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| 1 | Oral esomeprazole vs injectable omeprazole for the prevention of hemorrhage after endoscopic submucosal dissection显示文摘AIM To evaluate the effectiveness of oral esomeprazole(EPZ) vs injectable omeprazole(OPZ) therapy to prevent hemorrhage after endoscopic submucosal dissection(ESD).METHODS A case-control study was conducted using a quasirandomized analysis with propensity score matching. A total of 258 patients were enrolled in this study. Patients were treated with either oral EPZ or injectable OPZ. The endpoint was the incidence of hemorrhage after ESD.RESULTS Data of 71 subjects treated with oral EPZ and 172 subjects treated with injectable OPZ were analyzed. Analysis of 65 matched samples revealed no difference in the incidence of hemorrhage after ESD between the oral EPZ and injectable OPZ groups(OR = 0.89, 95%CI:0.35-2.27, P ≥ 0.99).CONCLUSION We conclude that oral EPZ therapy is a useful alternative to injectable PPI therapy for the prevention of hemorrhage after ESD. | Takashi Uchiyama Takuma Higurashi Hitoshi Kuriyama Yoshinobu Kondo Yasuo Hata Atsushi Nakajima | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，10： | 8 |
| 2 | Can endoscopic atrophy predict histological atrophy? Historical study in United Kingdom and Japan显示文摘AIM: To assess the diagnostic concordance between endoscopic and histological atrophy in the United Kingdom and Japan.METHODS: Using published data,a total of 252 patients,126 in the United Kingdom and 126 in Japan,aged 20 to 80 years,were evaluated. The extent of endoscopic atrophy was classified into five subgroups according to a modified Kimura-Takemoto classification system and was compared with histological findings of atrophy at five biopsy sites according to the updated Sydney system.RESULTS: The strength of agreement of the extent of atrophy between histology and visual endoscopic inspection showed good reproducibili ty,wi th a weighted kappa value of 0.76(P < 0.001). Multivariate analysis showed that three factors were associated with decreased concordance: Japanese ethnicity [odds ratio(OR) 0.22,95% confidence interval(CI) 0.11-0.43],older age(OR = 0.32,95%CI: 0.16-0.66) and endoscopic atrophy(OR = 0.10,95%CI: 0.03-0.36). The strength of agreement between endoscopic and histological atrophy,assessed by cancer risk-oriented grading,was reproducible,with a kappa value of 0.81(95%CI: 0.75-0.87). Only nine patients(3.6%) were endoscopically underdiagnosed with antral predominant rather than extensive atrophy and were considered false negatives.CONCLUSION: Endoscopic grading can predict histological atrophy with few false negatives,indicating that precancerous conditions can be identified during screening endoscopy,particularly in patients in western countries. | Shin Kono Takuji Gotoda Shigeaki Yoshida Ichiro Oda Hitoshi Kondo Luigi Gatta Greg Naylor Michael Dixon Fuminori Moriyasu Anthony Axon | 2015 | World Journal of Gastroenterology2015，21，46： | 6 |
| 3 | Effects of Ethephon and Abscisic Acid Application on Ripening-Related Genes in ‘Kohi' Kiwifruit (Actinidia chinensis) on the Vine显示文摘The effects of ethephon and abscisic acid(ABA) application on ripening-related genes of pre-harvest ‘Kohi' kiwifruit(Actinidia chinensis) were studied to clarify the possibility of the fruit ripening on the vine. The fruits were treated on the vine at mature stage with 250 μL·L^(-1)ethephon or 100 μmol·L^(-1)ABA, and the expression levels of chlorophyll synthase(Ac CLS), chlorophyllase1(Ac CLH1), polygalacturonase(Ac PG), expansin(Ac EXP),β-amylase(Acβ-AM), sucrose