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| 1 | Effect of heat treatment on LPSO morphology and mechanical properties of Mg-Zn-Y-Gd alloys显示文摘The mechanical properties and microstructure were investigated under different Zn content and heat treatment conditions in a Mg-Zn-YGd cast alloy.A part of the long period stacking order(LPSO)phases transformed to W-M^ZnaRE?phases with an increase in Zn content from 0.9 at.%to 1.8 at.%,and the ultimate tensile strength(UTS)increased from 229 MPa to 248 MPa.With solution treatment at 480°C,the content of the LPSO phase and strength sharply decreased in the Mg-1.8Zn-0.8Y-0.8Gd alloy,whereas this change was not significantly observed in the Mg-0.9Zn-O.8Y-O.8Gd alloy.After solution treatment,the elongation significantly improved and the UTS sharply decreased in both alloys.The lamellar and filminess LPSO phases were observed with aging treatment at 200℃.Moreover,the strengthening efficiency of lamellar and filminess LPSO phases was lower than that of the block LPSO phases.Therefore,the UTS of the T6 state was lower than that of the as-cast alloy. | Hongxin Liao Jonghyun Kim Taekyung Lee Jiangfeng Song Jian Peng Bin Jiang Fusheng Pan | 2020 | Journal of Magnesium and Alloys2020，8，4： | 14 |
| 2 | Signaling pathways and targeted therapy for myocardial infarction显示文摘Although the treatment of myocardial infarction(MI)has improved considerably,it is still a worldwide disease with high morbidity and high mortality.Whilst there is still a long way to go for discovering ideal treatments,therapeutic strategies committed to cardioprotection and cardiac repair following cardiac ischemia are emerging.Evidence of pathological characteristics in MI illustrates cell signaling pathways that participate in the survival,proliferation,apoptosis,autophagy of cardiomyocytes,endothelial cells,fibroblasts,monocytes,and stem cells.These signaling pathways include the key players in inflammation response,e.g.,NLRP3/caspase-1 and TLR4/MyD88/NF-κB;the crucial mediators in oxidative stress and apoptosis,for instance,Notch,Hippo/YAP,RhoA/ROCK,Nrf2/HO-1,and Sonic hedgehog;the controller of myocardial fibrosis such as TGF-β/SMADs and Wnt/β-catenin;and the main regulator of angiogenesis,PI3K/Akt,MAPK,JAK/STAT,Sonic hedgehog,etc.Since signaling pathways play an important role in administering the process of MI,aiming at targeting these aberrant signaling pathways and improving the pathological manifestations in MI is indispensable and promising.Hence,drug therapy,gene therapy,protein therapy,cell therapy,and exosome therapy have been emerging and are known as novel therapies.In this review,we summarize the therapeutic strategies for MI by regulating these associated pathways,which contribute to inhibiting cardiomyocytes death,attenuating inflammation,enhancing angiogenesis,etc.so as to repair and re-functionalize damaged hearts. | Qing Zhang Lu Wang Shiqi Wang Hongxin Cheng Lin Xu Gaiqin Pei Yang Wang Chenying Fu Yangfu Jiang Chengqi He Quan Wei | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 11 |
| 3 | Efficacy of Lubeikangru formulation in mice with hyperplasia of the mammary glands induced by estrogen and progesterone显示文摘OBJECTIVE: To evaluate the protective effects of Lubeikangru formula(LF) on hyperplasia of the mammary glands(HMG) induced by estrogen and progesterone in mice.METHODS: Female mice were divided randomly into five groups: normal, model, tamoxifen(3 mg/kg),Rupixiao(900 mg/kg) and LF(900 mg/kg). All mice except those in the normal group were treated sequentially with estradiol and progesterone to induce HMG. From the tenth day of induction, mice in normal and model groups received distilled water and mice in the other groups were given the corresponding drugs by gavage, once a day, for 30 d.At the end of treatment, the mammary glands, ovaries, hypothalamus, and serum was collected for whole-mount and hematoxylin and eosin(HE)staining, enzyme-linked immunosorbent assays(ELISAs), or western blotting.RESULTS: Whole-mount and HE staining of mammary glands showed that LF rescued(at least in part) the hyperplasic morphology of the mammary glands, and the number of branch points decreased after LF treatment(P < 0.05). ELISAs revealed that levels of estrogen and progesterone were decreased following LF treatment, whereas levels of gonadotropin-releasing hormone, follicle-stimulating hormone, and luteinizing hormone were increased in serum and tissues. Western blotting confirmed that LF treatment led to a reduction in expression of phosphorylated(p)-Erk, p-p38 and p-c-Jun N-terminal kinase. LF was also confirmed to be safe by acute-toxicity tests.CONCLUSION: LF can protect the mammary glands of mice from estrogen-and progesterone-induced hyperplasia by adjusting hormone levels and regulating the mitogen-activated protein kinase pathway. | Sun Li Guo Donghui Liu Qian Xue Yanan Jiang Ning Zheng Hongxin | 2019 | Journal of Traditional Chinese Medicine2019，39，2： | 8 |
