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| 1 | A novel mutation in the MITF may be digenic with GJB2 mutations in a large Chinese family of Waardenburg syndrome type Ⅱ显示文摘Waardenburg syndrome typeⅡ(WS2) is associated with syndromic deafness.A subset of WS2,WS2A,accounting for approximately 15%of patients,is attributed to mutations in the microphthalmia-associated transcription factor(MITF) gene.We examined the genetic basis of WS2 in a large Chinese family.All 9 exons of the MITF gene,the single coding exon(exon 2) of the most common hereditary deafness gene GJB2 and the mitochondrial DNA(mtDNA) 12S rRNA were sequenced.A novel heterozygous mutation c.[742_743delAAinsT;746_747delCA]in exon 8 of the MITF gene co-segregates with WS2 in the family.The MITF mutation results in a premature termination codon and a truncated MITF protein with only 247 of the 419 wild type amino acids.The deaf proband had this MITF gene heterozygous mutation as well as a c.[109G>A]+ [235delC]compound heterozygous pathogenic mutation in the GJB2 gene.No pathogenic mutation was found in mtDNA 12S rRNA in this family.Thus,a novel compound heterozygous mutation,c.[742_743delAAinsT;746_747delCA]in MITF exon 8 was the key genetic reason for WS2 in this family,and a digenic effect of MITF and GJB2 genes may contribute to deafness of the proband. | Xukun Yan Tianyu Zhang Zhengmin Wang Yi Jiang Yan Chen Hongyan Wang Duan Ma Lei Wang Huawei Li | 2011 | Journal of Genetics and Genomics2011，38，12： | 8 |
| 2 | A Robust Collaborative Recommendation Algorithm Based on k-distance and Tukey M-estimator显示文摘The existing collaborative recommendation algorithms have lower robustness against shilling attacks.With this problem in mind,in this paper we propose a robust collaborative recommendation algorithm based on k-distance and Tukey M-estimator.Firstly,we propose a k-distancebased method to compute user suspicion degree(USD).The reliable neighbor model can be constructed through incorporating the user suspicion degree into user neighbor model.The influence of attack profiles on the recommendation results is reduced through adjusting similarities among users.Then,Tukey M-estimator is introduced to construct robust matrix factorization model,which can realize the robust estimation of user feature matrix and item feature matrix and reduce the influence of attack profiles on item feature matrix.Finally,a robust collaborative recommendation algorithm is devised by combining the reliable neighbor model and robust matrix factorization model.Experimental results show that the proposed algorithm outperforms the existing methods in terms of both recommendation accuracy and robustness. | YI Huawei ZHANG Fuzhi LAN Jie | 2014 | China Communications2014，11，9： | 6 |
| 3 | Bioinspired Unidirectional Liquid Transport Micro-nano Structures:A Review显示文摘Unidirectional liquid transport without any need of external energy has drawn worldwide attention for its potential applications in various fields such as microfluidics,biomedicine and mechanical engineering.In nature,numerous creatures have evolved such extraordinary unidirectional liquid transport ability such as spider sik,Sarracenia's trichomes,and Nepenthes alata's peristome,etc.This review summarizes the current progresses of natural unidirectional liquid transport on 1-Dimensional(1D)linear structure and 2-Dimensional(2D)surface stucture.The driving force of unidirectional