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| 1 | Bio-inspired polygonal skeleton structure for vibration isolation:Design,modelling,and experiment显示文摘Inspired by the safe landing of a cat falling from a high altitude,a bio-inspired polygonal skeleton(BIPS) structure is proposed,and its nonlinear characteristics are systematically studied to explore its potential application in the suppression of vibration. The polygon is formed by the skeleton structure of the cat’s entire body and the ground. The BIPS system consists of two symmetrical bionic legs with three robs(as skeleton) and four horizontal springs(as muscle). Two bionic legs are connected through the bearing platform(as spine),which could adjust the distance between the two bionic legs. A theoretical model is developed to characterize its stiffness nonlinearity through geometrical and mechanical analysis. Parameter analysis reveals that the BIPS structure has diverse stiffness,including nonlinear positive stiffness and negative stiffness. By imitating adjustment of leg posture and telescopic function of the spine(control the distance between legs),these flexible stiffness properties can be adjusted by structure parameters. In addition,the load capacity and working range can also be designed by the length of the bars,the initial angle,the mounting position,and the spring stiffness. The experimental setup is established,and the vibration isolation performance under various excitation is tested. The experimental results verify the accuracy of the dynamic model and also show that the proposed BIPS structure can suppress the vibration effectively under a variety of excitations. These peculiarities may provide potential possibility of an innovative approach to passive vibration control and isolation. | YAN Ge WANG Sen ZOU HongXiang ZHAO LinChuan GAO QiuHua ZHANG WenMing | 2020 | Science China(Technological Sciences)2020，63，12： | 5 |
| 2 | Design,modeling and experimental investigation of a magnetically modulated rotational energy harvester for low frequency and irregular vibration显示文摘Vibration energy harvesting is a promising approach for sustainable energy generation from ambience to meet the development of self-powered systems.Here,we propose a novel compact non-resonant magnetically modulated rotational energy harvester(MMR-EH)for low frequency and irregular vibration.Through the rational arrangement of multiple magnetic fields in space,a ring route with low potential energy is established.A movable magnet can be non-contact modulated by the magnetic force to move along the ring route under irregular vibration,which is instrumental in electromechanical energy conversion.A dynamic model of the MMR-EH is developed based on the energy method and verified experimentally.The effects of key parameters on the magnetically modulated route are analysed.The simulation and experimental results demonstrate that the MMR-EH can effectively harvest the energy from ultra-low frequency(3 Hz)and irregular vibration.At a reciprocating vibration frequency of 10 Hz and an amplitude of 20 mm,the harvester can produce an average power of 0.29 mW. | ZHAO LinChuan ZOU HongXiang GAO QiuHua YAN Ge WU ZhiYuan LIU FengRui WEI KeXiang YANG Bin ZHANG WenMing | 2020 | Science China(Technological Sciences)2020，63，10： | 5 |
| 3 | Ultra-strong and thermally stable nanocrystalline CrCoNi alloy显示文摘Grain refinement to the nanocrystalline regime is the most effective way to strengthen materials but this often deteriorates the grain-size thermal stability and plasticity. Here we manufactured a nanocrystalline face centred cubic Cr Co Ni medium entropy alloy with columnar grains via magnetron sputtering. Compression of CrCoNi pillars with diameters of ~1 μm revealed a record high yield strength of ~5 GPa for pillars with face centred cubic structures and engineering plastic strain of > 30%. The alloy possessed an outstanding grain-size thermal stability even at 1073 K. Both nanocrystalline grain size and a high density of nanotwins/stacking faults are critical to the exceptional yield strength. Deformation twinning, grains refinement during deformation, grain boundary sliding and random grain orientation all contribute to the large plasticity. The outstanding thermal stability is attributed to the sluggish diffusion effect and the low energy of twin boundaries. | Peng Gao Shuo Sun Heng Li Ranming Niu Shuang Han Hongxiang Zong Hao Wang Jianshe Lian Xiaozhou Liao | 2022 | Journal of Materials Science & Technology2022，，11： | 3 |
