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| 1 | Effect of Substructure on Toughness of Lath Martensite/Bainite Mixed Structure in Low-Carbon Steels显示文摘The quantitative analysis of substructure in the martensite/bainite mixed structure, which is obtained from low-carbon NiCrMoV steels under different cooling conditions, was made by means of optical microscope (OM), scanning electron microscope (SEM), electron backscatter diffraction (EBSD), and transmission electron microscope (TEM), in order to research the effect on toughness. The test results indicate that the toughness of the steel is enhanced with the decrease in the packet and block size under the condition of the same prior austenite grain size mixed with different ratios of martensite and bainite while the lath width is about 0.38 μm. The calculation shows that both the packet and block boundaries have the same hindering effect on crack extension. Furthermore, the effect of the block width on impact energy is much larger than that of the packet. Therefore, the block can be used as microstructural substructure to affect the toughness in low-carbon martensite steels, suggesting that the block size is 'the effective grain size' for controlling toughness. | LUO Zhi-jun SHEN Jun-chang SU Hang DING Yue-hua YANG Cai-fu ZHU Xing | 2010 | Journal of Iron and Steel Research(International)2010，17，11： | 24 |
| 2 | Revised Chronostratigraphic Framework of the Metamorphic Strata in the Jiangnan Orogenic Belt,South China and its Tectonic Implications显示文摘In a re-study of regional geology by the China Geological Survey(CGS),the key problem is in the stratigraphical division and correlation.According to the new isotopic dating of the Meso-and Neoproterozoic in China,there have been great changes in the strata correlation and tectonic explanation.The authors obtained four zircon sensitive high resolution ion micro-probe(SHRIMP) U-Pb datings from the bentonite of the Lengjiaxi Group(822±10 Ma,823±12 Ma and 834±11 Ma) and Banxi Group(802.6±7.6 Ma) in north Hunan Province,which is considered to be the middle part of the Jiangnan Orogenic Belt.On the basis of the zircon dating mentioned above,the end of the Wuling orogen is first limited in the period from 822 Ma to 802 Ma in one continued outcrop(Lucheng section) in Linxiang city,Hunan Province.Combining a series of new zircon U-Pb datings in the Yangtze and Cathaysia blocks,several Neoproterozoic volcanic events and distribution of the metamorphic rocks in the Jiangnan Orogenic Belt have been distinguished.In the context of the global geodynamics,it is useful to set up a practical and high precision chronological framework and basic and unified late Precambrian section in South China. | GAO Linzhi DING Xiaozhong ZHANG Chuanheng CHENJun LIU Yaorong ZHANG Hang LIU Xanxue PANG Weihua | 2012 | Acta Geologica Sinica(English Edition)2012，86，2： | 14 |
| 3 | Change of asphaltene and resin properties after catalytic aquathermolysis显示文摘Resin and asphaltene were separated from Liaohe heavy oil. Catalytic aquathermolysis of asphaltene and resin was investigated by using water soluble catalysts (NiSO4 and FeSO4) and oil soluble catalysts (nickel naphthenate and iron naphthenate). Before and after aquathermolysis, the properties of the resin and asphaltene was compared by means of ultimate analysis, vapor pressure osmometer (VPO) average molecular weight, X-ray diffraction (XRD), 13C and 1H nuclear magnetic resonance (NMR). The conversion sequence was as follows: No-catalyst | Yi Yufeng Li Shuyuan Ding Fuchen Yu Hang | 2009 | Petroleum Science2009，6，2： | 12 |
| 4 | Strengths, weaknesses, opportunities and threats (SWOT) analysis of reinitiation into methamphetamine abusers: qualitative findings from an exploration of methamphetamine abusers in Shanghai, China显示文摘Background Despite high relapse rate among methamphetamine (MA) abusers, there still have been little empirical data to date detecting the risk factors related to craving and relapse from the perspective of MA abusers. Therefore, the aim of this study was to use qualitative research methods exploring the strengths, weaknesses, opportunities and threat factors that could facilitate or impede individuals' abstinence in a real-life context from the perspectives of MA abusers. Aim To use qualitative research methods exploring the strengths, weaknesses, opportunities and threat factors relating to individuals' abstinence