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| 1 | Distribution of high-risk human papillomavirus genotype prevalence and attribution to cervical precancerous lesions in rural North China显示文摘Objective: Precise prevention is more desired for cervical cancer due to the huge population, high prevalence of human papillomavirus(HPV) infection in China and the vision of screen-and-treat strategies in low-and middleincome countries(LMICs). Considerations of combining type-specific prevalence and attribution proportion to high-grade cervical intraepithelial neoplasia are informative to more precise and effective region-specific cervical cancer prevention and control programs. The aim of the current study was to determine the genotype distribution of HPV and attribution to cervical precancerous lesions among women from rural areas in North China.Methods: A total of 9,526 women participated in the cervical cancer screening project in rural China. The samples of women who tested positive for HPV were retested with a polymerase chain reaction(PCR)-based HPV genotyping test. The attribution proportion of specific high-risk human papillomavirus(HR-HPV) types for different grades of cervical lesions was calculated by using the type contribution weighting method.Results: A total of 22.2%(2,112/9,526) of women were HR-HPV positive and HPV52(21.7%) was the most common HR-HPV genotype, followed by HPV58(18.2%), HPV53(18.2%) and HPV16(16.2%). The top three genotypes detected in HR-HPV-positive cervical intraepithelial neoplasia(CIN)1 were HPV16(36.7%), HPV58(20.4%), HPV56(15.3%). Among CIN2+, the most frequent genotypes were HPV16(75.6%), HPV52(17.8%),HPV58(16.7%). HPV16, 56, 58, 53, 52, 59, 68, and 18 combined were attributed to 84.17% of all CIN1 lesions,and HPV16, 58, and 52 combined were attributed to 86.98% of all CIN2+ lesions.Conclusions: The prevalence of HR-HPV infection among women from rural areas in North China was high and HPV16, HPV58, HPV52 had paramount attributable fraction in CIN2+. Type-specific HPV prevalence and attribution proportion to cervical precancerous lesions should be taken into consideration in the development of vaccines and strategy for screening in this population. | Shuang Zhao Xuelian Zhao Shangying Hu Jessica Lu Xianzhi Duan Xun Zhang Feng Chen Fanghui Zhao | 2019 | Chinese Journal of Cancer Research2019，31，4： | 30 |
| 2 | Gut Microbiota and Short Chain Fatty Acids:Influence on the Autonomic Nervous System显示文摘Reaching across multiple fields of focus,spanning from periodontistry to gastroenterology to neurobiology to behavior,interest in the influence of the microbiome in human physiology and pathology has risen over the past few decades.Microbiota co-exist in and on humans forming an evolutionarily symbiotic biological unit,a halobiont,in which disruptions in the relationship can occur through genomic alterations and mutations[1],The human microbiome consists of bacteria,viruses,fungi,and protozoans that contribute 450 times more genes to this relationship and slightly outnumber human host cells[2,3].The bacteria in the gastrointestinal(GI)tract are of the most interest and exist within five phyla:Bacteroidetes,Firmicutes,Pro-teobacteria,Actinobacteria,and Verrucomicrobi&.Within the Verrucomicrobia an interesting bacterium has emerged. | Jessica Bruning Andrew Chapp Gregory A.Kaurala Renjun Wang Stephen Techtmann Qing-Hui Chen | 2020 | Neuroscience Bulletin2020，36，1： | 7 |
| 3 | Risk calculators for hepatocellular carcinoma in patients affected with chronic hepatitis B in Asia显示文摘Risk calculators are widely used in many clinical fields,and integrate several important risk factors through the conversion of a risk function into a single measure of risk.Several studies have been carried out to create risk calculators for the prediction of hepatocellular carcinoma(HCC)in patients with chronic hepatitis B(CHB).Most of them were hospital-based,with limited sample sizes and insufficient external validation.These study groups collaborated to establish the REACH-B risk score,which incorporated five clinical variables to predict HCC risk.This risk score was then validated ininternational clinical cohorts.Evidence suggests that quantitative serum HBsAg level provides additional predictability of HCC,especially in patients with low levels of hepatitis B virus DNA.This novel marker was incorporated into a risk calculator and was internally validated.This tool will hopefully be externally validated in the near future.Risk calculators can be used to support clinical practice,and to establish preventive measures;several'off-label'extension usages have also been implemented.Albeit beneficial,several precautions and discussions should be noted in using the risk calculators.The future development of risk calculators for CHB patients can be extended by applying them to additional CHB-related outcomes,and by incorporating emerging risk parameters. | Hwai-I Yang Mei-Hsuan Lee Jessica Liu Chien-Jen Chen | 2014 | World Journal of Gastroenterology2014，20，20： | 5 |