| 4 | Why 90%of clinical drug development fails and how to improve it?显示文摘Ninety percent of clinical drug development fails despite implementation of many successful strategies,which raised the question whether certain aspects in target validation and drug optimization are overlooked?Current drug optimization overly emphasizes potency/specificity using structure-activityrelationship(SAR)but overlooks tissue exposure/selectivity in disease/normal tissues using structure-tissue exposure/selectivity—relationship(STR),which may mislead the drug candidate selection and impact the balance of clinical dose/efficacy/toxicity.We propose structure-tissue exposure/selectivity—activity relationship(STAR)to improve drug optimization,which classifies drug candidates based on drug’s potency/selectivity,tissue exposure/selectivity,and required dose for balancing clinical efficacy/toxicity.ClassⅠdrugs have high specificity/potency and high tissue exposure/selectivity,which needs low dose to achieve superior clinical efficacy/safety with high success rate.ClassⅡdrugs have high specificity/potency and low tissue exposure/selectivity,which requires high dose to achieve clinical efficacy with high toxicity and needs to be cautiously evaluated.ClassⅢdrugs have relatively low(adequate)specificity/potency but high tissue exposure/selectivity,which requires low dose to achieve clinical efficacy with manageable toxicity but are often overlooked.ClassⅣdrugs have low specificity/potency and low tissue exposure/selectivity,which achieves inadequate efficacy/safety,and should be terminated early.STAR may improve drug optimization and clinical studies for the success of clinical drug development. | Duxin Sun Wei Gao Hongxiang Hu Simon Zhou | 2022 | Acta Pharmaceutica Sinica B2022，12，7： | 3 |
| 5 | Magnetic levitation using diamagnetism:Mechanism,applications and prospects显示文摘As a typical contact-free manipulation technique that removes friction and contamination risk,levitation has gradually become a preferred candidate for various applications.Magnetic levitation using diamagnetism,beyond Earnshaw’s theorem,is a kind of passive stable levitation that can be achieved at normal temperatures with no energy input.Appealingly,most seemingly nonmagnetic materials can be levitated in a magnetic field and can stabilize free levitation of magnetic materials.This review focuses on the fundamental principles of magnetic levitation using diamagnetism,with emphasis on its burgeoning applications.The theoretical basis associated with the magnetic levitation using diamagnetism is discussed by elucidating the characteristics of diamagnetic materials,and the key levitation mechanisms are clarified.Afterwards,state-of-the-art applications in various aspects,including sensing and measurement,actuating and micromanipulation,energy harvesting and magnetic gravity compensation,are summarized and compared.Finally,the review concludes with a brief outlook on future perspectives. | GAO QiuHua YAN Han ZOU HongXiang LI WenBo PENG ZhiKe MENG Guang ZHANG WenMing | 2021 | Science China(Technological Sciences)2021，64，1： | 3 |
| 6 | Machining Deformation Prediction of Thin-Walled Part Based on Finite Element Analysis显示文摘For the problems of machining distortion and the low accepted product during milling process of aluminum alloy thin-walled part,this paper starts from the analysis of initial stress state in material preparation process,the change process of residual stress within aluminum alloy pre-stretching plate is researched,and the distribution law of residual stress is indirectly obtained by delamination measurement methods,so the effect of internal residual stress on machining distortion is considered before finite element simulation. Considering the coupling effects of residual stress,dynamic milling force and clamping force on machining distortion,a threedimensional