|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Use of portal pressure studies in the management of variceal haemorrhage显示文摘Portal hypertension occurs as a complication of liver cirrhosis and complications such as variceal bleeding lead to significant demands on resources. Endoscopy is the gold standard method for screening cirrhotic patients however universal endoscopic screening may mean a lot of unnecessary procedures as the presence of oesophageal varices is variable hence a large time and cost burden on endoscopy units to carry out both screening and subsequent follow up of variceal bleeds. A less invasive method to identify those at high risk of bleeding would allow earlier prophylactic measures to be applied. Hepatic venous pressure gradient (HVPG) is an acceptable indirect measurement of portal hypertension and predictor of the complications of portal hypertension in adult cirrhotics. Varices develop at a HVPG of 10-12 mmHg with the appearance of other complications with HPVG > 12 mmHg. Variceal bleeding does not occur in pressures under 12 mmHg. HPVG > 20 mmHg measured early after admission is a significant prognostic indicator of failure to control bleeding varices, indeed early transjugular intrahepatic portosystemic shunt (TIPS) in such circumstances reduces mortality significantly. HVPG can be used to identify responders to medical therapy. Patients who do not achieve the suggested reduction targets in HVPG have a high risk of rebleeding despite endoscopic ligation and may not derive significant overall mortality benefit from endoscopic intervention alone, ultimately requiring TIPS or liver transplantation. Early HVPG measurements following a variceal bleed can help to identify those at risk of treatment failure who may benefit from early intervention with TIPS. Therefore, we suggest using HVPG measurement as the investigation of choice in those with confirmed cirrhosis in place of endoscopy for intitial variceal screening and, where indicated, a trial of B-blockade, either intravenously during the initial pressure study with assessment of response or oral therapy with repeat HVPG six weeks later. In those with elevated pressures, primary medical prophylaxis could be commenced with subsequent close monitoring of HVPG thus negating the need for endoscopy at this point. All patients presenting with variceal haemorrhage should undergo HVPG measurement and those with a gradient greater than 20 mmHg should be considered for early TIPS. By introducing portal pressure studies into a management algorithm for variceal bleeding, the number of endoscopies required for further intervention and follow up can be reduced leading to significant savings in terms of cost and demand on resources. | Jennifer Addley Tony CK Tham William Jonathan Cash | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，7： | 37 |
| 2 | SPIRIT 2013声明:定义临床研究方案的标准条目显示文摘临床研究方案是临床研究设计、实行、报告和评价的基础。然而,临床研究方案及现存的临床研究方案指引在内容和质量上差异很大。本文描述了《规范临床研究方案内容》(Standard Protocol Items:Recommendations for Interventional Trials 2013 ),简称SPIRIT2013声明,一个临床研究方案必须报告的条目指引的系统建立和范围。 | An-Wen Chan Jennifer M.Tetzlaff Douglas G.Altman Andreas Laupacis Peter C.GΦtzsche Karmela Krleza-Jeri AsbjΦrn Hróbjartsson Howard Mann Kay Dickersin Jesse A.Berlin Caroline J.Doré Wendy R.Parulekar William S.M.Summerskill Trish Groves Kenneth F.Schulz Harold C.Sox Frank W.Rockhold Drummond Rennie David Moher 钟丽丹 郑颂华 吴泰相 李幼平 商洪才 张伯礼 唐旭东 吕爱平 卞兆祥 | 2013 | 中国循证医学杂志2013，13，12： | 23 |
| 3 | 学龄前儿童体力活动研究的10大问题显示文摘本文目的是回顾与3~5岁儿童体力活动有关的重要研究问题。本文将从三个主要研究领域进行分析:健康效果、体力活动模式、干预和政策。研究的主要问题包括:确定体力活动的健康效果,确定体力活动对保持健康体重的影响,探明体力活动对学习和行为习惯的影响,以及静坐行为对健康的影响。与体力活动模式相关的研究问题包括3~5岁儿童满足现有体力活动推荐量的情况;影响体力活动的社会和环境因素,包括家庭、幼儿园、社区环境;体力活动如何对学龄儿童期、青少年时期和成年以后产生影响。关于干预和政策方面的研究问题包括确定在家庭、保育机构、社区环境最有效的促进体力活动的干预策略,以及不同幼儿适用的干预方案;确定有效的干预手段和宣传策略;制定有效的能够增加幼儿体力活动水平的国家、州、地方和机构的政策。总之,全面了解体力活动对3~5岁儿童健康的影响,以便于掌握该群体的体力活动特点,探索如何促进幼儿的体力活动。 | Russell R.Pate Jennifer R.O'Neill William H.Brown Kerry L.McIver Erin K.Howie Marsha Dowda | 2015 | 北京体育大学学报2015，38，6： | 19 |
