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| 1 | Responses of Soil Microbial Community Structure and Diversity to Agricultural Deintensification显示文摘Using a scheme of agricultural fields with progressively less intensive management (deintensification), different manage- ment practices in six agroecosystems located near Goldsboro, NC, USA were tested in a large-scale experiment, including two cash-grain cropping systems employing either tillage (CT) or no-tillage (NT), an organic farming system (OR), an integrated cropping system with animals (IN), a successional field (SU), and a plantation woodlot (WO). Microbial phos- pholipid fatty acid (PLFA) profiles and substrate utilization patterns (BIOLOG ECO plates) were measured to examine the effects of deintensification on the structure and diversity of soil microbial communities. Principle component analyses of PLFA and BIOLOG data showed that the microbial community structure diverged among the soils of the six systems. Lower microbial diversity was found in lowly managed ecosystem than that in intensive and moderately managed agro- ecosystems, and both fungal contribution to the total identified PLFAs and the ratio of microbial biomass C/N increased along with agricultural deintensification. Significantly higher ratios of C/N (P < 0.05) were found in the WO and SU systems, and for fungal/bacterial PLFAs in the WO system (P < 0.05). There were also significant decreases (P < 0.05) along with agricultural deintensification for contributions of total bacterial and gram positive (G+) bacterial PLFAs. Agricultural deintensification could facilitate the development of microbial communities that favor soil fungi over bacteria. | ZHANG Wei- Jian RUI Wen-Yi C. TU H. G. DIAB F. J. LOUWS J. P. MUELLER N. CREAMER M. BELL M.G. WAGGER S. HU | 2005 | Pedosphere2005，15，4： | 29 |
| 2 | Coronavirus membrane-associated papain-like proteases induce autophagy through interacting with Beclinl to negatively regulate antiviral innate immunity显示文摘 | Xiaojuan Chen Kai Wang Yaling Xing Jian Tu Xingxing Yang Qian Zhao Kui Li Zhongbin Chen | 2014 | Protein & Cell2014，5，12： | 14 |
| 3 | Decomposition of Different Litter Fractions in a Subtropical Bamboo Ecosystem as Affected by Experimental Nitrogen Deposition显示文摘As an important component of the global carbon (C) budget, litter decomposition in terrestrial ecosystems is greatly affected by the increasing nitrogen (N) deposition observed globally. We hypothesized that different litter fractions derived from a single tree species may respond to N deposition differently depending on the quality of the litter substrate. To test the hypothesis, a two-year field experiment was conducted using the litterbag method in a Pleioblastus amarus plantation in the rainy region of Southwest China. Four N treatment levels were applied: control (no N added), low-N (50 kg N ha-1 year-1), medium-N (150 kg N ha-1 year-1), and high-N (300 kg N ha-1 year-1). We observed different patterns of mass loss for the three P. amarus litter fractions (leaves, sheaths, and twigs) of varying substrate quality in the control plots. There were two decomposition stages with different decay rates (fast rate in early stages and slow rate in the later stages) for leaves and sheaths, while we did not observe a slower phase for the decay of twigs during the 2-year study period. The annual decomposition rate (k) of twigs was significantly lower than that of leaves or sheaths. Addition of N slowed the decomposition of leaves and twigs in the later stages of decomposition by inhibiting the decay of lignin and cellulose, while addition of N did not affect the mass loss of sheaths during the study period. In the decomposition of all three litter fractions, experimental N deposition reduced the net N accumulation in the early stages and also decreased the net N release in the later stages. The results of this study suggest that litter substrate quality may be an important factor affecting litter decomposition in a bamboo ecosystem affected by N deposition. | TU Li-Hua HU Hong-Ling HU Ting-Xing ZHANG Jian LIU Li LI Ren-Hong DAI Hong-Zhong LUO Shou-Hua | 2011 | Pedosphere2011，21，6： | 13 |