in a real-life context. Method Semistructured interviews were conducted with 32 MA abusers recruited in Shanghai guided by open-ended questions on narrating the real-life catalysts and inhibitors related to craving, initiation, relapse and abstinence. All data were transcribed verbatim and analysed using a strengths, weaknesses, opportunities and threats (SWOT) analysis. Results The results of the SWOT analysis revealed that contextual factors including peer influence, prevalence and availability of MA, familiar venue of MA use, discrimination, sexual behaviours, alcohol, emotional states and their attitudes towards smoking MA were important factors that contribute to reinitiation and relapse. Surveillance systems, antidrug social workers, vocational skills trainings, moving to another city and family responsibility might serve as counter measures targeti叩 those mentioned weaknesses and threats above. Conclusion This SWOT analysis highlights the complex nature of relapse. Comprehensive interventions strengtheni叩 coping skills such as virtual reality techniques are desperately needed to facilitate individuals1 sustained abstinence. | Youwei Zhu Na Zhong Hang Su Xiaolu Ruan Jiayi Bao Lei Zhang Jiang Du Ding Xu Rongjie Ding Ke Xiao Min Zhao | 2019 | General Psychiatry2019，32，3： | 9 |
| 5 | Assessment of different biomarkers provides valuable diagnostic standards in the evaluation of the risk of acute rejection显示文摘尖锐拒绝(AR ) 是为长期的拒绝在的一个强壮的风险因素肾移植接受者。AR 事件的精确、及时的诊断为疾病控制和预后是很重要的。因此,客观地评估了病人的有免疫力的地位在移植以后的治疗的地里是必要的。这纵的研究在外部血 mononuclear 房间( PBMC )和活体检视在 sera ,CD4+ T 房间的细胞内部的腺苷 triphosphate ( iATP )版本水平,和 granzyme B/perforin 表示调查了五 biomarkers ,人的白血球抗原( HLA ) -G5 和 sCD30 水平的实用性,总共肾的移植的 84 个案例的检测 AR 和 biomarkers 的决定。数据证明接受者与临床或证明的活体检视拒绝显著地增加了 CD4+ T 房间的 iATP 版本水平,并且提高了 sCD30,但是与稳定的接枝功能与个人相比在 sera 降低了 HLA-G5 水平。granzyme B 和 perforin 的表示层次也在 PBMC 和 AR 病人的接枝活体检视被提高。一起拿,我们鉴别 HLA-G5 的 sCD30, iATP, granzyme B, perforin,和 downregulation 的 upregulation 能提供珍贵诊断标准在 AR 的风险识别那些接受者。并且 iATP 可以比为预言接枝拒绝事件的其它是更好的 biomarker。 | Jin Zheng Xiaoming Ding Xiaohui Tian Zhankui Jin Xiaoming Pan Hang Yan Xinshun Feng Jun Hou Heli Xiang Li Ren Puxun Tian Wujun Xue | 2012 | Acta Biochimica et Biophysica Sinica2012，44，9： | 8 |
| 6 | Evaluation of the safety and efficacy of therapeutic bandage contact lenses on post-cataract surgery patients显示文摘AIM: To evaluate the safety of therapeutic bandage contact lens for post-cataract surgery patients and to illustrate its efficacy on post-operative comfort and tear-film stability. METHODS: A total of 40 participants were recruited and randomly divided into two groups. Group one was instructed to wear bandage contact lenses for a week and use antibiotic eye drops for a month since the first day after surgery. Group two received sub-conjunctival injection of tobramycin and was asked to wear eye pads on the first day after surgery and then were instructed to use antibiotic eye drops as the first group did. Ocular surface disease index(OSDI) questionnaire, slit-lamp microscope examination of tear break-up time(TBUT), corneal fluorescein score(CFS), tear meniscus height(TMH) together with anterior segment optical coherence tomography(AS-OCT) and corneal topography were evaluated preoperatively and postoperatively. RESULTS: The subjective feeling(P=0.004), TBUT(P<0.001) and TMH(P=0.02) post-surgery had improved in patients who used bandage contact lenses compared with those who did not at 1wk post-surgery. Until three month postoperatively, the comfort degree(P=0.004) and TMH(P=0.01) of group two were still worse than group one. Moreover, TBUT(P<0.001) and CFS(P=0.004) of the group with eye pads got worse than the results before, whereas the group with bandage contact lenses recovered to normal. None of these patients had infections or other complications. CONCLUSION: Wearing therapeutic bandage contact lens after cataract surgery, compared with traditional eye-pads, is a safe method to improve tear-film stability and reduce post-operative discomfort without hindering corneal incision recovery. | Dan-Na Shi Hang Song Tong Ding Wei-Qiang Qiu Wei Wang | 2018 | International Journal of Ophthalmology(English edition)2018，11，2： | 6 |
