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| 1 | Tooth loss inhibits neurogenesis in the dentate gyrus of adult mice显示文摘Tooth loss has been shown to affect learning and memory in mice and increases the risk of Alzheimer's disease. The dentate gyrus is strongly associated with cognitive function. This study hypothesized that tooth loss affects neurons in the dentate gyrus. Adult male mice were randomly assigned to either the tooth loss group or normal control group. In the tooth loss group, the left maxillary and mandibular molars were extracted. Normal control mice did not receive any intervention. Immunofluorescence staining revealed that the density and absorbance of doublecortin- and neuronal nuclear antigen-positive cells were lower in the tooth loss group than in the normal control group. These data suggest that tooth loss may inhibit neurogenesis in the dentate gyrus of adult mice. | Shaochen Su Tao Qi Baoli Su Huibin Gu Jianlin Wang Lan Yang | 2014 | Neural Regeneration Research2014，9，17： | 4 |
| 2 | Nanosecond photoelectric effects in all-oxide p-n junction of La_(0.9)Sr_(0.1)MnO_(3)/SrNb_(0.01)Ti_(0.99)O_(3)显示文摘Nanosecond (ns) photoelectric effects have been observed in all-oxide p-n junctions of La0.9Sr0.1MnO3/SrNb0.01Ti0.99O3 for the first time. The rise time was about 23 ns and the full width at half maximum was about 125 ns for the open-circuit photovoltaic pulse when the La0.9Sr0.1MnO3 thin film in the p-n junction was irradiated by a laser of ~20 ns pulse duration and 308 nm wavelength. The photovoltaic sensitivity was 80 mV/mJ for a 308 nm laser pulse. | HUANG Yanhong L(U) Huibin HE Meng ZHAO Kun CHEN Zhenghao CHENG Bolin ZHOU Yueliang JIN Kuijuan DAI Shouyu YANG Guozhen | 2005 | Science China(Physics,Mechanics & Astronomy)2005，48，3： | 4 |
| 3 | Label-free and real-time detection of antigen-antibody interactions by Oblique-incidence Reflectivity Difference(OIRD) method显示文摘We label-free and real-time detected three interaction processes of antigen-antibodies,Human Immunoglobulin G(IgG),Rabbit IgG,and Mouse IgG as the targets,and Goat Anti-human IgG,Goat Anti-rabbit IgG,and Goat Anti-mouse IgG as the probe,by the Oblique-incidence Reflectivity Difference(OIRD) method.The interaction dynamic curves of the OIRD signal,corresponding to the interaction processes of antigen-antibodies,are generated.The reaction times from beginning to equilibrium state are about 1800,900,and 1200 s for Human IgG,Rabbit IgG,and Mouse IgG,respectively.The experimental results demonstrate that the OIRD method not only can distinguish biomolecular interactions,but also can be used in real-time detection of interactions and dynamic processes of biomolecules. | HE LiPing SUN Yue DAI Jun WANG JingYi LU HuiBin WANG ShuFang JIN KuiJuan ZHOU YueLiang YANG GuoZhen | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，9： | 4 |
| 4 | 雷公藤红素通过靶向核受体Nur77促进损伤线粒体自噬而抑制炎症反应显示文摘文章简介线粒体在细胞死亡、自噬、免疫和炎症中起着不可或缺的作用。前期研究发现,孤儿核受体Nur77通过靶向线粒体诱导细胞凋亡。本文报道了Nur77作为具有抗炎作用的雷公藤红素的直接靶点,介导雷公藤红素通过自噬清除损伤线粒体,抑制炎症反应而达到治疗炎症疾病包括肥胖症的功能。 | Mengjie Hu Qiang Luo Gulimiran Alitongbieke Shuyi Chong Chenting Xu Lei Xie Xiaohui Chen Duo Zhang Yuqi Zhou Zhaokai Wang Xiaohong Ye Lijun Cai Fang Zhang Huibin Chen Fuquan Jiang Hui Fang Shanjun Yang Jie Liu Maria T.Diaz-Meco Ying Su Hu Zhou Jorge Moscat Xiangzhi Lin 张晓坤 | 2018 | 科学新闻2018，0，4： | 3 |
