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| 1 | H7N9 virulent mutants detected in chickens in China pose an increased threat to humans显示文摘 | Jianzhong Shi Guohua Deng Huihui Kong Chunyang Gu Shujie Ma Xin Yin Xianying Zeng Pengfei Cui Yan Chen Huanliang Yang Xiaopeng Wan Xiurong Wang Liling Liu Pucheng Chen Yongping Jiang Jinxiong Liu Yuntao Guan Yasuo Suzuki Mei Li Zhiyuan Qu Lizheng Guan Jinkai Zang Wenli Gu Shuyu Han Yangming Song Yuzhen Hu Zeng Wang Linlin Gu Wenyu Yang Libin Liang Hongmei Bao Guobin Tian Yanbing Li Chuanling Qiao Li Jiang Chengjun Li Zhigao Bu Hualan Chen | 2017 | Cell Research2017，27，12： | 70 |
| 2 | Regional difference of annual precipitation and discharge variation over west China during the last 50 years显示文摘Using annual precipitation and discharge data measured in the past five decades,this paper analyzed the regional differences over west China in terms of climate and discharge variations,and investigated the relationship between the regional characteristics and the activities of South and East Asian sum-mer monsoon. Results revealed that the precipitation and discharge in the upper reaches of the Yellow River (Central West China) have a negative correlation with those in Xinjiang (northwest China) and the Yarlung Zangbo River (the upper reaches of the Brahmaputra Rive,southwest China) regions. The geographical patterns of precipitation and discharge variations are different over west China,i.e. the regional climate displays the alteration of dry-wet-dry or wet-dry-wet from north to south in west China. The negative correlation of annual discharges between Xinjiang and the upper reaches of the Yellow River is found statistically significant in the decadal scale,and that between the Yarlung Zangbo River and the upper reaches of the Yellow River is found active in the interannual scale. The regional char-acteristics indicate that the discharge/precipitation variations in the upper reaches of the Yellow River are dominated by the East Asian summer monsoon while their variations in Xinjiang are affected by both the west wind and East Asian summer monsoon. | DING YongJian YE BaiSheng HAN TianDing SHEN YongPing LIU ShiYin | 2007 | Science China Earth Sciences2007，50，6： | 7 |
| 3 | Chinese expert consensus on the management of chimeric antigen receptor T cell therapy-associated coagulopathy显示文摘Chimeric antigen receptor T-cell(CAR-T)therapy has greatly improved the disease remission rate and long-term survival rate of patients with relapsed/refractory hematological malignancies.[1-3]Currently,several commercial CAR-T products are available in the market and numerous CAR-T clinical trials have been conducted.Attention should be paid to the safety of CAR-T therapy.The main adverse effects of CAR-T therapy are cytokine release syndrome(CRS)and immune effector cell-associated neurotoxicity syndrome(ICANS).[4] | Heng Mei Fangping Chen Yue Han Ming Hou He Huang Xiaojun Huang Yuhua Li Aibin Liang Qifa Liu Ting Niu Jun Peng Wenbin Qian Yongping Song Jianxiang Wang Ying Wang Depei Wu Kailin Xu Linhua Yang Renchi Yang Lei Zhang Liansheng Zhang Xi Zhang Xiaohui Zhang Weili Zhao Weidong Han Yu Hu | 2022 | Chinese Medical Journal2022，，14： | 4 |
| 4 | 2022 Chinese expert consensus and guidelines on clinical management of toxicity in anti-CD19 chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma显示文摘Adoptive cellular immunotherapy with chimeric antigen receptor(CAR)T cells has emerged as a novel modality for treating relapsed and/or refractory B-cell non-Hodgkin lymphoma(B-NHL).With increasing approval of CAR T-cell products and advances in CAR T cell therapy,CAR T cells are expected to be used in a growing number of cases.However,CAR T-cell-associated toxicities can be severe or even fatal,thus compromising the survival benefit from this therapy.Standardizing and studying the clinical management of these toxicities are imperative.In contrast to other hematological malignancies,such as acute lymphoblastic