| 4 | Sampled-data feedback and stability for a class of uncertain nonlinear systems based on characteristic modeling method显示文摘In this paper, we investigate the tracking problem for a class of second-order uncertain nonlinear systems using sampled-data output feedback. Our controller is designed based on the characteristic modeling method. We first derive the corresponding characteristic model and then give the sampled-data feedback control law, which is referred to as 'golden-section adaptive control based on characteristic models'. The closedloop system is shown to be stable and, concurrently, it is demonstrated that the tracking error can be made arbitrarily small by taking a sufficiently small sampling period. Our results improve upon the findings of previous work by removing the persistent excitation condition, and also lay certain theoretical foundations for practical applications of golden-section adaptive control. | Tiantian JIANG Hongxin WU | 2016 | Science China(Information Sciences)2016，59，9： | 5 |
| 5 | Overview of the Solar Polar Orbit Telescope Project for Space Weather Mission显示文摘The Solar Polar ORbit Telescope(SPORT) project for space weather mission has been under intensive scientific and engineering background studies since it was incorporated into the Chinese Space Science Strategic Pioneer Project in 2011.SPORT is designed to carry a suite of remote-sensing and in-situ instruments to observe Coronal Mass Ejections(CMEs),energetic particles,solar high-latitude magnetism,and the fast solar wind from a polar orbit around the Sun.The first extended view of the polar regions of the Sun and the ecliptic enabled by SPORT will provide a unique opportunity to study CME propagation through the inner heliosphere,and the solar high-latitude magnetism giving rise to eruptions and the fast solar wind.Coordinated observations between SPORT and other spaceborne/ground-based facilities within the International Living With a Star(ILWS) framework can significantly enhance scientific output.SPORT is now competing for official selection and implementation during China's 13 th Five-Year Plan period of 2016-2020. | XIONG Ming LIU Ying LIU Hao LI Baoquan ZHENG Jianhua ZHANG Cheng XIA Lidong ZHANG Hongxin RAO Wei CHEN Changya SUN Weiying WU Xia DENG Yuanyong HE Han JIANG Bo WANG Yuming WANG Chuanbing SHEN Chenglong ZHANG Haiying ZHANG Shenyi YANG Xuan SANG Peng WU Ji | 2016 | 空间科学学报2016，36，3： | 3 |
| 6 | Prognostic value of BCL2 and TP53 genetic alterations for diffuse large B-cell lymphoma patients treated with R-CHOP显示文摘Objective:Limited data about the prognostic significance of BCL2 mutations and BCL2 copy number variations in diffuse large B-cell lymphoma(DLBCL)are available.This study aimed to comprehensively describe BCL2 genetic alterations in DLBCL patients,and examine correlation of BCL2,TP53 and other genetic alterations with outcomes in patients treated with R-CHOP.Methods:Probe capture-based high-resolution sequencing was performed on 191 patients diagnosed with de novo DLBCL.MYC,BCL2,and BCL6 protein expressions were detected by immunohistochemistry.Results:The presence of BCL2 alterations significantly correlated with poor progression-free survival(PFS)(5-year PFS:13.7%vs.40.8%;P=0.003)and overall survival(OS)(5-year OS:34.0%vs.70.9%;P=0.036).Importantly,patients who harbored BCL2 gain/amplifications(BCL2GA/AMP)also had a remarkably inferior 5-year PFS(11.1%vs.38.3%;P<0.001)and OS(22.1%vs.69.6%;P=0.009).In contrast,neither BCL2 mutations nor BCL2 translocations were significantly prognostic for survival.Multivariable analyses showed that the presence of BCL2 alterations,especially BCL2GA/AMP,TP53 mutations,and International Prognostic Index(IPI)were significantly associated with inferior PFS and OS.Novel