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| 1 | Stable classi?cation with limited sample: transferring a 30-m resolution sample set collected in 2015 to mapping 10-m resolution global land cover in 2017显示文摘As the world strives to reduce the impact of population growth, urbanization, agricultural expansion, and climate change on food security, energy and water shortage, resource over-exploration, biodiversity loss, environmental pollution, and ultimately human health, timely and higher resolution land cover information is urgently needed to achieve the sustainable development goals of the United Nations. | Peng Gong Han Liu Meinan Zhang Congcong Li Jie Wang Huabing Huang Nicholas Clinton Luyan Ji Wenyu Li Yuqi Bai Bin Chen Bing Xu Zhiliang Zhu Cui Yuan Hoi Ping Suen Jing Guo Nan Xu Weijia Li Yuanyuan Zhao Jun Yang Chaoqing Yu Xi Wang Haohuan Fu Le Yu Iryna Dronova Fengming Hui Xiao Cheng Xueli Shi Fengjin Xiao Qiufeng Liu Lianchun Song | 2019 | Science Bulletin2019，64，6： | 166 |
| 2 | Current status of severe fever with thrombocytopenia syndrome in China显示文摘Severe fever with thrombocytopenia syndrome(SFTS) is an emerging infectious disease caused by SFTS virus(SFTSV). SFTSV is associated with a high mortality rate and has been reported in China, South Korea and Japan. SFTSV undergoes rapid changes owing to evolution, gene mutations, and reassortment between different strains of SFTSV. In this review, we summarize the recent cases and general properties of SFTS, focusing on the epidemiology, genetic diversity,clinical features, and diagnostics of SFTSV in China. From 2010 to October 2016, SFTS cases were reported in 23 provinces of China, with increased numbers yearly. Infection and death cases are mainly found in central China, where the Haemaphysalis longicornis ticks are spread. The national average mortality rate of SFTS infection was 5.3%, with higher risk to elder people. The main epidemic period was from May to July, with a peak in May. Thus, SFTS reminds a significant public health problem, and development of prophylactic vaccines and effective antiviral drugs will be highly needed. | Jianbo Zhan Qin Wang Jing Cheng Bing Hu Jing Li Faxian Zhan Yi Song Deyin Guo | 2017 | Virologica Sinica2017，32，1： | 71 |
| 3 | 刚性钢框架梁柱连接试验研究显示文摘为了检验刚性钢框架梁柱连接的抗震性能,对六个大尺寸的连接试件进行了循环加载试验,试验过程中在柱端施加了轴向压力。试验中,刚性连接试件在循环荷载作用下没有表现出足够的延性。试验结果表明:全焊梁柱连接的滞回性能好于栓焊连接;较弱节点板的梁柱连接能产生较大的塑性变形;翼缘对接焊缝的质量对梁柱刚性连接的滞回性能有很大影响。根据试验结果提出了设计施工建议。 | 宋振森 顾强 郭兵 SONG Zhensen GU Qiang GUO Bing | 2001 | 建筑结构学报2001，22，1： | 44 |
| 4 | Risk factors for intracranial aneurysm in a Chinese ethnic population显示文摘背景 Intracranial 动脉瘤( IAN )在一根大脑动脉上是一个耸出的水泡或囊汽球外面随着时间的过去,它可以导致自发的 subarachnoid 出血( SAH ),最终,残疾和 mortality.Current 研究显示疾病由于多重原因,包括环境因素和血容器的各种各样的先天的畸形。除了先天的倾向,象性别,年龄,高血压,和动脉粥样硬化那样的各种各样的高风险的因素涉及 intracranial 动脉瘤的形成。这研究的目的是调查在中国汉种族 patients.Methods 与分散的 intracranial 动脉瘤的形成联系的风险因素有 intracranial 动脉瘤的 251 个病人和有另外的服的疾病(控制组) 的 338 个病人的一个总数在这研究被注册。单个因素和逻辑回归模型被用来与年龄分析 intracranial 动脉瘤的协会;性别;香烟吸烟;酒精或可卡因消费;高血压,冠的动脉疾病,糖尿病 mellitus 和继承结缔组织疾病的历史;并且 fasting 血的层次葡萄糖和血脂肪。数据表示了同样吝啬的敤摡攠摮吗? | GU Yu-xiang CHEN Xian-cheng SONG Dong-lei LENG Bing ZHAO Fan | 2006 | Chinese Medical Journal2006，，16： | 28 |
