation. [CaHCO3]+ is a predominant compound species of Ca (II). Gd (III) can compete with Ca (II) for biological molecules. The presence of Gd (III) results in a increase of concentration of free Ca (II) and a decrease of concentration of Ca (II) compounds. | Yue WANG, Xing LU, Shu Yun WANG, Jing Fen HAN, Kui Yue YANG, Chun Ji NIU*, Jia Zuan NI Key Laboratory of Rare Earth Chemistry and Physics, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022 | 2001 | Chinese Chemical Letters2001，12，2： | 2 |
| 10 | Repurposing econazole as a pharmacological autophagy inhibitor to treat pancreatic ductal adenocarcinoma显示文摘Pancreatic ductal adenocarcinoma(PDAC)is characterized by the highest mortality among carcinomas.The pathogenesis of PDAC requires elevated autophagy,inhibition of which using hydroxychloroquine has shown promise.However,current realization is impeded by its suboptimal use and unpredictable toxicity.Attempts to identify novel autophagy-modulating agents from already approved drugs offer a rapid and accessible approach.Here,using a patient-derived organoid model,we performed a comparative analysis of therapeutic responses among various antimalarial/fungal/parasitic/viral agents,through which econazole(ECON),an antifungal compound,emerged as the top candidate.Further testing in cell-line and xenograft models of PDAC validated this activity,which occurred as a direct consequence of dysfunctional autophagy.More specifically,ECON boosted autophagy initiation but blocked lysosome biogenesis.RNA sequencing analysis revealed that this autophagic induction was largely attributed to the altered expression of activation transcription factor 3(ATF3).Increased nuclear import of ATF3 and its transcriptional repression of inhibitor of differentiation-1(ID-1)led to inactivation of the AKT/mammalian target of rapamycin(m TOR)pathway,thus giving rise to autophagosome accumulation in PDAC cells.The magnitude of the increase in autophagosomes was sufficient to elicit ER stress-mediated apoptosis.Furthermore,ECON,as an autophagy inhibitor,exhibited synergistic effects with trametinib on PDAC.This study provides direct preclinical and experimental evidence for the therapeutic efficacy of ECON in PDAC treatment and reveals a mechanism whereby ECON inhibits PDAC growth. | Ningna Weng Siyuan Qin Jiayang Liu Xing Huang Jingwen Jiang Li Zhou Zhe Zhang Na Xie Kui Wang Ping Jin Maochao Luo Liyuan Peng Edouard C.Nice Ajay Goel Suxia Han Canhua Huang Qing Zhu | 2022 | Acta Pharmaceutica Sinica B2022，12，7： | 2 |
| 11 | Robust Quantum Secure Direct Communication and Deterministic Secure Quantum Communication over Collective Dephasing Noisy Channel显示文摘We propose two schemes for quantum secure direct communication (QSDC) and deterministic securequantum communication (DSQC) over collective dephasing noisy channel.In our schemes,four special two-qubit statesare used as the quantum channel.Since these states are unchanged through the collective dephasing noisy channel,the effect of the channel noise can be perfectly overcome.Simultaneously,the security against some usual attacks canbe ensured by utilizing the various checking procedures.Furthermore,these two schemes are feasible with present-daytechnique. | YUAN Hao SONG Jun HE Qin HAN Lian-Fang HOU Kui HU Xiao-Yuan SHI Shou-Hua | 2008 | Communications in Theoretical Physics2008，50，9： | 2 |
| 12 | NANOG Alleviates the Damage of Human Hair Follicle Mesenchymal Stem Cells Caused by H_2O_2 through Activation of AKT Pathway显示文摘Objective To explore the protective effect of NANOG against hydrogen peroxide(H_2O_2)-induced cell damage in the human hair follicle mesenchymal stem cells(hHF-MSCs). Methods NANOG was expressed from a lentiviral vector, pLVX-IRES-ZsGreen. NANOG hHF-MSCs and vector hHF-MSCs were treated with 400 μmol/L hydrogen peroxide(H_2O_2) for 2 h, the cell survival rate, cell morphology, ROS production, apoptosis and expression of AKT, ERK, and p21 were determined and compared. Results Our results showed that NANOG could activate AKT and upregulate the expression of p-AKT, but not p-ERK. When treated with 400 μmol/L H_2O_2, NANOG hHF-MSCs showed higher cell survival rate, lower ROS production and apoptosis, higher expression of p-AKT, higher ratio of p-AKT/AKT. Conclusion Our results suggest that NANOG could protect hHF-MSCs against cell damage caused by H_2O_2 through activating AKT signaling pathway. | SHI Jia Hong ZUO Kui Yang ZHANG Ying Yao WANG Bo HAN Xing LIAN Ao Bo LIU Jin Yu | 2019 | Biomedical and Environmental Sciences2019，32，4： | 2 |