leukemia and multiple myeloma,anti-CD19 CAR T-cell-associated toxicities in B-NHL have several distinctive features,most notably local cytokine-release syndrome(CRS).However,previously published guidelines have provided few specific recommendations for the grading and management of toxicities associated with CAR T-cell treatment for B-NHL.Consequently,we developed this consensus for the prevention,recognition,and management of these toxicities,on the basis of published literature regarding the management of anti-CD19 CAR T-cell-associated toxicities and the clinical experience of multiple Chinese institutions.This consensus refines a grading system and classification of CRS in B-NHL and corresponding measures for CRS management,and delineates comprehensive principles and exploratory recommendations for managing anti-CD19 CAR T-cell-associated toxicities in addition to CRS. | Ping Li Yang Liu Yun Liang Jian Bo Sujun Gao Yongxian Hu Yu Hu He Huang Xiaojun Huang Hongmei Jing Xiaoyan Ke Jianyong Li Yuhua Li Qifa Liu Peihua Lu Heng Mei Ting Niu Yongping Song Yuqin Song Liping Su Sanfang Tu Jianxiang Wang Depei Wu Zhao Wang Kailin Xu Zhitao Ying Qingming Yang Yajing Zhang Fengxia Shi Bin Zhang Huilai Zhang Xi Zhang Mingfeng Zhao Weili Zhao Xiangyu Zhao Liang Huang Jun Zhu Wenbin Qian Weidong Han Aibin Liang | 2023 | Cancer Biology & Medicine2023，20，2： | 3 |
| 5 | A novel lignite pre-drying system with low-grade heat integration for modern lignite power plants显示文摘The lignite pre-drying process plays an important role in modern lignite power plants and the fluidized bed dryer with internal heat utilization is a promising drying method which has both high efficiency and cost-effectiveness. After conducting an in-depth analysis of a typical lignite pre-drying power plant, this work proposed a novel lignite pre-drying system with low-grade heat integration. Through system integration, the low-temperature evaporation of the lignite was recovered to heat the combustion air, while the residual heat from the flue gases was used to heat the feed or condensed water, thereby saving a portion of heat from the steam bleeds of the high and intermediate pressure turbines. The results for a1,000 MW lignite-fired power plant showed that, the proposed pre-drying system could yield an increase in net plant efficiency of approximately 3.6 % points and a reduction in the cost of electricity of $1.83/(MW h). The thermodynamic and economic performances were each superior to those of the existing pre-drying system, convincingly demonstrating that the research of this paper may provide a promising integrated lignite pre-drying method for the next-generation of lignite-fired power plants. | Cheng Xu Gang Xu Yu Han Feifei Liang Yaxiong Fang Yongping Yang | 2014 | Chinese Science Bulletin2014，59，33： | 2 |
| 6 | Culturing adequate CAR-T cells from less peripheral blood to treat B-cell malignancies显示文摘Objective:Chimeric antigen receptor-modified T(CAR-T)cells have shown impressive results against relapsed/refractory B cell malignancies.However,the traditional manufacture of CAR-T cells requires leukapheresis to isolate large amounts of peripheral blood T cells,thus making some patients ineligible for the procedure.Methods:We developed a simple method for CAR-T cell preparation requiring small volumes of peripheral blood.First,CD3+T cells isolated from 50 mL peripheral blood from patients(B-cell malignancies)were stimulated with immobilized anti-CD3/RetroNectin in 6-well plates and then transduced with CAR-expressing lentiviral vector.After 4 d,the T cells were transferred to culture bags for large-scale CAR-T cell expansion.In vitro and animal experiments were performed to evaluate the activity of the manufactured CAR-T cells.Finally,29 patients with B-cell acute lymphoblastic leukemia(B-ALL)and 9 patients with B-cell lymphoma were treated with the CAR-T cells.Results:The CAR-T cells were expanded to 1–3×10^(8) cells in 8–10 d and successfully killed B cell-derived