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| 1 | Western medication plus Traditional Chinese Medicine preparations in patients with chronic heart failure:a prospective,single-blind,randomized,controlled,and multicenter clinical trial显示文摘OBJECTIVE: To assess the efficacy and safety in patients with chronic heart failure(CHF) of Western medication plus Traditional Chinese Medicine(TCM) preparations.METHODS: This prospective, single-blind, randomized, controlled, and multicenter clinical trial began on September 17, 2008, and was completed on June 25, 2011. A total of 340 inpatients, aged 40-79 years, with exacerbating CHF from 10 hospitals were enrolled and randomly allocated within 24 h of admission. The trial included three intervention periods. During hospitalization, the control group received western medication for CHF and the treatment group received Danhong injection with Shenfu injection or Shenmai injection. After discharge,all patients were treated with Qiliqiangxin capsules and Buyiqiangxin tablets or a placebo for 6 months. After the 6-month intervention, both groups received only continuous western medication. The primary endpoint was all-cause mortality.The efficacy assessments were as follows: B-type natriuretic peptide(BNP), Lee's HF score, the 6-minute walking test(6 MWT), left ventricular ejection fraction(LVEF), and the Minnesota Living with Heart Failure Questionnaire(MLHFQ). The safety assessments were as follows: blood and urine routine examination, hepatic and renal function, electrolytes in blood and adverse events.RESULTS: Compared with the control group, the treatment group showed a 30.99% reduction in all-cause mortality and an improved survival rate.The treatment group showed greater improvement in 6 MWT(P = 0.02) than the control group on discharge, after 12-month follow-up, there was a time-group interaction for MLHFQ(P = 0.03). Incidence rate of adverse events and other relevant safety indexes were not statistically significant between the two groups.CONCLUSION: Western medication plus TCM treatment can increase 6-minute walking distance(improve exercise tolerance) and quality of life with heart failure patients. | Wang Xianliang Hou Yazhu Mao Jingyuan Zhao Yingqiang Niu Tianfu Yuan Ruyu Wang Yonggang Cui Jin-rong Shi Le Jia Xiuli Fan Ruihong Lin Qian Zhang Yan Li Zhijun Shang Hongcai Wang Baohe Wang Hongwu Wang Henghe Cui Xiaolei Soh Shanbin Ruan Jishou Zhang Boli | 2017 | Journal of Traditional Chinese Medicine2017，37，6： | 15 |
| 2 | Preparation and evaluation of poly(L-histidine) based pH-sensitive micelles for intracellular delivery of doxorubicin against MCF-7/ADR cells显示文摘In this study, a p H-sensitive micelle self-assembled from poly(L-histidine) based triblock copolymers of poly(ethylene glycol)–poly(D,L-lactide)–poly(L-histidine)(mPEG-PLA-PHis) was prepared and used as the intracellular doxorubicin(Dox) delivery for cancer chemotherapy. Dox was loaded into the micelles by thin-film hydration method and a Box–Behnken design for three factors at three levels was used to optimize the preparations. The optimized mPEG-PLA-Phis/Dox micelles exhibited good encapsulation efficiency of 91.12%,a mean diameter of 45 nm and narrow size distribution with polydispersity index of 0.256.In vitro drug release studies demonstrated that Dox was released from the micelles in a p Hdependent manner. Furthermore, the cellular evaluation of Dox loaded micelles displayed that the micelles possessed high antitumor activity in vitro with an IC50 of 35.30 μg/ml against MCF-7/ADR cells. The confocal microscopy and flow cytometry experiments indicated that m PEG-PLA-Phis micelles mediated efficient cytoplasmic delivery of Dox with the aid of poly(Lhistidine) mediated endosomal escape. In addition, blank m PEG-PLA-Phis micelles were shown to be nontoxic to MCF-7/ADR cells even at a high concentration of 200 μg/ml. The pHsensitive mPEG-PLA-PHis micelles have been demonstrated to be a promising nanosystem for the intracellular delivery of Dox for MDR reversal. | Nan Jia Yuqing Ye Qi Wang Xiuli Zhao Haiyang Hu Dawei Chen Mingxi Qiao | 2017 | Asian Journal of Pharmaceutical Sciences2017，12，5： | 6 |