| 5 | Extracellular heat-shock protein 70 aggravates cerulein-induced pancreatitis through toll-like receptor-4 in mice显示文摘在受不了尖锐胰腺炎的病人,的背景致病完全没被理解,并且在 vitro 的几最近的研究建议热吃惊蛋白质可能在房间发信号起一个重要作用。在胰腺炎调查细胞外的热吃惊蛋白质 70 的可能的角色( Hsp70 ),像使用费的 receptor-4 ( TLR4 )缺乏、野类型的老鼠在 导致cerulein 的胰腺炎( CIP )的功课期间与外长的 Hsp70 被管理 .Methods 尖锐胰腺炎被 cerulein 的 5 intraperitoneal 注射导致在时时间隔,然后通过尾的静脉与 recombinant 对待 Hsp70 在 cerulein 注射的开始以后的 4 个小时。随后,浆液淀粉酶和浆液 cytokines 层次被检测。胰的 Histologic 改变被评估。肿瘤坏死因素 alpha (TNF -- 一) 集中和 myeloperoxidase (军邮局) 在胰和肺的活动被分析。在胰腺的织物的原子因素 kappa B ( NF-KB )激活在 CIP 与 recombinant Hsp70 用一个敏感 RelA 连接酶的 immunosorbent assay.Results 处理被测量到野类型的老鼠在胰导致了发炎的重要恶化,浆液 cytokines 的提高的层次,肺的军邮局活动的起来规定和肺纸巾TNF-集中的增加。相反,有到TLR4缺乏的老鼠的 Hsp70 的处理在浆液 cytokines 层次上有小效果,胰腺的发炎,肺的军邮局活动和 TNF -- concentrations.Conclusions 结果建议细胞外的 HspTO 可能导致全身的煽动性的反应没有感染,在 vivo 和 TLR4 的症候群(先生) -Iike 反应可能在 CIP 的前进涉及煽动性的反应的 调停Hsp70 的激活。 | SONG Jun-min LIU Hong-xiang LI Yuan ZENG Yu-jian ZHOU Zong-guang LIU Hai-yi XU Bing WANG Ling ZHOU Bin WANG Rong | 2008 | Chinese Medical Journal2008，，15： | 27 |
| 6 | Collagen-binding basic fibroblast growth factor improves functional remodeling of scarred endometrium in uterine infertile women: a pilot study显示文摘Intrauterine adhesion(IUA) is a common cause of uterine infertility and one of the most severe clinical features is endometrial fibrosis namely endometrial scarring for which there are few cures currently. Blocked angiogenesis is the main pathological change in the scarred endometrium. The fibroblast growth factor 2(b FGF), a member of FGF family, is usually applied to promote healing of refractory ulcer and contributes to angiogenesis of tissues. In this study, the sustained-release system of b FGF100 μg was administrated around scarred endometrium guiding by ultrasound every 4 weeks in 18 patients(2–4 times). Results showed that after treatment, the menstrual blood volume, endometrial thickness and the scarred endometrial area were improved.Histological study showed blood vessel density increased obviously. Three patients(3/18) achieved pregnancy over 20 gestational weeks. Therefore, administrating the b FGF surrounding scarred endometrium may provide a new therapeutic approach for the patients with endometrial fibrosis. | Peipei Jiang Xiaoqiu Tang Huiyan Wang Chenyan Dai Jing Su Hui Zhu Minmin Song Jingyu Liu Ziqing Nan Tong Ru Yaling Li Jingmei Wang Jun Yang Bing Chen Jianwu Dai Yali Hu | 2019 | Science China(Life Sciences)2019，62，12： | 16 |
| 7 | Impact of alanyl-glutamine dipeptide on severe acute pancreatitis in early stage显示文摘AIM:To evaluate the therapeutic effect of alanyl- glutamine dipeptide (AGD) in the treatment of severe acute pancreatitis (SAP) in early and advanced stage. METHODS: Eighty patients with SAP were randomized and received 100 mL/d of 20% AGD intravenously for 10 d starting either on the day of (early treatment group) or 5 d after (late treatment group) admission. Groups had similar demographics, underlying diseases, Ranson score, Acute Physiology and Chronic Health Evaluation Ⅱ (APACHE Ⅱ) score, and Balthazar’s computed tomography (CT) score at the beginning of the study and underwent similar other medical and nutritional management. RESULTS: The duration of acute respiratory distress syndrome (2.7 ± 3.3 d vs 12.7 ± 21.0 d, P < 0.01), renal failure (1.3 ± 0.5 d vs 5.3 ± 7.3 d, P < 0.01), acute hepatitis (3.2 ± 2.3 d vs 7.0 ± 7.1 d, P < 0.01), shock (1.7 ± 0.4 d vs 4.8 ± 3.1 d, P < 0.05), encephalopathy (2.3 ± 1.9 d vs 9.5 ± 11.0 d, P < 0.01) and enteroparalysis (2.2 ± 1.4 d vs 3.5 ± 2.2 d, P < 0.01) and hospital stay (28.8 ± 9.4 d vs 45.2 ± 27.1 d, P < 0.01) were shorter in the early treatment group than in the late treatment group. The 15-d APACHE Ⅱ score was lower in the early treatment group than in the late treatment group (5.0 ± 2.4 vs 8.6 ± 3.6, P < 0.01). The infection rate (7.9% vs 26.3%, P < 0.05), operation rate (13.2% vs 34.2%, P < 0.05) and mortality (5.3% vs 21.1%, P < 0.05) in the early treatment group were lower than in the late treatment group.CONCLUSION: Early treatment with AGD achieved a better clinical outcome in SAP patients. | Ping Xue Li-Hui Deng Qing xia Zhao-Da Zhang Wei-Ming Hu Xiao-Nan Yang Bing Song Zong-Wen Huang | 2008 | World Journal of Gastroenterology2008，14，3： | 15 |