malignant tumor cells in vitro and in vivo.For patients with B-ALL,the complete remission rate was 93%1 month after CAR-T cell infusion;after 12 months,the overall survival(OS)and leukemia-free survival rates were 69%and 31%,respectively.For patients with lymphoma,the objective response rate(including complete and partial remission)was 78%2 months after CAR-T cell infusion,and after 12 months,the OS and progression-free survival rates were 71%and 43%,respectively.Cytokine-release syndrome(CRS)occurred in 65.51%and 55.56%of patients with B-ALL and B-cell lymphoma,respectively;severe CRS developed in 20.69%of patients with B-ALL and in no patients with lymphoma.Conclusions:Our novel method can generate sufficient numbers of CAR-T cells for clinical use from 50–100 mL peripheral blood,thus providing an alternative means of CAR-T cell generation for patients ineligible for leukapheresis. | Lu Han Jian Zhou Linlin Li Keshu Zhou Lingdi Zhao Xinghu Zhu Qingsong Yin Yufu Li Hongqin You Jishuai Zhang Yongping Song Quanli Gao | 2021 | Cancer Biology & Medicine2021，18，4： | 2 |
| 7 | 2021 Chinese consensus on the diagnosis and management of primary immune thrombocytopenia in pregnancy显示文摘Immune thrombocytopenia(ITP)is an acquired disease characterized by isolated thrombocytopenia,which is one of the most common causes of thrombocytopenia during pregnancy.Women with ITP who have severe thrombocytopenia are at an increased risk for life-threatening obstetric complications.Therefore,we established this consensus statement on the diagnosis and management of ITP during pregnancy(detailed information is available in the Supplementary File,http://links.lww.com7CM9/A978). | Zhang Xiaohui Chen Fangping Chen Xiequn Cheng Yunfeng Fang Meiyun Feng Jianming Fu Haixia Gao Hong Han Yue He Aili Hou Ming Hu Yu Huang Ruibin Huang Wenrong Jing Zhicheng Kong Peiyan Liang Aibin Liang Meiying Liu Daihong Liu Junling Liu Lin Liu Xiaowei Ma Liangming Mei Heng Ni Heyu Niu Ting Peng Jun Qiao Jianlin Ren Jinhai Song Yongping Tang Liang V Tong Tong Wang Shaoyuan Wang Xin Wang Zhao Wei Hui Wu Depei Wu Guangsheng Xu Caigang Xu Xue Xu Yajing Yang Linhua Yang Renchi Yang Tonghua Yin Chenghong Yu Li Zhang Guangsen Zhang Lei Zhang Liansheng Zhang Xi Zhao Weili Zhao Yongqiang Zhou Daobin Zhou Hu Zhou Zeping Zhu Tienan Wang Jianliu Huang Xiaojun | 2022 | Chinese Medical Journal2022，，8： | 2 |
| 8 | Mobile phone recognition method based on bilinear convolutional neural network显示文摘Model recognition of second-hand mobile phones has been considered as an essential process to improve the efficiency of phone recycling. However, due to the diversity of mobile phone appearances, it is difficult to realize accurate recognition. To solve this problem, a mobile phone recognition method based on bilinear-convolutional neural network(B-CNN) is proposed in this paper.First, a feature extraction model, based on B-CNN, is designed to adaptively extract local features from the images of secondhand mobile phones. Second, a joint loss function, constructed by center distance and softmax, is developed to reduce the interclass feature distance during the training process. Third, a parameter downscaling method, derived from the kernel discriminant analysis algorithm, is introduced to eliminate redundant features in B-CNN. Finally, the experimental results demonstrate that the B-CNN method can achieve higher accuracy than some existing methods. | HAN HongGui ZHEN Qi YANG HongYan DU YongPing QIAO JunFei | 2021 | Science China(Technological Sciences)2021，64，11： | 2 |
| 9 | Randomized trial of autologous bone marrow mesenchymal stem cells transplantation for hepatitis B virus cirrhosis: Regulation of T reg/ T h17 cells显示文摘 | Lanman Xu Yuewen Gong Benfu Wang Keqing Shi Yijun Hou Liping Wang Zuo Lin Yixiang Han Lu Lu Dazhi Chen Xiuli Lin Qiqiang Zeng Wenke Feng Yongping Chen | 2014 | J Gastroenterol Hepatol2014，，8： | 1 |