| 3 | xperimental investigation on cumulative propagation of thin film buckling under cyclic load显示文摘As instrument technology is needed for rapid determination of the smaller,thinner and lighter specimens,more stringent demands are related to thin films such as micro-electro-mechanical systems(MEMS),dielectric coatings and electronic packaging.Therefore,the requirement for testing platforms for rapidly determine the mechanical properties of thin films is increasing.Buckling of a film/substrate system could offer a variety of applications,ranging from stretchable electronics to micro-nanoscale metrology.In this paper,a fatigue-loading device has been designed to make the cyclic loading available for investigating the cumulative propagation of thin film buckling.The straight side buckling of thin compressed titanium film with the thickness of 50 nm deposited on organic glass substrates is investigated by using an optical microscope.The cumulative buckling propagation under the cyclic loading of a sequence of peak compression with the frequency 1 Hz is recorded by CCD camera.The buckling extension lengths are calculated by digital image measurement technology. | WANG ShiBin JIA HaiKun LI LinAn SUN Heng CUI DiQiang GUO ZhenShan XUE XiuLi | 2011 | Science China(Technological Sciences)2011，54，6： | 4 |
| 4 | Synthesis and Properties of UV-curable Hyperbranched Polyurethane and Its Application in the Negative-type Photoresist显示文摘UV-curable hyperbranched polyurethane(UV-HBPU) containing carboxyl groups was synthesized from isophorone diisocyanate(IPDI), diethanolamine(DEOA), polyethylene glycol(PEG-400), hydroxyethyl acrylate(HEA), and 2,2-bis(hydroxymethyl) propionic acid(DMPA). The UV-HBPU was used as a negative-type photoresist for a printed circuit board(PCB). Fourier-transform infrared spectroscopy(FTIR) and proton nuclear magnetic resonance(1HNMR) spectroscopy of UV-HBPUs indicated that the synthesis was successful. Differential scanning calorimetry(DSC) and thermogravimetric analysis(TGA) showed that the thermal stability of the UV-HBPUs decreased as the HEA content increased. The polymer exhibited excellent photoresist properties, and the resolution of circuits based on this negative-type photoresist reached 10 μm. | 刘敬成 LIN Licheng JIA Xiuli LIU Ren ZHANG Shengwen 刘晓亚 | 2014 | Journal of Wuhan University of Technology(Materials Science)2014，29，1： | 3 |
| 5 | Dasatinib inhibits proliferation of liver cancer cells,but activation of Akt/mTOR compromises dasatinib as a cancer drug显示文摘Dasatinib is a multi-target protein tyrosine kinase inhibitor.Due to its potent inhibition of Src,Abl,the platelet-derived growth factor receptor(PDGFR)family kinases,and other oncogenic kinases,it has been investigated as a targeted therapy for a broad spectrum of cancer types.However,its efficacy has not been significantly extended beyond leukemia.The mechanism of resistance to dasatinib in a wide array of cancers is not clear.In the present study,we investigated the effect of dasatinib on hepatocellular carcinoma cell growth and explored the underlying mechanisms.Our results showed that dasatinib potently inhibited the proliferation of SNU-449 cells,but not that of other cell lines,such as SK-Hep-1,even though it inhibited the phosphorylation of Src on both negative and positive regulation sites in all these cells.Dasatinib activated the phosphoinositide-dependent protein kinase1(PDK1)/protein kinase B(Akt)/mammalian target of rapamycin(mTOR)signaling pathway in SK-Hep-1 cells,but not in SNU-449 cells.Blocking the Akt/mTOR signaling pathway strongly promoted the efficacy of dasatinib in SK-Hep-1 cells.In SNU-449 cells,dasatinib promoted apoptosis and the cleavage of caspase-3 and caspase-7,induced cell cycle arrest in the G1 phase,and inhibited the expression of Cyclin-dependent kinase(CDK4)/6/CyclinD1 complex.These findings demonstrate that dasatinib exerts its anti-proliferative effect on hepatocellular cell proliferation by blocking the Src family kinases;however,it causes Akt activation,which compromises dasatinib as an anti-cancer drug. | Chang Liu Xiaoxia Zhu Yuqi Jia Fenqing Chi Keru Qin Jinhong Pei Chan Zhang Xiuli Mu Hongwei Zhang Xiushan Dong Jun Xu Baofeng Yu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，7： | 2 |
| 6 | Dynamic inventory management with financial constraints显示文摘 | Chao Xiuli Chen Jia Wang Shouyang | 2005 | International Symposium on OR and Its Applications2005，4，1： | 1 |
