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| 1 | I-IBV life cycle is restricted in mouse hepatocytes .~xpressing human NTCP显示文摘 | Hanjie Li Qiuyu Zhuang Yuze Wang Tianyi'ng Zhang Jinghua Zhao Yali Zhang Junfang Zhang Yi Lin Quan Yuan Ningshao Xia Jiahuai Han | 2014 | Cellular & Molecular Immunology2014，11，2： | 14 |
| 2 | Calculating models of mass action concentrations for NaBr(aq), LiNO_3(aq), HNO_3(aq), and KF(aq) binary solutions显示文摘The calculating models of mass action concentrations for electrolyte aqueous solutions NaBr-H2O, LiNO3-H2O, HNO3-H2O, and KF-H2O have been developed at 298.15 K and their molalities ranging from 0.1 mol/kg to saturation according to the ion and molecule coexistence theory as well as mass action law. The calculated mass action concentration is based on pure species as the standard state and the mole fraction as the concentration unit, and the reported activities are usually based on infinite dilution as the standard state and molality as the concentration unit. Hence, the calculated mass action concentration must be transformed to the same standard state and concentration unit. The transformation coefficients between calculated mass action concentrations and reported ac- tivities of the same component fluctuate in a very narrow range. Thus, the transformed mass action concentrations not only agree well with reported activities, but also strictly obey mass action law. The calculated results show that the new developed models can embody the intrinsic structure of investigated four electrolyte aqueous solutions. The results also indicate that mass action law has its wide- spread applicability to electrolyte binary aqueous solutions. | Hanjie Guo Weijie Zhao Xuemin Yang | 2007 | Journal of University of Science and Technology Beijing2007，14，3： | 8 |
| 3 | Universal thermodynamic model of calculating the mass action concentrations of omponents in a ternary strong electrolyte aqueous solution and its application in the NaCl-KCl-H_2O system显示文摘A universal thermodynamic model of calculating the mass action concentrations of components in a ternary strong elec-trolyte aqueous solution has been developed based on the ion and molecule coexistence theory,and verified in the NaCl-KCl-H2O ternary system at 298.15 K. To compare the difference of the thermodynamic model in binary and ternary strong electrolyte aqueous solutions,the mass action concentrations of components in the NaCl-H2O binary strong electrolyte aqueous solution were also com-puted at 298.15K. A transformation coefficient was required to compare the calculated mass action concentration and reported activ-ity because they were obtained at different standard states and concentration units. The results show that the transformation coeffi-cients between calculated mass action concentrations and reported activities of the same components change in a very narrow range. The calculated mass action concentrations of components in the NaCl-H2O and NaCl-KCl-H2O systems are in good agreement with the reported activities. This indicates that the developed thermodynamic model can reflect the structural characteristics of solutions,and the mass action concentration also strictly follows the mass action law. | Weijie Zhao Hanjie Guo Xuemin Yang Zhigang Dan | 2008 | Journal of University of Science and Technology Beijing2008，15，5： | 5 |
| 4 | Late Mesozoic rifting and its deep dynamic mechanisms in the central Sulu orogenic belt: Records from Lingshan Island显示文摘The Lingshan Island scientific drill confirms that two episodes(Laiyang period and Qingshan period) of rifting developed in the central Sulu orogenic belt(SOB) in Late Mesozoic. With a set of methods including fieldwork, drilling, core logging, zircon U-Pb dating and whole rock geochemistry applied, the age, the depositional sequence and the deep dynamic mechanisms of rift evolution were unraveled. The stratigraphic sequence of the Laiyang-Qingshan Groups on Lingshan Island was composed of two different rifting sequences:(1) Laiyang Group(147–125 Ma), which consists of deep-water gravity flow deposits with interlayers of intermediate volcanic rocks;and(2) Lower Qingshan