| 4 | Cardioprotective mechanism of SGLT2 inhibitor against myocardial infarction is through reduction of autosis显示文摘Sodium-glucose cotransporter 2(SGLT2)inhibitors reduce cardiovascular mortality in patients with diabetes mellitus but the protective mechanism remains elusive.Here we demonstrated that the SGLT2 inhibitor,Empagliflozin(EMPA),suppresses cardiomyocytes autosis(autophagic cell death)to confer cardioprotective effects.Using myocardial infarction(Ml)mouse models with and without diabetes mellitus,EMPA treatment significantly reduced infarct size,and myocardial fibrosis,thereby leading to improved cardiac function and survival.In the context of ischemia and nutritional glucose deprivation where autosis is already highly stimulated,EMPA directly inhibits the activity of the Na^(+)/H^(+)exchanger 1(NHE1)in the cardiomyocytes to regulate excessive autophagy.Knockdown of NHE1 significantly rescued glucose deprivation-induced autosis.In contrast,overexpression of NHE1 aggravated the cardiomyocytes death in response to starvation,which was effectively rescued by EMPA treatment.Furthermore,in vitro and in vivo analysis of NHE1 and Beclin 1 knockout mice validated that EMPA s cardioprotective effects are at least in part through downregulation of autophagic flux.These findings provide new insights for drug development,specifically targeting NHE1 and autosis for ventricular remodeling and heart failure after Ml in both diabetic and non-diabetic patients. | Kai Jiang Yue Xu Dandan Wang Feng Chen Zizhuo Tu Jie Qian Sheng Xu Yixiang Xu John Hwa Jian Li Hongcai Shang Yaozu Xiang | 2022 | Protein & Cell2022，13，5： | 13 |
| 5 | Analysis of the Sending-Side System Instability Caused by Multiple HVDC Commutation Failure显示文摘As high-voltage direct current(HVDC)lines with large capacity are being commissioned with higher frequency,the characteristics of“strong”DC and“weak”AC transmission in the power grid are topics of interest.In particular,the coupling and interaction between the sending-side and receivingside AC systems interconnected by large-scale DC links is gaining importance.In this paper,the impact of the multiple HVDC commutation failure on the stability of the sending system under different power flow directions is analyzed based on the threearea AC/DC equivalent model.The main influencing factors and the counter-measures are discussed,and the single HVDC line blocking is taken as a comparison.Finally,the results are verified using the North China-Central China-East China power grid case system.The study provides a basis and reference to ensure security and stability of the ultra-high-voltage(UHV)AC/DC hybrid power grid. | Jingzhe Tu Jian Zhang Guangquan Bu Jun Yi Yonghua Yin Junchuan Jia | 2015 | CSEE Journal of Power and Energy Systems2015，1，4： | 12 |
| 6 | Comparison of amplicon-sequencing, pyrosequencing and real-time PCR for detection of YMDD mutants in patients with chronic hepatitis B显示文摘AIM: To compare the sequencing of PCR products, pyro- sequencing, and real-time PCR for detection of Tyrosine- methionine-aspartate-aspartate (YMDD) mutants in patients with chronic hepatitis B. METHODS: Mixtures of plasmids and serum samples from 69 chronic hepatitis B patients treated with lamivu- dine were tested for YMDD mutations by sequencing of PCR products, pyrosequencing, and real-time PCR, re- spectively. Time required and reagent costs of the