| 7 | Two case reports and literature review for hepatic epithelioid angiomyolipoma: Pitfall of misdiagnosis显示文摘BACKGROUND Hepatic epithelioid angiomyolipoma(HEAML) is a rare liver disease and is easily misdiagnosed. Enhanced recognition of HEAML is beneficial to the differential diagnosis of rare liver diseases.CASE SUMMARY We presented two cases of HEAML in Changzheng Hospital, Naval Medical University, and then collected and analyzed all reports about HEAML recorded in PubMed, MEDLINE, China Science Periodical Database, and VIP database from January 2000 to March 2018. A total of 409 cases of HEAML in 97 reports were collected, with a ratio of men to women of 1:4.84 and an age range from 12 years to 80 years(median 44 years). Among the patients with clinical symptoms mentioned, 61.93%(205/331) were asymptomatic, 34.74%(115/331) showed upper or right upper quadrant abdomen discomfort, while a few of them showed abdominal mass, gastrointestinal symptoms, low fever, or weight loss. The misdiagnosis rate of HEAML was as high as 40.34%(165/409) due to its nonspecific imaging findings. Most of the tumors were solitary and round in morphology, with clear boundaries. Ultrasound scan indicated low echo with internal nonuniformity and rich blood supply in most cases. Computer tomography/magnetic resonance imaging enhanced scan showed varied characteristics. The ratio of fast wash-in and fast wash-out, fast wash-in and slow wash-out, and delayed enhancement was roughly 4:5:1. A definite diagnosis of HEAML depended on the pathological findings of the epithelioid cells in lesions and the expression of human melanoma black 45, smooth muscle actin,melanoma antigen, and actin by immunohistochemical staining. HEAML had a relatively low malignant rate of 3.91%. However, surgical resection was the main treatment for HEAML, due to the difficulty diagnosing before operation.CONCLUSION HEAML is a rare and easily misdiagnosed disease, and it should be diagnosed carefully, taking into account clinical course, imaging, pathological,and immunohistochemical findings. | Jia-Xi Mao Fei Teng Cong Liu Hang Yuan Ke-Yan Sun You Zou Jia-Yong Dong Jun-Song Ji Jun-Feng Dong Hong Fu Guo-Shan Ding Wen-Yuan Guo | 2019 | World Journal of Clinical Cases2019，7，8： | 6 |
| 8 | Petrogenesis and tectonic implications of Indosinian granitoids from Western Qinling Orogen,China:Products of magma-mixing and fractionation显示文摘The Western Qinling Orogen(WQO) is characterized by voluminous distribution of Indosinian granitoids,the formation of which provides an important window to unravel the geochemical and geodynamic evolution and associated metallogeny.Here we investigate a group of intrusions termed 'Five Golden Flowers' based on petrological,geochemical,zircon U-Pb geochronological and Lu-Hf isotopic studies on the granitoids and their mafic microgranular enclaves(MMEs).Our results show that these intrusions are genetically divided into two types,namely,magma-mixing and highly fractionated.The Jiaochangba,Lujing,Zhongchuan,and Luchuba granitoids are biotite monzogranites(220±0.8 Ma to 217±2.6 Ma) with abundant coeval MMEs(220±.1 Ma to 217±2.7 Ma).The rocks contain moderate to high SiO2,high MgO,Rb,Sr,Ba,and Th contents,but low TiO2,P2 O5,and Sc values,A/CNK of <1.1,and a range of εHf(t) values of-11.7 to +2.23 with corresponding TDM2values of 1967-1228 Ma.The MMEs possess K-feldspar megacrysts,abundant acicular apatites,and show lopsided textures.They have lower SiO2,Al2 O3,and Th contents,but higher MgO,TiO2,and Sc,with εHf(t) values of-18.0 to +3.18 and TDM1 of 849-720 Ma.The data indicate that the MMEs were derived from a magma sourced from the enriched lithospheric mantle.We suggest that these host granitoids were produced by partial melting of latePaleoproterozoic to early-Mesoproterozoic lower crust with the involvement of Neoproterozoic SCLM-derived mafic magmas.The Baijiazhuang pluton is dominantly composed of leucogranite(muscovite granite and twomica monzogranite,216±1.5 Ma) without MMEs.The rocks are peraluminous with high A/CNK(1.06-1.27).Compared with the other four granitoids,the Baijiazhuang leucogranite shows higher SiO2 content,markedly lower concentrations of TiO2,MgO,Al2 O3,CaO,and Fe2 O3T,and lower LREE/HREE and(La/Yb)N values.These leucogranites are also rich in Rb,Th,and U,and display marked depletions in Ba,Sr,Ti,and Eu,indicating that they experienced significant fractionation.Zircon εHf(t) values(-10.2 to-3.27) and TDM2(1868-1424 Ma),as well as the Nb/Ta and K2 O/Na2 O values are similar to the other four granitoids,indicating that they are likely to have been derived from a similar