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| 1 | Use of Voltage Limits for Current Limitations in Grid-forming Converters显示文摘Renewable generation interfaced through gridforming converters are proposed as a replacement for synchronous generators in power systems.However,compared to the synchronous generator,the power electronics converter has a strict limit on the current to avoid overcurrent damage.The gridforming converter acts like a voltage source,directily controlling the voltage.This conflicts with the operation of the conventional current limit control,which is applied to a current source.The switch between the voltage control and current control aimed to impose the current limit leads to synchronization instability.This paper proposes a novel control scheme which can be applied to the grid forming voltage control in order to enforce current limits.The proposed method has been verified through simulation and hardware tests in both symmetrical and asymmetrical faults to perform current suppression while maintaining synchronization stability in the voltage control mode. | Junru Chen Federico Prystupczuk Terence O’Donnell | 2020 | CSEE Journal of Power and Energy Systems2020，6，2： | 12 |
| 2 | Determining the optimal time for bortezomib-based induction chemotherapy followed by autologous hematopoietic stem cell transplant in the treatment of multiple myeloma显示文摘In our study, we determined the efficacy of bortezomib-based induction therapy followed by autologous stem cell transplant (ASCT) in newly diagnosed and relapsed/refractory (R/R) multiple myeloma (MM) patients and compared the advantages of early versus late transplant. We used a retrospective analysis to examine 62 patients, including 46 cases of newly diagnosed MM (early transplant group) and 16 cases of relapsed/refractory MM (late transplant group). All of these patients received bortezomib-based induction therapy followed by ASCT. The efficacy and side effects of the treatment regimen were analyzed. Patients' overall survival (OS) and progression-free survival (PFS) times were determined. The ratio of complete remission to near-complete remission (CR/nCR) was 69.5% versus 56.2% (P=0.361), respectively, for the early transplant group versus the late transplant group, respectively, after receiving bortezomib-based induction therapy; the overall response rates of the two group were 91.3% and 81.2%, respectively (P=0.369). After receiving ASCT, the CR/nCR of the two groups increased to 84.8% and 81.3%, respectively. The median time required for neutrophil engraftment of the early transplant group and the late transplant group was 11 and 14.5 days, respectively (P=0.003); the median time required for platelet engraftment was 13 and 21.5 days (P=0.031), respectively. There were no significant differences in the toxic side effects observed during induction therapy and ASCT between the two groups. The OS of the two groups was not statistically different (P=0.058). The PFS of the early transplant group and the late transplant group was 41.6 and 26.5 months, respectively (P=0.008). Multivariate analysis demonstrated that the time of receiving ASCT, the types of M protein, and the International Staging System (ISS) stage were all independent factors that influenced PFS. In conclusion, patients in a suitable condition for ASCT should be recommended to have an early ASCT immediately after diagnosis. | Junru Liu Juan Li Beihui Huang Dong Zheng Mei Chen Zhenhai Zhou Duorong Xu Waiyi Zou | 2013 | Chinese Journal of Cancer Research2013，25，2： | 4 |
| 3 | CRISPR/Cas systems for the detection of nucleic acid and nonnucleic acid targets显示文摘Clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated(Cas)systems are becoming powerful tools for disease biomarkers detection.Due to the specific recognition,cis-cleavage and nonspecific trans-cleavage capabilities,CRISPR/Cas systems have implemented the detection of nucleic acid targets(DNA and RNA)as well as non-nucleic acid targets(e.g.,proteins,exosomes,cells,and small molecules).In this review,we first summarize the principles and characteristics of various CRISPR/Cas systems,including CRISPR/Cas9,Cas12,Cas13 and Cas14 systems.Then,various types of applications of CRISPR/Cas systems used in detecting nucleic and non-nucleic acid targets are introduced emphatically.Finally,the prospects and challenges of their applications in biosensing are discussed. | Weiran Su Junru Li Chen Ji Congshuo Chen Yuzheng Wang Huili Dai Fengqin Li Peifeng Liu | 2023 | Nano Research2023，16，7： | 3 |