three assays were evaluated. RESULTS: Real-time PCR detected 100%, 50%, 10%, 1% and 0.1% of YVDD plasmid in mixtures with 106 copies/mL of YMDD plasmid, whereas sequencing and pyrosequencing only detected 100% and 50% of YVDD plasmid in aliquots of the corresponding mixtures. Com- pletely concordant results were obtained from 60 (87%) out of the 69 clinical serum samples by the three assays. Mutants were detected by real-time PCR in less than 20% of the total virus population, but no mutant was de- tected by sequencing and pyrosequencing. In addition, real-time PCR required less time and was more cost-ef- fective than the other two assays. However, throughput of pyrosequencing was the highest. CONCLUSION: Among the three assays compared, real-time PCR is the most sensitive, cost-effective, and time saving for monitoring YMDD mutants in patients with chronic hepatitis B on lamivudine therapy. | Zhi-Jun Yang Mei-Zeng Tu Jian Liu Xiao-Ling Wang Hong-Zhi Jin | 2006 | World Journal of Gastroenterology2006，12，44： | 12 |
| 7 | Apolipoprotein A-I inhibits LPS-induced atherosclerosis in ApoE-/- mice possibly via activated STAT3-mediated upregulation of tristetraprolin显示文摘 | Kai YIN Shi-lin TANG Xiao-hua YU Guang-hui TU Rong-fang HE Jin-feng LI Di XIE Qing-jun GUI Yu-chang FU Zhi-sheng JIANG Jian TU Chao-ke TANG | 2013 | Acta Pharmacologica Sinica2013，34，6： | 11 |
| 8 | Outcomes in children with biliary atresia following liver transplantation显示文摘BACKGROUND: Congenital biliary atresia is a rare condition characterized by idiopathic dysgenesis of the bile ducts. If untreated, congenital biliary atresia leads to liver cirrhosis, liver failure and premature death. The present study aimed to evaluate the outcomes of orthotopic liver transplantation in children with biliary atresia. METHOD: We retrospectively analyzed 45 patients with biliary atresia who had undergone orthotopic liver transplantation from September 2006 to August 2012. RESULTS: The median age of the patients was 11.0 months (5-102). Of the 45 patients, 41 were younger than 3 years old. Their median weight was 9.0 kg (4.5-29.0), 34 of the 45 patients were less than 10 kg. Thirty-one patients had undergone Kasai portoenterostomy prior to orthotopic liver transplantation. We performed 30 living donor liver transplants and 15 split liver transplants. Six patients died during a follow-up. The median follow-up time of surviving patients was 11.4 months (1.4-73.7). The overall 1-, 2- and 3-year survival rates were 88.9%, 84.4% and 84.4%, respectively. CONCLUSION: With advances in surgical techniques and management, children with biliary atresia after liver transplantation can achieve satisfactory survival in China, although there remains a high risk of complications in the early postoperative period. | Li-Ying Sun Yun-Sheng Yang Zhi-Jun Zhu Wei Gao Lin Wei Xiao-Ye Sun Wei Qu Wei Rao Zhi-Gui Zeng Chong Dong Jin-Peng Tu Jian Wang Yi-He Liu Yuan Liu Li-Xin Yu Yu Wang Jing Li Zhong-Yang Shen | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，2： | 8 |
| 9 | Litterfall,Litter Decomposition,and Nutrient Dynamics in Two Subtropical Bamboo Plantations of China显示文摘Bamboos are one of the fast-growing and multiple use species in the world,and thus bamboo forests/plantations play an important role in C sequestration at regional and global levels.We studied aboveground litterfall,litter decomposition and nutrient dynamics for two years in two subtropical bamboo ecosystems in Southwest China so as to test the hypothesis that litter quality determine the rate and nutrient dynamics during decomposition of different litter fractions.Mean annual total aboveground litter production ranged from 494 to 434 g m^(-2)in two bamboo stands(P stand,dominated by Pleioblastus amarus and H stand,hybrid bamboo