| 5 | A study on surface symmetry and interfacial enhancement of SrTiO_3 by second harmonic generation显示文摘The symmetry of the surfaces of SrTiO3and slightly Nb-doped SrTiO3crystals was investigated by the optical reflected second harmonic generation technique.The good agreement between experimental and theoretical results of the second harmonic intensity dependence on the azimuth angle indicates that the SrTiO3(001)surface is with 4mm symmetry and the Nb-doped SrTiO3(111)surface with 3m symmetry.The measurements of the polarization dependent second harmonic intensity confirm that conclusion.The enhancement of the surface polarization in the structure of SrTiO3capped La0.9Sr0.1MnO3films compared with that in the La0.9Sr0.1MnO3films has been obtained. | ZHAO RuiQiang JIN KuiJuan GUO HaiZhong LU HuiBin YANG GuoZhen | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，12： | 3 |
| 6 | Oxygen vacancy induced magnetism in BaTiO_(3-δ) and Nb:BaTiO_(3-δ) thin films显示文摘The unusual magnetic properties are observed in oxygen deficient BaTiO3-δ(BTO) and Nb:BaTiO3-δ(BNTO) thin films fabricated on SrTiO3 substrates by laser molecular beam epitaxy.The distinct magnetic hysteresis loops are observed in the oxygen deficient BTO and BNTO thin films in a temperature range of 5 to 300 K,whereas the diamagnetism is observed in both BTO and BNTO annealed at 1 atm of oxygen.The dopant Nb only enhances the magnetization in BNTO thin films,but has little effect on the coercivity.The magnetism of BTO and BNTO films is proposed to be the oxygen vacancies by origin. | YANG Fang,JIN KuiJuan,LU HuiBin,HE Meng,WANG Cong,WEN Juan & YANG GuoZhen Beijing National Laboratory for Condensed Matter Physics,Institute of Physics,Chinese Academy of Sciences,Beijing 100190,China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，5： | 3 |
| 7 | Colossal magnetoresistive p-n junctions of perovskite oxide La_(0.9)Sr_(0.1)MnO_3/SrNb_(0.01)Ti_(0.99)O_3显示文摘We have successfully fabricated the colossal magnetoresistive (CMR) p-n junctions of perovskite oxide La0.9Sr0.1MnO3/SrNb0.01Ti0.99O3 (LSMO/SNTO) with laser molecular beam epitaxy. The I-V characteristics of the LSMO/SNTO p-n junctions as a function of applied magnetic field (05 T) were studied between 100 and 300 K. We found that the p-n junction exhibited the CMR behavior. The CMR ratio rR/R0 (rR = RH - R0) is positive in magnetic fields below 0.13 T and at high temperature, while it displays a negative CMR near 100 K and in magnetic fields over 0.13 T. The CMR ratio values are 8% at 0.1 T and 13% at 5 T and 300 K, 40% at 0.1 T and 150 K, 10% at 0.13 T and 60% at 5 T and 100 K. The CMR behavior of the p-n junction is different from those of the LaMnO3 compound family. | L Huibin, DAI Souyu, CHEN Zhenghao, YAN Lei, ZHOU Yueliang & YANG Guozhen Laboratory of Optical Physics, Institute of Physics & Center for Condensed Matter Physics, Chinese Academy of Sciences, 100080 Beijing, China | 2003 | Chinese Science Bulletin2003，48，13： | 2 |
| 8 | Label-free and real-time detection of specific binding of IgG proteins by oblique-incidence reflectivity difference method显示文摘The entire interaction process between anti-mouse immunoglobulin-G (IgG) and mouse IgG with a concentration range from 1 to 0.25 mg/mL has been label-free detected by the oblique incidence reflectivity difference (OIRD) method.We achieved the two-dimensional scanning images of OIRD Re{△ p △s } intensities before and after interactions as well as the curves of reaction dynamic processes.The experimental results suggest that OIRD method not only can label-free distinguish the different concentrations of proteins and detect biological microarrays,but also can real-time monitor the kinetic processes of biomolecular interactions. | SUN Yue HE LiPing DAI Jun WANG JingYi LÜ HuiBin WANG ShuFang JIN KuiJuan ZHOU YueLiang YANG GuoZhen | 2012 | Chinese Science Bulletin2012，57，22： | 2 |