| 4 | High prevalence of hepatitis B virus infection in multiple myeloma显示文摘 | Beihui Huang Juan Li Zhenhai Zhou Dong Zheng Junru Liu Mei Chen | 2012 | Leukemia & Lymphoma2012，，： | 2 |
| 5 | Adaptive Virtual Synchronous Generator Considering Converter and Storage Capacity Limits显示文摘A virtual synchronous generator(VSG)control has been proposed as a means to control a voltage source converter interfaced generation and storage to retain the dynamics of a conventional synchronous generator.The storage is used to provide the inertia power and droop power in the VSG control to improve the frequency stability.Since the parameters in the VSG control can be varied,it is necessary for it to be tuned to be adaptive,in order to achieve an optimal response to grid frequency changes.However,the storage cannot provide infinite power and the converter has a strict power limitation which must be observed.The adaptive VSG control should consider these limitations,which have not been considered previously.This paper proposes an adaptive VSG control aimed at obtaining the optimal grid supporting services during frequency transients,accounting for converter and storage capacity limitations.The proposed control has been validated via hardware-in-the-loop testing.It is then implemented in storage co-located with wind farms in a modified IEEE 39-bus system.The results show that the proposed control stabilizes the system faster and has better cooperation with other VSGs,considering storage and converter limits. | Junru Chen Muyang Liu Federico Milano Terence O’Donnell | 2022 | CSEE Journal of Power and Energy Systems2022，8，2： | 2 |
| 6 | Comparison of dominant frequency attenuation of blasting vibration for different charge structures显示文摘Dominant frequency attenuation is a significant concern for frequency-based criteria of blasting vibration control.It is necessary to develop a concise and practical prediction equation describing dominant frequency attenuation.In this paper,a prediction equation of dominant frequency that accounts for primary parameters influencing the dominant frequency was proposed based on theoretical and dimensional analyses.Three blasting experiments were carried out in the Chiwan parking lot for collecting blasting vibration data used to conduct regression analysis of the proposed prediction equation.The fitting equations were further adopted to compare the reliability of three different types of dominant frequencies in the proposed equation and to explore the effects of different charge structures on the dominant frequency attenuation.The apparent frequency proved to be more reliable to express the attenuation law of the dominant frequency.The reliability and superiority of the proposed equation employing the apparent frequency were verified by comparison with the other five prediction equations.The smaller blasthole diameter or decoupling ratio leads to the higher initial value and corresponding faster attenuation of the dominant frequency.The blasthole diameter has a greater influence on the dominant frequency attenuation than the decoupling ratio does.Among the charge structures applied in the experiments,the charge structure with decoupling ratio of 1.5 and blasthole diameter of 48 mm results in the greatest initial value and corresponding fastest attenuation of the dominant frequency. | Pengchang Sun Wenbo Lu Junru Zhou Xincheng Huang Ming Chen Qi Li | 2022 | Journal of Rock Mechanics and Geotechnical Engineering2022，14，2： | 2 |
| 7 | Modification mech-anism of Sn4 + for hydrogenation of p-chloronitrobenzene overPVP-Pd/7_Al2O3 显示文摘 | XuQiong Liu Xinmei Chen Junru | 2006 | Journal of Molecular Catalysis A Chemical2006，260，12： | 1 |