dominated by Bambusa pervariabilis x Dendrocalamopsis daii).Bulk(~80%)of litter production was contributed by leaf litter in two stands followed by twigs and sheathes.Different litter fractions represented considerable variations in the rates of mass loss and nutrient release.Variation of the mass remaining after 2 years of decomposition was significantly explained by initial C/N ratio and initial P concentration.Initial concentrations of N,P,Ca,and Mg explained 57.9%,95.0%,99.8%and 98.1%,respectively,of the variations of these elements mass remaining after 2 years of decomposition.The patterns of nutrient dynamics and the final amount remaining were mainly determined by their initial litter substrate quality in these two subtropical bamboo plantations. | TU Li-Hua HU Hong-Ling HU Ting-Xing ZHANG Jian LI Xian-Wei LIU Li XIAO Yin-Long CHEN Gang LI Ren-Hong | 2014 | Pedosphere2014，24，1： | 8 |
| 10 | Design,methodology,and baseline of whole city‑million scale children and adolescents myopia survey(CAMS)in Wenzhou,China显示文摘Background:Myopia is the most common visual impairment in children and adolescents worldwide.This study described an economical and effective population-based screening pipeline and performed the project of a million scale children and adolescents myopia survey(CAMS),which will shed light on the further study of myopia from the level of epidemiology and precision medicine.Methods:We developed a novel population-based screening pattern,an intelligent screening process and internetbased information transmission and analysis system to carry out the survey consisting of school children in Wenzhou,China.The examination items include unaided distance visual acuity,presenting distance visual acuity,and noncycloplegic autorefraction.Myopia and high myopia were defined as spherical equivalent(SE)≤−1.00 diopters(D)and SE≤−6.00 D,respectively.Next,the reports of the vision checking were automatically sent to parents and the related departments.The CAMS project will be done two to four times annually with the support of the government.An online eyesight status information management system(OESIMS)was developed to construct comprehensive and efficient electronic vision health records(EVHRs)for myopia information inquiry,risk pre-warning,and further study.Results:The CAMS completed the first-round of screening within 30 days for 99.41%of Wenzhou students from districts and counties,in June 2019.A total of 1,060,925 participants were eligible for CAMS and 1,054,251(99.37%participation rate)were selected through data quality control,which comprised 1305 schools,and 580,609,251,050 and 170,967 elementary,middle,and high school students.The mean age of participants was 12.21±3.32 years(6-20 years),the female-to-male ratio was 0.82.The prevalence of myopia in elementary,middle,and high school students was 38.16%,77.52%,and 84.00%,respectively,and the high myopia incidence was 0.95%,6.90%,and 12.98%.Conclusions:The CAMS standardized myopia screening model involves automating large-scale information collection,data transmission,data analysis and early warning,thereby supporting myopia prevention and control.The entire survey reduced 90%of staff,cost,and time consumption compared with previous surveys.This will provide new insights for decision support for public health intervention. | Liangde Xu Youyuan Zhuang Guosi Zhang Yunlong Ma Jian Yuan Changseng Tu MiaoMiao Li Wencan Wang Yaru Zhang Xiaoyan Lu Jing Li Xinting Liu Zhengbo Xue Meng Zhou Jie Sun Jinhua Bao Ming Li Fan Lu Hong Wang Jianzhong Su Jia Qu | 2021 | Eye and Vision2021，8，1： | 7 |