| 9 | Ring-restricted N-nitrosated rhodamine as a green-light triggered,orange-emission calibrated and fast-releasing nitric oxide donor显示文摘Nitric oxide(NO) donors are versatile tools for nitric oxide biology. The biological response of NO is dependent on the transient concentration and the sustained duration. N-Nitrosated rhodamines are photo-triggered and photo-calibrated NO donors. We recently discovered that suppression of the dihedral angle between the N-nitroso fragment with the rhodamine scaffold facilitates NO release.Inspired by this discovery, we developed a fast-releasing NO donor (NOD575) suitable for biological applications, e.g., the pulmonary arterial smooth muscle cells(PASMCs). | Haihong He Tingting He Ziqian Zhang Xiu Xu Huibin Yang Xuhong Qian Youjun Yang | 2018 | Chinese Chemical Letters2018，29，10： | 2 |
| 10 | The selective deposition of Fe species inside ZSM-5 for the oxidation of cyclohexane to cyclohexanone显示文摘The design of efficient iron-based catalysts remains a great challenge for selective cyclohexane oxidation to cyclohexanone under mild conditions.Because of the complex distribution of iron location on the support,the selectivity is always low.Here,we report a general strategy to selectively deposit highly-dispersed FeO_(x) into the micropore of ZSM-5 by atomic layer deposition(ALD).The framework of ZSM-5 and the Bronsted acid sites are intact during ALD,and the Fe species are selectively deposited onto the defect and Lewis acid sites of ZSM-5.Besides,more Fe–O–Si bonds are formed over FeO_(x)/ZSM-5 with a low loading of Fe,while FeO_(x) nanoparticles are generated at high Fe loading.They cannot be realized by the traditional solution method.The obtained FeO_(x)/ZSM-5 catalysts perform high selectivity of cyclohexanone(92%–97%),and ALD cycle numbers of FeO_(x) control the activity.Compared with the Fe nanoparticles,the Fe–O–Si species performs higher turnover frequency and stability in the oxidation reaction. | Liming Zhai Bin Zhang Haojie Liang Huibin Wu Xinchun Yang Gen Luo Shichao Zhao Yong Qin | 2021 | Science China Chemistry2021，64，7： | 2 |
| 11 | Assessment of Serum PRL,MLT,TSH,FSH and LH Concentrations in the Goat (Capra hircus) Exposing to Different Photoperiod Regimes显示文摘In many seasonally breeding species,photoperiod is an important factor involved in reproduction. Capra hircus breeds are normally considered short-day breeders. An experiment was carried out to evaluate whether or not photoperiodic regimens influence circulating hormone levels( prolactin,melatonin,thyrotropin stimulating hormine,luteinizing hormone,follicle stimulating hormone) of Henan huai local goat exposing to different photoperiodic regimens. The results showed that plasma levels of prolactin,melatonin,thyrotropin stimulating hormine,luteinizing hormone and follicle stimulating hormone were higher in the 8 L∶ 16 D photoperiodic regimen than that in the 16 L∶ 8 D photoperiodic regimen. Levels of those hormones decreased on day 7 and day 28 when the 16 L∶ 8 D photoperiodic regimen was used continuously. It was concluded that serum concentrations of the hormones increased in summer when short day( 8 L∶ 16 D) was used and decreased when the goats were transferred from short day for 42 d to long day exposure for 28 d. We suggest that in summer,levels of hormones changing may be due to short day animals. Changing of related hormones is still determined by the mechanism of internal regulation of short day animal's exposure to light changes. Shortening light may also help increase the reproductive activity of goat and thus increase productivity. | Huibin SHI Zhilong TIAN Yuqin WANG Zhibo WU Fang YANG Jianping WANG Mingxing CHU CaiHong WEI | 2018 | Agricultural Biotechnology2018，7，4： | 1 |