Group(125–119 Ma), which unconformably overlies the former sequence and contains subaerial volcanic deposits and terrestrial deposits. The tectonic environment changed during the evolution of these two episodes of rifting: the rift was in a NNW-SSE extensional environment in the Laiyang period and showed the typical passive rifting character that “lithospheric extension and rifting preceded volcanism”. The passive rifting period was ended by a short WNW-ESE compression at about 125 Ma. After that, the tectonic environment transferred to a strong NW-SE extensional environment and the rifting evolved into a volcanic arc basin in the Qingshan period. The igneous rocks are shoshonitic to high-K calc-alkaline trachyandesites to trachytes with a few intercalated lamprophyres and a rhyolite.The geochemical characteristics of the igneous rocks indicate that they are mantle-derived melts with a metasomatized mantle source and/or crustal contamination. In addition, an increased thinning of the lithosphere happened during the rifting episodes.The low-angle subduction of the Paleo-Pacific plate in the Jurassic weakened the thickened SOB lithospheric mantle. The rollback of the subducting plate started in late Jurassic to early Cretaceous, and the SOB lithospheric mantle was delaminated synchronously because of the gravity collapse. Thus, this caused passive rifting in the Laiyang period. Thereafter, the rollback and trench retreat of the high-angle subducting Paleo-Pacific plate would have achieved its climax, resulting in the strong regional extension. Passive rifting was ended by the crustal uplift caused by asthenospheric upwelling beneath the rift. The lower crust was heated by the upwelling asthenosphere and partially melted to form felsic melts, which were emplaced upwards and erupted explosively. The rift evolved into a volcanic arc basin in the Qingshan period and showed some characteristics of active rifting. Above all, a passive rifting in the Laiyang period and a volcanic arc basin in the Qingshan period developed successively in the Lingshan Island area(the central SOB). This records the transfer of the study area from the Paleo-Tethys tectonic domain to the circum-Pacific tectonic domain. The delamination of SOB lithospheric mantle and the upwelling of asthenospheric material were the deep dynamic mechanisms driving the development and evolution of two rift episodes. Additionally, the rift development was controlled remotely by the subduction of the Paleo-Pacific plate. | Tengfei ZHOU Yaoqi ZHOU Nina SФAGER Paul Martin HOLM Zhenkai ZHANG Jun WANG Zhao LIANG Hongyu MU Yanjun CHENG Feifei LIU Miao WANG Yue ZHANG Hui ZHANG Yangjian GU Shihui DONG Hanjie ZHAO Manjie LI Yang CHEN Yanzi LIU | 2022 | Science China Earth Sciences2022，65，9： | 3 |
| 5 | Immune fluorescence test strips based on quantum dots for rapid and quantitative detection of carcino-embryonic antigen显示文摘At present,many researchers focused on the point-of-care testing(POCT),a method of disease markers detection without large-scale instruments and specialized persons.However,most POCT diagnostic methods were suffered from poor detection sensitivity or inefficiency in quantitative detection.Herein,we developed a newly QD-immune fluorescence test strips(QD-IFTS) based on quantum dots(QDs) as the fluorescence nanocarrier to prepare the immune fluorescence probes in the classical immunochromatography detection system for sensing carcino-embryonic antigen(CEA),a kind of glycoprotein produced by intestinal tissue and a broad spectrum of tumor marker for cancer diagnosis.And we designed a homemade strips fluorescence reader for detection of fluorescence intensity of QDs on the QD-IFTS.Under the optimized reaction conditions,chromatographic time of the newly QD-IFTS was only25 min,sample volume of the newly QD-IFTS was only 40 m L and the LOD of the newly QD-IFTS was 0.72 ng/m L.In addition,the efficiency and robustness of the newly QD-IFTS were confirmed by successfully application in 300 clinical serum samples,and the results revealed great potential in clinical POCT of other biomarkers. | Yudong Wu Weipan Peng Qian Zhao Jiafang Piao Bo Zhang Xiaoli Wu Hanjie Wang Zhihong Shi Xiaoqun Gong Jin Chang | 2017 | Chinese Chemical Letters2017，28，9： | 3 |
