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| 1 | Meta-analysis of the relationship of peripheral retinal nerve fiber layer thickness to Alzheimer's disease and mild cognitive impairment显示文摘 | Meijuan WANG Yinbo ZHU Zhongyong SHI Chunbo LI Yuan SHEN | 2015 | 上海精神医学2015，27，5： | 5 |
| 2 | The mechanosensitive lncRNA Neat1 promotes osteoblast function through paraspeckle-dependent Smurf1 mRNA retention显示文摘Mechanical stimulation plays an important role in bone remodeling. Exercise-induced mechanical loading enhances bone strength,whereas mechanical unloading leads to bone loss. Increasing evidence has demonstrated that long noncoding RNAs(lnc RNAs) play key roles in diverse biological, physiological and pathological contexts. However, the roles of lnc RNAs in mechanotransduction and their relationships with bone formation remain unknown. In this study, we screened mechanosensing lnc RNAs in osteoblasts and identified Neat1, the most clearly decreased lnc RNA under simulated microgravity. Of note, not only Neat1 expression but also the specific paraspeckle structure formed by Neat1 was sensitive to different mechanical stimulations, which were closely associated with osteoblast function. Paraspeckles exhibited small punctate aggregates under simulated microgravity and elongated prolate or larger irregular structures under mechanical loading. Neat1 knockout mice displayed disrupted bone formation, impaired bone structure and strength, and reduced bone mass. Neat1 deficiency in osteoblasts reduced the response of osteoblasts to mechanical stimulation. In vivo, Neat1 knockout in mice weakened the bone phenotypes in response to mechanical loading and hindlimb unloading stimulation. Mechanistically, paraspeckles promoted nuclear retention of E3 ubiquitin ligase Smurf1 m RNA and downregulation of their translation, thus inhibiting ubiquitination-mediated degradation of the osteoblast master transcription factor Runx2, a Smurf1 target. Our study revealed that Neat1 plays an essential role in osteoblast function under mechanical stimulation, which provides a paradigm for the function of the lnc RNA-assembled structure in response to mechanical stimulation and offers a therapeutic strategy for long-term spaceflight-or bedrest-induced bone loss and age-related osteoporosis. | Caizhi Liu Xingcheng Gao Yuheng Li Weijia Sun Youjia Xu Yingjun Tan Ruikai Du Guohui Zhong Dingsheng Zhao Zizhong Liu Xiaoyan Jin Yinlong Zhao Yinbo Wang Xinxin Yuan Junjie Pan Guodong Yuan Youyou Li Wenjuan Xing Guanghan Kan Yanqing Wang Qi Li Xuan Han Jianwei Li Shukuan Ling Yingxian Li | 2022 | Bone Research2022，10，2： | 3 |
| 3 | HSP70 alleviates sepsis-induced cardiomyopathy by attenuating mitochondrial dysfunction-initiated NLRP3 inflammasome-mediated pyroptosis in cardiomyocytes显示文摘Background:Sepsis-induced cardiomyopathy(SIC)is an identified serious complication of sepsis that is associated with adverse outcomes and high mortality.Heat shock proteins(HSPs)have been implicated in suppressing septic inflammation.The aim of this study was to investigate whether HSP70 can attenuate cellular mitochondrial dysfunction,exuberated inflammation and inflammasome-mediated pyroptosis for SIC intervention.Methods:Mice with cecal ligation plus perforation(CLP)and lipopolysaccharide(LPS)-treated H9C2 cardiomyocytes were used as models of SIC.The mouse survival rate,gross profile,cardiac function,pathological changes and mitochondrial function were observed by photography,echocardiography,hematoxylin-eosin staining and transmission electron microscopy.In addition,cell proliferation and the levels of cardiac troponin I(cTnI),interleukin-1β(IL-1β)and tumor necrosis factor-α(TNF-α)were determined by Cell Counting Kit-8,crystal violet staining and enzyme-linked immunosorbent assay.Moreover,mitochondrial membrane potential was assessed by immunofluorescence staining,and dynamin-related protein 1 and pyroptosis-related molecules[nucleotide-binding domain,leucine-rich-repeat containing family pyrin domain-containing 3(NLRP3),caspase-1,gasdermin-D(GSDMD),gasdermin-D N-terminal(GSDMD-N)]were measured by western blotting,immunoprecipitation and immunoblotting.Finally,hsp70.1 knockout mice with CLP were used to verify the effects of HSP70 on SIC and the underlying mechanism.Results:Models of SIC were successfully established,as reduced consciousness and activity with liparotrichia in CLP mice were observed,and the survival rate and cardiac ejection