| 8 | A Deep Learning Method for Bias Correction of ECMWF 24–240 h Forecasts显示文摘Correcting the forecast bias of numerical weather prediction models is important for severe weather warnings.The refined grid forecast requires direct correction on gridded forecast products,as opposed to correcting forecast data only at individual weather stations.In this study,a deep learning method called CU-net is proposed to correct the gridded forecasts of four weather variables from the European Centre for Medium-Range Weather Forecast Integrated Forecasting System global model(ECMWF-IFS): 2-m temperature,2-m relative humidity,10-m wind speed,and 10-m wind direction,with a forecast lead time of 24 h to 240 h in North China.First,the forecast correction problem is transformed into an image-toimage translation problem in deep learning under the CU-net architecture,which is based on convolutional neural networks.Second,the ECMWF-IFS forecasts and ECMWF reanalysis data(ERA5) from 2005 to 2018 are used as training,validation,and testing datasets.The predictors and labels(ground truth) of the model are created using the ECMWF-IFS and ERA5,respectively.Finally,the correction performance of CU-net is compared with a conventional method,anomaly numerical correction with observations(ANO).Results show that forecasts from CU-net have lower root mean square error,bias,mean absolute error,and higher correlation coefficient than those from ANO for all forecast lead times from 24 h to 240 h.CU-net improves upon the ECMWF-IFS forecast for all four weather variables in terms of the above evaluation metrics,whereas ANO improves upon ECMWF-IFS performance only for 2-m temperature and relative humidity.For the correction of the 10-m wind direction forecast,which is often difficult to achieve,CU-net also improves the correction performance. | Lei HAN Mingxuan CHEN Kangkai CHEN Haonan CHEN Yanbiao ZHANG Bing LU Linye SONG Rui QIN | 2021 | Advances in Atmospheric Sciences2021，38，9： | 15 |
| 9 | Molecular Epidemiological Characteristics of Streptococcus pyogenes Strains Involved in an Outbreak of Scarlet Fever in China,2011显示文摘Objective To investigate molecular characterization of streptococcus pyogenes isolates involved in an outbreak of scarlet fever in China in 2011.Methods Seventy-four Streptococcal pyogenes involved in an outbreak of scarlet fever were isolated from pediatric patients in the areas with high incidence in China from May to August of 2011.Emm genotyping,pulsed-field gel electrophoresis (PFGE),superantigen (SAg) genes and antimicrobial susceptibility profiling were analyzed for these isolates.Results A total of 4 different emm types were identified.Emm12 was the most prevalent type which contained four predominating PFGE patterns corresponding to four different virulence and superantigen profiles.Emm12 (79.7%) and emml (14.9%) accounted for approximately 94%of all the isolates.The speA gene was all negative in emm12 isolates and positive in emml isolates.All strains were resistant to erythromycin,and 89.4%of them were resistant to erythromycin,tracycline,and clindamycin simultaneously.Conclusion Several highly diversified clones with a high macrolide resistance rate comprise a predominant proportion of circulating strains,though no new emm type was found in this outbreak.The data provide a baseline for further surveillance of scarlet fever,which may contribute to the explanation of the outbreak and development of a GAS vaccine in China. | YOU Yuan Hai SONG Yan Yan YAN Xiao Mei WANG Hai Bin ZHANG Meng Han TAO Xiao Xia Li Lei Lei ZHANG Yu Xin JIANG Xi Hong ZHANG Bing Hua ZHOU Hao XIAO Di JIN Lian Mei FENG Zi Jian LUO Feng Ji ZHANG Jian Zhong | 2013 | Biomedical and Environmental Sciences2013，26，11： | 15 |