| 7 | Seed germinating characteristics of 54 gramineous species in the alpine meadow on the eastern Qinghai-Tibet plateau显示文摘The germination experiment was started on March 3,2004,and seeds were collected from July to October in 2003.We analyzed the percentage of germination,days to first germination,germination period and days to 50%germination.Among the 54 examined species,26 species exceeded 80%germination,11 species exceeded 60%–80%germination,8 exceeded 40%–0%,5 exceeded 20%–40%,and 4 showed less than 20%.A principalcomponent analysis revealed that the species were distributed along two statistically independent axes,the first primarily represented the germination rate and the second represented the time of germination process.Based on scores of germination characteristics,cluster analysis of the 54 gramineous species could be divided into 4 distinct groups:rapid,slow,intermediate germinating(germination percentage>50%),and low germinating(germination percentage<50%).The meaning of different groups to the vegetation regeneration was discussed. | Haiyan BU Qingji REN Xiuli XU Kun LIU Peng JIA Shujun WEN Dashuai SUN Guozhen DU | 2008 | Frontiers in Biology2008，3，2： | 1 |
| 8 | Recombinant adenovirus-mediated overexpression of 3β-hydroxysteroid-Δ24 reductase显示文摘3β-Hydroxysteroid-Δ24 reductase(DHCR24) is a multifunctional enzyme that localizes to the endoplasmic reticulum and has neuroprotective and cholesterol-synthesizing activities. DHCR24 overexpression confers neuroprotection against apoptosis caused by amyloid β deposition. The present study aimed to construct two recombinant adenoviruses driving DHCR24 expression specifically in neurons. Two SYN1 promoter DNA fragments were obtained from human(h) and rat(r). Recombinant Ad-r(h)SYN1-DHCR24 was transfected into AD-293, N2A(mouse neuroblastoma), and MIN6(mouse pancreatic carcinoma) cells. Western blot analysis showed DHCR24 was specially expressed in 293 and N2A cells, but no specific band was found in MIN6 cells. This demonstrates that the recombinant adenoviruses successfully express DHCR24, and no expression is observed in non-neuronal cells. TUNEL assay results showed apoptosis was inhibited in adenovirus-transfected neurons. Detecting reactive oxygen species by immunofluorescence, we found that adenovirus transfection inhibits apoptosis through scavenging excess reactive oxygen species. Our findings show that the recombinant DHCR24 adenoviruses induce neuron-specific DHCR24 expression, and thereby lay the foundation for further studies on DHCR24 gene therapy for Alzheimer's disease. | Xiuli Lu Dan Jia Chenguang Zhao Weiqi Wang Ting Liu Shuchao Chen Xiaoping Quan Deliang Sun Bing Gao | 2014 | Neural Regeneration Research2014，9，5： | 1 |
| 9 | Research on Slot-pole Combination in High-power Direct-drive PM Vernier Generator for Fractional Frequency Transmission System显示文摘Offshore wind energy is an important part of clean energy,and the adoption of wind energy to generate electricity will contribute to the implementation of the carbon peaking and carbon neutrality goals.The combination of the fractional frequency transmission system(FFTS) and the direct-drive wind turbine generator will be beneficial to the development of the offshore wind power industry.The use of fractional frequency in FFTS is beneficial to the transmission of electrical energy,but it will also lead to an increase in the volume and weight of the generator,which is unfavorable for wind power generation.Improving the torque density of the generator can effectively reduce the volume of the generators.The vernier permanent magnet machine(VPM) operates on the magnetic flux modulation principle and has the merits of high torque density.In the field of electric machines,the vernier machine based on the principle of magnetic flux modulation has been proved its feasibility to reduce the volume and weight.However,in the field of low-speed direct-drive machines for high-power fractional frequency power generation,there are still few related researches.Therefore,this paper studies the application of magnetic flux modulation in fractional frequency and high-power direct-drive wind turbine generators,mainly analyzes the influence of different pole ratios and different pole pairs on the generator,and draws some conclusions to provide reference for the design of wind turbine generators. | Zhidong Yuan Shaofeng Jia Deliang Liang Xiuli Wang Yong Yang | 2022 | CES Transactions on Electrical Machines and Systems2022，6，4： | 1 |
