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| 1 | 皮质下小血管病诊断的共识声明显示文摘血管性认知损害是用于描述一组涉及大血管和小血管的散发性和遗传性异质性疾病的诊断术语。皮质下小血管病可导致腔隙性梗死和进行性白质损害。被称为宾斯旺格病(Binswanger's disease, BD)的进行性白质损害患者构成了从单纯血管性疾病到合并神经变性病变的疾病谱。BD患者是一个相对同质性的亚组,存在缺氧缺血、腔隙性梗死和炎症,它们协同作用破坏血脑屏障和髓鞘。通过临床、脑脊液、神经心理学和影像学检查获得的多模式疾病标记物能促进该亚组患者的鉴别。本共识声明确定了一系列基于基础病理学改变的潜在生物学标记物,这将有助于诊断以及将来协作性治疗试验的患者选择。 | Gary A Rosenberg Anders Wallin Joanna M Wardlaw Hugh S Markus Joan Montaner Leslie Wolfson Costantino Iadecola Berislav V Zlokovic Anne Joutel Martin Dichgans Marco Duering Reinhold Schmidt Amos D Korczyn Lea T Grinberg Helena C Chui Vladimir Hachinski 王训师 张劼 陈涵丰 俞娅美 徐子奇 罗本燕 | 2016 | 国际脑血管病杂志2016，24，6： | 18 |
| 2 | Modulation of faecal metagenome in Crohn's disease:Role of microRNAs as biomarkers显示文摘BACKGROUND The gut microbiota plays a key role in the maintenance of intestinal homeostasis and the development and activation of the host immune system. It has been shown that commensal bacterial species can regulate the expression of host genes. 16 S rRNA gene sequencing has shown that the microbiota in inflammatory bowel disease(IBD) is abnormal and characterized by reduced diversity. Micro RNAs(miRNAs) have been explored as biomarkers and therapeutic targets, since they are able to regulate specific genes associated with Crohn's disease(CD). In this work, we aim to investigate the composition of gut microbiota of active treatment-na?ve adult CD patients, with miRNA profile from gut microbiota.AIM To investigate the composition of gut microbiota of active treatment-na?ve adult CD patients, with miRNA profile from gut microbiota.METHODS Patients attending the outpatient clinics at Valme University Hospital without relevant co-morbidities were matched according to age and gender. Faecal samples of newonset CD patients, free of treatment, and healthy controls were collected. Faecal samples were homogenized, and DNA was amplified by PCR using primers directed to the 16 S bacterial rRNA gene. Pyrosequencing was performed using GS-Junior platform. For sequence analysis, MGRAST server with the database Ribosomal Project was used. MiRNA profile and their relative abundance were analyzed by quantitative PCR.RESULTS Microbial community was characterized using 16 S rRNA gene sequencing in 29 samples(n = 13 CD patients, and n = 16 healthy controls). The mean Shannon diversity was higher in the healthy control population compared to CD group(5.5 vs 3.7). A reduction in Firmicutes and an increase in Bacteroidetes were found. Clostridia class was also significantly reduced in CD. Principal components analysis showed a grouping pattern, identified in most of the subjects in both groups, showing a marked difference between control and CD groups. A functional metabolic study showed that a lower metabolism of carbohydrates(P = 0.000) was found in CD group, while the metabolism of lipids was increased. In CD patients, three miRNAs were induced in affected mucosa: mir-144(6.2 ± 1.3 fold), mir-519(21.8 ± 3.1) and mir-211(2.3 ± 0.4). CONCLUSION Changes in microbial function in active non-treated CD subjects and three miRNAs in affected vs non-affected mucosa have been found. miRNAs profile may serve as a biomarker. | María Rojas-Feria Teresa Romero-García Jose Angel Fernández Caballero-Rico Helena Pastor Ramírez Marta Avilés-Recio Manuel Castro-Fernandez Natalia Chueca Porcuna Manuel Romero-Gomez Federico García Lourdes Grande JoséA Del Campo | 2018 | World Journal of Gastroenterology2018，24，46： | 7 |