| 4 | Burden of Gastrointestinal Disease in the United States: 2012 Update显示文摘 | Anne F. Peery Evan S. Dellon Jennifer Lund Seth D. Crockett Christopher E. McGowan William J. Bulsiewicz Lisa M. Gangarosa Michelle T. Thiny Karyn Stizenberg Douglas R. Morgan Yehuda Ringel Hannah P. Kim Marco Dacosta DiBonaventura Charlotte F. Carroll Je | 2012 | Gastroenterology2012，，5： | 15 |
| 5 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 6 | Highly expressed BMP9/GDF2 in postnatal mouse liver and lungs may account for its pleiotropic effects on stem cell differentiation,angiogenesis,tumor growth and metabolism显示文摘Bone morphogenetic protein 9(BMP9)(or GDF2)was originally identified from fetal mouse liver cDNA libraries.Emerging evidence indicates BMP9 exerts diverse and pleiotropic functions during postnatal development and in maintaining tissue homeostasis.However,the expression landscape of BMP9 signaling during development and/or in adult tissues remains to be analyzed.Here,we conducted a comprehensive analysis of the expression landscape of BMP9 and its signaling mediators in postnatal mice.By analyzing mouse ENCODE transcriptome datasets we found Bmp9 was highly expressed in the liver and detectable in embryonic brain,adult lungs and adult placenta.We next conducted a comprehensive qPCR analysis of RNAs isolated from major mouse tissues/organs at various ages.We found that Bmp9 was highly expressed in the liver and lung tissues of young adult mice,but decreased in older mice.Interestingly,Bmp9 was only expressed at low to modest levels in developing bones.BMP9-associated TGFβ/BMPR type I receptor Alk1 was highly expressed in the adult lungs.Furthermore,the feedback inhibitor Smads Smad6 and Smad7 were widely expressed in mouse postnatal tissues.However,the BMP signaling antagonist noggin was highly expressed in fat and heart in the older age groups,as well as in kidney,liver and lungs in a biphasic fashion.Thus,our findings indicate that the circulating BMP9 produced in liver and lungs may account for its pleiotropic effects on postnatal tissues/organs although possible roles of BMP9 signaling in liver and lungs remain to be fully understood. | Wei Liu Zhongliang Deng Zongyue Zeng Jiaming Fan Yixiao Feng Xi Wang Daigui Cao Bo Zhang Lijuan Yang Bin Liu Mikhail Pakvasa William Wagstaff Xiaoxing Wu Huaxiu Luo Jing Zhang Meng Zhang Fang He Yukun Mao Huiming Ding Yongtao Zhang Changchun Niu Rex C.Haydon Hue H.Luu Jennifer Moriatis Wolf Michael J.Lee Wei Huang Tong-Chuan He Yulong Zou | 2020 | Genes & Diseases2020，7，2： | 9 |
| 7 | Review of the impact of heat stress on reproductive performance of sheep显示文摘Heat stress significantly impairs reproduction of sheep,and under current climatic conditions is a significant risk to the efficiency of the meat and wool production,with the impact increasing as global temperatures rise.Evidence from field studies and studies conducted using environmental chambers demonstrate the effects of hot temperatures(≥32℃)on components of ewe fertility(oestrus,fertilisation,embryo survival and lambing)are most destructive when experienced from 5 d before until 5 d after oestrus.Temperature controlled studies also demonstrate that ram fertility,as measured by rates of fertilisation and embryo survival,is reduced when mating occurs during the period 14 to 50 d post-heating.However,the contribution of the ram to heat induced reductions in flock fertility is difficult to determine accurately.Based primarily on temperature controlled studies,it is clear that