| 8 | Progress of the NTSC-F1 primary frequency standard显示文摘The SI 'second'is realized by caesium primary frequency standards( PFSs) using laser cooled atoms in a fountain configuration. Four sub systems and operation procedure of the NTSC-F1 primary frequency standard are introduced in the paper.The frequency stability of NTSC-F1 is 3.0×10-13/ τ-1 / 2compared to hydrogen maser. Four terms of frequency shift and uncertainty including second order Zeeman frequency shift,cold collision shift,gravity shift and blackbody shift are evaluated. The improvement of NTSC-F1 is introduced. | RUAN Jun WANG Xinliang LIU Dandan GUAN Yong ZHANG Hui CHEN Jiang LIN Rui YU Fengxiang SHI Junru ZHANG Shougang | 2015 | Instrumentation2015，2，4： | 1 |
| 9 | High-throughput fat quantifications of hematoxylin-eosin stained liver histopathological images based on pixel-wise clustering显示文摘Besides diagnosis of fatty liver disease(FLD) using multiple medical imaging techniques in clinic,accurate fat quantification of liver tissue slice, especially the fat droplets measurement, is still a critical indicator in related pathological researches. Stained by hematoxylin-eosin(HE), different tissue components with different colors need to be identified and measured manually in conventional approaches. Automated liver fat quantification of HE stained images remains challenging because forms and distributions of fat are extremely irregular with no clear boundaries, especially in conducting high-throughput analysis which demands quick processing and higher accuracy for the reference of pathologists. To solve this problem, we propose an automated liver fat quantifications pipeline of HE stained images based on pixel-wise clustering, which firstly extracts high-relevant pixel-level features with color mode transformation, then locates boundaries between nuclei, fat and other components by clustering image pixels in an unsupervised mode, and finally identifies indicative fat droplets based on a set of morphological criteria. The pipeline was verified in analysis of multifold fatty liver treatment assays, with experimental results showing high accuracy and adaptability in fat droplets quantification despite data variance. Quantitative indicators provide a reliable evidence for relevant pathological researches or therapy selection, in which number and average area of indicative fat droplets increased sharply in severe and moderate-grade FLD respectively. Those indicators might be utilized as surrogate biomarkers for further researches. | Peng SHI Junru CHEN Jinke LIN Lurong ZHANG | 2017 | Science China(Information Sciences)2017，60，9： | 1 |
| 10 | Hepatitis B virus infection status is an independent risk factor for multiple myeloma patients after autologous hematopoietic stem cell transplantation显示文摘 | Juan Li Junru Liu Beihui Huang Dong Zheng Mei Chen Zhenhai Zhou Duorong Xu Waiyi Zou | 2013 | Tumor Biology2013，，3： | 1 |
| 11 | Achieving Ultra-Wideband and Elevated Temperature Electromagnetic Wave Absorption via Constructing Lightweight Porous Rigid Structure显示文摘Realizing ultra-wideband absorption,desirable attenuation capability at high temperature and mechanical requirements for real-life applications remains a great challenge for microwave absorbing materials.Herein,we have constructed a porous carbon fiber/polymethacrylimide(CP)structure for acquiring promising microwave absorption performance and withstanding both elevated temperature and high strength in a low density.Given the ability of porous structure to induce desirable impedance matching and multiple reflection,the absorption bandwidth of CP composite can reach ultra-wideband absorption of 14 GHz at room temperature and even cover the whole X-band at 473 K.Additionally,the presence of imide ring group in polymethacrylimide and hard bubble wall endows the composite with excellent heat and compressive behaviors.Besides,the lightweight of the CP composite with a density of only 110 mg cm^(−3) coupled with high compressive strength of 1.05 MPa even at 453 K also satisfies the requirements in engineering applica-tions.Compared with soft and compressible aerogel materials,we envision that the rigid porous foam absorbing material is particularly suitable for environmental extremes. | Zibao Jiao Wenjun Huyan Feng Yang Junru Yao Ruiyang Tan Ping Chen Xuewei Tao Zhengjun Yao Jintang Zhou Peijiang Liu | 2022 | Nano-Micro Letters2022，14，11： | 1 |