prognostic models for OS were constructed based on 3 risk factors,including BCL2 alterations(Model 1)or BCL2GA/AMP(Model 2),TP53 mutations,and IPI,to stratify patients into 4 risk groups with different survival outcomes.Conclusions:This study showed that DLBCL patients treated with R-CHOP,BCL2 alterations,especially BCL2GA/AMP and TP53 mutations were significantly associated with inferior outcomes,which were independent of the IPI.The novel prognostic models we proposed predicted outcomes for DLBCL patients treated with R-CHOP,but further validation of the prognostic models is still warranted. | Yan Qin Haizhu Chen Peng Liu Changgong Zhang Jianliang Yang Lin Gui Xiaohui He Liqiang Zhou Shengyu Zhou Shiyu Jiang Hongxin Jiang Yuankai Shi | 2022 | Cancer Biology & Medicine2022，19，6： | 2 |
| 7 | The impact of carbon emission trading policy on firms’green innovation in China显示文摘This study aims to examine the green innovation effect of the carbon emissions pilot policy in China.First,using the difference-in-differences method and regressions of instrumental variables using the data from Chinese listed firms,we verify that the policy promotes green innovation among regulated firms and is more pronounced among state-owned enterprises,firms in the eastern region,and those with lower financing constraints.Furthermore,this positive effect spreads downstream relative to the regulated firms through input–output linkages,but reduces green innovation to upstream firms.Accordingly,such diffusion of innovation is achieved through the price mechanism.The results necessitate the introduction of various derivatives to mobilize the market to reduce the speculative volatility of carbon prices.In addition,relevant supporting policies must be established to encourage corporate innovation to reduce the crowding-out effect owing to emission reduction and the nonmarket factors. | Hongxin Yu Yaohui Jiang Zhaowen Zhang Wen-Long Shang Chunjia Han Yuanjun Zhao | 2022 | Financial Innovation2022，8，1： | 2 |
| 8 | Connexin 43 Reverses Malignant Phenotypes of Glioma Stem Cells by Modulating E‐Cadherin显示文摘 | Shi‐CangYu Hua‐LiangXiao Xue‐FengJiang Qing‐LiangWang YanLi Xiao‐JunYang Yi‐FangPing Jiang JieDuan Jian‐YongJiang Xian‐ZongYe Sen‐LinXu Yang‐HongXin Xiao‐HongYao Jian‐HongChen Wei‐HuaChu WeiSun BingWang Ji MingWang XiaZhang Xiu‐WuBian | 2012 | STEM CELLS2012，，2： | 1 |
| 9 | The role of Chinese medicine in the treatment of chronic diseases in China显示文摘 | JIANG Miao ZHANG Chi CAO Hongxin | 2011 | Planta Medica2011，77，9： | 1 |
| 10 | Science with the 2.5-meter Wide Field Survey Telescope(WFST)显示文摘The Wide Field Survey Telescope(WFST) is a dedicated photometric surveying facility being built jointly by University of Science and Technology of China(USTC) and the Purple Mountain Observatory(PMO). It is equipped with a 2.5-meter diameter primary mirror, an active optics system, and a mosaic CCD camera with 0.73 gigapixels on the primary focal plane for highquality image capture over a 6.5-square-degree field of view. The installation of WFST near the summit of Saishiteng mountain in the Lenghu region is scheduled in summer of 2023, and the operation is planned to start three months later. WFST will scan the northern sky in four optical bands(u, g, r and i) at cadences from hourly/daily in the deep high-cadence survey(DHS) program, to semi-weekly in the wide field survey(WFS) program. During a photometric night, a nominal 30 s exposure in the WFS program will reach a depth of 22.27, 23.32, 22.84, and 22.31(AB magnitudes) in these four bands, respectively, allowing for the detection of a tremendous amount of transients in the low-z universe and a systematic investigation of the variability of Galactic and extragalactic objects. In the DHS program, intranight 90 s exposures as deep as 23(u) and 24 mag(g), in combination with target of opportunity follow-ups, will provide a unique opportunity to explore energetic transients in demand for high sensitivities, including the electromagnetic counterparts of gravitational wave events, supernovae within a few hours of their explosions,tidal disruption events and fast, luminous optical transients even beyond redshift of unity. In addition, the final 6-year co-added images, anticipated to reach g■25.8 mag in WFS or 1.5 mags deeper in DHS, will be of fundamental importance to general Galactic and extragalactic