| 11 | Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma(CHANCE001)显示文摘There is considerable potential for integrating transarterial chemoembolization(TACE),programmed death-(ligand)1(PD-[L]1)inhibitors,and molecular targeted treatments(MTT)in hepatocellular carcinoma(HCC).It is necessary to investigate the therapeutic efficacy and safety of TACE combined with PD-(L)1 inhibitors and MTT in real-world situations.In this nationwide,retrospective,cohort study,826 HCC patients receiving either TACE plus PD-(L)1 blockades and MTT(combination group,n=376)or TACE monotherapy(monotherapy group,n=450)were included from January 2018 to May 2021.The primary endpoint was progression-free survival(PFS)according to modified RECIST.The secondary outcomes included overall survival(OS),objective response rate(ORR),and safety.We performed propensity score matching approaches to reduce bias between two groups.After matching,228 pairs were included with a predominantly advanced disease population.Median PFS in combination group was 9.5 months(95%confidence interval[CI],8.4-11.0)versus 8.0 months(95%CI,6.6-9.5)(adjusted hazard ratio[HR],0.70,P=0.002).OS and ORR were also significantly higher in combination group(median OS,19.2[16.1-27.3]vs.15.7 months[13.0-20.2];adjusted HR,0.63,P=0.001;ORR,60.1%vs.32.0%;P<0.001).Grade 3/4 adverse events were observed at a rate of 15.8%and 7.5%in combination and monotherapy groups,respectively.Our results suggest that TACE plus PD-(L)1 blockades and MTT could significantly improve PFS,OS,and ORR versus TACE monotherapy for Chinese patients with predominantly advanced HCC in real-world practice,with an acceptable safety profile. | Hai-Dong Zhu Hai-Liang Li Ming-Sheng Huang Wei-Zhu Yang Guo-Wen Yin Bin-Yan Zhong Jun-Hui Sun Zhi-Cheng Jin Jian-Jian Chen Nai-Jian Ge Wen-Bin Ding Wen-Hui Li Jin-Hua Huang Wei Mu Shan-Zhi Gu Jia-Ping Li Hui Zhao Shu-Wei Wen Yan-Ming Lei Yu-Sheng Song Chun-Wang Yuan Wei-Dong Wang Ming Huang Wei Zhao Jian-Bing Wu Song Wang Xu Zhu Jian-Jun Han Wei-Xin Ren Zai-Ming Lu Wen-Ge Xing Yong Fan Hai-Lan Lin Zi-Shu Zhang Guo-Hui Xu Wen-Hao Hu Qiang Tu Hong-Ying Su Chuan-Sheng Zheng Yong Chen Xu-Ya Zhao Zhu-Ting Fang Qi Wang Jin-Wei Zhao Ai-Bing Xu Jian Xu Qing-Hua Wu Huan-Zhang Niu Jian Wang Feng Dai Dui-Ping Feng Qing-Dong Li Rong-Shu Shi Jia-Rui Li Guang Yang Hai-Bin Shi Jian-Song Ji Yu-E Liu Zheng Cai Po Yang Yang Zhao Xiao-Li Zhu Li-Gong Lu Gao-Jun Teng | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 7 |
| 12 | Uncompromised NK cell activation is essential for virus-specific CTL activity during acute influenza virus infection显示文摘Natural killer (NK) cells are indispensable components of both the innate and adaptive immune response. However,their precise roles in the cross-talk between innate and adaptive immunity during influenza virus infection remaincontroversial. By comparing NK cell dynamics and activity under a sub-lethal dose and high dose of influenza virusinfection, we showed that influenza virus PR8 directly infected NK cells during natural infection, which wasconsistent with our previous findings obtained from an in vitro investigation of human NK cells. The impairments incytotoxicity and IFN-γ production by spleen NK cells following high-dose infection were accompanied by decreasedvirus-specific killing mediated by cytotoxic T lymphocytes (CTLs). Importantly, the weakened CTL activity could bereversed by adoptive transfer of spleen NK cells harvested from low-dose-infected mice but not healthy donors.Taken together, our data provide direct evidence supporting the contribution of NK cells to antiviral T-cellresponses. This study also indicates that a novel NK-targeted immune evasion strategy is used by influenza virusto shrink both innate and adaptive immune responses. | Yuan Liu Jian Zheng Yinping Liu Liyan Wen Lei Huang Zheng Xiang Kwok-Tai Lam Aizhen Lv Huawei Mao Yu-Lung Lau Wenwei Tu | 2018 | Cellular & Molecular Immunology2018，15，9： | 6 |