| 10 | Pre-Compression Volume on Flow Ripple Reduction of a Piston Pump显示文摘Axial piston pump with pre-compression volume(PCV)has lower flow ripple in large scale of operating condition than the traditional one.However,there is lack of precise simulation model of the axial piston pump with PCV,so the parameters of PCV are difficult to be determined.A finite element simulation model for piston pump with PCV is built by considering the piston movement,the fluid characteristic(including fluid compressibility and viscosity)and the leakage flow rate.Then a test of the pump flow ripple called the secondary source method is implemented to validate the simulation model.Thirdly,by comparing results among the simulation results,test results and results from other publications at the same operating condition,the simulation model is validated and used in optimizing the axial piston pump with PCV.According to the pump flow ripples obtained by the simulation model with different PCV parameters,the flow ripple is the smallest when the PCV angle is 13°,the PCV volume is 1.3′10–4m3at such operating condition that the pump suction pressure is 2 MPa,the pump delivery pressure 15 MPa,the pump speed 1 000 r/min,the swash plate angle 13°.At the same time,the flow ripple can be reduced when the pump suction pressure is 2 MPa,the pump delivery pressure is 5 MPa,15 MPa,22MPa,pump speed is 400 r/min,1 000 r/min,1 500 r/min,the swash plate angle is 11°,13°,15°and 17°,respectively.The finite element simulation model proposed provides a method for optimizing the PCV structure and guiding for designing a quieter axial piston pump. | XU Bing SONG Yuechao YANG Huayong | 2013 | Chinese Journal of Mechanical Engineering2013，26，6： | 15 |
| 11 | Municipal wastewater treatment in China:Development history and future perspectives显示文摘China has the world's largest and still growing wastewater sector and water market,thus its future development will have profound influence on the world.The high-speed development of China's wastewater sector over the past 40 years has forged its global leading treatment capacity and innovation ability.However,many problems were left behind,including underdeveloped sewers and sludge disposal facilities,low sustainability of the treatment processes,questionable wastewater treatment plant(WWTP)effluent discharge standards,and lacking global thinking on harmonious development between wastewater management,human society and the nature.Addressing these challenges calls for fundamental changes in target design,policy and technologies.In this mini-review,we revisit the development history of China's municipal wastewater management and identify the remaining challenges.Also,we highlight the future needs of sustainable development and exploring China's own wastewater management path,and outlook the future from several aspects including targets of wastewater management,policies and technologies,especially the new concept WWTP.Furthermore,we envisage the establishment of new-generation WWTPs with the vision of turning WWTP from a site of pollutant removal into a plant of energy,water and fertilizer recovery and an integrated part urban ecology in China. | Jiuhui Qu Hongchen Wang Kaijun Wang Gang Yu Bing Ke Han-Qing Yu Hongqiang Ren Xingcan Zheng Ji Li Wen-Wei Li Song Gao Hui Gong | 2019 | Frontiers of Environmental Science & Engineering2019，13，6： | 13 |