| 3 | 通过手术导致的重量损失由胃绕过在疾病的肥胖的病人改进非含酒精的脂肪肝疾病显示文摘 AIM:To evaluate the effects of surgical weight loss(Roux-en-Y gastric bypass with a modified Fobi-Capella technique) on non alcoholic fatty liver disease in obese patients.METHODS:A group of 26 morbidly obese patients aged 45 ± 2 years and with a body mass index > 40 kg/m 2 who underwent open surgical weight loss operations had paired liver biopsies,the first at surgery and the second after 16 ± 3 mo of weight loss.Biopsies were evaluated and compared in a blinded fashion.The presence of metabolic syndrome,anthropometric and biochemical variables were also assessed at baseline and at the time of the second biopsy.RESULTS:Percentage of excess weight loss was 72.1% ± 6.6%.There was a reduction in prevalence of metabolic syndrome from 57.7%(15 patients) to 7.7%(2 patients)(P < 0.001).Any significance difference was observed in aspartate aminotransferase or alanine aminotransferase between pre and postsurgery.There were improvements in steatosis(P < 0.001),lobular(P < 0.001) and portal(P < 0.05) inflammation and fibrosis(P < 0.001) at the second biopsy.There were 25(96.1%) patients with non alcoholic steatohepatitis(NASH) in their index biopsy and only four(15.3%) of the repeat biopsies fulfilled the criteria for NASH.The persistence of fibrosis(F > 1) was present in five patients at second biopsy.Steatosis and fibrosis at surgery were predictors of significant fibrosis postsurgery.CONCLUSION:Restrictive mildly malabsorptive surgery provides significant weight loss,resolution of metabolic syndrome and associated abnormal liver histological features in most obese patients. | Víctor Vargas Helena Allende Albert Lecube Maria Teresa Salcedo Juan A Baena-Fustegueras José M Fort Joaquín Rivero Roser Ferrer Roberto Catalán Eva Pardina Santiago Ramón y Cajal Jaime Guardia Julia Peinado-Onsurbe | 2012 | World Journal of Hepatology2012，4，12： | 6 |
| 4 | Effect of physiological integration in self/non-self genotype recognition on the clonal invader Carpobrotus edulis显示文摘Aims biological invasions represent one of the most important threats to the conservation of biodiversity;however,the mechanisms underlying successful invaders remain unsolved.many of the most aggres-sive invaders show clonal growth,and capacity for clonal integration has been pointed out recently as an important trait explaining the success of invasive plants.We aim to determine the role of physi-ological integration in the capacity for self/non-self genotype recog-nition in the clonal invader Carpobrotus edulis and the implications of this capacity for the expansion of this aggressive invader.Methods We used connected and severed ramets of identical or different gen-otype and we determined the capacity for self/non-self recognition by comparing changes in biomass partitioning to avoid competition for resources between pairs of ramets.Important Findings Physiological integration allowed self/non-self genotype recogni-tion in the invader C.edulis.results showed a significant effect of physiological integration on the biomass allocated to roots by genetically identical ramets:older ramets specialize in acqui-sition of soil-based resources and younger ramets specialize in lateral expansion.this specialization could be considered a form of division of labour,which reduce intra-genotype competition.this is the first evidence that division of labour could be inter-preted as a form of self/non-self recognition between genetically identical ramets.Capacity for self/non-self discrimination could contribute to increase the colonization capacity of the aggressive invader C.edulis.this is the first study showing an association between self/non-self recognition and invasiveness in a clonal plant. | Sergio R.Roiloa Susana Rodríguez-Echeverría Helena Freitas | 2014 | Journal of Plant Ecology2014，7，4： | 5 |