| 13 | Chemoprophylaxis, diagnosis, treatments, and discharge management of COVID-19: An evidence-based clinical practice guideline(updated version)显示文摘The novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the cause of a rapidly spreading illness,coronavirus disease 2019(COVID-19),affecting more than seventeen million people around the world.Diagnosis and treatment guidelines for clinicians caring for patients are needed.In the early stage,we have issued'A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV)infected pneumonia(standard version)';now there are many direct evidences emerged and may change some of previous recommendations and it is ripe for develop an evidence-based guideline.We formed a working group of clinical experts and methodologists.The steering group members proposed 29 questions that are relevant to the management of COVID-19 covering the following areas:chemoprophylaxis,diagnosis,treatments,and discharge management.We searched the literature for direct evidence on the management of COVID-19,and assessed its certainty generated recommendations using the Grading of Recommendations,Assessment,Development and Evaluation(GRADE)approach.Recommendations were either strong or weak,or in the form of ungraded consensus-based statement.Finally,we issued 34 statements.Among them,6 were strong recommendations for,14 were weak recommendations for,3 were weak recommendations against and 11 were ungraded consensus-based statement.They covered topics of chemoprophylaxis(including agents and Traditional Chinese Medicine(TCM)agents),diagnosis(including clinical manifestations,reverse transcription-polymerase chain reaction(RT-PCR),respiratory tract specimens,IgM and IgG antibody tests,chest computed tomography,chest X-ray,and CT features of asymptomatic infections),treatments(including lopinavirritonavir,umifenovir,favipiravir,interferon,remdesivir,combination of antiviral drugs,hydroxychloroquine/chloroquine,interleukin-6 inhibitors,interleukin-1 inhibitors,glucocorticoid,qingfei paidu decoction,lianhua qingwen granules/capsules,convalescent plasma,lung transplantation,invasive or noninvasive ventilation,and extracorporeal membrane oxygenation(ECMO)),and discharge management(including discharge criteria and management plan in patients whose RT-PCR retesting shows SARS-CoV-2 positive after discharge).We also created two figures of these recommendations for the implementation purpose.We hope these recommendations can help support healthcare workers caring for COVID-19 patients. | Ying-Hui Jin Qing-Yuan Zhan Zhi-Yong Peng Xue-Qun Ren Xun-Tao Yin Lin Cai Yu-Feng Yuan Ji-Rong Yue Xiao-Chun Zhang Qi-Wen Yang Jianguang Ji Jian Xia Yi-Rong Li Fu-Xiang Zhou Ya-Dong Gao Zhui Yu Feng Xu Ming-Li Tu Li-Ming Tan Min Yang Fang Chen Xiao-Ju Zhang Mei Zeng Yu Zhu Xin-Can Liu Jian Yang Dong-Chi Zhao Yu-Feng Ding Ning Hou Fu-Bing Wang Hao Chen Yong-Gang Zhang Wei Li Wen Chen Yue-Xian Shi Xiu-Zhi Yang Xue-Jun Wang Yan-Jun Zhong Ming-Juan Zhao Bing-Hui Li Lin-Lu Ma Hao Zi Na Wang Yun-Yun Wang Shao-Fu Yu Lu-Yao Li Qiao Huang Hong Weng Xiang-Ying Ren Li-Sha Luo Man-Ru Fan Di Huang Hong-Yang Xue Lin-Xin Yu Jin-Ping Gao Tong Deng Xian-Tao Zeng Hong-Jun Li Zhen-Shun Cheng Xiao-Mei Yao Xing-Huan Wang | 2020 | Military Medical Research2020，7，3： | 6 |