synthase(Ac SUSY), MADS-box SEPALLATA4/RIPENING INHIBITOR-like(Ac SEP4/RIN) and FRUITFUL-like(Ac TDR4/FUL) genes were analyzed. The expression levels of Ac PG, Ac EXP, Acβ-AM, and Ac SUSY increased in the ethephon-treated fruit, but those of Ac CLH1 at 6and 9 days after treatment and Ac CLS decreased. Moreover, the expression levels of Ac SEP4/RIN and Ac TDR4/FUL, the latter of which is associated with ethylene biosynthesis, were higher in the ethephon-treated fruit. The expression level of each gene in ABA-treated fruit was not significantly different from that of the untreated control. The results suggest that ethephon application increases the expression levels of Ac PG,Ac EXP, Acβ-AM, Ac SUSY, Ac SEP4/RIN, and Ac TDR4/FUL in ‘Kohi' kiwifruit on the vine. | Kongsuwan Ampa Takanori Saito Katsuya Okawa Hitoshi Ohara Satoru Kondo | 2017 | Horticultural Plant Journal2017，3，1： | 5 |
| 4 | Assessment of disease progression in patients with transfusion-associated chronic hepatitis C using transient elastography显示文摘AIM:To evaluate the relationship between liver stiffness and duration of infection in blood transfusion-associated hepatitis C virus (HCV) patients with or without hepatocellular carcinoma (HCC).METHODS:Between December 2006 and June 2008,a total of 524 transfusion-associated HCV-RNA positive patients with or without HCC were enrolled.Liver stiffness was obtained noninvasively by using Fibroscan (Echosens,Paris,France).The date of blood transfusion was obtained by interview.Duration of infection was derived from the interval between the date of bloodtransfusion and the date of liver stiffness measurement (LSM).Patients were stratified into four groups based on the duration of infection (17-29 years;30-39 years;40-49 years;and 50-70 years).The difference in liver stiffness between patients with and without HCC was assessed in each group.Multiple linear regression analysis was used to determine the factors associated with liver stiffness.RESULTS:A total of 524 patients underwent LSM.Eight patients were excluded because of unsuccessful measurements.Thus 516 patients were included in the current analysis (225 with HCC and 291 without).The patients were 244 men and 272 women,with a mean age of 67.8 ± 9.5 years.The median liver stiffness was 14.3 kPa (25.8 in HCC group and 7.6 in nonHCC group).The patients who developed HCC in short duration of infection were male dominant,having lower platelet count,with a history of heavier alcohol consumption,showing higher liver stiffness,and receiving blood transfusion at an old age.Liver stiffness was positively correlated with duration of infection in patients without HCC (r=0.132,P=0.024) but not in patients with HCC (r=-0.103,P=0.123).Liver stiffness was significantly higher in patients with HCC than in those without in each duration group (P < 0.0001).The factors significantly associated with high liver stiffness in multiple regression were age at blood transfusion (P < 0.0001),duration of infection (P=0.0015),and heavy alcohol consumption (P=0.043) CONCLUSION:Although liver stiffness gradually increases over time,HCC develops in patients with high stiffness value regardless of the duration of infection. | Ryota Masuzaki Ryosuke Tateishi Haruhiko Yoshida Toru Arano Koji Uchino Kenichiro Enooku Eriko Goto Hayato Nakagawa Yoshinari Asaoka Yuji Kondo Tadashi Goto Hitoshi Ikeda Shuichiro Shiina Masao Omata Kazuhiko Koike | 2012 | World Journal of Gastroenterology2012，18，12： | 4 |