| 12 | Longitudinal follow-up survey of effects of oral health education on ECC显示文摘Objective To investigate the effect of oral comprehensive health care measures on the prevalence of early childhood caries in urban areas of China.Methods A total of 345 children aged 4 to 5 years old in Qingdao city were recruited for a year to conduct a single blind randomized controlled clinical trial. The children from four different kindergartens were included in the study. They were randomly divided into an experimental group(160 children) and a control group(185 children). The experimental group received oral health examination, while the children in the control group received oral health examination only. After 1 year's intervention, the oral health status of two groups of children was statistically analyzed, in order to explore the effect of dental care on early childhood caries.Results One year after intervention,the dmft and dmfs of the experimental group were significantly different from those in the control group(P < 0.05).One year later, the oral hygiene habits and eating habits of the children and parents in two groups were significantly different from those before(P< 0.001).Conclusion Studies have shown that the implementation of oral health education have a certain effect on the prevention and reduction of early childhood caries. | Ting Cui XiaoXiao Yang Ting Li Zeyu Li HuiBin Sun | 2018 | 世界最新医学信息文摘2018，18，42： | 1 |
| 13 | Label-free high-throughput and real-time detections of protein interactions by oblique-incidence reflectivity difference method显示文摘Selected Mouse IgG of 1 mg/mL as target was fabricated on microarray for 500 sample dots.Label-free and real-time reaction dynamic processes were detected between the microarrays with Goat Anti-mouse IgG of 0.02 mg/mL using the obliqueincidence reflectivity difference(OIRD)method.We obtained the reaction results and the reaction dynamic curves of 500 protein dots.In addition,we also used label-free detection of protein microarrays of 10080 sample dots,including BSA and different concentrations of Mouse IgG and Rabbit IgG,by OIRD.The obtained reaction results between the protein microarray with 1 mg/mL Goat Anti-mouse IgG and 1 mg/mL Goat Anti-rabbit IgG are reported herein.Experimental results show that OIRD can be not only label-free high-throughput detection method for biological microarrays but also label-free real-time detection in the interaction processes of biomolecules. | HE LiPing LIU Shuang DAI JunBeijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Lü HuiBin JIN KuiJuan YANG GuoZhen | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，4： | 1 |
| 14 | 显示文摘 | L Huibin DAI Souyu CHEN Zhenghao YAN Lei ZHOU Yueliang & YANG Guozhen Laboratory of Optical Physics Institute of Physics & Center for Condensed Matter Physics Chinese Academy of Sciences 100080 Beijing China | 2003 | Chinese Science Bulletin2003，，13： | 1 |
| 15 | Interface structure changes during vibration liquid phase bonding of SiC p /A356 composites in air显示文摘 | Huibin Xu Jiuchun Yan Zhiwu Xu Baoyou Zhang Shiqin Yang | 2005 | Composites Part A2005，，9： | 1 |
| 16 | High-sensitivity photovoltage based on the interfacial photoelectric effect in the SrTiO_(3-δ)/Si heterojunction显示文摘A high sensitivity photovoltaic effect has been observed in a heterojunction composed of n-type wide bandgap oxide SrTiO 3-δ and p-type Si fabricated by laser molecular beam epitaxy.The responsivity of open-circuit photovoltage can reach 10 4 V/W without any amplification under zero bias for the wavelength range from visible to near infrared light in nW-μW order.We attribute the high performance of the photovoltage responsivity to the interfacial photoelectric effects in the SrTiO 3-δ /Si heterojunction.From the experimental results,some ideas can be generalized to improve photovoltaic efficiency and develop high sensitivity photodetectors with wide bandgap oxide materials and Si. | WEN Juan 1,GUO HaiZhong 1,XING Jie 2,Lü HuiBin 1,JIN Kui-Juan 1,HE Meng 1 & YANG GuoZhen 1 1 Beijing National Laboratory for Condensed Matter Physics,Institute of Physics,Chinese Academy of Sciences,Beijing 100190,China 2 School of Materials Sciences and Technology,China University of Geosciences,Beijing 100083,China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，11： | 1 |