science. The highly uniform legacy surveys of WFST will serve as an indispensable complement to those of the Vera C. Rubin Observatory's Legacy Survey of Space and Time(LSST) that monitors the southern sky. | Tinggui Wang Guilin Liu Zhenyi Cai Jinjun Geng Min Fang Haoning He Ji-an Jiang Ning Jiang Xu Kong Bin Li Ye Li Wentao Luo Zhizheng Pan Xuefeng Wu Ji Yang Jiming Yu Xianzhong Zheng Qingfeng Zhu Yi-Fu Cai Yuanyuan Chen Zhiwei Chen Zigao Dai Lulu Fan Yizhong Fan Wenjuan Fang Zhicheng He Lei Hu Maokai Hu Zhiping Jin Zhibo Jiang Guoliang Li Fan Li Xuzhi Li Runduo Liang Zheyu Lin Qingzhong Liu Wenhao Liu Zhengyan Liu Wei Liu Yao Liu Zheng Lou Han Qu Zhenfeng Sheng Jianchun Shi Yiping Shu Zhenbo Su Tianrui Sun Hongchi Wang Huiyuan Wang Jian Wang Junxian Wang Daming Wei Junjie Wei Yongquan Xue Jingzhi Yan Chao Yang Ye Yuan Yefei Yuan Hongxin Zhang Miaomiao Zhang Haibin Zhao Wen Zhao | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，10： | 1 |
| 11 | A framework for stability analysis of high-order nonlinear systems based on the CMAC method显示文摘A framework for analyzing the stability of a class of high-order minimum-phase nonlinear systems of relative degree two based on the characteristic model-based adaptive control(CMAC) method is presented. In particular, concerning the tracking problem for such high-order nonlinear systems, by introducing a consistency condition for quantitatively describing modeling errors corresponding to a group of characteristic models together with a certain kind of CMAC laws, we prove closed-loop stability and show that such controllers can make output tracking error arbitrarily small. Furthermore, following this framework, with a specific characteristic model and a golden-section adaptive controller, detailed sufficient conditions to stabilize such groups of highorder nonlinear systems are presented and, at the same time, tracking performance is analyzed. Our results provide a new perspective for exploring the stability of some high-order nonlinear plants under CMAC, and lay certain theoretical foundations for practical applications of the CMAC method. | Tiantian JIANG Hongxin WU | 2016 | Science China(Information Sciences)2016，59，11： | 1 |
| 12 | Reduced smooth muscle-fibroblasts transformation potentially decreases intestinal wound healing and colitis-associated cancer in ageing mice显示文摘Cancer and impaired tissue wound healing with ageing are closely related to the quality of life of the elderly population.Given the increased incidence of cancer and the population ageing trend globally,it is very important to explore how ageing impairs tissue wound healing and spontaneous cancer.In a murine model of DSS-induced acute colitis and AOM/DSS-induced colitis-associated cancer(CAC),we found ageing significantly decreases intestinal wound healing and simultaneous CAC initiation,although ageing does not affect the incidence of AOM-induced,sporadic non-inflammatory CRC.Mechanistically,reduced fibroblasts were observed in the colitis microenvironment of ageing mice.Through conditional lineage tracing,an important source of fibroblasts potentially derived from intestinal smooth muscle cells(ISMCs)was identified orchestrating intestinal wound healing and CAC initiation in young mice.However,the number of transformed fibroblasts from ISMCs significantly decreased in ageing mice,accompanied by decreased intestinal wound healing and decreased CAC initiation.ISMCs-fibroblasts transformation in young mice and reduction of this transformation in ageing mice were also confirmed by ex-vivo intestinal muscular layer culture experiments.We further found that activation of YAP/TAZ in ISMCs is required for the transformation of ISMCs into fibroblasts.Meanwhile,the reduction of YAP/TAZ activation in ISMCs during intestinal wound healing was observed in ageing mice.Conditional knockdown of YAP/TAZ in ISMCs of young mice results in reduced fibroblasts in the colitis microenvironment,decreased intestinal wound healing and decreased CAC initiation,similar to the phenotype of ageing mice.In addition,the data from intestine samples derived from inflammatory bowel disease(IBD)patients show that activation of YAP/TAZ also occurs in ISMCs from these patients.Collectively,our work reveals an important role of the ageing stromal microenvironment in intestinal wound healing and CAC initiation.Furthermore,our work also identified a potential source of fibroblasts involved in colitis and CAC. | Yi Liu Yanhong Ji Ruiyi Jiang Chao Fang Gang Shi Lin Cheng Yinan Zuo Yixin Ye Xiaolan Su Junshu Li Huiling Wang Yuan Wang Yi Lin Lei Dai Shuang Zhang Hongxin Deng | 2023 | Signal Transduction and Targeted Therapy2023，8，9： | 0 |