| 5 | Case of pediatric traditional serrated adenoma resected via endoscopic submucosal dissection显示文摘Traditional serrated adenoma(TSA)is a type of serrated polyp of the colorectum and is thought to be a precancerous lesion.There are three types of serrated polyps,namely,hyperplastic polyps,sessile serrated adenomas/polyps,and TSAs.TSA is the least common of the three types and accounts for about 5% of serrated polyps.Here we report a pediatric case of TSA that was successfully resected by endoscopic submucosal dissection(ESD).This rare case report describes a pediatric patient with no family history of colonic polyp who was admitted to our hospital with hematochezia.On colonoscopy,we found a polypoid lesion measuring 10 mm in diameter in the lower rectum.We selected ESD as a surgical option for en bloc resection,and histopathological examination revealed TSA.The findings in this case suggest that TSA with precancerous potential can occur in children,and that ESD is useful for treating this lesion. | Sonoko Kondo Hirohito Mori Noriko Nishiyama Takeo Kondo Ryuichi Shimono Hitoshi Okada Takashi Kusaka | 2017 | World Journal of Gastroenterology2017，23，24： | 4 |
| 6 | Reversed portal flow: Clinical influence on the long-term outcomes in cirrhosis显示文摘AIM: To elucidate the natural history and the longitudinal outcomes in cirrhotic patients with non-forward portal flow(NFPF).METHODS: The present retrospective study consisted of 222 cirrhotic patients(120 males and 102 females; age, 61.7 ± 11.1 years). The portal hemodynamics were evaluated at baseline and during the observation period using both pulsed and color Doppler ultrasonography. The diameter(mm), flow direction, mean flow velocity(cm/s), and mean flow volume(m L/min) were assessed at the portal trunk, the splenic vein, the superior mesenteric vein, and the collateral vessels. The average values from 2 to 4 measurements were used for the data analysis. The portal flow direction was defined as follows: forward portal flow(FPF) for continuous hepatopetal flow; bidirectional flow for to-and-fro flow; and reversed flow for continuous hepatofugal flow. The bidirectional flow and the reversed flow were classified as NFPF in this study. The clinical findings and prognosis were compared between the patients with FPF and those with NFPF. The median follow-up period was 40.9 mo(range, 0.3-156.5 mo).RESULTS: Twenty-four patients(10.8%) demonstrated NFPF, accompanied by lower albumin level, worse ChildPugh scores, and model for end-stage liver disease scores. The portal hemodynamic features in the patients with NFPF were smaller diameter of the portal trunk;presence of short gastric vein, splenorenal shunt, or inferior mesenteric vein; and advanced collateral vessels(diameter > 8.7 mm, flow velocity > 10.2 cm/s, and flow volume > 310 m L/min). The cumulative incidence rates of NFPF were 6.5% at 1 year, 14.5% at 3 years, and 23.1% at 5 years. The collateral vessels characterized by flow velocity > 9.5 cm/s and those located at the splenic hilum were significant predictive factors for developing NFPF. The cumulative survival rate was significantly lower in the patients with NFPF(72.2% at 1 year, 38.5% at 3 years, 38.5% at 5 years) than in those with forward portal flow(84.0% at 1 year, 67.8% at 3 years, 54.3% at 5 years, P = 0.0123) using the Child-Pugh B and C classifications.CONCLUSION: NFPF has a significant negative effect on the prognosis of patients with worse liver function reserve, suggesting the need for careful management. | Takayuki Kondo Hitoshi Maruyama Tadashi Sekimoto Taro Shimada Masanori Takahashi Osamu Yokosuka | 2015 | World Journal of Gastroenterology2015，21，29： | 3 |