| 6 | RING finger 138 deregulation distorts NF-κB signaling and facilities colitis switch to aggressive malignancy显示文摘Prolonged activation of nuclear factor(NF)-кB signaling significantly contributes to the development of colorectal cancer(CRC).New therapeutic opportunities are emerging from targeting this distorted cell signaling transduction.Here,we discovered the critical role of RING finger 138(RNF138)in CRC tumorigenesis through regulating the NF-кB signaling,which is independent of its Ubiquitin-E3 ligase activity involved in DNA damage response.RNF138^(−/−) mice were hyper-susceptible to the switch from colitis to aggressive malignancy,which coincided with sustained aberrant NF-кB signaling in the colonic cells.Furthermore,RNF138 suppresses the activation of NF-кB signaling pathway through preventing the translocation of NIK and IKK-Beta Binding Protein(NIBP)to the cytoplasm,which requires the ubiquitin interaction motif(UIM)domain.More importantly,we uncovered a significant correlation between poor prognosis and the downregulation of RNF138 associated with reinforced NF-кB signaling in clinical settings,raising the possibility of RNF138 dysregulation as an indicator for the therapeutic intervention targeting NF-кB signaling.Using the xenograft models built upon either RNF138-dificient CRC cells or the cells derived from the RNF138-dysregulated CRC patients,we demonstrated that the inhibition of NF-кB signaling effectively hampered tumor growth.Overall,our work defined the pathogenic role of aberrant NF-кB signaling due to RNF138 downregulation in the cascade events from the colitis switch to colonic neoplastic transformation and progression,and also highlights the possibility of targeting the NF-кB signaling in treating specific subtypes of CRC indicated by RNF138-ablation. | Yalan Lu Rong Huang Jianming Ying Xingchen Li Tao Jiao Lei Guo Haitao Zhou Han Wang Amannisa Tuersuntuoheti Jianmei Liu Qichen Chen Yanhong Wang Luying Su Changyuan Guo Fu Xu Ziyi Wang Yan Lu Kai Li Junbo Liang Zhen Huang Xiao Chen Jinjie Yao Hanjie Hu Xiaowen Cheng Yufeng Wan Xinyan Chen Ning Zhang Shiying Miao Jianqiang Cai Linfang Wang Changzheng Liu Wei Song Hong Zhao | 2022 | Signal Transduction and Targeted Therapy2022，7，7： | 0 |
| 7 | Planting uniformity performance of motor-driven maize precision seeding systems显示文摘Low accuracy planting uniformity affects yield.Seed meter type and forward speed typically interfere with the planting uniformity accuracy of motor-driven seeding systems.Two types of maize precision planters equipped with motor-driven planting systems are investigated in this study to ascertain the rule of planting uniformity in both simulated and field speeds.The simulated speed increases from 5 to 12 km/h at a 1 km/h interval in a laboratory environment.The test results show that the quality of feed index(QTFI)of the two planters decreased by 16.79%and 9.88%.This is primarily attributed to the increase in the miss index(MISS)by 11.62%and 9.70%,respectively.The field speed was set to four levels from 5 to 12 km/h in a field environment.The plant spacing scatter distribution results were analyzed,and the results of the two planters indicated that the average positive difference of the two planters linearly increased with the forward speed,and the negative difference of the two planters did not exhibit a linear correlation.The number of positive moving average points was 2.49 times greater than that of the negative moving average points of the finger pick-up maize precision planter,and 4.49 times in the air-suction maize precision planter.The results indicated that the increase of the positive difference of plant spacing is the major effect factor in the field planting uniformity of the two motor-driven maize precision planters.In addition,the plant spacing corresponded to the distribution frequency of the two planters in field was close to the target seed spacing of 25 cm with a max coefficient of variation(CV)of 21.55%and 20.66%,respectively,and those plant spacing values corresponded to max distribution frequency of the two planters at the four level field speeds were(24.69±0.63)cm and(25.63±0.32)cm,respectively.However,the multiples index(MUL)changed randomly affected by the increasing speed.The research results provide a direction for the optimization design of motor-driven maize precision planters. | Shuo Yang Changyuan Zhai Yuanyuan Gao Hanjie Dou Xueguan Zhao Yakai He Xiu Wang | 2022 | International Journal of Agricultural and Biological Engineering2022，15，5： | 0 |