sustained exposure to high temperatures(≥32℃)during pregnancy reduces lamb birthweight and will,therefore,decrease lamb survival under field conditions.It is concluded that both ewe and ram reproduction is affected by relatively modest levels of heat stress(≥32℃)and this is a concern given that a significant proportion of the global sheep population experiences heat stress of this magnitude around mating and during pregnancy.Despite this,strategies to limit the impacts of the climate on the homeothermy,behaviour,resource use and reproduction of extensively grazed sheep are limited,and there is an urgency to improve knowledge and to develop husbandry practices to limit these impacts. | William H.E.J.van Wettere Karen L.Kind Kathryn L.Gatford Alyce M.Swinbourne Stephan T.Leu Peter T.Hayman Jennifer M.Kelly Alice C.Weaver David O.Kleemann Simon K.Walker | 2021 | Journal of Animal Science and Biotechnology2021，12，3： | 6 |
| 8 | Influence of Transfusions on Perioperative and Long-Term Outcome in Patients Following Hepatic Resection for Colorectal Metastases显示文摘 | David A. Kooby Jennifer Stockman Leah Ben-Porat Mithat Gonen William R. Jarnagin Ronald P. Dematteo Scott Tuorto David Wuest Leslie H. Blumgart Yuman Fong | 2003 | Annals of Surgery2003，，6： | 4 |
| 9 | Using quality improvement methods to increase use of pain prevention strategies for childhood vaccination显示文摘AIM To increase evidence-based pain prevention strategy use during routine vaccinations in a pediatric primary care clinic using quality improvement methodology.METHODS Specific intervention strategies(i.e.,comfort positioning,nonnutritive sucking and sucrose analgesia,distraction) were identified,selected and introduced in three waves,using a Plan-Do-Study-Act framework.System-wide change was measured from baseline to post-intervention by:(1) percent of vaccination visits during which an evidence-based pain prevention strategy was reported as being used; and(2) caregiver satisfaction ratings following the visit.Additionally,self-reported staff and caregiver attitudes and beliefs about pain prevention were measured at baseline and 1-year post-intervention to assess for possible long-term cultural shifts.RESULTS Significant improvements were noted post-intervention.Use of at least one pain prevention strategy was documented at 99% of patient visits and 94% of caregivers were satisfied or very satisfied with the pain prevention care received.Parents/caregivers reported greater satisfaction with the specific pain prevention strategy used [t(143) = 2.50,P ≤ 0.05],as well as greater agreement that the pain prevention strategies used helped their children's pain [t(180) = 2.17,P ≤ 0.05] and that they would be willing to use the same strategy again in the future [t(179) = 3.26,P ≤ 0.001] as compared to baseline.Staff and caregivers also demonstrated a shift in attitudes from baseline to 1-year post-intervention.Specifically,staff reported greater agreement that the pain felt from vaccinations can result in harmful effects [2.47 vs 3.10; t(70) =-2.11,P ≤ 0.05],less agreement that pain from vaccinations is 'just part of the process' [3.94 vs 3.23; t(70) = 2.61,P ≤ 0.05],and less agreement that parents expect their children to experience pain during vaccinations [4.81 vs 4.38; t(69) = 2.24,P ≤ 0.05].Parents/caregivers reported more favorable attitudes about pain prevention strategies for vaccinations across a variety of areas,including safety,cost,time,and effectiveness,as well as less concern about the pain their children experience with vaccination [4.08 vs 3.26; t(557) = 6.38,P ≤ 0.001],less need for additional pain prevention strategies [3.33 vs 2.81; t(476) = 4.51,P ≤ 0.001],and greater agreement that their doctors' office currently offers pain prevention for vaccinations [3.40 vs 3.75; t(433) =-2.39,P ≤ 0.05].CONCLUSION Quality improvement methodology can be used to help close the gap in implementing pain prevention strategies during routine vaccination procedures for children. | Jennifer Verrill Schurman Amanda D Deacy Rebecca J Johnson Jolynn Parker Kristi Williams Dustin Wallace Mark Connelly Lynn Anson Kevin Mroczka | 2017 | World Journal of Clinical Pediatrics2017，6，1： | 3 |