| 12 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 13 | Research on crystal growth and properties of a new nonlinear optical crystal:Bismuth borate BiB_3O_6显示文摘BiB3O6 (BIBO) single crystals with sizes of 44 mm × 24 mm × 10 mm and weight of 24.7 g have been successfully grown by the top-seeded method. In this note, the preparation of seed, the growth of crystal and some problems encountered are reported. The lattice parameters of BIBO are a =7.1203(7)A, b = 4.9948(7)A, c = 6.5077(7)A, β= 105.586(8) ', V=222.93(5)A3, which were determined by BRUKER-P4 four-circle diffractometer. BIBO is biaxial crystal and the relative orientation of (X, Y, Z) with regard to (a, b, c) is: X|| b, (Y, c) =47.2°, (Z, a) = 31.6°, determined by the X-ray analysis combined with polarized microscopy. The second-harmonic-generation (SHG) conversion efficiency of the sample for 1.064 μm light is up to 67.7%. We have also obtained the third harmonic generation (THG) of 1.064 μm, namely, 1.064 μm + 0.532 μn →0.355 μm. BIBO crystal is free of moisture and hygroscopy. | TENG Bing, WANG Jiyang, WANG Zhengping, JIANG Huaidong, SONG Renbo, LIU Hong, HU Xiaobo, LIU Yaogang, WEI Jingqian & SHAO ZongshuState Key Laboratory of Crystal Materials, Shandong University, Ji’nan 250100, China | 2001 | Chinese Science Bulletin2001，46，21： | 10 |
| 14 | Three-dimensional (3D) interconnected networks fabricated via in-situ growth of N-doped graphene/ carbon nanotubes on Co-containing carbon nanofibers for enhanced oxygen reduction显示文摘把高度传导性的框架与丰富的活跃地点相结合的策略在到为氧减小反应(ORR ) 的商业 Pt/C 的其他的催化剂的准备是合乎需要的。在这研究,做 N 的 graphene (NG ) 和碳 nanotubes (CNT ) 在共同包含上在原处被种碳 nanofibers (CNF ) 到表格三维(3D ) 互连网络。NG 和 CNT 一起绑了交叉 CNF,便于电子转移并且提供另外的活跃地点。3D 互连纤维网络有 0.924 V 的一个发作潜力的展出优秀 ORR 催化行为(对可逆的氢电极) 并且更高当前的密度比在 0.720 V 以外的 Pt/C。另外,混合系统在碱的媒介展出了优异稳定性和甲醇忍耐到 Pt/C。这个方法能被扩大到另外的 3D 的设计为精力的互连的网络体系结构存储和变换应用程序。 | Qi Shi Yingde Wang Zhongmin Wang Yongpeng Lei Bing Wang Nan Wu Cheng Han Song xieJ Yanzi Gou | 2016 | Nano Research2016，9，2： | 9 |
| 15 | A Facile Synthetic Route to L-Phosphinothricin显示文摘A convenient and effective method for synthesis of L-phosphinothricin was described.The highlight was involved in a simple access to the key intermediate L-2-amino-4-chlorobutyricacid derivative from the inexpensive L-methionine. | Xue Song XU Han Bing TENG Guo Fu QIU Shu Cai LIANG Xian Ming HU | 2006 | Chinese Chemical Letters2006，17，2： | 9 |
| 16 | 钢纤维混凝土(SFRC)及其应用研究显示文摘文中论述了钢纤维砼(Steelfiberreinferedconcrete)基本力学性能的研究试验及其应用研究———城市道路窨井盖的试制开发,结果表明:SFRC的抗压、抗劈拉及抗折强度分别为素砼的118、215和15倍,用其制作的窨井盖初裂荷载可达50~80KN,完全能满足国家公路路面设计规范的要求. | Song Wanming Dong Bing | 1998 | 昆明理工大学学报(理工版)1998，23，1： | 9 |
| 17 | Clinicopathological features and trend changes of gastric carcinoma in Southern China显示文摘AIM:To investigate the clinicopathological features of gastric carcinoma in southern China and disease trends changes over the last 18 years.METHODS:We designed a retrospective study in the Department of Gastrointestinal Surgery,the first affiliated hospital,Sun Yat-sen University.A total of 2100adult patients with definitely diagnosed,histologically proven gastric carcinomas treated with radical gastrectomy from 1994 to 2013 were examined retrospectively.In all cases patient age,gender,tumor location,Borrmann type,histopathological type and grade,and pTNM stage were identified and recorded.The information was obtained from hospital records.The data were analyzed with Stata12.0 software.RESULTS:In this study,the mean age of patients was 57 years with a range from 19-89 years.A higher incidence was found in patients over 60 years of age.In the study population,67.38%of patients were male and 32.62%were female.Women had a higher disease incidence than men in patients less than 40 years of age(P<0.001).No obvious change of patient age and gender was observed in the last 18 years.The rates of disease by location were the