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| 1 | Isolation,fractionation and evaluation of the antiplasmodial properties of Phyllanthus niruri resident in its chloroform fraction显示文摘Objective:To investigate the antiplasmodial activity of Phyllanthus niniri(P.niruri) methanol extract(ME) and its fractions in mice.Methods:P.niruri methanol extract and its chloroform. ethanol and aqueous portions were tested against chloroquine-sensitive Plasmodium berghei berghei in early,established and repository models of infection using Knight and Peter’s 4-day suppressive model,Rvlev and Peters curative model and Peters prophylactic model respectively. Results:Chemosuppression of parasitemia(37.65%-50.53%) was elicited by 100-400 mg/kg(b.w.) of ME.Al doses of 100 mg/kg b.w..the chloroform fraction(F1) significantly(P<0.01) suppressed parasitaemia by 85.29%,while ethanol and aqueous fractions(F2 and F3.respectively) elicited 67.06%and 51.18%chemosuppression.the most active fraction.F1 was selected for further antiplasmodial screening.In established infection.ME reduced parasitaemia(15.81%- 62.96%) while F1 significantly(P<0.01) reduced parasitaemia(44.369—90.48%).with effects comparable to that of chloroquine(96.48%).The prophylactic antiplasmodial activity of ME(92.50%suppression) was also significant(P<0.01) and was more effective than pyrimethamine(85.00%).additionally, cell membrane integrity of non-parasitized erythrocytes intubated with 125-500 mg/mL F1 was maintained.Conclusions:These findings indicate the antiplasmodial efficacy of P.niruri methanol extract,and the localization of this effect in its chloroform fraction. | Obidike Ifeoma Okhale Samuel Aboh Mercy Itohan Salawu Oluwakanyinsola Adeola | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，3： | 1 |
| 2 | The effects of combination of methanolic leaf extract of Azadirachta indica and diminazene diaceturate in the treatment of experimental Trypanosoma brucei brucei infection in rats显示文摘Objective:To investigate the effects of combination therapy of methanolic leaf extract of Azadirachta indica(A.indica) and diminazene diaceturate(DDA) in the treatment of experimental Trypanosoma brucei brucei(T.brucei brucei) infection in rats.Methods:Acute toxicity study of the drug and extract combinations were done.Selection of the best drug and extract combinations was carried out using fifty four rats of both sexes separated into 9 groups.Three dose combinations were derived from selection of the best drug and extract combinations used for the final study viz:7 mg/kg bw DDA plus 125 mg/kg bw extract(group B),3.5 mg/kg bw DDA plus 250 mg/kg bw extract(group C),and 1.8 mg/kg bw DDA plus 500 mg/kg bw extract(group D).The final study had in addition to the three groups derived from the dose response study,four other groups viz:uninfected untreated negative control(group F),infected and treated with 3 000 mg/kg bw extract alone(group E),infected and treated with 7 mg/kg bw DDA alone(group A),and infected untreated positive control(group G).The parameters assessed were onset of parasitaemia(OP), level of parasitaemia(LOP),clearance of parasites post treatment(COPPT),relapse infection period(RIP),post infection survival period(PIST).Results:There was no significant difference in OP between the groups(P<0.05).One day post treatment,the mean LOP of groups A,B,and C were found to be significantly lower than that of group D which in turn was lower than that of group E and G respectively.The mean LOP of group E was significantly lower than group G two days post treatment and this trend continued throughout the experimental period.Mean COPPT of group D was significantly longer than that of groups A,C and B.There was no significant difference in the mean COPPT among groups B,C and A.The mean RIP of group D was significantly shorter than group C,and that of group C was significantly shorter than that of group A.There was no relapse of infection in group B.The PIST of group E did not differ significantly from group G.Conclusions:This experiment stands to conclude that combination of 125 mg/kg bw extract and 7 mg/kg bw DDA is very effective in the treatment of trypanosomosis,caused by T. brucei.This combination therapy proved to be better than single therapy of DDA. | Omoja VU Anaga AO Obidike IR Ihedioha TE Umeakuana PU Mhomga LI Asuzu IU Anika SM | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，5： | 1 |
| 3 | Studies on the possible mechanisms of antidiabetic activity of extract of aerial parts of Phyllanthus niruri显示文摘 | C.O. Okoli I.C. Obidike A.C. Ezike P.A. Akah O.A. Salawu | 2011 | Pharmaceutical Biology2011，，3： | 1 |
| 4 | The Anti-Inflammatory and Antinociceptive Properties of the Chloroform Fraction From Phyllanthus niruri Plant Is Mediated via the Peripheral Nervous System显示文摘 | Ifeoma Chinwude Obidike Oluwakanyinsola Adeola Salawu Mary Ndukuba Charles Ogbonnaya Okoli Uche Alex Osunkwo | 2010 | Journal of Dietary Supplements2010，，4： | 1 |
| 5 | Epistemic Analysis of Kantian Ethics of Duty Call vis-a-vis Paranormal in Nigerian Society Among Nigerian Clergymen显示文摘This work is geared to carry out epistemic analysis of Kantian ethics of duty call vis-à-vis paranormal in Nigerian society among clergymen.The recent changes in Nigerian and other African countries like colonialism that brought Western education,globalization,urbanization,and new religion(Islam and Christianity)have made it that divination in traditional African religion is no longer in vogue in this contemporary period.Divination and fortune telling have taken a new dimension in form of faith healing and miracles by some prophets and so called men of God like pastors,priests,and imam.The quest for materialism among the ministers and clerics of Islamic,Christian and traditional religion has made them abuse their religious calling for their selfish interests.This work makes use of analytic and critical methods of data analysis.This work postulates that Immanuel Kant’s ethics of duty call serves to provide a guiding principle to Nigeria clergymen of different religions on the need for them to carry out their religious duties out of good will.On the other hand,twisting or distorting the teachings of their religion to serve their various selfish interests contravenes Immanuel Kant’s ethics of duty call.Finally,they have to contribute positively to nation building by propagating or fostering the positive ideology,theories,or doctrines that will promote love and national unity in a multicultural country like Nigeria. | Charles Paul Chikelo Obidike Raphael Olisa Maduabuchi Innocent Anthony Uke | 2023 | Journal of Philosophy Study2023，13，8： | 0 |
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