| 8 | Dimethylamino group modified polydopamine nanoparticles with positive charges to scavenge cell-free DNA for rheumatoid arthritis therapy显示文摘Excessive cell-free DNA(cfDNA)released by damaged or apoptotic cells can cause inflammation,impacting the progression of rheumatoid arthritis(RA).cfDNA scavengers,such as cationic nanoparticles(NPs),have been demonstrated as an efficient strategy for treating RA.However,most scavengers are limited by unfavorable biocompatibility and poor scavenging efficacy.Herein,by exploiting the favorable biocompatibility,biodegradability and bioadhesion of polydopamine(P),we modified P with dimethylamino groups to form altered charged DPs to bind negatively charged cfDNA for RA therapy.Results showed that DPs endowed with superior binding affinity of cfDNA and little cytotoxicity,which effectively inhibited lipopolysaccharide(LPS)stimulated inflammation in vitro,resulting in the relief of joint swelling,synovial hyperplasia and cartilage destruction in RA rats.Significantly,DPs with higher DS of bis dimethylamino group exhibited higher positive charge density and stronger cfDNA binding affinity,leading to excellent RA therapeutic effect among all of the treated groups,which was even close to normal rats.These finding provides a novel strategy for the treatment of cfDNA-associated diseases. | Ying Chen Yonglin Wang Xianfang Jiang Jinhong Cai Yuting Chen Hanji Huang Yuan Yang Li Zheng Jinmin Zhao Ming Gao | 2022 | Bioactive Materials2022，7，12： | 0 |
| 9 | Investigation of the degradation and stability of acrylamide-based polymers in acid solution: Functional monomer modified polyacrylamide显示文摘Acrylamide copolymers are often used as acidizing diverting and thickening agents for their advantageous thickening,flocculation,adhesion and resistance reduction properties.Experimental results indicate that the acid concentration greatly affects the properties of acrylamide polymers,which varies from results reported by other researchers.Considering the theoretical and field application value of the present study,four comparable acrylamide-based polymers were synthesized,and their macro-and micro-changes as well as the related changes in viscosity and molecular weight were studied in high-concentration hydrochloric acid.A proposed mechanism of acrylamide copolymer stability and degradation is provided,and further suggestions are made for the modification of acrylamide copolymers. | Yuxin Pei Liqiang Zhao Guangyan Du Nianyin Li Kun Xu Hanjie Yang | 2016 | Petroleum2016，2，4： | 0 |
| 10 | MET fusions and splicing variants convergently defne a subgroup of glioma sensitive to MET inhibitors显示文摘Purpose:Our previous study has shown that PTPRZ1-MET(ZM)fusion is a viable target for MET inhibitors in gliomas.However,the diversity and prevalence of somatic MET alterations in difuse gliomas are still elusive and need to be extensively characterized for identifying novel therapeutic targets.Methods:Totally,1,350 glioma patients and 31 patient-derived cells were collected from the Chinese Glioma Genome Atlas(CGGA)and published data.All kinds of MET fusions and/or splicing variants(MET F/SVs)were identifed by bioinformatical methods.Single-cell RNA sequencing(scRNA-seq)were used for validation.In vitro experiments of drug resistance were conducted for the possibility of MET-targeted treatment.Results:MET F/SVs but not genomic amplifcation,were highly enriched in the secondary glioblastomas(sGBM)and marked worse prognosis.Further molecular and scRNA-seq analysis revealed that MET F/SVs were induced in the course of glioma evolution and highly associated with MET overexpression.Subsequent in vitro and the clinical study showed that cells and