| 14 | Nano-cerium-element-doped titanium dioxide induces apoptosis of Bel 7402 human hepatoma cells in the presence of visible light显示文摘AIM: To investigate the apoptotic effect of photoexcited titanium dioxide (TiO2) nanoparticles in the presence of visible light on human hepatoma cell line (Bel 7402) and to study the underlying mechanism. METHODS: Cerium-element-doped titanium dioxide nanoparticles were prepared by impregnation method. Bel 7402 human hepatoma cells were cultured in RPMI 1640 medium in a humidified incubator with 50 mL/L CO2 at 37℃. A 15 W fluorescent lamp with continuous wavelength light was used as light source in the photocatalytic test. Fluorescence morphology and agarose gel eletrophoresis pattern were performed to analyze apoptotic cells. RESULTS: The Ce (Ⅳ)-doped TiO2 nanoparticles displayed their superiority. The adsorption edge shifted to the 400-450 nm region. With visible light illuminated for 10 min, 10 μg/cm3 Ce (Ⅳ)-doped TiO2 induced micronuclei and significant apoptosis in 4 and 24 h, respectively. Hochest 33 258 staining of the fixed cells revealed typical apoptotic structures (apoptotic bodies), agarose gel electrophoresis showed typical DNA ladder pattern in treated cells but not in untreated ones. CONCLUSION: Ce (Ⅳ) doped TiO2 nanoparticles can induce apoptosis of Bel 7402 human hepatoma cells in the presence of visible light. | Long Wang Jian Mao Gao-Hua Zhang Ming-Jing Tu | 2007 | World Journal of Gastroenterology2007，13，29： | 6 |
| 15 | yδ-T cells: an unpolished sword in human anti-infection immunity显示文摘γ δ -T 房间代表有免疫力的房间的一张小人口,但是对外长的病原体,内长的致病的有免疫力的监视甚至免疫系统的动态平衡在主人防卫起一个不可缺少的作用。γ 的激活和扩大; δ -T 房间通常与他们的前进和预后在多样的人的传染疾病和相互关联被观察。γ δ -T 房间有两 ‘ innate’并且 ‘ adaptive’在有免疫力的反应的特征,和他们的反感染活动被在由另外的有免疫力的部件的精致的规定下面的多重小径调停。在这评论,我们在 γ 总结文学和最近的前进的当前的状态; δ -T 对普通人的传染病原体的调停房间的有免疫力的回答。尽管进一步的调查被需要改进我们不同 γ 的特征的理解; δ在特定的条件下面的 -T 房间 subpopulations, γ δ -T 基于房间的治疗为传染疾病的治疗有大潜力。 | Jian Zheng Yinping Liu Yu-Lung Lau Wenwei Tu | 2013 | Cellular & Molecular Immunology2013，10，1： | 6 |
| 16 | CD40-activated B cells are more potent than immature dendritic cells to induce and expand CD41 regulatory T cells显示文摘CD4^(+)regulatory T cells(Tregs)play an important role in maintaining immune tolerance by suppressing pathologic immune responses.,The generation of large numbers of antigen-specific Tregs ex vivo is critical for the development of clinical immunotherapy based on the adoptive transfer of Tregs.Both CD40-activated B cells(CD40-B)and immature dendritic cells(imDCs)have been used as professional antigen-presenting cells(APCs)to generate antigen-specific Tregs.However,the efficiencies of CD40-B and imDCs to generate CD4^(+)Tregs have not been compared directly and the mechanism driving the generation of these Tregs remains largely unknown.In this study,we found that CD40-B exhibited mature phenotypes and were more able to induce and expand CD4^(high)'CD25^(+)Tregs than imDCs.Moreover,Tregs induced by CD40-B had greater suppressive capacity than those induced by imDCs.The generation of CD4^(high)CD25^(+)Tregs by CD40-B and imDCs is cell-cell contact dependent and partially relies on the expression of human leukocyte antigen(HLA)-DR and CD80/86.Differences in CD4^(high)CD25^(+)Treg generation efficiency were largely explained by the production of endogenous IL-2 by CD40-B.Our results suggest that CD40-B is better able to generate large numbers of antigen-specific Tregs than imDCs.Additionally,using CD40-B to generate Tregs may accelerate the clinical use of Treg-based immunotherapy in the treatment of allograft rejection,graft versus host disease(GVHD)and autoimmune diseases. | Jian Zheng Yinping Liu Yu-Lung Lau Wenwei Tu | 2010 | Cellular & Molecular Immunology2010，7，1： | 5 |
| 17 | Characteristics of Twin Lamellar Structure in Magnesium Alloy during Room Temperature Dynamic Plastic Deformation显示文摘The microstructures of the as-rolled magnesium alloy subjected to dynamic plastic deformation along the rolling direction have been investigated.Mostly one {1012} twin variant or a twin variant pair is activated in a grain,leading to a parallel {1012} twin lamellar structure.At the stage of twinning-dominated deformation(ε<~8%),lamellar thickness decreases significantly with strain,from 5.55 to 2.49μm.The evolution of lamellar thickness during deformation is directly related to {1012} twin activity.When plastic strain is greater than ~8%,the twin lamellar structure disappears because the volume fraction of twins almost saturates at a value of ~90%. | Chao Lou Xiyan Zhang Gaolin Duan Jian Tu Qing Liu | 2014 | Journal of Materials Science & Technology2014，30，1： | 5 |