| 12 | Paclitaxel-liposome–microbubble complexes as ultrasound-triggered therapeutic drug delivery carriers显示文摘 | Fei Yan Lu Li Zhiting Deng Qiaofeng Jin Juanjuan Chen Wei Yang Chih-Kuang Yeh Junru Wu Robin Shandas Xin Liu Hairong Zheng | 2013 | Journal of Controlled Release2013，，3： | 1 |
| 13 | Paclitaxel-liposome–microbubble complexes as ultrasound-triggered therapeutic drug delivery carriers显示文摘 | Fei Yan Lu Li Zhiting Deng Qiaofeng Jin Juanjuan Chen Wei Yang Chih-Kuang Yeh Junru Wu Robin Shandas Xin Liu Hairong Zheng | 2013 | Journal of Controlled Release2013，，3： | 1 |
| 14 | The Change Features of the West Boundary Bifurcation Line of the North Equatorial Current in the Pacific显示文摘The equatorial Current in the North Pacific(NEC) is an upper layer westward ocean current, which flows to the west boundary of the ocean, east of the Philippines, and bifurcates into the northerly Kuroshio and the main body of the southerly Mindanao current. Thus, NEC is both the south branch of the Subtropical Circulation and the north branch of the Tropical Circulation. The junction of the two branches extends to the west boundary to connect the bifurcation points forming the bifurcation line. The position of the North Pacific Equatorial Current bifurcation line of the surface determines the exchange between and the distribution of subtropical and tropical circulations, thus affecting the local or global climate. A new identification method to track the line and the bifurcation channel was used in this study, focusing on the climatological characteristics of the western boundary of the North Equatorial Current bifurcation line. The long-term average NEC west boundary bifurcation line shifts northwards with depth. In terms of seasonal variation, the average position of the western boundary of the bifurcation line is southernmost in June and northernmost in December, while in terms of interannual variation, from spring to winter in the years when ENSO is developing, the position of the west boundary bifurcation line of NEC is relatively to the north(south) in EI Ni?o(La Ni?a) years as compared to normal years. | GUO Junru LIU Yulong SONG Jun BAO Xianwen LI Yan CHEN Shaoyang YANG Jinkun | 2015 | Journal of Ocean University of China2015，14，6： | 0 |
| 15 | Temporal and Spatial Characteristics of Lightning Activity in Huai'an during 2011-2014显示文摘Based on the monitoring data of lightning activity in Huai'an from 2011 to 2014,the temporal and spatial distribution of lightning activity and lightning density were analyzed. The results show that positive and negative lightning activity in Huai'an had obvious seasonal variations and diurnal variations during 2011-2014. The month changes of positive and negative lightning activity had a single peak and valley,while the diurnal variations of both positive and negative lightning activity had double peaks and valleys. The high-value areas of ground flash density in Huai'an had obvious randomness. Seen from the spatial distribution of annual average of ground flash density,lightning activity was mainly distributed in Xuyi County,Jinhu County and Huai'an District. | Zhu Junru Zhang Dehong Chen Jiayi Ni Yuhong | 2017 | Meteorological and Environmental Research2017，8，3： | 0 |
| 16 | Modeling and Simulation of Dynamic Unloading of Prestressed Rockmass显示文摘During the excavation of deep rock,a sudden change in boundary conditions will cause the in-situ stress on the excavation surface to release instantaneously.This disturbance propagates in the form of an unloading stress wave,which will enlarge the damage field of surrounding rock.In this paper,the dynamic unloading problem of the insitu stress in deep rock excavation is studied using theoretical,numerical,and experimental methods.First,the dynamic unloading process of rock is analyzed through adopting the wave equation,and the equivalent viscous damping coefficient of the material is taken into consideration.Calculations show that there is significant tensile strain in the rock bar when the strain rate is above 10^-1 s^-1.With an increase in the length or damping coefficient,the wave state will change from an underdamped to an overdamped state.Second,implicit and explicit solvers of the finite element method are employed to simulate rock unloading processes,which can be used to verify the theoretical results from one-dimensional to three-dimensional stress states.Finally,the dynamic unloading experiment of a onedimensional bar is used to further verify the validity and accuracy of the theoretical analysis. | Liang Wu Xiaorui Xiang Yang Chen Karrech Ali Junru Zhou Ming Chen | 2019 | Computer Modeling in Engineering & Sciences2019，，8： | 0 |