| 4 | Breast cancer in China显示文摘 | Lei Fan Kathrin Strasser-Weippl Jun-Jie Li Jessica St Louis Dianne M Finkelstein Ke-Da Yu Wan-Qing Chen Zhi-Ming Shao Paul E Goss | 2014 | Lancet Oncology2014，，7： | 4 |
| 5 | Mobility in China,2020:a tale of four phases显示文摘2020 was an unprecedented year;with rapid and drastic changes in human mobility due to the COVID-19 pandemic.To understand the variation in commuting patterns among the Chinese population across stable and unstable periods,we used nationwide mobility data from 318 million mobile phone users in China to examine the extreme fluctuations of population movements in 2020,ranging from the Lunar New Year travel season(chunyun),to the exceptional calm of COVID-19 lockdown,and then to the recovery period.We observed that cross-city movements;which increased substantially in chunyun and then dropped sharply during the lockdown,are primarily dependent on travel distance and the socio-economic development of cities.Following the Lunar New Year holiday,national mobility remained low until mid-February,and COVID-19 interventions delayed more than 72.89 million people returning to large cities.Mobility network analysis revealed clusters of highly connected cities,conforming to the social-economic division of urban agglomerations in China.While the mass migration back to large cities was delayed,smaller cities connected more densely to form new clusters.During the recovery period after travel restrictions were lifted,the netflows of over 55%city pairs reversed in direction compared to before the lockdown.These findings offer the most comprehensive picture of Chinese mobility at fine resolution across various scenarios in China and are of critical importance for decision making regarding future public-health-emergency response,transportation planning and regional economic development,among others. | Suoyi Tan Shengjie Lai Fan Fang Ziqiang Cao Bin Sai Bing Song Bitao Dai Shuhui Guo Chuchu Liu Mengsi Cai Tong Wang Mengning Wang Jiaxu Li Saran Chen Shuo Qin Jessica R.Floyd Zhidong Cao Jing Tan Xin Sun Tao Zhou Wei Zhang Andrew J.Tatem Petter Holme Xiaohong Chen Xin Lu | 2021 | National Science Review2021，8，11： | 3 |
| 6 | Prediction models of long‐term Cirrhosis and hepatocellular carcinoma risk in chronic hepatitis B patients: Risk scores integrating host and virus profiles显示文摘 | Mei‐Hsuan Lee Hwai‐I. Yang Jessica Liu Richard Batrla‐Utermann Chin‐Lan Jen Uchenna H. Iloeje Sheng‐Nan Lu San‐Lin You Li‐Yu Wang Chien‐Jen Chen | 2013 | Hepatology2013，，2： | 3 |
| 7 | A Predictive Scoring System for the Seroclearance of HBsAg in HBeAg-seronegative Chronic Hepatitis B Patients with Genotype B or C Infection显示文摘 | Jessica Liu Mei-Hsuan Lee Richard Batrla-Utermann Chin-Lan Jen Uchenna H. Iloeje Sheng-Nan Lu Li-Yu Wang San-Lin You Chuhsing K. Hsiao Hwai-I. Yang Chien-Jen Chen | 2012 | Journal of Hepatology2012，，： | 2 |
| 8 | Curcumin-loaded polymeric nanoparticles for neuro-protection in neonatal rats with hypoxic-ischemic encephalopathy显示文摘 | Andrea Joseph Thomas Wood Chih-Chung Chen Kylie Corry Jessica M. Snyder Sandra E. Juul Pratik Parikh Elizabeth Nance | 2018 | Nano Research2018，11，10： | 2 |
| 9 | External stimuli controlled multiferroic charge-transfer crystals显示文摘Multiferroic 费用转移晶体拉了重要兴趣由于他们的同时偶极并且订的纺纱。众多的理论、试验性的研究证明了在施主和领受人建筑群之间的分子的叠在调节费用转移起一个重要作用启用的 multifunctionality。此处,我们证明费用转移相互作用能被分离的栈控制,由 polythiophene 施主组成 -- 并且 fullerene 基于领受人的结合所有的块共聚物。房间温度磁场效果,铁电性,和各向异性的磁力在费用转移晶体被观察,它能被 photoexcitation 并且充电做进一步控制。而且,费用转移分离了栈晶体证明外部刺激控制了极化和磁化,它为所有器官的 multiferroics 开创他们的多功能的应用程序。 | Wei Qin Xiaomin Chen Jessica Lohrman Maogang Gong Guoliang Yuan Manfred Wuttig Shenqiang Ren | 2016 | Nano Research2016，9，4： | 2 |