| 10 | Luteolin attenuates neuronal apoptosis in the hippocampi of diabetic encephalopathy rats显示文摘Luteolin (3',4',5,7-tetrahydroxyflavone) has powerful anti-apoptotic and antioxidant properties. This study aimed to investigate the effects of luteolin on hyperglycemia-mediated apoptosis in the hippocampi of rats with streptozotocin-induced diabetic encephalopathy after injection into the tail veins, and the molecular mechanisms involved. Biochemistry and terminal deoxynucleotidyl transferase mediated dUTP nick end labelling detection results showed that luteolin treatment (given twice daily for 15 days) significantly inhibited hyperglycemia-mediated apoptosis, decreased malondialdehyde levels and increased glutathione levels in the hippocampi of streptozotocin-induced diabetic rats. Western blot analysis revealed that luteolin also inhibited the expression of apoptosis-related factors and cytochrome c release from mitochondria. Luteolin also improved the learning and memory abilities of rats with diabetic encephalopathy in a water maze test. Further western blot analysis revealed that luteolin treatment facilitated neuronal cell survival through activation of the phosphatidylinositol 3-kinase/Akt signaling pathway, an extracellular signal pathway involved in the suppression of cell apoptosis and promotion of cell survival. These experimental findings indicate that luteolin can inhibit apoptosis of hippocampal nerve cells in rats with diabetic encephalopathy, and that this effect is mediated by an indirect antioxidative effect, the inhibition of activation of apoptosis-related factors and the activation of phosphatidylinositol 3-kinase/Akt signal pathway. | Guiru Ren Jingjing Kong Ning Jia Xiuli Shang | 2013 | Neural Regeneration Research2013，8，12： | 1 |
| 11 | Relationship between Ti/Al ratio and stress-rupture properties in nickel-based superalloy显示文摘 | Yulai Xu Lei Zhang Jun Li Xueshan Xiao Xiuli Cao Guoqing Jia Zhi Shen | 2012 | Materials Science & Engineering A2012，，： | 1 |
| 12 | Dynamic inventory management with cash flow constraints显示文摘 | Xiuli Chao Jia Chen Shouyang Wang | 2008 | Naval Research Logis- tics2008，8，55： | 1 |
| 13 | Dynamic inventory management with cash flow constraints显示文摘 | Xiuli Chao Jia Chen Shouyang Wang | 2008 | Naval Research Logistics2008，8，55： | 1 |
| 14 | Oxygen evolution:the mechanism of formation of porous anodic alumina显示文摘 | Xiuli Yang Xufei Zhu Hongbing Jia | 2009 | Monatsh Chem2009，，140： | 1 |
| 15 | Seismic response comparison and sensitivity analysis of pile foundation in liquefiable and non-liquefiable soils显示文摘Case history investigations have shown that pile foundations are more critically damaged in liquefiable soils than non-liquefiable soils.This study examines the differences in seismic response of pile foundations in liquefiable and non-liquefiable soils and their sensitivity to numerical model parameters.A two-dimensional finite element(FE)model is developed to simulate the experiment of a single pile foundation centrifuge in liquefiable soil subjected to earthquake motions and is validated against real-world test results.The differences in soil-pile seismic response of liquefiable and non-liquefiable soils are explored.Specifically,the first-order second-moment method(FOSM)is used for sensitivity analysis of the seismic response.The results show significant differences in seismic response for a soil-pile system between liquefiable and non-liquefiable soil.The seismic responses are found to be significantly larger in liquefiable soil than in non-liquefiable soil.Moreover,the pile bending moment was mainly affected by the kinematic effect in liquefiable soil,while the inertial effect was more significant in non-liquefiable soil.The controlling parameters of seismic response were PGA,soil density,and friction angle in liquefiable soil,while the pile bending moment was mainly controlled by PGA,the friction angle of soil,and shear modulus of loose sand in non-liquefiable soil. | Jia Kemin Xu Chengshun Du Xiuli Cui Chunyi Dou Pengfei Song Jia | 2023 | Earthquake Engineering and Engineering Vibration2023，22，1： | 1 |
| 16 | Dynamic inventory management with cash flow constraints显示文摘 | Chao Xiuli Chen Jia Wang Shouhang | | 0，，08： | 1 |