| 17 | Impact of Frequency Anti-windup Limiter on Synchronization Stability of Grid Feeding Converter显示文摘Loss of synchronization is one of the main issues for a grid-feeding converter in a weak grid after being subjected to a large disturbance.The synchronous transient is highly nonlinear due to phase movement and frequency limiters.However,none of the previous research has considered the anti-windup PI in the phase-locked loop,which is commonly implemented in reality and introduced as an additional nonlinear transient.This work provides a taxonomy to evaluate and compare the effect of different anti-windup PI limiters on synchronization stability,including clamping,back-calculation and combined method.Different anti-windup PI limiters allocate zeros and poles differently and have different impacts on damping and stability enhancement.A case study implemented in Matlab/Simulink serves to compare the trajectory of the converter phase and frequency using different anti-windup PI in the scenario of both with and without equilibrium points during the fault.Simulation results show that anti-windup PI limiters increase damping during the fault and thus improve the synchronization stability margin. | Junru Chen Chenchen Ge Di Qiang Hua Geng Terence O'Donnell Federico Milano | 2023 | CSEE Journal of Power and Energy Systems2023，9，5： | 0 |
| 18 | New genetic and epigenetic insights into the chemokine system: the latest discoveries aiding progression toward precision medicine显示文摘Over the past thirty years,the importance of chemokines and their seven-transmembrane G protein-coupled receptors(GPCRs)has been increasingly recognized.Chemokine interactions with receptors trigger signaling pathway activity to form a network fundamental to diverse immune processes,including host homeostasis and responses to disease.Genetic and nongenetic regulation of both the expression and structure of chemokines and receptors conveys chemokine functional heterogeneity.Imbalances and defects in the system contribute to the pathogenesis of a variety of diseases,including cancer,immune and inflammatory diseases,and metabolic and neurological disorders,which render the system a focus of studies aiming to discover therapies and important biomarkers.The integrated view of chemokine biology underpinning divergence and plasticity has provided insights into immune dysfunction in disease states,including,among others,coronavirus disease 2019(COVID-19).In this review,by reporting the latest advances in chemokine biology and results fromanalyses of a plethora of sequencing-based datasets,we outline recent advances in the understanding of the genetic variations and nongenetic heterogeneity of chemokines and receptors and provide an updated view of their contribution to the pathophysiological network,focusing on chemokine-mediated inflammation and cancer.Clarification of the molecular basis of dynamic chemokine-receptor interactions will help advance the understanding of chemokine biology to achieve precision medicine application in the clinic. | Hanli Xu Shuye Lin Ziyun Zhou Duoduo Li Xiting Zhang Muhan Yu Ruoyi Zhao Yiheng Wang Junru Qian Xinyi Li Bohan Li Chuhan Wei Keqiang Chen Teizo Yoshimura Ji Ming Wang Jiaqiang Huang | 2023 | Cellular & Molecular Immunology2023，20，7： | 0 |