dynamic finite element simulation model is established,and the whole cutting process is simulated from the blank material to finished product,a novel prediction method is proposed,which can availably predict the machining distortion accurately. The machining distortion state of the thin-walled part is achieved at different processing steps,the machining distortion of the thin-walled part is detected with three coordinate measuring machine tools,show that the simulation results are in good agreement with experimental data. | Hongxiang Wang Yabin Tang Zhanshan Liu Shi Gao | 2015 | Journal of Harbin Institute of Technology(New Series)2015，22，4： | 2 |
| 7 | Neuronal Mitochondrial Toxicity of Malondialdehyde: Inhibitory Effects on Respiratory Function and Enzyme Activities in Rat Brain Mitochondria显示文摘 | Jiangang Long Changsheng Liu Lijuan Sun Hongxiang Gao Jiankang Liu | 2009 | Neurochemical Research2009，，4： | 1 |
| 8 | New Core-Expanded Naphthalene Diimides for n-Channel Organic Thin Film Transistors显示文摘膨胀核心的萘 diimides 的四个班(1a, 1b, 2a, 2b, 3 和 4 ) 那头熊不同的电子缺乏的硫 heterocycles 被设计并且综合。1a 的处理答案的薄电影, 2a, 3 和 4 作为 n 隧道在空中操作了很好有电子活动性从 106 ~ 0.14 cm2/Vs 的器官的晶体管,取决于不同结合的脊梁。薄电影微观结构研究也被执行为 1a 的薄电影理解电子活动性的变化, 2a, 3 和 4。 | Yunbin Hu Xu Zhang Xiaodi Yang Hongxiang Li Xike Gao | 2013 | Chinese Journal of Chemistry2013，31，11： | 1 |
| 9 | Isolation and expression of McF3H gene in the leaves of crabapple显示文摘 | Hongxiang Shen Jie Zhang Yuncong Yao Ji Tian Tingting Song Jian Geng Junping Gao | 2012 | Acta Physiologiae Plantarum2012，，4： | 1 |
| 10 | CTCs Detection and Whole-exome Sequencing Might Be Used to Differentiate Benign and Malignant Pulmonary Nodules显示文摘Background and objective Low-density computed tomography(LDCT)improved early lung cancer diagnosis but introduces an excess of false-positive pulmonary nodules data.Hence,accurate diagnosis of early-stage lung cancer remains challenging.The purpose of the study was to assess the feasibility of using circulating tumour cells(CTCs)to differentiate malignant from benign pulmonary nodules.Materials and methods 122 patients with suspected malignant pulmonary nodules detected on chest CT in preparation for surgery were prospectively recruited.Peripheral blood samples were collected before surgery,and CTCs were identified upon isolation by size of epithelial tumour cells and morphological analysis.Laser capture microdissection,MALBAC amplification,and whole-exome sequencing were performed on 8 samples.The diagnostic efficacy of CTCs counting,and the genomic variation profile of benign and malignant CTCs samples were analysed.Results Using 2.5 cells/5 m L as the cut-off value,the area under the receiver operating characteristic curve was of 0.651(95%confidence interval:0.538-0.764),with a sensitivity and specificity of 0.526 and 0.800,respectively,and positive and negative predictive values of 91.1%and 30.3%,respectively.Distinct sequence variations differences in DNA damage repair-related and driver genes were observed in benign and malignant samples.TP53 mutations were identified in CTCs of four malignant cases;in particular,g.7578115T>C,g.7578645C>T,and g.7579472G>C were exclusively detected in all four malignant samples.Conclusion CTCs play an ancillary role in the diagnosis of pulmonary nodules.TP53 mutations in CTCs might be used to identify benign and malignant pulmonary nodules. | Changdan XU Xiaohong XU Weipeng SHAO Hongliang SUN Xiaohong LIU Hongxiang FENG Xianbo ZUO Jingyang GAO Guohui WANG Xiongtao YANG Runchuan GU Shutong GE Shijie WANG Liwei GAO Guangying ZHU | 2023 | 中国肺癌杂志2023，26，6： | 1 |