| 13 | Biological control of Phytophthora blight in red pepper (Capsicum annuum L.) using Bacillus subtilis显示文摘 | Kui Jae Lee Seralathan Kamala-Kannan Han Sang Sub Cho Kyu Seong Gun Woong Lee | 2008 | World Journal of Microbiology and Biotechnology2008，，7： | 1 |
| 14 | Phase Evolution of Aluminum-Chromium-Phosphate Binders during HeatTreatmen显示文摘 | Chao Zou Dai Hai Zhang YiLi Wen Jian Wang Kui Cheng Chen Lu Song Gao Ling Zhao Pi Yi Du Ge ShenJian Xun Wang Gao Rong Han | | 0，，： | 1 |
| 15 | Scaling behavior of the time-fractional equations for molecular-beam epitaxy growth: scaling analysis versus numerical stimulations显示文摘 | XIA Hui TANG Gang HAN Kui | 2009 | Euro Phys J B2009，71，2： | 1 |
| 16 | Need for surveillance of concomitant peripheral artery disease in patients with coronary disease: results of the AGATHA survey in Malaysia显示文摘Background For patients with cardiovascular disease (CVD), co-existence of peripheral artery disease (PAD) predicts increased mortality, and such patients are also more likely to benefit from aggressive therapy. Surveillance of PAD is often neglected at health clinics. Our aim is to highlight the importance and ease of surveillance of PAD in patients with CVD. Objective To determine the prevalence of symptomatic and asymptomatic PAD in a Malaysian patient population with documented CVD. Methods and Results A total of 393 subjects with established CVD were recruited from three centres (85 women and 308 men), as part of a larger international (AGATHA) survey. PAD, determined by presence of claudicant symptoms on interview and/or abnormal ankle-brachial index (ABI) score of less than 0.9, was present in 21.4% of patients-of whom 64% were asymptomatic. Abnormal ABI is associated with higher systolic blood pressure and number of arterial beds affected. Conclusions Concomitant PAD is prevalent among CVD patients in Malaysia. ABI screening is simple and yields a high proportion of patients with extensive atherosclerosis who may require more aggressive atherosclerotic risk management.(J Geriatr Cardiol 2007;4:195-199.) | Kui Hian Sim Kok Han Chee Inderjit Singh Choon Kiat Ang HoungBang Liew Kim Heung Tan Omar Ismail | 2007 | Journal of Geriatric Cardiology2007，4，4： | 1 |
| 17 | Neuronal differentiation of embryonic midbrain cells by upregulation of peroxisome proliferator-activated receptor-gamma via the JNK-dependent pathway显示文摘 | Ki Sook Park Rhee Da Lee Sun-Kyung Kang Soon Young Han Kui Lae Park Ki Hwa Yang Youn Sook Song Hye Ji Park Yoot Mo Lee Yeo Pyo Yun Ki Wan Oh Dae Joong Kim Young Won Yun Se Jin Hwang Sung Eun Lee Jin Tae Hong | 2004 | Experimental Cell Research2004，，2： | 1 |
| 18 | A multi-channel chemical sensor and its application in detecting hydrothermal vents显示文摘There are well-established chemical and turbidity anomalies in the plumes occurring vicinity of hydrothermal vents, which are used to indicate their existence and locations. We here develop a small, accurate multi-channel chemical sensor to detect such anomalies which can be used in deep-sea at depths of more than 4 000 m. The design allowed five all-solid-state electrodes to be mounted on it and each (apart from one reference electrode) could be changed according to chemicals to be measured. Two experiments were conducted using the chemical sensors. The first was a shallow-sea trial which included sample measurements and in situ monitoring. pH, Eh, CO3^2- and SO4^2- electrodes were utilized to demonstrate that the chemical sensor was accurate and stable outside the laboratory. In the second experiment, the chemical sensor was integrated with pH, Eh, CO3^2- and H2S electrodes, and was used in 29 scans of the seabed along the Southwest Indian Ridge (SWIR) to detect hydrothermal vents, from which 27 sets of valid data were obtained. Hydrothermal vents were identified by analyzing the chemical anomalies, the primary judging criteria were decreasing voltages of Eh and H2S, matched by increasing voltages of pH and CO3^2- . We proposed that simultaneous detection of changes in these parameters will indicate a hydrothermal vent. Amongst the 27 valid sets of data, five potential hydrothermal vents were targeted using the proposed method. We suggest that our sensors could be widely employed by marine scientists. | Zhen Cai A J Mur Luis Jiwan Han Kui Wang Huawei Qin Ying Ye | 2019 | Acta Oceanologica Sinica2019，38，9： | 1 |
| 19 | Embeddingmeshesintolocallytwistedcubes显示文摘 | HAN Yuejuan FAN Jianxi ZHANG Shukui etal | 2010 | InformationSciences2010，180，19： | 1 |
| 20 | Mass sensitivity evaluation and device design of a LOVE wave device for bond rupture biosensors using the finite element method显示文摘 | HAN Kui YUAN Y J | 2014 | IEEE Sensors Journal2014，14，8： | 1 |
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