| 10 | internalization in technology innovation : a case of CRM adoption 显示文摘 | CHEN Jessica H F WANG Eric T G | 2001 | IEEE TRANSACTIONS ON POWER SYSTEMS2001，16，2： | 1 |
| 11 | Chitosan coatings with distinct innate immune bioactivities differentially stimulate angiogenesis,osteogenesis and chondrogenesis in poly-caprolactone scaffolds with controlled interconnecting pore size显示文摘This study tested whether osseous integration into poly(ε-caprolactone)(PCL)bioplastic scaffolds with fully-interconnecting 155±8μm pores is enhanced by an adhesive,non-inflammatory 99% degree of deacetylation(DDA)chitosan coating(99-PCL),or further incorporation of pro-inflammatory 83% DDA chitosan microparticles(83-99-PCL)to accelerate angiogenesis.New Zealand White rabbit osteochondral knee defects were press-fit with PCL,99-PCL,83-99-PCL,or allowed to bleed(drill-only).Between day 1 and 6 weeks of repair,drill-only defects repaired by endochondral ossification,with an 8-fold higher bone volume fraction(BVF)versus initial defects,compared to a 2-fold(99-PCL),1.1-fold(PCL),or 0.4-fold(83-99-PCL)change in BVF.Hematoma innate immune cells swarmed to 83-99-PCL,elicited angiogenesis throughout the pores and induced slight bone resorption.PCL and 99-PCL pores were variably filled with cartilage or avascular mesenchyme near the bone plate,or angiogenic mesenchyme into which repairing trabecular bone infiltrated up to 1 mm deep.More repair cartilage covered the 99-PCL scaffold(65%)than PCL(18%)or 83-99-PCL(0%)(p<0.005).We report the novel finding that non-inflammatory chitosan coatings promoted cartilage infiltration into and over a bioplastic scaffold,and were compatible with trabecular bone integration.This study also revealed that in vitro osteogenesis assays have limited ability to predict osseous integration into porous scaffolds,because(1)in vivo,woven bone integrates from the leading edge of regenerating trabecular bone and not from mesenchymal cells adhering to scaffold surfaces,and(2)bioactive coatings that attract inflammatory cells induce bone resorption. | Caroline D.Hoemann Javier Rodríguez Gonzalez Jessica Guzman-Morales Gaoping Chen Ebrahim Jalali Dil Basil D.Favis | 2022 | Bioactive Materials2022，7，4： | 1 |
| 12 | Deter-mining image origin and integrity using senmr noise显示文摘 | Chen Mo Fridrich Jessica Goljan Miroslav | 2008 | IEEE Transactions on Information Forensics and Security2008，3，1： | 1 |
| 13 | Efficacy and safety of entecavir compared to lamivudine in nucleoside-na?ve patients with chronic hepatitis B: a randomized double-blind trial in China显示文摘 | Guangbi Yao Chengwei Chen Weilun Lu Hong Ren Deming Tan Yuming Wang Daozheng Xu Zhengrong Jiang Jessica Liu Dong Xu Laurie MacDonald | 2007 | Hepatology International2007，，3： | 1 |
| 14 | Tumor-derived CD4 + CD25 + regulatory T cell suppression of dendritic cell function involves TGF- β and IL-10显示文摘 | Nicolas Larmonier Marilyn Marron Yi Zeng Jessica Cantrell Angela Romanoski Marjan Sepassi Sylvia Thompson Xinchun Chen Samita Andreansky Emmanuel Katsanis | 2006 | Cancer Immunology, Immunotherapy2006，，1： | 1 |
| 15 | The Influence of Governance E- quilibrium on ERP Project Success显示文摘 | Eric T G Wang Jessica H F Chen | 2006 | Decision Support Systems2006，41，4： | 1 |
| 16 | Characterizing Alzheimer’s disease using a hypometabolic convergence index显示文摘 | Kewei Chen Napatkamon Ayutyanont Jessica B.S. Langbaum Adam S. Fleisher Cole Reschke Wendy Lee Xiaofen Liu Dan Bandy Gene E. Alexander Paul M. Thompson Leslie Shaw John Q. Trojanowski Clifford R. Jack Susan M. Landau Norman L. Foster Danielle J. Harvey Mi | 2011 | Neuroimage2011，，1： | 1 |
| 17 | Cancer‐associated molecular signature in the tissue samples of patients with cirrhosis显示文摘 | Jin Woo Kim Qinghai Ye Marshonna Forgues Yidong Chen Anuradha Budhu Jessica Sime Lorne J. Hofseth Rashmi Kaul Xin Wei Wang | 2004 | Hepatology2004，，2： | 1 |
| 18 | The Influence of Governance Equilibrium on ERP Project Success 显示文摘 | Eric T G Wang Jessica H F Chen | 2006 | Decision Support Sys- tems2006，，41： | 1 |
| 19 | Regulation of hypothalamic NPY by diet and smoking显示文摘 | H CHEN MICHELLE J H JESSICA E J | 2007 | Peptides2007，，28： | 1 |
| 20 | Resting-state BOLD networks versus task-associated functional MRI for distinguishing Alzheimer’s disease risk groups显示文摘 | Adam S. Fleisher Ayesha Sherzai Curtis Taylor Jessica B.S. Langbaum Kewei Chen Richard B. Buxton | 2009 | Neuroimage2009，，4： | 1 |
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