fraction(EF)were decreased;conversely,the levels of cTnI,TNF-αand IL-1βand myocardial tissue damage were increased in CLP mice.In addition,LPS stimulation resulted in a reduction in cell viability,mitochondrial destabilization and activation of NLRP3-mediated pyroptosis molecules in vitro.HSP70 treatment improved myocardial tissue damage,survival rate and cardiac dysfunction caused by CLP.Additionally,HSP70 intervention reversed LPS-induced mitochondrial destabiliza-tion,inhibited activation of the NLRP3 inflammasome,caspase-1,GSDMD and GSDMD-N,and decreased pyroptosis.Finally,knockout of hsp70.1 mice with CLP aggravated cardiac dysfunction and upregulated NLRP3 inflammasome activity,and exogenous HSP70 significantly rescued these changes.It was further confirmed that HSP70 plays a protective role in SIC by attenuating mitochondrial dysfunction and inactivating pyroptotic molecules.Conclusions:Our study demonstrated that mitochondrial destabilization and NLRP3 inflammasome activation-mediated pyroptosis are attributed to SIC.Interestingly,HSP70 ameliorates sepsis-induced myocardial dysfunction by improving mitochondrial dysfunction and inhibiting the acti-vation of NLRP3 inflammasome-mediated pyroptosis,and such a result may provide approaches for novel therapies for SIC. | Chenlu Song Yiqiu Zhang Qing Pei Li Zheng Meiyu Wang Youzhen Shi Shan Wu Wei Ni Xiujun Fu Yinbo Peng Wen Zhang Min Yao | 2022 | Burns & Trauma2022，10，1： | 2 |
| 4 | ADMETNet:The knowledge base of pharmacokinetics and toxicology network显示文摘A good drug or drug candidate should not only interact with its target molecule effectively and specifically,but also be absorbed into the body,distributed to the right location,metabolized into right compounds,and eliminated out of the body in proper manner.The processes of drug getting into and out of the body involve Absorption,Distribution,Metabolism,and Excretion(ADME),which | Quan Xu Ke Liu Xingming Lin Yangmei Qin Linshan Chen Jiao Cheng Mindong Zhong Qiushun He Yinbo Li Tingwu Wang Jianbo Pan Menglu Peng Lixia Yao Zhiliang Ji | 2017 | Journal of Genetics and Genomics2017，44，5： | 2 |
| 5 | Low Molecular Weight Apple Polysaccharides Induced Cell Cycle Arrest in Colorectal Tumor显示文摘 | Yuhua Li Lin Mei Yinbo Niu Yang Sun Haitao Huang Qian Li Xianghe Kong Li Liu Zhiquan Li Qibing Mei | 2012 | Nutrition and Cancer2012，，3： | 1 |
| 6 | Modified apple polysaccharide prevents against tumorigenesis in a mouse model of colitis-associated colon cancer: role of galectin-3 and apoptosis in cancer prevention显示文摘 | Yuhua Li Li Liu Yinbo Niu Juan Feng Yang Sun Xianghe Kong Yongchun Chen Xiaoyan Chen Hongquan Gan Shousong Cao Qibing Mei | 2012 | European Journal of Nutrition2012，，1： | 1 |
| 7 | Column test-based optimization of the permeable reactive barrier(PRB)technique for remediating groundwater contaminated by landfill leachates显示文摘 | Zhou Dan Li Yan Zhang Yinbo | 2014 | J Contam Hydrol2014，168，： | 1 |
| 8 | Asperosaponin VI, A Saponin Component from Dipsacus asper Wall, induces Osteoblast Differentiation through Bone Morphogenetic Protein‐2/p38 and Extracellular Signal‐regulated Kinase 1/2 Pathway显示文摘 | Yinbo Niu Yuhua Li Haitao Huang Xianghe Kong Rong Zhang Li Liu Yang Sun Tingmei Wang Qibing Mei | 2011 | Phytother Res2011，，11： | 1 |
| 9 | Immunomodulation of Rheum tanguticum polysaccharide (RTP) on the immunosuppressive effects of dexamethasone (DEX) on the treatment of colitis in rats induced by 2,4,6-trinitrobenzene sulfonic acid显示文摘 | Li Liu Shifang Yuan Yin Long Zhenjun Guo Yang Sun Yuhua Li Yinbo Niu Chen Li Qibing Mei | 2009 | International Immunopharmacology2009，，13： | 1 |
| 10 | Xylanase pretreatment leads to enhanced soda pulping of wheat straw显示文摘 | Jian Zhao Xuezhi Li Yinbo Qu | 2002 | Enzyme and Microbial Technology2002，30，： | 1 |
| 11 | Improving lignocellulolytic enzyme production with Penicillium : from strain screening to systems biology显示文摘 | Guodong Liu Yuqi Qin Zhonghai Li Yinbo Qu | 2013 | Biofuels2013，，5： | 1 |
| 12 | Synthesis and Insecticidal Evaluation of Novel Phthalic Diamides Containing 1,2,3-Triazoles via Click Reaction显示文摘A series of novel phthalic diamide derivatives containing 1,2,3-triazole moiety were synthesized using one-pot click chemistry approach and characterized by ^(1)H NMR and HRMS.The insecticidal activity against armyworm(Mythimna separata),Tetranychus cinnabarinus and cowpea aphid(Aphis craccivora)was evaluated.Compounds 4Ⅱ-a and 4Ⅱ-i showed 50%insecticidal activity against armyworm(Mythimna separata)at the concentration of 4 mg/L and one-third of the compounds had moderate activity against Tetranychus cinnabarinus at 500 mg/L. | Yinbo Chen Youxin Xiao Xusheng Shao Xiaoyong Xu Zhong Li | 2014 | Chinese Journal of Chemistry2014，32，7： | 1 |