| 11 | A wearable real-time telemonitoring electrocardiogram device compared with traditional Holter monitoring显示文摘Arrhythmias are very common in the healthy populations as well as patients with cardiovascular diseases.Among them,atrial fibrillation(AF)and malignant ventricular arrhythmias are usually associated with some clinical events.Early diagnosis of arrhythmias,particularly AF and ventricular arrhythmias,is very important for the treatment and prognosis of patients.Holter is a gold standard commonly recommended for noninvasive detection of paroxysmal arrhythmia.However,it has some shortcomings such as fixed detection timings,delayed report and inability of remote real-time detection.To deal with such problems,we designed and applied a new wearable 72-hour triple-lead H3-electrocardiogram(ECG)device with a remote cloud-based ECG platform and an expertsupporting system.In this study,31 patients were recruited and 24-hour synchronous ECG data by H3-ECG and Holter were recorded.In the H3-ECG group,ECG signals were transmitted using remote real-time modes,and confirmed reports were made by doctors in the remote expert-supporting system,while the traditional modes and detection systems were used in the Holter group.The results showed no significant differences between the two groups in 24-hour total heart rate(HR),averaged HR,maximum HR,minimum HR,premature atrial complexes(PACs)and premature ventricular complexes(PVCs)(P>0.05).The sensitivity and specificity of capture and remote automatic cardiac events detection of PACs,PVCs,and AF by H3-ECG were 93%and 99%,98%and 99%,94%and 98%,respectively.Therefore,the long-term limb triple-lead H3-ECG device can be utilized for domiciliary ECG self-monitoring and remote management of patients with common arrhythmia under medical supervision. | Qin Shen Jianqing Li Chang Cui Xingyao Wang Hongxiang Gao Chengyu Liu Minglong Chen | 2021 | The Journal of Biomedical Research2021，35，3： | 1 |
| 12 | Multiomics approach reveals the ubiquitination-specific processes hijacked by SARS-CoV-2显示文摘The Coronavirus Disease 2019(COVID-19)caused by Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2)is a global pandemic that seriously threatens health and socioeconomic development,but the existed antiviral drugs and vaccines still cannot yet halt the spread of the epidemic.Therefore,a comprehensive and profound understanding of the pathogenesis of SARS-CoV-2 is urgently needed to explore effective therapeutic targets.Here,we conducted a multiomics study of SARS-CoV-2-infected lung epithelial cells,including transcriptomic,proteomic,and ubiquitinomic.Multiomics analysis showed that SARS-CoV-2-infected lung epithelial cells activated strong innate immune response,including interferon and inflammatory responses.Ubiquitinomic further reveals the underlying mechanism of SARS-CoV-2 disrupting the host innate immune response.In addition,SARS-CoV-2 proteins were found to be ubiquitinated during infection despite the fact that SARS-CoV-2 itself didn’t code any E3 ligase,and that ubiquitination at three sites on the Spike protein could significantly enhance viral infection.Further screening of the E3 ubiquitin ligases and deubiquitinating enzymes(DUBs)library revealed four E3 ligases influencing SARS-CoV-2 infection,thus providing several new antiviral targets.This multiomics combined with high-throughput screening study reveals that SARS-CoV-2 not only modulates innate immunity,but also promotes viral infection,by hijacking ubiquitination-specific processes,highlighting potential antiviral and anti-inflammation targets. | Gang Xu Yezi Wu Tongyang Xiao Furong Qi Lujie Fan Shengyuan Zhang Jian Zhou Yanhua He Xiang Gao Hongxiang Zeng Yunfei Li Zheng Zhang | 2022 | Signal Transduction and Targeted Therapy2022，7，10： | 1 |
| 13 | The effect of M 23 C 6 on the high-temperature tensile strength of two austenitic heat-resistant steels: 22Cr–25Ni–Mo–Nb–N and 25Cr–20Ni–Nb–N显示文摘 | Bicao Peng Hongxiang Zhang Jie Hong Jiaqiang Gao Hanqian Zhang Qijiang Wang Jinfu Li | 2011 | Materials Science & Engineering A2011，，10： | 1 |
| 14 | The combination effects of phenolic compounds and fluconazole on the formation of ergosterol in Candida albicans determined by high-performance liquid chromatography/tandem mass spectrometry显示文摘 | Shujuan Sun Yanhui Gao Xiao Ling Hongxiang Lou | 2004 | Analytical Biochemistry2004，，1： | 1 |
| 15 | Liquid chromatography–tandem mass spectrometric method for the analysis of fluconazole and evaluation of the impact of phenolic compounds on the concentration of fluconazole in Candida albicans显示文摘 | Shujuan Sun Hongxiang Lou Yanhui Gao Peihong Fan Bin Ma Weiying Ge Xiaoning Wang | 2003 | Journal of Pharmaceutical and Biomedical Analysis2003，，5： | 1 |