source;with sediments playing only a minor role in the magma generation.The low contents of Yb and Y suggest that their partial melting was controlled by garnets and micrographic texture of K-feldspar reflects high-temperature melting through undercooling.Based on the above features,we infer that the Baijiazhuang leucogranite likely represents the product of high degree fractionation of the I-type biotite monzogranite magma which generated the other four granitoids at relatively high temperatures,within magma chambers at mid-crust depths.We propose that the granitoid suite was formed in the transitional setting from synto post-collision during the collisional orogeny between the SCB and NCB,following break-off of the subducted South China Block lithosphere during 220-216 Ma. | Xiao Xiong Laimin Zhu Guowei Zhang M.Santosh Hang Jiang Jun Zheng Anlin Guo Lele Ding | 2020 | Geoscience Frontiers2020，11，4： | 6 |
| 9 | Optimizing accuracy of a parabolic cylindrical deployable antenna mechanism based on stiffness analysis显示文摘Accuracy of the fitted surface is of great importance to the performance of deployable antennas utilized in space.This paper proposes a stiffness analysis based fitting accuracy optimization method for achieving the optimal parameters of the parabolic cylindrical deployable antenna mechanism.The stiffness matrix of the proposed cylindrical antenna mechanism is established by assembling the stiffness of beams and tension cables.Structural deformations of the mechanism are calculated where the tensioned cable is substituted by a 2-node truss element and an equivalent force acting on the joint.Consideration of the tensity of tension cables,namely tensioned or slack,is transformed into a typical linear complementarity problem.Comparison between structural deformations of the mechanism fixed at different points is performed.Sensitivities of the geometric and structural parameters on fitting accuracy are investigated.Influence of force of the driven cable on structural deformations of antenna operated in different orbits is conducted.A fitting optimization method is proposed to minimize the structural deformations subject to constraints on volume and mass.Simulation result shows that the fitting accuracy of the antenna mechanism is improved significantly through the optimization.The proposed method can be utilized for the optimal design of other deployable mechanisms constructed by joining rigid links. | Hang XIAO Shengnan LYU Xilun DING | 2020 | Chinese Journal of Aeronautics2020，33，5： | 6 |
| 10 | MicroRNA-99b-3p promotes angiotensin II-induced cardiac fibrosis in mice by targeting GSK-3β显示文摘Cardiac fibrosis is a typical pathological change in various cardiovascular diseases. Although it has been recognized as a crucial risk factor responsible for heart failure, there is still a lack of effective treatment. Recent evidence shows that microRNAs (miRNAs) play an important role in the development of cardiac fibrosis and represent novel therapeutic targets. In this study we tried to identify the cardiac fibrosis-associated miRNA and elucidate its regulatory mechanisms in mice. Cardiac fibrosis was induced by infusion of angiotensin II (Ang II, 2 mg·kg^(−1)·d^(−1)) for 2 weeks via osmotic pumps. We showed that Ang II infusion induced cardiac disfunction and fibrosis accompanied by markedly increased expression level of miR-99b-3p in heart tissues. Upregulation of miR-99b-3p and fibrotic responses were also observed in cultured rat cardiac fibroblasts (CFs) treated with Ang II (100 nM) in vitro. Transfection with miR-99b-3p mimic resulted in the overproduction of fibronectin, collagen I, vimentin and α-SMA, and facilitated the proliferation and migration of CFs. On the contrary, transfection with specific miR-99b-3p inhibitor attenuated Ang II-induced fibrotic responses. Similarly, intravenous injection of specific miR-99b-3p antagomir could prevent Ang II-infused mice from cardiac dysfunction and fibrosis. We identified glycogen synthase kinase-3 beta (GSK-3β) as a direct target of miR-99b-3p. In CFs, miR-99b-3p mimic significantly reduced the expression of GSK-3β, leading to activation of its downstream profibrotic effector Smad3, whereas miR-99b-3p inhibitor caused anti-fibrotic effects. GSK-3β knockdown ameliorated the anti-fibrotic role of miR-99b-3p inhibitor. These results suggest that miR-99b-3p contributes to Ang II-induced cardiac fibrosis at least partially through GSK-3β. The modulation of miR-99b-3p may provide a new approach for tackling fibrosis-related cardiomyopathy. | You-hui Yu Yu-hong Zhang Yan-qing Ding Xue-ying Bi Jing Yuan Hang Zhou Pan-xia Wang Li-li Zhang Jian-tao Ye | 2021 | Acta Pharmacologica Sinica2021，42，5： | 5 |