| 5 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 6 | Behaviors and Hygiene Habits of Complete Denture Wearers 显示文摘 | Amanda P Ingrid A Helena P | 2010 | Braz Dent J2010，21，3： | 1 |
| 7 | Insight into p95HER2 in Breast Cancer: Molecular Mechanisms and Targeted Therapies显示文摘 | Ramon Andrade de Mello Alessandro de Vasconcelos Ronaldo A Ribeiro Ines Pousa Noemia Afonso Deolinda Pereira Helena Rodrigues | 2012 | Recent Patents on DNA and Gene Sequences2012，，1： | 1 |
| 8 | Ethnic and Socioeconomic Differences in Cardiovascular Disease Risk Factors显示文摘 | Marilyn A Helena C David K | 1998 | JAMA1998，280，： | 1 |
| 9 | Efficient Genetic Transformation System for the Ochratoxigenic Fungus Aspergillus carbonarius显示文摘 | Luiz Rodrigo I. Morioka Márcia C. Furlaneto Andréa C. Bogas Patrícia Pompermayer Rubens T. D. Duarte Maria Lúcia C. Vieira Maria Angélica Ehara Watanabe Maria Helena P. Fungaro | 2006 | Current Microbiology2006，，6： | 1 |
| 10 | Chemical Composition and Larvicidal Activity of Essential Oils Extracted from Brazilian Legal Amazon Plants against Aedes aegypti L. (Diptera: Culicidae)显示文摘 | Clarice Noleto Dias Luciana Patrícia Lima Alves Klinger Antonio da Franca Rodrigues Maria Cristiane Aranha Brito Carliane dos Santos Rosa Flavia Maria Mendon?a do Amaral Odair dos Santos Monteiro Eloisa Helena de Aguiar Andrade José Guilherme Soares Maia | 2015 | Evidence-Based Complementary and Alternative Medicine2015，，： | 1 |
| 11 | Evaluation of an aroma similar to that of sparkling wine:Sensory and gas chromatography analyses of fermented grape musts显示文摘 | Maria E O Mamede Helena M A B Cardello Glaucia M Pastore | 2005 | Food Chemistry2005，89，： | 1 |
| 12 | Highly porous and interconnected starch-based scaffolds Production,characterization and surface modification显示文摘 | Iva P Paula M L P Azevedo Helena S A | 2010 | Materials Science and Engineering C2010，30，： | 1 |
| 13 | Decreasing the apoptotic threshold of tumor cells through protein kinase C inhibition and sphingomyelinase activation increases tumor killing by ionizing radiation 显示文摘 | Steven J Helena J Sunil A | 1997 | Cancer Res1997，57，19： | 1 |
| 14 | Aroma volatiles from two fruit varieties of jackfruit(ArtocarpusHeterophyllus Lam)显示文摘 | Jose Guilherme S Maia Eloisa Helena A Andrade Mariadas Gragas BZoghbi | 2004 | Food Chemistry2004，85，： | 1 |
| 15 | Analysis of trendsin myocardial infarction case-fatality,incidence,and mortality ratesin Girona,Spain,1990-1999显示文摘 | Miguel Gil Helena Martí Roberto Elosúa | 2007 | Rev Esp Cardiol2007，60，4： | 1 |
| 16 | The neglec- ted role of proaetive behavior and outcomes in newcomer socialization显示文摘 | Alan M S Jamie A G Helena C T | 2011 | Journal of Vocational Behavior2011，79，1： | 1 |
| 17 | Reduced-energy cranberry juice increases folic acid and adiponectin and reduces homocysteine and oxidative stress in patients with the metabolic syndrome显示文摘 | Tathiana Name Colado Sim?o Marcell Alysson Batisti Lozovoy Andréa Name Colado Sim?o Sayonara Rangel Oliveira Danielle Venturini Helena Kaminami Morimoto Lúcia Helena Silva Miglioranza Isaias Dichi | 2013 | British Journal of Nutrition2013，，10： | 1 |
| 18 | Changes occurring in phenoliccontent,tocopherol composition and oxidative stability of Camelinasativa oil during storage显示文摘 | HELENA A BOJAN B VOJKO N | 2007 | Food Chemistry2007，104，3： | 1 |
| 19 | Student Satisfaction Index in Por- tuguese public higher education 显示文摘 | Helena A Raposom M | 2007 | The Service Industries Journal2007，27，6： | 1 |
| 20 | Evolution of Bacillus thuringiensis Cry toxins insecticidal activity显示文摘 | Alejandra Bravo Isabel Gómez Helena Porta Blanca Ines García‐Gómez Claudia Rodriguez‐Almazan Liliana Pardo Mario Soberón | 2012 | Microbial Biotechnology2012，，1： | 1 |
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