| 17 | Interfacial-Strain-Induced Structural and Polarization Evolutions in Epitaxial Multiferroic BiFeO_3(001) Thin Films显示文摘Varying the film thickness is a precise route to tune the interfacial strain to manipulate the properties of the multiferroic materials.Here,to explore the effects of the interfacial strain on the properties of the multiferroic BiFeO_3films,we investigated thickness-dependent structural and polarization evolutions of the BiFeO_3 films.The epitaxial growth with an atomic stacking sequence of BiO/TiO_2 at the interface was confirmed by scanning transmission electron microscopy.Combining X-ray diffraction experiments and first-principles calculations,a thickness-dependent structural evolution was observed from a fully strained tetragonality to a partially relaxed one without any structural phase transition or rotated twins.The tetragonality(c/a) of the BiFeO_3 films increases as the film thickness decreases,while the polarization is in contrast with this trend,and the size effect including the depolarization field plays a crucial role in this contradiction in thinner films.These findings offer an alternative strategy to manipulate structural and polarization properties by tuning the interfacial strain in epitaxial multiferroic thin films. | 郭海中 Ruiqiang Zhao Kui-juan Jin Lin Gu Dongdong Xiao Zhenzhong Yang Xiaolong Li Le Wang Xu He Junxing Gu Qian Wan Can Wang Huibin Lu Chen Ge Meng He Guozhen Yang | 2015 | 功能材料信息2015，12，3： | 1 |
| 18 | Evaluation of simulated reservoirs by using the oblique-incidence reflectivity difference technique显示文摘Dear Editors,The evaluation of the oil-gas resources’potential depends on the characterization of reservoirs.The geometry of the pore-crack structures and the compositions of the pore walls have influence on hydrocarbon production about capillarity and permeability[1].Besides,it has been known that the adsorption phenomenon in micro-structure plays a significant role in oil-gas reservoirs.Some techniques have been applied to characterize conventional and unconventional reservoirs, | Jin Wang HongLei Zhan LiPing He Kun Zhao HuiBin Lü KuiJuan Jin GuoZhen Yang | 2016 | Science China(Physics,Mechanics & Astronomy)2016，59，11： | 1 |
| 19 | The ras-GRF1 exchange factor coordinates activation of H-Ras and racl to control neuronal morphology显示文摘 | Huibin Yang Raymond R Mattingly | 2006 | Molecu- lar Biology of the Cell2006，，17： | 1 |
| 20 | Thiazolylhydrazone dervatives as inhibitors for insect N-acetyl-β-D-hexosaminidase and chitinase显示文摘Insect chitinase and N-acetyl-β-D-hexosaminidases(Hex)are potential targets for developing new pesticides.Here,a series of thiazolylhydrazonesⅠ(with substituted group R1 at N3)andⅡ(with substituted group R1 at N2)were designed,synthesised and evaluated as competitive inhibitors of OfHexl and OfChi-h,from the agricultural pest Ostrinia furnacalis,DerivativesⅠ-3 d andⅡ-3 d,with phenoxyethyl group at R1,demonstrated the best inhibitory activities against OfHexl and OfChi-h.Molecular docking analysis indicated that the branched conformation compound II-3 d(Ki=1.5μmol/L)formed more hydrogen bonds with OfHexl than the stretched conformation compound I-3 d(Ki=5.9μmol/L).The differences in compounds’binding conformations with OfChi-h explained differences in inhibitory activity of compounds I-3 d(Ki=1.9μmol/L)and II-3 d(Ki=4.1μmol/L).This work suggests a novel scaffold for developing specific Hex and Chi-h inhibitors. | Huibin Yang Huitang Qi Zesheng Hao Xusheng Shao Tian Liu Qing Yang Xuhong Qian | 2020 | Chinese Chemical Letters2020，31，5： | 1 |
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