| 11 | Modeling and predicting low-speed vehicle emissions as a function of driving kinematics显示文摘An instantaneous emission model was developed to model and predict the real driving emissions of the low-speed vehicles. The emission database used in the model was measured by using portable emission measurement system(PEMS)under actual traffic conditions in the rural area,and the characteristics of the emission data were determined in relation to the driving kinematics(speed and acceleration)of the low-speed vehicle. The input of the emission model is driving cycle,and the model requires instantaneous vehicle speed and acceleration levels as input variables and uses them to interpolate the pollutant emission rate maps to calculate the transient pollutant emission rates,which will be accumulated to calculate the total emissions released during the whole driving cycle. And the vehicle fuel consumption was determined through the carbon balance method. The model predicted the emissions and fuel consumption of an in-use low-speed vehicle type model,which agreed well with the measured data. | Lijun Hao Wei Chen Lei Li Jianwei Tan Xin Wang Hang Yin Yan Ding Yunshan Ge | 2017 | Journal of Environmental Sciences2017，29，5： | 5 |
| 12 | Chemical and Isotopic Characters of the Water and Suspended Particulate Materials in the Yellow River and Their Geological and Environmental Implications显示文摘The chemical and isotopic characteristics of the water and suspended particulate materials(SPM)in the Yellow River were investigated on the samples collected from 29 hydrological monitoring stations in the mainstem and several major tributaries during 2004 to 2007.TheδD andδ^(18)O values of the Yellow River water vary in large ranges from-32‰to-91‰and from-3.1‰to-12.5‰,respectively.The characters of H and O isotope variations indicate that the major sources of the Yellow River water are meteoric water and snow melting water,and water cycle in the Yellow River basin is affected strongly by evaporation process and human activity.The average SPM content(9.635g/L)of the Yellow River is the highest among the world large rivers.Compared with the Yangtze River,the Yellow River SPM has much lower clay content and significantly higher contents of clastic silicates and carbonates.In comparison to the upper crust rocks,the Yellow River SPM contains less SiO_2,CaO,K_2O and Na_2O,but more TFe_2O_3,Co,Ni,Cu,Zn,Pb and Cd.The abnormal high Cd contents found in some sample may be related to local industrial activity.The REE contents and distribution pattern of the Yellow River SPM are very close to the average value of the global shale.The averageδ^(30)Si_(SPM)in the Yellow River(-0.11‰)is slightly higher than the average value(-0.22‰)of the Yangtze River SPM.The major factors controlling theδ^(30)Si_(SPM)of the Yellow River are the soil supply,the isotopic composition of the soil and the climate conditions.The TDS in the Yellow River are the highest among those of world large rivers.Fair correlations are observed among Cl^-,Na^+,K^+,and Mg^(2+)contents of the Yellow River water,indicating the effect of evaporation.The Ca^(2+)and Sr^(2+)concentrations show good correlation to the SO_4^(2-)concentration rather than HCO_3^-concentration,reflecting its origin from evaporates.The NO_3^-contents are affected by farmland fertilization.The Cu,Zn and Cd contents in dissolved load of the Yellow River water are all higher than those of average world large rivers,reflecting the effect of human activity.The dissolved load in the Yellow River water generally shows a REE distribution pattern parallel to those for the Yangtze River and the Xijiang River.Theδ^(30)Si values of the dissolved silicon vary in a range from 0.4‰to 2.9‰,averaging1.34‰.The major processes controlling the D_(Si)andδ^(30)Si_(Diss)of the Yellow River water are the weathering process of silicate rocks,growth of phytolith in plants,evaporation,dissolution of phytolith in soil,growth of fresh water diatom,adsorption and desorption of aqueous monosilicic acid on iron oxide and human activities.The averageδ^(30)Si_(Diss)value of the Yellow