liquid transport which is determined by unique structure exist distinct differences in physics.The fundamental understanding of 1D and 2D unidirectionaliquid transport especially about hierarchical structural characteristics and their transport mechanism were concentrated,and various bioinspired fabrication methods are also introduced.The applications of bioinspired directional liquid transport are demonstrated especially in fields of microfluidies,biomedical devices and anti-icing surfaces.With newly developed smart materials,various liquid transport regulation strategies are also summarized for the control of transport speed,direction guiding,etc.Finally,we provide new insights and future perspectives of the directional transport materials. | Liwen Zhang Guang Liu Huawei Chen Xiaolin Liu Tong Ran Yi Zhang Yang Gan Deyuan Zhang | 2021 | Journal of Bionic Engineering2021，18，1： | 4 |
| 4 | Robust Recommendation Algorithm Based on Kernel Principal Component Analysis and Fuzzy C-means Clustering显示文摘面临先令攻击,存在建议算法有更低的坚韧性。就这个问题而言,我们在场一个柔韧的建议算法基于聚类的核主管部件分析和模糊 c 工具。第一,我们使用核主管部件分析方法减少原来的等级矩阵的维数,它能提取用户和项目的有效特征。根据在攻击侧面之间的减少尺寸的等级矩阵和高关联特征,然后,我们使用聚类方法聚类用户概况的模糊 c 工具,它能认识到真侧面和攻击侧面的有效分离。最后,我们基于攻击察觉结果构造指示物功能到攻击的影响在建议上介绍的减少,并且把它合并到矩阵因式分解技术设计相应柔韧的建议算法。实验结果显示建议算法比在建议精确性和坚韧性的存在方法优异。 | YI Huawei NIU Zaiseng ZHANG Fuzhi LI Xiaohui WANG Yajun | 2018 | Wuhan University Journal of Natural Sciences2018，23，2： | 2 |
| 5 | Salubrinal protects against Clostridium difficile toxin B-induced CT26 cell death显示文摘Clostridium 顽固(C。顽固) 被认为在动物和人是联系抗菌素的腹泻和 pseudomembranous 大肠炎的主要原因。C 的流行。自从 2000,顽固感染(CDI ) 一直在增加。C 的二外毒素。顽固,毒素 A (TcdA ) 和毒素 B (TcdB ) , CDI 的主要毒力因素,能在宿主 cytosol 导致 Rho GTPases 的 glucosylation,正在导致细胞词法变化,细胞 apoptosis,和细胞死亡。导致 TcdB 的房间死亡的机制被调查十年了,但是它仍然不完全被理解。TcdB 经由在 CT26 房间线(BALB/C 老鼠冒号肿瘤房间) 表明小径的 PERK-eIF2 导致 endoplasmic 蜂窝胃应力,这被报导了。在这研究,我们发现了那 salubrinal, eIF2 dephosphorylation 的一个选择禁止者,高效地保护 CT26 房间线免于导致 TcdB 的房间死亡并且试着探索在这保护的效果位于下面的机制。我们的结果证明那 salubrinal 保护 CT26 房间免受的伤害调停 TcdB 细胞毒素并且 cytopathic 效果,经由 caspase-9-dependent 小径, eIF2 发信号小径,和 autophagy 禁止暴露毒素的房间的 apoptosis 和死亡。这些调查结果将对 CDI 治疗的发展有用。 | Shuyi Chen Chunli Sun Huawei Gu Haiying Wang Shan Li Yi Ma Jufang Wang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，3： | 2 |
| 6 | High-mobility group box 1 protein contributes to the immunogenicity of rTcdB-treated CT26 cells显示文摘 | Huawei Gu Ji Liu Shuyi Chen Haonan Qi Kan Shi Shan Li Yi Ma Jufang Wang | 2018 | Acta Biochimica et Biophysica Sinica2018，50，9： | 1 |
| 7 | Fbxl4作为节律输出分子通过周期性降解GABAA受体调控睡眠行为显示文摘文章简介睡眠是一种保守、可逆的行为状态,该过程受到生物节律和睡醒稳态的调控。然而生物节律到底是以何种输出形式调控睡眠的一直不清楚。 | Qian Li Yi Li Xiao Wang Junxia Qi Xi Jin Huawei Tong Zikai Zhou Zi Chao Zhang 韩俊海 | 2018 | 科学新闻2018，0，4： | 0 |
| 8 | Enabling high-efficiency ethanol oxidation on NiFe-LDH via deprotonation promotion and absorption inhibition显示文摘Nucleophile oxidation reaction(NOR), represented by ethanol oxidation reaction(EOR), is a promising pathway to replace oxygen evolution reaction(OER). EOR can effectively reduce the driving voltage of hydrogen production in direct water splitting. In this work, large current and high efficiency of EOR on a Ni, Fe layered double hydroxide(NiFe-LDH) catalyst were simultaneously achieved by a facile fluorination strategy. F in NiFe-LDH can reduce the activation energy of the dehydrogenation reaction, thus promoting the deprotonation process of NiFe-LDH to achieve a lower EOR onset potential. It also weakens the