| 7 | Clinical impact of c-Met expression and its gene amplification in hepatocellular carcinoma显示文摘 | Shunsuke Kondo Hidenori Ojima Hitoshi Tsuda Jun Hashimoto Chigusa Morizane Masafumi Ikeda Hideki Ueno Kenji Tamura Kazuaki Shimada Yae Kanai Takuji Okusaka | 2013 | International Journal of Clinical Oncology2013，，2： | 2 |
| 8 | 多层螺旋CT计算心室容积的准确性及最佳层厚选择显示文摘目的(1)确定Simpson方法计算心室容积的最佳层厚;(2)评价多层螺旋CT计算心室容积的准确性。方法采用多层螺旋CT(东芝Aquilion)扫描系统对14个人的左室铸型和15个右室铸型进行扫描。分别以2.0、3.5、5.0、7.0及10.0mm层厚重建左、右心室短轴多平面重组(multiplanarreformattedimage,MPR)图像。采用标准Simpson法计算左、右心室铸型的容积。心室铸型的实际容积通过铸型排除水的容量来计算。结果各层厚计算的心室容积均高估相应心室的实际容积[左心室高估值介于(3.21±5.95)ml至(12.58±8.56)ml之间,右心室高估值介于(10.22±8.45)ml至(23.91±12.24)ml之间]。各层厚计算的心室容积均与相应的实际心室容积高度相关(左心室r值均>0.97,右心室r值均>0.95);心室容积的高估程度与选择的层厚呈显著正相关(左心室r=0.998,右心室r=0.996)。当层厚降至5mm时,计算的心室容积对实际容积的高估值与2mm层厚相比不再差异有统计学意义。结论采用多排Simpson法计算左、右心室容积时,5mm层厚是最有效率的层厚。MSCT可以准确计算左、右心室容积。 | 崔炜 Takeshi Kondo Hirofumi Anno 郭玉印 Takahisa Sato Masayoshi Sarai Hitoshi Shinozaki Satoshi Kakizawa Atsushi Sugiura Keita Oshima Kazuhiro Katada Hitoshi Hishida | 2005 | 中华放射学杂志2005，39，12： | 2 |
| 9 | Curative resection with endoscopic submucosal dissection of early gastric cancer in Helicobacter pylori-negative Ménétrier’s disease:A case report显示文摘BACKGROUND Adult-onset Ménétrier’s disease is strongly associated with Helicobacter pylori(H.pylori)infection and an elevated risk of carcinogenesis.Cases of early-stage gastric cancer developed in H.pylori-negative Ménétrier’s disease are extremely rare.We report a case of early gastric cancer in H.pylori-negative Ménétrier’s disease that was curatively resected with endoscopic submucosal dissection(ESD).CASE SUMMARY A 60-year-old woman was referred to our hospital after her medical examination detected anemia.Contrast-enhanced upper gastrointestinal(UGI)radiography revealed translucency of the nodule-aggregating surface with giant rugae.Blood tests showed hypoproteinemia and were negative for serum H.pylori immunoglobulin G antibodies.The 99mTc-DTPA-human serum albumin scintigraphy showed protein loss from the stomach.UGI endoscopy showed a 40-mm protruding erythematous lesion on giant rugae of the greater curvature of lower gastric body,suggesting early-stage gastric cancer due to Ménétrier’s disease.En bloc resection with ESD was performed for diagnosis and treatment.Histology of ESD showed well-differentiated tubular adenocarcinoma.The cancer was confined to the mucosa,and complete curative resection was achieved.Foveolar hyperplasia and atrophy of the gastric glands were observed in non-tumor areas,histologically corresponding to Ménétrier’s disease.Three years after ESD,gastric cancer had not recurred,and Ménétrier’s disease remained in remission with spontaneous regression of giant gastric rugae.CONCLUSION Complete curative resection was achieved through ESD in a patient with earlystage gastric cancer and H.pylori-negative Ménétrier’s disease. | Koh Fukushi Kenichi Goda Hitoshi Kino Masayuki Kondo Mimari Kanazawa Ken Kashima Akira Kanamori Keiichiro Abe Tsunehiro Suzuki Keiichi Tominaga Hidetsugu Yamagishi Atsushi Irisawa | 2022 | World Journal of Gastroenterology2022，28，5： | 1 |
| 10 | Clinical proteomics identified ATP-dependent RNA helicase DDX39 as a novel biomarker to predict poor prognosis of patients with gastrointestinal stromal tumor显示文摘 | Kazutaka Kikuta Daisuke Kubota Tsuyoshi Saito Hajime Orita Akihiko Yoshida Hitoshi Tsuda Yoshiyuki Suehara Hitoshi Katai Yasuhiro Shimada Yoshiaki Toyama Koichi Sato Takashi Yao Kazuo Kaneko Yasuo Beppu Yasufumi Murakami Akira Kawai Tadashi Kondo | 2011 | Journal of Proteomics2011，，4： | 1 |