| 18 | Microstructure and dry sliding wear behavior of laser clad AlCrNiSiTi multi-principal element alloy coatings显示文摘The approximately equimolar ratio AlCrNiSiTi multi-principal element alloy(MPEA) coatings were fabricated by laser cladding on Ti-6A1-4V(Ti64) alloy.Scanning electron microscopy(SEM),equipped with an energy-dispersive spectroscopy(EDS),and X-ray diffraction(XRD) were used to characterize the microstructure and composition.Investigations show that the coatings consist of(Ti,Cr)_5Si_3 and NiAl phases,formed by in situ reaction.The phase composition is initially explicated according to obtainable binary and ternary phase diagrams,and the formation Gibbs energy of Ti_5Si_3,V_5Si_3 and Cr_5Si_3.Dry sliding reciprocating friction and wear tests of the AlCrNiSiTi coating and Ti64 alloy substrate without coating were evaluated.A surface mapping profiler was used to evaluate the wear volume.The worn surface was characterized by SEM-EDS.The hardness and wear resistance of the AlCrNiSiTi coating are well compared with that of the basal material(Ti64).The main wear mechanism of the AlCrNiSiTi coating is slightly adhesive transfer from GCr15 counterpart,and a mixed layer composed of transferred materials and oxide is formed. | Can Huang Yi-Zhou Tang Yong-Zhong Zhang An-Ping Dong Jian Tu Lin-Jiang Chai Zhi-Ming Zhou | 2017 | Rare Metals2017，36，7： | 5 |
| 19 | Timing of internal fixation and effect on Schatzker IV-VI tibial plateau fractures显示文摘内部固定的效果在 Schatzker IV-VI 胫骨的高原破裂的 42 个盒子的临床的数据在我们的部门对待的 Schatzker IV-VI 胫骨的高原 fractures.MethodsThe 的治疗学的结果上在不同时间执行了的 ObjectiveTo 学习回顾地被分析。在这 42 个病人之中, 21 在 12 以内接受了外科的治疗;在损害以后的 h (组我) ,另外的 21 被在胀大的软织物减退了以后,推迟的内部固定跟随的拖拉或灰浆固定(组 II ) 首先对待。外科的时间,复杂并发症,一些医院停留,住院的费用,和骨折联合的时间,以及功能的恢复被分析并且在二 groups.ResultsAfter 10-28 月后续(平均数 16.5 月)之间比较了,除了 5 个盒子输了到后续,没有差别在后续的结束关于外科的时间,外科手术前、手术后的复杂并发症,特殊外科( HSS )分数的愈合的时间或医院在二个组之间被发现。 | TANG Xin LIU Lei TU Chong-qi YANG Tian-fu WANG Guang-lin FANG Yue LI Jian LI Qi PEI Fu-xing | 2012 | Chinese Journal of Traumatology2012，15，2： | 5 |
| 20 | Evolution of surface microstructure of Cu-50Cr alloy treated by high current pulsed electron beam显示文摘A Cu-50Cr alloy was treated by the high current pulsed electron beam(HCPEB)at 20 and 30 ke V with pulse numbers ranging from 1 to 100.Surface morphologies and microstructures of specimens before and after the treatments were investigated by employing scanning electron microscopy and X-ray diffraction.Results show that the HCPEB technique is able to induce remarkable surface modifications for the Cu-50Cr alloy.Cracks in Cr phases appear even after one-pulse treatment and their density always increases with the pulse number.Formation reason for these cracks is attributed to quasi-static thermal stresses accumulated along the specimen surface.Craters with typical morphologies are formed due to the dynamic thermal field induced by the HCPEB and they are found to prefer the sites near cracks or boundaries between neighboring Cr phases.Another microstructural characteristic produced by the HCPEB is the fine Cr spheroids,which are determined to be due to occurrence of liquid phase separation in the Cu-50Cr alloy.Finally,a general microstructural evolution profile that incorporates various HCPEB-induced surface features is tentatively outlined. | CHAI LinJiang ZHOU ZhiMing XIAO ZhiPei TU Jian WANG YaPing HUANG WeiJiu | 2015 | Science China(Technological Sciences)2015，58，3： | 5 |
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