patients harboring MET F/SVs have better response to MET inhibitors.Conclusion:Our fndings expanded the percentage of gliomas with abnormal MET alterations and suggested that a subgroup of gliomas harboring MET F/SVs may beneft from MET-targeted therapy. | Ke-Nan Zhang Zheng Zhao Jing Chen Zhaoshi Bao Rui-Chao Chai Zhiyan Sun Lingxiang Wu Zhiliang Wang Hanjie Liu Quanhua Mu Huimin Hu Fan Zeng Zheng Wang Guanzhang Li Yuanhao Chang Qiangwei Wang Fan Wu Ying Zhang Yuqing Liu Chunjie Jiang Ulf Dietrich Kahlert Do-Hyun Nam Wei Zhang Chunsheng Kang Jiguang Wang Rongjie Tao Qianghu Wang Tao Jiang | 2022 | Holistic Integrative Oncology2022，1，1： | 0 |
| 11 | High-precision double-spike Cd isotopic measurements of seawater by MC-ICP-MS and its application to seawater affected by hydrothermal vent fluids显示文摘Cadmium(Cd)isotopes in seawater have been proven as an important geochemical tool for tracing ocean Cd circulation in the modern ocean.In this study,we evaluated a new method to separate Cd(*60 ng)from seawater using Chelex resin(1.0 g)coupled with AG-MP-1M resin.The results show that the Chelex resin is suffi-cient to remove Cd from Na and Mg matrix with Cd recoveries at 98.3±3.5%(2SD,N=6);while AG-MP-1M resin could separate Cd from the residual Na,Mg,and isobaric inferences.The total Cd recoveries of the method are 96.3±1.5%(2SD;N=4)and the salinity of the samples has no significant impacts on Cd recovery.Cd isotope ratios were measured using a Nu PlasmaⅢMC-ICP-MS and^(111)Cd–^(110)Cd double spike technique.By comparing theδ^(114/110)Cd values(0.00±0.06%)of synthetic seawaters doped with Cd isotope standard(NIST-3108;treated by Chelex+AG-MP-1M resin)and the reference value(-0.00%),no variations were observed.We also analyzed the Cd isotope compositions of three deep seawaters from a column at the Southwest Indian Ocean Ridges(SWIR).Theδ^(114/110)Cd values of the col-umn are decreased from 1.05±0.05%at 3200 m to 0.36±0.05%at 2800 m,differing from reportedδ^(114/110)Cd values of deep seawater in other oceans.Considering the spatial distance between the column and active hydrothermal vents in SWIR(-13 km),we propose that such positiveδ^(114/110)Cd values of deep seawater were likely contaminated by vent fluids,which could provide heavy Cd isotope to deep seawaters.This study demon-strates that Cd isotope is more sufficient to distinguish the impact of plumes on deep seawater. | Chuanwei Zhu Yunzhu Wu Hanjie Wen Guanghai Wu Wenrui Song Yuxu Zhang Bo Zhao | 2023 | Acta Geochimica2023，42，5： | 0 |
| 12 | On-Surface Bottom-Up Construction of COF Nanoshells towards Photocatalytic H_(2)Production显示文摘The rational design of an outer shell is of great significance to promote the photocatalytic efficiency of core-shell structured photocatalysts.Herein,a covalent organic framework(COF)nanoshell was designed and deposited on the cadmium sulfide(CdS)core surface.A typical COF material,TPPA,featuring exceptional stability,was synthesized through interfacial polymerization using 1,3,5-triformylphloroglucinol(TP)and p-phenylenediamine(PA)as monomers.The nanoshell endows the CdS@TPPA nanosphere with ordered channels for unimpeded light-harvesting and fast diffusion of reactants/products and well-defined modular building blocks for spatially charge separation.Moreover,the heterojunction formed between CdS and TPPA can further facilitate the effective charge separation at the interface via lower exciton binding energy compared with that of pristine TPPA.By modulating the thickness of TPPA nanoshell,the CdS@TPPA nanosphere photocatalyst with the nanoshell thickness of about 8±1 nm exhibits the highest photocatalytic H2 evolution of 194.1μmol h^(-1)(24.3 mmol g^(-1)h^(-1),8 mg),which is superior to most of the reported COF-based photocatalysts.The framework nanoshell in this work may stimulate the thinking about how to design advanced shell architecture in the core-shell structured photocatalysts to achieve coordinated charge and molecule transport. | Yao Chen Dong Yang Yuchen Gao Runlai Li Ke An Wenjing Wang Zhanfeng Zhao Xin Xin Hanjie Ren Zhongyi Jiang | 2021 | Research2021，，1： | 0 |
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