River is significantly lower than that of the Nile River,Yangtze River and Siberia rivers,but higher than those of other rivers,reflecting their differences in chemical weathering and biological activity.Theδ^(34)S_(SO4)values of the Yellow River water range from-3.8‰to 14.1‰,averaging 7.97‰.There is some correlation between SO_4^(2-)content andδ^(34)S_(SO4).The factors controlling theδ^(34)S_(SO4)of the Yellow River water are the SO_4 in the meteoric water,the SO_4 from gypsum or anhydrite in evaporite rocks,oxidation and dissolution of sulfides in the mineral deposits,magmatic rocks and sedimentary rocks,the sulfate reduction and precipitation process and the sulfate from fertilizer.The^(87)Sr/^(86)Sr ratios of all samplesrange from 0.71041 to 0.71237,averaging 0.71128.The variations in the^(87)Sr/^(86)Sr ratio and Sr concentration of river water are primarily caused by mixing of waters of various origins with different^(87)Sr/^(86)Sr ratios and Sr contents resulting from water-rock interaction with different rock types. | DING Tiping GAO Jianfei TIAN Shihong WANG Huaibai LI Ming WANG Chengyu LUO Xurong HANG Dan | 2016 | Acta Geologica Sinica(English Edition)2016，90，1： | 4 |
| 13 | Atmospheric fine particles in a typical coastal port of Yangtze River Delta显示文摘In recent decades, coastal ports have experienced rapid development and become an important economic and ecological hub in China. Atmospheric particle is a research hotspot in atmospheric environmental sciences in inland regions. However, few studies on the atmospheric particle were conducted in coastal port areas in China, which indeed suffers atmospheric particle pollution. Lack of the physicochemical characteristics of fine particles serves as an obstacle toward the accurate control for air pollution in the coastal port area in China. Here, a field observation was conducted in an important coastal port city in Yangtze River Delta from March 6 to March 19, 2019. The average PM2.5 concentration was 63.7 ±27.8 μg/m^3 and NO3^-, SO4^2-, NH4^+, and organic matter accounted for ?60% of PM 2.5. Fe was the most abundant trace metal element and V as the ship emission indicator was detected. Transmission electron microscopy images showed that SK-rich, soot, Fe, SK-soot and SK-Fe were the major individual particles in the coastal port. V and soluble Fe were detected in sulfate coating of SK-Fe particles. We found that anthropogenic emissions, marine sea salt, and secondary atmosphere process were the major sources of fine particles. Backward trajectory analysis indicated that the dominant air masses were marine air mass, inland air mass from northern Zhejiang and inland-marine mixed air mass from Shandong and Shanghai during the sampling period. The findings can help us better understand the physicochemical properties of atmospheric fine particles in the coastal port of Eastern China. | Qi Yuan Xiaomi Teng Shaoxuan Tu Binxin Feng Zhiyu Wu Hang Xiao Qiuliang Cai Yinxiao Zhang Qiuhan Lin Zhaoce Liu Mengmeng He Xiaokun Ding Weijun Li | 2020 | Journal of Environmental Sciences2020，32，12： | 4 |
| 14 | High-efficiency extraction synthesis for high-purity copper nanowires and their applications in flexible transparent electrodes显示文摘Copper nanowires(Cu NWs)are considered an excellent alternative to indium tin oxide(ITO)in flexible transparency electrodes(FTEs).However,the mixed particles and surface oxidation of Cu NWs degrade the transmittance and conductivity of the electrodes.Therefore,highly purified Cu NWs without oxidation are vital for high-performance FTEs.Herein,a facile and effective purification process is introduced to purify Cu NWs in a water and n-hexane system,which takes advantage of the differences in hydrophilicity between Cu NWs and Cu NPs caused by their different adsorption affinities to octadecylamine(ODA).At the same sheet resistance,the transmittance of the purified Cu NW-based FTEs improved approximately 2%compared to that of non-purified Cu NW-based FTEs.Immersion of the electrode in glacial acetic acid removed the surface organics and oxides.After only 40 s of treatment,the sheet resistance dramatically decreased from 10^5 Ohm/sq to 31 Ohm/sq with a transmittance of 85%.In addition,the Cu NW-based FTE conductors showed excellent flexibility(remaining stable after 1000 bending cycles).The Cu NW-based FTEs were further applied to fabricate a flexible transparent heater.At a voltage of 10 V,the temperature of the heater reached 73℃,demonstrating the potential applications of this material in various fields. | He Zhang Shang Wang Yanhong Tian Jiayue Wen Chunjin Hang Zhen Zheng Yilong Huang Su Ding Chenxi Wang | 2020 | Nano Materials Science2020，2，2： | 4 |