| 11 | Successful treatment of multiple hepatocellular carcinoma with tumor thrombi in the major portal branches by intraarterial 5-fluorouracil perfusion chemotherapy combined with subcutaneous interferon-alpha and hepatectomy显示文摘 | Tameyoshi Yamamoto Hiroaki Nagano Yasuharu Imai Kazuto Fukuda Hitoshi Matsumoto Motoi Kondo Hideo Ota Masato Nakamura Hiroshi Wada Takehiro Noda Bazarragchaa Damdinsuren Keizo Dono Koji Umeshita Shoji Nakamori Masato Sakon Kenichi Wakasa Morito Monden | 2007 | International Journal of Clinical Oncology2007，，2： | 1 |
| 12 | Proteomic-based identification of the APC-binding protein EB1 as a candidate of novel tissue biomarker and therapeutic target for colorectal cancer显示文摘 | Yutaka Sugihara Hirokazu Taniguchi Ryoji Kushima Hitoshi Tsuda Daisuke Kubota Hiroshi Ichikawa Kano Sakamoto Yukiko Nakamura Takeshi Tomonaga Shin Fujita Tadashi Kondo | 2012 | Journal of Proteomics2012，，17： | 1 |
| 13 | Endorectal Ultrasonography and Treatment of Early Stage RectalCancer显示文摘 | Takayuki Akasu Hitoshi Kondo Yoshihiro Moriya Kenichi Sugihara Takuji Gotoda Shin Fujita Tetsuichiro Muto Tadao Kakizoe | 2000 | World Journal of Surgery2000，，9： | 1 |
| 14 | Fabrication of New Porous Metal-Bonded Grinding Wheels by Hip Method and Machining Electronic Ceramics显示文摘 | Hitoshi Onishi Masaki Kobayashi Atushi Takata Kozo Ishizaki Tokimune Shioura Yoshihito Kondo Akira Tukuda | 1997 | Journal of Porous Materials1997，，3： | 1 |
| 15 | High Frequency Band Dispersed-Tone Power Line Communication modern for Networked Appliances显示文摘 | Hitoshi Kubota Kazumasa Suzuki Isarnu Kawakami Mamoru Sakugawa and Hiroyuki Kondo | 2006 | IEEE Transactions on Consumer Electronics2006，52，1： | 1 |
| 16 | Correlation between long-term outcome and steroid therapy in type 1 autoimmune pancreatitis: relapse, malignancy and side effect of steroid显示文摘 | Shuya Shimizu Itaru Naitoh Takahiro Nakazawa Kazuki Hayashi Katsuyuki Miyabe Hiromu Kondo Yuji Nishi Michihiro Yoshida Shuichiro Umemura Yasuki Hori Akihisa Kato Fumihiro Okumura Hitoshi Sano Yoshikazu Hirata Hiroki Takada Hirotaka Ohara Takashi Joh | 2015 | Scandinavian Journal of Gastroenterology2015，，11： | 1 |
| 17 | Assessment of clinical features in transient left ventricular apical ballooning显示文摘 | Yoshiteru Abe Makoto Kondo Ryota Matsuoka Makoto Araki Kiyoshi Dohyama Hitoshi Tanio | | Journal of the American College of Cardiology0，，： | 1 |
| 18 | 单平面Simpson法计算右室容积的可行性研究显示文摘目的 评价单平面Simpson法计算右心室容积的可行性。方法 采用Toshiba多层螺旋CT对 15个人的右心室铸型进行扫描 ,然后沿右心室长轴重建出右心室矢状面的多平面重组(multiplanarreformattedimage ,MPR)图像 ,采用单平面Simpson法对右心室铸型的容积进行计算。右心室铸型的实际容积采用阿基米德原理计算。结果 右室铸型的实际容积为 (6 4 .2 3± 2 4 .5 1)ml,单平面Simpson法右心室容积计算值为 (5 3.18± 2 6 .2 2 )ml,平均低估右心室实际容积 (11.0 5± 13.0 9)ml(t=3.2 7,P =0 .0 0 6 )。单平面Simpson法计算的右心室容积值与右室铸型的实际容积显著相关 (r=0 86 9,P <0 .0 0 1)。结论 单平面Simpson方法可以用于右心室容积的计算 。 | 崔炜 Hirofumi Anno Takeshi Kondo Yoshihiro Ida Takahisa Sato Masayoshi Sarai Hitoshi Shinoza kiSatoshi Kakizawa Kouji Sugiura Keita Oshima Kazuhiro Katada Hitoshi Hishida | 2003 | 中华放射学杂志2003，37，9： | 1 |
| 19 | Effect of ethylene glycol dimethacrylate derivatives on photografting of methacrylic acid on low-density polyethylene 显示文摘 | TAKASHI KONDO HITOSHI KUBOTA RYOICHI KATAKAI | 1998 | European Polymer Journal1998，34，8： | 1 |
| 20 | A new endoscopic mucosal resection procedure using an insulation-tipped electrosurgical knife for rectal flat lesions: report of two cases显示文摘 | Takuji Gotoda Hitoshi Kondo Hiroyuki Ono Yutaka Saito Hajime Yamaguchi Daizo Saito Toshihiro Yokota | 1999 | Gastrointestinal Endoscopy1999，，4： | 1 |
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