| 10 | Verification of a model of thermal storage incorporated with an extended lumped capacitance method for various solid–fluid structural combinations显示文摘 | Peiwen Li Ben Xu Jingxiao Han Yongping Yang | 2014 | Solar Energy2014，，： | 1 |
| 11 | Microarray analy- sis of two single-nucleotide polymorphisms of transforming growth factor alpha in patients with nonsyndromic cleft of north china显示文摘 | Wei Xu Weitian Han Yongping Lu | 2014 | CPCJ2014，51，4： | 1 |
| 12 | Reusable electronic products value prediction based on reinforcement learning显示文摘With the appearance of a huge number of reusable electronic products,the precise value evaluation has become an urgent problem to be solved in the recycling process.Traditional methods rely on manual intervention mostly.In order to make the model more suitable for the dynamic updating,this paper proposes the reinforcement learning based electronic products value prediction model which integrates market information to achieve timely and stable prediction results.The basic attributes and depreciation attributes of the product are modeled by two parallel neural networks separately to learn the different effects for prediction.Most importantly,the double deep Q network is adopted to fuse market information by reinforcement learning strategy,and the training on the old product data can be used to predict the following appeared product,which alleviates the cold start problem.Experiments on the real mobile phone recycling platform data verify that the model has achieved higher accuracy and it has a better generalization ability. | DU YongPing JIN XingNan HAN HongGui WANG LuLin | 2022 | Science China(Technological Sciences)2022，65，7： | 1 |
| 13 | The compari- son of BP network and RBF network in wind power predic- tion application显示文摘 | Han Shuang Yang Yongping Liu Yongqian | 2007 | IEEE2007，16，5： | 1 |
| 14 | Study on frictionand wear properties of nano-Al203 modified PTFE显示文摘 | Niu Yongping Han Ming Du Sanming | 2010 | EngineeringPlastics Application2010，38，2： | 1 |
| 15 | Positive regulation of migration and invasion by vasodilator-stimulatedphosphoprotein via Rac1 pathway in human breast cancer cells显示文摘 | Guoge Han Biao Fan Yimin Zhang Xuan Zhou Yongping Wang Huimin Dong Yun Wei Shengrong Sun Mingbo Hu Jingwei Zhang Lei Wei | 2008 | Oncology Reports2008，，4： | 1 |
| 16 | Comparative expression analysis of heavy metal ATPase subfamily genes between Cd-tolerant and Cd-sensitive turnip landraces显示文摘The heavy metal ATPase(HMA)subfamily is mainly involved in heavy metal(HM)tolerance and transport in plants,but an understanding of the definite roles and mechanisms of most HMA members are still limited.In the present study,we identified 14 candidate HMA genes named BrrHMAl—BrrHMA8 from the turnip genome and analyzed the phylogeny,gene structure,chromosome distribution,and conserved domains and motifs of HMAs in turnip(Brassica rapa var.rapa).According to our phylogenetic tree,the BrrHMAs are divided into a Zn/Cd/Co/Pb subclass and Cu/Ag subclass.The BrrHMA members show similar structural characteristics within subclasses.To explore the roles of BrrHMAs in turnip,we compared the gene sequences and expression patterns of the BrrHMA genes between a Cd-tolerant landrace and a Cd-sensitive landrace.Most BrrHMA genes showed similar spatial expression patterns in both Cd-tolerant and Cd-sensitive turnip landraces;some BrrHMA genes,however,were differentially expressed in specific tissue in Cd-tolerant and Cd-sensitive turnip.Specifically,BrrHMA genes in the Zn/Cd/Co/Pb subclass shared the same coding sequence but were differentially expressed in Cd-tolerant and Cd-sensitive turnip landraces under Cd stress.Our findings suggest that the stable expression and up-regulated expression of BrrHMA Zn/Cd/Co/Pb subclass genes under Cd stress may contribute to the higher Cd tolerance of turnip landraces. | Yuansheng Wu Xiong Li Di Chen Xi Han Boqun Li Yonghong Yang Yongping Yang | 2019 | Plant Diversity2019，41，4： | 1 |