| 15 | The effects of diltiazem in renal transplantation patients treated with cyclosporine A显示文摘Objective:To investigate the effects of diltiazem and cyclosporine A(CsA)combination therapy on protecting the kidney,promoting graft functioning and improving post-transplanted kidney recovery.Methods:The blood concentrations of CsA,the condition of the post-transplant kidney,the rate of acute rejection(AR),as well as hepatic and renal toxicity in 636 cases of renal transplant recipients were determined after being treated by CsA,with or without diltiazem.Results:Compared with the control group which received CsA,mycophenolate mofetil(MMF) and prednisolone(Pred)but lacked diltiazem,the group receiving these agents together with diltiazem required reduced dosage of CsA(P<0.01),while blood concentrations of CsA were significantly increased(P<0.01);the recovery time of graft function was reduced from(6.2±1.5)d to(3.9±1.4)d(P<0.01),and the rate of AR was decreased from 13.2%to 7.9%(P<0.01).Conclusion:In renal transplantation patients treated with CsA and diltiazem,blood concentrations of CsA were increased while the dosage was decreased.This efficient combination therapy reduced patients'economic burden,at the same time retained kidney function,promoted graft function recovery and decreased hepatic and renal toxicity and the rate of AR. | Wujun Xue Yong Song Puxun Tian Xiaoming Ding Xiaoming Pan Hang Yan Jun Hou Xinshun Feng Heli Xiang Xiaohui Tian | 2010 | The Journal of Biomedical Research2010，24，4： | 4 |
| 16 | Magnetic cell sorting and flow cytometry sorting methods for the isolation and function analysis of mouse CD^4+ CD25^+ Treg cells显示文摘Objective: In this paper we compared the two methods of cell sorting (magnetic cell sorting and flow cytometry sorting) for the isolation and function analysis of mouse CD4+ CD25+ regulatory T (Treg) cells, in order to inform further studies in Treg cell function. Methods: We separately used magnetic cell sorting and flow cytometry sorting to identify CD4+ CD25+ Treg cells. After magnetic cell separation, we further used flow cytometry to analyze the purity of CD4+ CD25+ Treg cells, trypan blue staining to detect cell viability, and propidium iodide (PI) staining to assess the cell viability. We detected the immune inhibition of CD4+ CD25+ Treg cells in the in vitro proliferation experiments. Results: The results showed that compared to flow cytometry sorting, magnetic cell sorting took more time and effort, but fewer live cells were obtained than with flow cytometry sorting. The CD4+ CD25+ Treg cells, however, obtained with both methods have similar immunosuppressive capacities. Conclusion: The result suggests that both methods can be used in isolating CD4+ CD25+ Treg cells, and one can select the best method according to specific needs and availability of the methodologies. | Hang YAN Chen-guang DING Pu-xun TIAN Guan-qun GE Zhan-kui JIN Li-ning JIA Xiao-ming DING Xiao-ming PAN Wu-jun XUE | 2009 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2009，10，12： | 4 |
| 17 | Refractive Index Engineering as a Novel Strategy toward Highly Transparent and Tough Sustainable Polymer Blends显示文摘High transparency and toughness are prerequisites for sustainable polymers if they are to find wide application as alternatives to petroleum-based polymers.However,the utility of sustainable polymers such as commercially available polylactide(PLA)is limited by their inherent brittleness and high cost.Unfortunately,toughening PLA-based materials via cost-effective blending strategies without sacrificing transparency remains a challenge.Herein,we report a novel strategy involving active refractive index matching for creation of highly transparent and tough PLA blends.Specifically,we engineered the refractive index of a promising renewable poly(epichlorohydrin-co-ethylene oxide)elastomer by introducing polar ionic moieties via a simple chemical method,and we blended the resulting ionomers with PLA.The best blend showed an impact strength of>80 kJ/m2,an elongation at break of 400%,and high transparency(90%).These characteristics are of great importance for potential applications such as packaging.Our strategy offers a versatile new way to prepare high-performance sustainable polymer materials with excellent transparency. | Si-Ting Sun Hang Wang Dong Huang Ying-Li Ding Yang Zhang Dong-Po Song Kun-Yu Zhang Li Pan Yue-Sheng Li | 2020 | Chinese Journal of Polymer Science2020，38，12： | 3 |