| 16 | d-Galactose toxicity in mice is associated with mitochondrial dysfunction: protecting effects of mitochondrial nutrient R-alpha-lipoic acid显示文摘 | Jiangang Long Xuemin Wang Hongxiang Gao Zhi Liu Changsheng Liu Mingyong Miao Xu Cui Lester Packer Jiankang Liu | 2007 | Biogerontology2007，，3： | 1 |
| 17 | Structure-tissue exposure/selectivity relationship(STR) correlates with clinical efficacy/safety显示文摘Drug optimization, which improves drug potency/specificity by structure-activity relationship(SAR) and drug-like properties, is rigorously performed to select drug candidates for clinical trials. However,the current drug optimization may overlook the structure-tissue exposure/selectivity-relationship(STR) in disease-targeted tissues vs. normal tissues, which may mislead the drug candidate selection and impact the balance of clinical efficacy/toxicity. In this study, we investigated the STR in correlation with observed clinical efficacy/toxicity using seven selective estrogen receptor modulators(SERMs) that have similar structures, same molecular target, and similar/different pharmacokinetics. The results showed that drug’s plasma exposure was not correlated with drug’s exposures in the target tissues(tumor, fat pad, bone, uterus),while tissue exposure/selectivity of SERMs was correlated with clinical efficacy/safety. Slight structure modifications of four SERMs did not change drug’s plasma exposure but altered drug’s tissue exposure/selectivity.Seven SERMs with high protein binding showed higher accumulation in tumors compared to surrounding normal tissues, which is likely due to tumor EPR effect of protein-bound drugs. These suggest that STR alters drug’s tissue exposure/selectivity in disease-targeted tissues vs. normal tissues impacting clinical efficacy/toxicity. Drug optimization needs to balance the SAR and STR in selecting drug candidate for clinical trial to improve success of clinical drug development. | Wei Gao Hongxiang Hu Lipeng Dai Miao He Hebao Yuan Huixia Zhang Jinhui Liao Bo Wen Yan Li Maria Palmisano Mohamed Dit Mady Traore Simon Zhou Duxin Sun | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 1 |
| 18 | Synthesis of bulk glassyFe- C - Si - B - P - Ga alloys with high glass-forming bility and good soft-magnetic properties显示文摘 | Li Hongxiang Jiao Zengbao Gao Jingen | 2010 | Intermetallics2010，18，： | 1 |
| 19 | Formation of bulk magnetic ternary Fe 80 P 13 C 7 glassy alloy显示文摘 | Qiang Li Jinfeng Li Pan Gong Kefu Yao Jingen Gao Hongxiang Li | 2012 | Intermetallics2012，，： | 1 |
| 20 | SARS-CoV-2 helicase NSP13 hijacks the host protein EWSR1 to promote viral replication by enhancing RNA unwinding activity显示文摘Background:Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)emerged in December 2019 and has led to a global coronavirus disease 2019(COVID-19)pandemic.Currently,incomplete understanding of how SARS-CoV-2 arrogates the host cell to establish its life cycle has led to slow progress in the development of effective drugs.Results:In this study,we found that SARS-CoV-2 hijacks the host protein EWSR1(Ewing Sarcoma breakpoint region 1/EWS RNA binding protein 1)to promote the activity of its helicase NSP13 to facilitate viral propagation.NSP13 is highly conserved among coronaviruses and is crucial for virus replication,providing chemical energy to unwind viral RNA replication intermediates.Treatment with different SARS-CoV-2 NSP13 inhibitors in multi-ple cell lines infected with SARS-CoV-2 effectively suppressed SARS-CoV-2 infection.Using affinity-purification mass spectrometry,the RNA binding protein EWSR1 was then identified as a potent host factor that physically associated with NSP13.Furthermore,silencing EWSR1 dramatically reduced virus replication at both viral RNA and protein levels.Mechanistically,EWSR1 was found to bind to the NTPase domain of NSP13 and potentially enhance its dsRNA unwinding ability.Conclusions:Our results pinpoint EWSR1 as a novel host factor for NSP13 that could potentially be used for drug repurposing as a therapeutic target for COVID-19. | Hongxiang Zeng Xiang Gao Gang Xu Shengyuan Zhang Lin Cheng Tongyang Xiao Wenhong Zu Zheng Zhang | 2022 | Infectious Medicine2022，1，1： | 0 |
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