following:antrum(44.57%),followed by fundus/body(24.95%)and cardia/gastroesophageal junction(23.00%).The mean tumor diameter was 5.57 cm,and advanced gross type BorrmannⅢwas most common.Most patients were at advanced stages when first diagnosed,and patients with early stage disease were relatively rare.More early stage patients were detected in recent years,especially after 2000(P<0.001).Gastric carcinoma has different features in young and old patients.The young patients had the following features:more frequently female,tumors in the antrum,larger tumor size,poorly differentiated carcinoma,high rate of metastasis to other sites and advanced stages(P<0.05).CONCLUSION:In southern China,gastric carcinoma was more frequent in old men and young women.Young and old patients should be treated differently for having different features. | Jian-Jun Peng Ping Xiao Jian-Bo Xu Wu Song Bing Liao Yu-Long He | 2014 | World Journal of Gastroenterology2014，20，15： | 9 |
| 18 | Mesoporous silicon carbide nanofibers with in situ embedded carbon for co-catalyst free photocatalytic hydrogen production显示文摘硅碳化物(原文如此) 由于它的唯一的 photoelectrical 性质和热 / 化学的稳定性被认为有希望的没有金属的光催化剂。然而,它的表演受不了费用搬运人的快再结合。此处,我们原文如此报导 mesoporous nanofibers 与在 situ 嵌入 graphitic 碳(原文如此 NFs-Cx ) 经由在 electrospun 碳 nanofibers 和 Si 粉末之间的一步舞 carbothermal 减小综合了。当高贵金属合作催化剂不在时,氢进化效率原文如此, NFs-Cx 显著地在两个都模仿的太阳的光下面被改进(180.2 摩尔 ? 慬敳 ? | Bing Wang Yingde Wang Yongpeng Lei Nan Wu Yanzi Gou Cheng Han Song Xie Dong Fang | 2016 | Nano Research2016，9，3： | 8 |
| 19 | High Staphylococcus epidermidis Colonization and Impaired Permeability Barrier in Facial Seborrheic Dermatitis显示文摘 | Qian An Meng Sun Rui-Qun Qi Li Zhang Jin-Long Zhai Yu-Xiao Hong Bing Song Hong-Duo Chen Xing-Hua Gao | 2017 | Chinese Medical Journal2017，，14： | 8 |
| 20 | Coxsackievirus B3 Infection Triggers Autophagy through 3 Pathways of Endoplasmic Reticulum Stress显示文摘Objective Autophagy is a highly conserved intracellular degradation pathway. Many picornaviruses induce autophagy to benefit viral replication, but an understanding of how autophagy occurs remains incomplete. In this study, we explored whether coxsackievirus B3(CVB3) infection induced autophagy through endoplasmic reticulum(ER) stress. Methods In CVB3-infected HeLa cells, the specific molecules of ER stress and autophagy were detected using Western blotting, reverse transcription polymerase chain reaction(RT-PCR), and confocal microscopy. Then PKR-like ER protein kinase(PERK) inhibitor, inositol-requiring protein-1(IRE1) inhibitor, or activating transcription factor-6(ATF6) inhibitor worked on CVB3-infected cells, their effect on autophagy was assessed by Western blotting for detecting microtubule-associated protein light chain 3(LC3). Results CVB3 infection induced ER stress, and ER stress sensors PERK/eIF2α, IRE1/XBP1, and ATF6 were activated. CVB3 infection increased the accumulation of green fluorescent protein(GFP)-LC3 punctuation and induced the conversion from LC3-Ⅰ to phosphatidylethanolamine-conjugated LC3-1(LC3-Ⅱ). CVB3 infection still decreased the expression of mammalian target of rapamycin(mTOR) and p-mTOR. Inhibition of PERK, IRE1, or ATF6 significantly decreased the ratio of LC3-Ⅱ to LC3-Ⅰ in CVB3-infected HeLa cells. Conclusion CVB3 infection induced autophagy through ER stress in HeL a cells, and PERK, IRE1, and ATF6 a pathways participated in the regulation of autophagy. Our data suggested that ER stress may inhibit mTOR signaling pathway to induce autophagy during CVB3 infection. | LUO Xiao Nuan YAO Hai Lan SONG Juan SONG Qin Qin SHI Bing Tian XIA Dong HAN Jun | 2018 | Biomedical and Environmental Sciences2018，31，12： | 8 |
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