| 19 | Characterization of wavy root 1,an agravitropism allele,reveals the functions of OsPIN2 in fine regulation of auxin transport and distribution and in ABA biosynthesis and response in rice(Oryza sativa L.)显示文摘Root system architecture is influenced by gravity.How the root senses gravity and directs its orientation,so-called gravitropism,is not only a fundamental question in plant biology but also theoretically important for genetic improvement of crop root architecture.However,the mechanism has not been elucidated in most crops.We characterized a rice agravitropism allele,wavy root 1(war1),a loss-of-function allele in OsPIN2,which encodes an auxin efflux transporter.With loss of OsPIN2 function,war1 leads to altered root system architecture including wavy root,larger root distribution angle,and shallower root system due to the loss of gravitropic perception in root tips.In the war1 mutant,polar auxin transport was disrupted in the root tip,leading to abnormal auxin levels and disturbed auxin transport and distribution in columella cells.Amyloplast sedimentation,an important process in gravitropic sensing,was also decreased in root tip columella cells.The results indicated that OsPIN2 controls gravitropism by finely regulating auxin transport,distribution and levels,and amyloplast sedimentation in root tips.We identified a novel role of OsPIN2 in regulating ABA biosynthesis and response pathways.Loss of OsPIN2 function in the war1 resulted in increased sensitivity to ABA in seed germination,increased ABA level,changes in ABA-associated genes in roots,and decreased drought tolerance in the seedlings.These results suggest that the auxin transporter OsPIN2 not only modulates auxin transport to control root gravitropism,but also functions in ABA signaling to affect seed germination and root development,probably by mediating crosstalk between auxin and ABA pathways. | Wenqiang Li Minjuan Zhang Lei Qiao Yunbo Chen Dapeng Zhang Xiuqing Jing Pengfei Gan Yangbin Huang Junru Gao Wenting Liu Chunhai Shi Hongchang Cui Haifeng Li Kunming Chen | 2022 | The Crop Journal2022，10，4： | 0 |
| 20 | Mutations in epigenetic regulator KMT2C detected by liquid biopsy are associated with worse survival in prostate cancer patients显示文摘Background:KMT2(lysine methyltransferase)family enzymes are epigenetic regulators that activate gene transcription.KMT2C is mainly involved in enhancer-associated H3K4me1,and is also one of the top mutated genes in cancer(6.6%in pan-cancer).Currently,the clinical significance of KMT2C mutations in prostate cancer is understudied.Methods:We included 221 prostate cancer patients diagnosed between 2014 and 2021 in West China Hospital of Sichuan University with cell-free DNA-based liquid biopsy test results in this study.We investigated the association between KMT2C mutations,other mutations,and pathways.Furthermore,we evaluated the prognostic value of KMT2C mutations,measured by overall survival(OS)and castration resistance-free survival(CRFS).Also,we explored the prognostic value of KMT2C mutations in different patient subgroups.Lastly,we investigated the predictive value of KMT2C mutations in individuals receiving conventional combined anti-androgen blockade(CAB)and abiraterone(ABI)as measured by PSA progression-free survival(PSA-PFS).Results:The KMT2C mutation rate in this cohort is 7.24%(16/221).KMT2C-mutated patients showed worse survival than KMT2C-wild type(WT)patients regarding both CRFS and OS(CRFS:mutated:9.9 vs.WT:22.0 months,p=0.015;OS:mutated:71.9 vs.WT 137.4 months,p=0.012).KMT2C mutations were also an independent risk factor in OS[hazard ratio:3.815(1.461,9.96),p=0.006]in multivariate analyses.Additionally,we explored the association of KMT2C mutations with other genes.This showed that KMT2C mutations were associated with Serine/Threonine-Protein Kinase 11(STK11,p=0.004)and Catenin Beta 1(CTNNB1,p=0.008)mutations.In the CAB treatment,KMT2C-mutated patients had a significantly shorter PSA-PFS compared to KMT2C-WT patients.(PSA-PFS:mutated:9.9 vs.WT:17.6 months,p=0.014).Moreover,KMT2C mutations could effectively predict shorter PSA-PFS in 10 out of 23 subgroups and exhibited a strong trend in the remaining subgroups.Conclusions:KMT2C-mutated patients showed worse survival compared to KMT2C-WT patients in terms of both CRFS and OS,and KMT2C mutations were associated with STK11 and CTNNB1 mutations.Furthermore,KMT2C mutations indicated rapid progression during CAB therapy and could serve as a potential biomarker to predict therapeutic response in prostate cancer. | SHA ZHU NANWEI XU JIAYU LIANG FENGNIAN ZHAO ZILIN WANG YUCHAO NI JINDONG DAI JINGE ZHAO XINGMING ZHANG JUNRU CHEN GUANGXI SUN PENGFEI SHEN HAO ZENG | 2023 | Oncology Research2023，31，4： | 0 |
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