| 13 | Modified Apple Poly- saccharides Could Induce Apoptosis in Co|orectal Cancer Cell 显示文摘 | Yuhua Li Yinbo Niu Huanjie Wu | 2010 | Journal of Food Science2010，75，8： | 1 |
| 14 | Reduced conductivity in sandwich-structured BFT@DA/PVDF flexible nanocomposites for high energy storage density in lower electric field显示文摘The Ba(Fe_(0.5)Ta_(0.5))O_(3)@DA/PVDF flexible composite films with sandwich-structured are prepared by solution-casting method.According to SEM image,the thickness of the composite film is about 15 mm and the each layer is about 5 mm.The sandwich-structured nanocomposite films not only have higher permittivity but also lower AC conductivity.The high permittivity is due to the large permittivity of BFT and the enhanced interface polarization between ceramic particles and polymer matrix.The low AC conductivity is due to the absence of conductive pathways in the PVDF layer.At low electric field strength of 150 MV/m,the energy density of sandwich-structure composite films filled with 1 vol% is 1.93 J/cm^(3).When the breakdown strength is 250 MV/m,the maximum energy storage density is increased to 4.87 J/cm^(3).The sandwich-structure Ba(Fe_(0.5)Ta_(0.5))O_(3)@DA/PVDF flexible composite films with outstanding energy storage properties in lower electric field can be used for wearable devices in the future. | Zhuo Wang Yinbo Li Xiaoying Wang Jiahao Fan Zhihui Yi Menglei Kong Ning Xu | 2020 | Journal of Materiomics2020，6，2： | 0 |
| 15 | RsERF40 contributes to cold stress tolerance and cell expansion of taproot in radish (Raphanus sativus L.)显示文摘The growth and development of taproots are inhibited by cold stress in radish(Raphanus sativus L.).Ethylene-responsive element binding factors(ERF)are key participators in the cold stress response and growth regulation of plants.However,the function of ERF genes in cold tolerance and root development in radish remains elusive.Here,we showed that the secondary growth of radish taproots was inhibited by cold stress.Comparative transcriptome analysis demonstrated that the RsERF40 gene is an important regulator of the cold stress response and root growth regulation.The cold tolerance of transgenic Arabidopsis plants overexpressing the RsERF40 gene was significantly improved.Overexpressing RsERF40 in the cold-sensitive radish genotype and silencing RsERF40 in the cold-tolerant radish genotype indicated that RsERF40 was beneficial for alleviating oxidative damage under cold stress in radish.Transgenic Arabidopsis seedlings showed an increase in the elongation and radial growth of dark-grown roots.RT-qPCR analysis showed that the expression of the cold-related genes(CORs)RsCOR78 and RsCOR413PM1 and the cell wall strengthening-related genes RsCESA6 and RsEXPB3 was upregulated in transgenic Arabidopsis seedlings.Yeast one-hybrid(Y1H)and dual-luciferase reporter assays(DLA)revealed that RsERF40 directly regulates RsCOR78,RsCOR413PM1,RsCESA6 and RsEXPB3 expression,illustrating that RsERF40 enhances cold tolerance and taproot growth by modulating osmotic adjustment and cell wall mechanical strength in radish.In this study,the RsERF40-regulon was firstly found to be a new cold response pathway independent of the CBF-COR pathway conferring cold stress tolerance with increasing radish taproot growth.These results provided novel insight into the molecular mechanism underlying cold stress response and would facilitate the genetic improvement of cold tolerance in radish and other root vegetable crops. | Cui Li Baozhen Mao Kai Wang Liang Xu Lianxue Fan Yan Wang Ying Li Yinbo Ma Lun Wang Liwang Liu | 2023 | Horticulture Research2023，10，3： | 0 |