| 10 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 11 | A case-control study of maternal recreational physical activity and risk of gestational diabetes mellitus显示文摘 | Jennifer C. Dempsey Carole L. Butler Tanya K. Sorensen I-Min Lee Mary Lou Thompson Raymond S. Miller Ihunnaya O. Frederick Michelle A. Williams | 2004 | Diabetes Research and Clinical Practice2004，，2： | 2 |
| 12 | Expression of Bcl-x L in ovarian carcinoma is associated with chemoresistance and recurrent disease显示文摘 | Jennifer Williams Peter C. Lucas Kent A. Griffith Milheon Choi Sarah Fogoros Yuan Yuan Hu J. Rebecca Liu | 2004 | Gynecologic Oncology2004，，2： | 2 |
| 13 | Infliximab for Crohn’s Disease: The First 500 Patients Followed Up Through 2009显示文摘 | Jennifer L. Seminerio Edward V. Loftus Jean-Frédéric Colombel Prabin Thapa William J. Sandborn | 2013 | Digestive Diseases and Sciences2013，，3： | 2 |
| 14 | The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease显示文摘 | Guy M. McKhann David S. Knopman Howard Chertkow Bradley T. Hyman Clifford R. Jack Claudia H. Kawas William E. Klunk Walter J. Koroshetz Jennifer J. Manly Richard Mayeux Richard C. Mohs John C. Morris Martin N. Rossor Philip Scheltens Maria C. Carrillo Bil | 2011 | Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association2011，，3： | 2 |
| 15 | Blockade of PD1 and TIM3 Restores Innate and Adaptive Immunity in Patients with Acute Alcoholic Hepatitis显示文摘 | Lee J.L. Markwick Antonio Riva Jennifer M. Ryan Helen Cooksley Elena Palma Tom H. Tranah Godhev K. Manakkat Vijay Nikhil Vergis Mark Thursz Alex Evans Gavin Wright Sarah Tarff John O’Grady Roger Williams Debbie L. Shawcross Shilpa Chokshi | 2014 | Gastroenterology2014，，： | 2 |
| 16 | Relationships Between Disease Activity and Serum and Fecal Biomarkers in Patients With Crohn’s Disease显示文摘 | Jennifer Jones Edward V. Loftus Remo Panaccione Li–Sheng Chen Sandra Peterson Joseph Mcconnell Linnea Baudhuin Karen Hanson Brian G. Feagan Scott W. Harmsen Alan R. Zinsmeister Emelie Helou William J. Sandborn | 2008 | Clinical Gastroenterology and Hepatology2008，，11： | 2 |
| 17 | Pancreatic Fistula Following Pancreaticoduodenectomy: Clinical Predictors and Patient Outcomes显示文摘 | C. Max Schmidt Jennifer Choi Emilie S. Powell Constantin T. Yiannoutsos Nicholas J. Zyromski Attila Nakeeb Henry A. Pitt Eric A. Wiebke James A. Madura Keith D. Lillemoe William Jarnagin | 2009 | HPB Surgery2009，，： | 2 |
| 18 | Identification of functional single nucleotide polymorphism haplotypes in the cytidine deaminase promoter显示文摘 | Sara M. Fitzgerald Rakesh K. Goyal William R. A. Osborne Jennifer D. Roy John W. Wilson R. E. Ferrell | 2006 | Human Genetics2006，，3： | 1 |
| 19 | Levels of Neonatal Thyroid Hormone in Preterm Infants and Neurodevelopmental Outcome at 5? Years: Millennium Cohort Study显示文摘 | Caroline Delahunty Shona Falconer Robert Hume Lesley Jackson Paula Midgley Marie Mirfield Simon Ogston Oliver Perra Judith Simpson Jennifer Watson Peter Willatts Fiona Williams | 2010 | The Journal of Clinical Endocrinology & Metabolism2010，，11： | 1 |
| 20 | Prognostic models of abdominal wound dehiscence after laparotomy显示文摘 | Clinton Webster Leigh Neumayer Randall Smout Susan Horn Jennifer Daley William Henderson Shukri Khuri | 2003 | Journal of Surgical Research2003，，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员