| 13 | Opportunities and Challenges:Internationalized Higher Education in the Pandemic and Post-Pandemic Age显示文摘The COVID-19 pandemic has created an unprecedented crisis all over the world,while it also marks the coming of a new era of opportunities and challenges,especially for higher education.Universities should be more inclusive and innovative in communication and cooperation,promoting opportunities for collaborations in all aspects and reshaping international education. | Hongxin Jiang | 2021 | Journal of Foreign Languages and Cultures2021，5，2： | 0 |
| 14 | Enantioselective Recognition of Neutral Molecules in Water by a Pair of Chiral Biomimetic Macrocyclic Receptors显示文摘Enantioselective recognition in water remains an ongoing challenge in supramolecular chemistry but is routine in nature.Herein,we report the first enantiopure pair of biomimetic macrocyclic receptors with hydrogen bonding donors in their deep hydrophobic cavities.The chiral naphthotubes can be efficiently synthesized through a chirality-directed macrocyclization strategy and are able to discriminate the enantiomers of neutral chiral molecules in water.Density functional theory calculations reveal that the“three-point contact”model effectively explains their enantioselectivity.The differential noncovalent interactions inside the hydrophobic cavity are responsible for the enantioselective recognition.Moreover,these chiral naphthotubes are both fluorescent and circular dichroism(CD)-active.In CD spectroscopy,they have been demonstrated to have the ability to detect nonchromophoric,achiral molecules in water.And,the use of fluorescence spectroscopy has aided in the determination of the enantiomeric excess(ee)values of chiral molecules.The results and conclusions obtained with these chiral biomimetic receptors can be used to better understand enantioselective recognition in biological systems. | Hongxin Chai Zhao Chen Sheng-Hua Wang Mao Quan Liu-Pan Yang Hua Ke Wei Jiang | 2020 | CCS Chemistry2020，2，6： | 0 |
| 15 | Perspectives on point cloud-based 3D scene modeling and XR presentation within the cloud-edge-client architecture显示文摘With the support of edge computing,the synergy and collaboration among central cloud,edge cloud,and terminal devices form an integrated computing ecosystem known as the cloud-edge-client architecture.This integration unlocks the value of data and computational power,presenting significant opportunities for large-scale 3D scene modeling and XR presentation.In this paper,we explore the perspectives and highlight new challenges in 3D scene modeling and XR presentation based on point cloud within the cloud-edge-client integrated architecture.We also propose a novel cloud-edge-client integrated technology framework and a demonstration of municipal governance application to address these challenges. | Hongjia Wu Hongxin Zhang Jiang Cheng Jianwei Guo Wei Chen | 2023 | Visual Informatics2023，7，3： | 0 |
| 16 | On the Genesis of Zhongshu Qian’s Fortress Besieged显示文摘Significant portions of Zhongshu Qian’s classic twentieth century novel,Fortress Besieged,are closely correlated with Hunan.This article explores the connections between the novel and Qian’s experiences in National Hunan Normal College(NHNC),later to become Hunan Normal University(HNNU).More than one third of Fortress Besieged describes the experiences of its main character,Hongjang Fang,at the fictional SanlüUniversity.This article argues that Qian’s time at NHNC had formative impact on Fortress Besieged,in which four pivotal chapters are fictionalized versions of his actual encounters in Hunan.Drawing on archival documents,this article analyzes the novel to determine the relative levels of historical veracity versus imaginative recreations.The ultimate goal is to demonstrate where depictions are realistic or fantastic,and the ways in which Fortress Besieged and NHNC become mutually constitutive reflections of each other. | Hongxin Jiang | 2017 | Journal of Foreign Languages and Cultures2017，1，1： | 0 |
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