| 17 | 2017年中国出现的H7N9高致病性病毒的快速进化显示文摘文章简介为了防控H7N9病毒,中国2017年9月开始对鸡进行了H5/H7二价禽流感灭活疫苗。为了解H7N9病毒在中国家禽中的分布情况,研究团队进行了系统的禽流感病毒监测。2017年2月至2017年5月之间在379个活禽市场和665个家禽养殖场共采集30201份样品(其中活禽市场采集12504份. | Jianzhong Shi Guohua Deng Shujie Ma Xianying Zeng Xin Yin Mei Li Bo Zhang Pengfei Cui Yan Chen Huanliang Yang Xiaopeng Wan Liling Liu Pucheng Chen Yongping Jiang Yuntao Guan Jinxiong Liu Wenli Gu Shuyu Han Yangming Song Libin Liang Zhiyuan Qu Yujie Hou Xiurong Wang Hongmei Bao Guobin Tian Yanbing Li Li Jiang Chengjun Li 陈化兰 | 2019 | 科学新闻2019，0，2： | 1 |
| 18 | Co-suppression of miR-221/222 cluster suppresses human glioma cell growthby targeting p27kip1 in vitro and in vivo显示文摘 | Chunzhi Zhang Chunsheng Kang Yongping You Peiyu Pu Weidong Yang Peng Zhao Guangxiu Wang Anling Zhang Zhifan Jia Lei Han Hao Jiang | 2009 | International Journal of Oncology2009，，6： | 1 |
| 19 | Fault characteristics and control on hydrocarbon accumulation of middle-shallow layers in the slope zone of Mahu sag, Junggar Basin, NW China显示文摘The development, evolution and formation mechanism of faults and their control on the migration and accumulation of Mesozoic oil and gas in the middle-shallow layers of the slope zone of Mahu sag were studied by the interpretation of seismic and drilling data. Two types of faults, normal and strike-slip, are developed in the middle-shallow layers of the slope zone of the Mahu sag and they are mostly active in the Yanshanian period. They are divided into four grade faults: The grade I strike-slip faults with NWW to near EW direction are related to the left-lateral transpressive fault zones in the northwest of Junggar Basin since the end of the Triassic. The grade II faults with NE to NNE direction are the normal faults located at the junction of the fault zone and the slope zone, and their formation is related to the extension at the top of the nose-like structures in the fault zone. The grade III faults, which are also the normal faults, are the result of the extension at the top of the lower uplifts in the slope zone and differential compaction. The grade IV faults with NE direction are normal faults, which may be related to the extension environment at the tip of the lower uplifts. Faults not only are the channel for the vertical migration of oil and gas, but also control the oil-gas accumulation. There are two types of oil-gas reservoirs in the middle-shallow layers of slope zone of Mahu sag: fault block reservoirs and fault-lithologic reservoirs. They have large traps and promising exploration potential. | CHEN Yongbo CHENG Xiaogan ZHANG Han LI Chunyang MA Yongping WANG Guodong | 2018 | Petroleum Exploration and Development2018，45，6： | 0 |
| 20 | Study on the Fouling Propensity of Effluent from the MBR System for the Electronics Wastewater with High Salinity显示文摘To the electronics wastewater with high salinity,the fouling propensity of effluent from the membrane bioreactor( MBR) system played an important role for the design and long-term operational sustainability of the MBR + Reverse Osmosis( RO) system. In this text,the effluent quality,settling performance and membrane fouling were researched with three dimension excitation-emission fluorescence spectra( EEM) and scanning electron microscope( SEM)-Energy Dispersive Spectrometer( EDS). The results showed that there were few organics with a strong adhesion in the effluent. The metal ions in the effluent not only had a complexation reaction with the macromolecules fulvic acid and protein but also with silicon colloid. It caused a compact fouling layer on the RO membrane surface. But the organics and most of inorganic matters could form settling of flocs and be removed from the effluent by improving p H of the effluent,which would relieve the membrane fouling. In addition,the removal of metal ions in the fouling layer was critical for enhancing the cleaning efficiency of RO membrane. | Han Yongping Li Keyi Li Haiyan Zhou Wenping Li Hongmei | 2018 | Meteorological and Environmental Research2018，9，2： | 0 |
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