absorption of OH-and nucleophile electrooxidation products on the surface of NiFe-LDH at a higher potential, achieving a high current density and EOR selectivity, according to density functional theory calculations. Based on our experiment results, the optimized fluorinated NiFe-LDH catalyst achieves a low potential of 1.386 V to deliver a 10 mA cm^(-2)EOR. Moreover, the Faraday efficiency is greater than 95%, with a current density ranging from 10 to 250 mA cm^(-2). This work provides a promising pathway for an efficient and cost-effective NOR catalyst design for economic hydrogen production. | Jiawei Shi Huawei He Yinghua Guo Feng Ji Jing Li Yi Zhang Chengwei Deng Liyuan Fan Weiwei Cai | 2023 | Journal of Energy Chemistry2023，，10： | 0 |
| 9 | Applications of bioinspired approaches and challenges inmedical devices显示文摘Urgent requirements of medical devices Precision medicine has gradually become a development strategy in many countries and attracted worldwide attention in recent years due to the increasing concerns in public health.Although the definition of precision medicine has less or more difference from the viewpoints of different fields,the demands on the properties of medical devices or medical materials involving biocompatibility and anti-thrombosis are gradually growingmuch more diverse and much more urgent than ever[1].This trend brings up many new research topics about materials,mechanical systems and sensors to develop advanced medical devices.How to design and on-demand fabricate the bio-materials,bio-interface and bio-systems to meet the urgent demands of medical devices is still a challenge for us. | Huawei Chen Yi Zhang Liwen Zhang Xilun Ding Deyuan Zhang | 2021 | Bio-Design and Manufacturing2021，4，1： | 0 |
| 10 | Over 18% binary organic solar cells enabled by isomerization of non-fullerene acceptors with alkylthiophene side chains显示文摘Side-chain engineering has been demonstrated as an effective method for fine-tuning the optical,electrical,and morphological properties of organic semiconductors toward efficient organic solar cells(OSCs).In this work,three isomeric non-fullerene small molecule acceptors(SMAs),named as BTP-4F-T2C8,BTP-4F-T2EH and BTP-4F-T3EH,with linear and branched alkyl chains substituted on the α or β positions of thiophene as the side chains,were synthesized and systematically investigated.The results demonstrate that the size and substitution position of alkyl side chains can greatly affect the electronic properties,molecular packing as well as crystallinity of the SMAs.After blending with donor polymer D18-Cl,the prominent device performance of 18.25% was achieved by the BTP-4F-T3EH-based solar cells,which is higher than those of the BTP-4F-T2EH-based(17.41%)and BTP-4F-T2C8-based(15.92%)ones.The enhanced performance of the BTP-4F-T3EH-based devices is attributed to its stronger crystallinity,higher electron mobility,suppressed bimolecular recombination,and the appropriate intermolecular interaction with the donor polymer.This work reveals that the side chain isomerization strategy can be a practical way in tuning the molecular packing and blend morphology for improving the performance of organic solar cells. | Ao Shang Siwei Luo Jianquan Zhang Heng Zhao Xinxin Xia Mingao Pan Chao Li Yuzhong Chen Jicheng Yi Xinhui Lu Wei Ma He Yan Huawei Hu | 2022 | Science China Chemistry2022，65，9： | 0 |
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