| 17 | Synthesis, characterization and electrochemical properties of three-dimensionally ordered macroporous α-Fe 2 O 3显示文摘 | Zhi Liu Junhua Mi Yuan Yang Jia Li Xiuli Tan | 2012 | Materials Science & Engineering B2012，，18： | 1 |
| 18 | Potential factors and mechanism of particulate matters explosive increase induced by free radicals oxidation显示文摘Atmospheric particulate pollution in China has attracted much public attention.Occasionally, the particle number concentration increases sharply in a short time period,which is defined as a 'particulate matter explosive increase'. Heavy particulate matter pollution not only reduces visibility but also has an adverse effect on human health. Hence,there is an urgent need to discover the causes of particulate matter explosive increase.During this campaign, the particle number concentration and free radicals were measured at a tall building on the campus of Lanzhou University of Technology. Additionally, we examined a series of chemicals to reproduce the observed particulate matter explosive increase in a smog chamber to determine its potential factors. Then, we analyzed the mechanism of particulate matter explosive increase in the presence of free radicals. We found that, among the potential inorganic and organic sources analyzed, a mixture of organic and SO_2 in the research region had a major effect on particulate matter explosive increase. Moreover, free radical oxidation has a large effect, especially in the formation of organic particulates. | Guoying Wang Shiming Jia Xiuli Niu Haoqi Tian Yanrong Liu Zhong Xie Chao Liu Yucan Dong Ying Su Jianglei Yu Gaofeng Shi Xuefu Chen Lan Li Peng Zhang | 2019 | Journal of Environmental Sciences2019，31，7： | 0 |
| 19 | Research on A Checking Method of Vibration Characteristics for Test System显示文摘To ensure the accuracy and precision of vibration test,a universal checking method is proposed.The use of the method is discussed and an actual example is given.First,the calibration of the 7703A-500 type sensor is analyzed on the basis of frequency response method.The frequency range of normal working can be determined by the exact calibration of sensitivity,frequency response and linearity.For the basic problem of abnormal signals appearing in test system,the method of zero check and loading vibration source are developed.The frequency spectrum of output signals is employed to distinguish the noise signal,unknown source signal and useful signal effectively.Finally,the experimental results reveal the importance to improve the accuracy of the results of practical vibration test. | Men Xiu hua Xu Jia LiuBaojian Fu Xiuli | 2013 | 仪器仪表学报2013，34，S1： | 0 |
| 20 | Small-signal Stability Analysis and Improvement with Phase-shift Phase-locked Loop Based on Back Electromotive Force Observer for VSC-HVDC in Weak Grids显示文摘Voltage source converter based high-voltage direct current(VSC-HVDC)transmission technology has been extensively employed in power systems with a high penetration of renewable energy resources.However,connecting a voltage source converter(VSC)to an AC weak grid may cause the converter system to become unstable.In this paper,a phase-shift phaselocked loop(PS-PLL)is proposed wherein a back electromotive force(BEMF)observer is added to the conventional phaselocked loop(PLL).The BEMF observer is used to observe the voltage of the infinite grid in the stationaryαβframe,which avoids the problem of inaccurate observations of the grid voltage in the dq frame that are caused by the output phase angle errors of the PLL.The VSC using the PS-PLL can operate as if it is facing a strong grid,thus enhancing the stability of the VSC-HVDC system.The proposed PS-PLL only needs to be properly modified on the basis of a traditional PLL,which makes it easy to implement.In addition,because it is difficult to obtain the exact impedance of the grid,the influence of shortcircuit ratio(SCR)estimation errors on the performance of the PS-PLL is also studied.The effectiveness of the proposed PSPLL is verified by the small-signal stability analysis and timedomain simulation. | Yongqing Meng Haibo Wang Ziyue Duan Feng Jia Zhengchun Du Xiuli Wang | 2023 | Journal of Modern Power Systems and Clean Energy2023，11，3： | 0 |
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