| 18 | Dihydromyricetin promotes apoptosis, suppresses proliferation and tumor necrosis factor-α-mediated nuclear factor kappa-B activation in nasopharyngeal carcinoma CNE-2 cells显示文摘OBJECTIVE: To investigate the efficacy of dihydromyricetin(DMY) on nasopharyngeal carcinoma(NPC) cell proliferation, apoptosis and to reveal the underlying mechanism in vitro experiments.METHODS: The CNE-2 cell line was treated with different concentrations of DMY and the effects of DMY on cell viability and proliferation were evaluated using cell counting kit-8(CCK-8) assay and plate colony formation assay. Cellular apoptosis was detected by flow cytometry following Annexin V fluorescein isothiocyanate/propidine iodide staining.Nuclei morphology was observed under a fluorescence microscope following Hoechst 333258 staining. The expression of phosphorylated inhibitor of nuclear factor kappa-B kinase subunit beta(p-IKKβ), phosphorylated inhibitor of nuclear factor kappa-B kinase subunit alpha(p-IKKα), inhibitor of nuclear factor kappa-B alpha(IκB-α), nuclear factor kappa-B(NF-κB)/p65 was examined by Western blot analysis and the nuclear translocation of NF-κB/p65 was observed using a confocal laser scanning microscopy.RESULTS: DMY inhibited the proliferative capability and colony formation of NPC CNE-2 cells. Meanwhile, DMY induced apoptosis of CNE-2 cells in a dose and time-dependent manner via upregulating B-cell lymphoma-2 associated X, but downregulating B-cell lymphoma-2 and pro-caspase-3. Importantly, we found that DMY suppressed tumor necrosis factor alpha(TNF-α)-mediated NF-κB activation via inhibiting p-IKKβ, p-IKKα and blocking NF-κB subunit p65.CONCLUSION: Our experiments demonstrated that DMY had significant antiproliferative and apoptosisinducing effects on CNE-2 cells. Additionally, DMY promoted inactivation of p-IKKβ, p-IKKα,and blocked the nuclear translocation of NF-κB subunit p65. These results suggest that DMY may be an important therapeutic approach for NPC. | LI Caihong SHI Jinlian HUANG Bo DING Hang LIN Hanguang ZENG Jincheng ZHAO Yang LUO Guoqing | 2021 | Journal of Traditional Chinese Medicine2021，41，3： | 3 |
| 19 | Primary hepatic squamous cell carcinoma with abdominal incision metastasis after hepatectomy显示文摘To the Editor:Primary hepatic squamous cell carcinoma(PHSCC)is a rare and easily misdiagnosed disease.We reported a PHSCC case with abdominal incision metastasis after hepatectomy,and reviewed the clinical course,imaging,pathology and immunohistochemical findings.Our case may provide a better understanding of PHSCC. | Jia-Xi Mao Fei Teng Hang Yuan Cong Liu Hong Fu Ke-Yan Sun Guo-Shan Ding Wen-Yuan Guo | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，2： | 3 |
| 20 | Adhesive anastomosis for organ transplantation显示文摘The recent development of tough tissue adhesives has stimulated intense interests among material scientists and medical doctors.However,these adhesives have seldom been tested in clinically demanding surgeries.Here we demonstrate adhesive anastomosis in organ transplantation.Anastomosis is commonly conducted by dense sutures and takes a long time,during which all the vessels are occluded.Prolonged occlusion may damage organs and even cause death.We formulate a tough,biocompatible,bioabsorbable adhesive that can sustain tissue tension and pressurized flow.We expose the endothelial surface of vessels onto a gasket,press two endothelial surfaces to the adhesive using a pair of magnetic rings,and reopen the bloodstream immediately.The time for adhesive anastomosis is shortened compared to the time for sutured anastomosis.We have achieved adhesive anastomosis of a great vein in transplanting the liver of a pig.After the surgery,the adhesive is absorbed,the vein heals,and the pig lives for over one month. | Kang Liu Hang Yang Gaobo Huang Aihua Shi Qiang Lu Shanpei Wang Wei Qiao Haohua Wang Mengyun Ke Hongfan Ding Tao Li Yanchao Zhang Jiawei Yu Bingyi Ren Rongfeng Wang Kailing Wang Hui Feng Zhigang Suo Jingda Tang Yi Lv | 2022 | Bioactive Materials2022，7，7： | 3 |
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