| 16 | Grading Evaluation and Ranking of CO_(2) Sequestration Capacity in Place(CSCIP) in China’s Major Oil Basins:Theoretical,Effective,Practical and CCUS-EOR显示文摘Because it is necessary to focus on differences in regional oil reservoirs and determine the priority of the CCUSEOR(Carbon capture,utilization,and storage-enhanced oil recovery) deployment under China’s net-zero CO_(2) emission target,systematic and regional evaluations of CO_(2) sequestration capacity in major oil basins are needed considering the geofluid properties―carbon sequestration capacity in place(CSCIP)―where the ’in place’ indicates actual geological formation conditions underground,e.g.,formation temperature and pressure.Therefore,physical properties of geofluids at different depths with different geologic temperatures and pressure conditions are considered for the CO_(2) sequestration capacity evaluation in place,including shallow(800–2000 m),medium(2000–3500 m),deep(3500–4500 m) and ultra-deep(4500–8000 m) depth intervals.A modified evaluation model with four grading levels is proposed,combining the P-V-T equations of state(EOS) and evaluation equations of the Carbon Sequestration Leadership Forum(CSLF),including theoretical,effective,practical,and CCUS-EOR CSCIP,which is more consistent with geofluid physical properties underground,to make the grading evaluation and ranking of the CSCIP in China’s major oil basins.Then,the grading CSCIP of 29 major oil basins in China was evaluated based on the petroleum resources evaluation results of the Ministry of Natural Resources of China(MNRC) during China’s 13th Five-Year Plan period.According to the grading evaluation results,suggestions for China’s CCUS-EOR prospective regions are given as follows:shallow oil fields of the Songliao Basin in Northeast China,shallow–medium oil fields of the Bohai Bay Basin in East China,medium oil fields of the Zhungeer Basin in West China,and medium oil fields of the Ordos Basin in Central China;all are potential areas for the CCUS-EOR geological sequestration in China’s onshore oil basins.In addition,in China’s offshore oil basins,shallow–medium oil fields of the Bohai Sea and shallow oil fields of the Pearl River Mouth Basin have potential for CCUS-EOR geological sequestration. | LI Yaohua WANG Yang SHI Yu YANG Leilei CUI Qiliang BI Caiqin XU Yinbo WANG Qianyou SHAN Yansheng LIU Weibin MIAO Miao WANG Ting | 2023 | Acta Geologica Sinica(English Edition)2023，97，3： | 0 |
| 17 | Characteristics of the vertical structure of the atmospheric turbulence in the Tibetan Plateau显示文摘The Tibetan Plateau(TP)has unique atmospheric dynamics and thermal structures that originate from its giant terrain and complex climate.High vertical-resolution thermal radiosondes were launched near the central(Lhasa,91°06′E,29°36′N,3670 m above sea level(ASL))and marginal(Da Qaidam,95°21′E,37°51′N,3180 m ASL)areas of the TP during the summers of 2018 and 2020,respectively.Atmospheric turbulence parameters were calculated,and the characteristics of the atmospheric turbulent vertical structure at sunset in these two areas were analyzed and compared.Affected by TP thermal forcing and stably controlled by the summer monsoon anticyclone,the atmospheric refractive index structure constant(C_(n)^(2))tended to increase and then decrease with increasing height,reaching a maximum at the tropopause(~18 km ASL)at the Lhasa site.Although C_(n)^(2) at the Da Qaidam site also tended to increase at the tropopause,the position of the strong turbulent band(STB)(5–7 km ASL)was below the tropopause height corresponding to the potential temperature lapse rate minimum.The vertical distribution of C_(n)^(2) at the two sites,particularly regarding the position of the STB,was highly correlated with the atmospheric stability(Ri)and the thermal mixing scale(L_(T)).The significant correlations among the three parameters(STB,Ri,and L_(T))indicated that the strong fluctuations in temperature caused by thermal mixing were the dominant factor causing the Ri to be less than its critical value of 0.25.Moreover,the suppression strength involving the upward transport of the heat sources was the main reason for the different turbulent vertical structures and STB positions at the two sites.The zonal mean thermodynamic and dynamical fields derived from the reanalysis data also showed a height difference in the heat sources transported to the troposphere at the two sites.In the marginal TP,the material and energy in the lower troposphere were transported by the turbulent atmosphere upward along the slope of the mountain and converged at the central TP(28°N–35°N)with strong thermal forcing up to the tropopause.In the STB of the Lhasa site,the turbulent dissipation rate and eddy diffusion coefficient increased sharply,indicating that the turbulent atmosphere in this central site was highly diffused,and the small-scale turbulence transported the material and energy upward. | Kun ZHANG Yang WU Feifei WANG Xuebin LI Shengcheng CUI Zihan ZHANG Xiaoqing WU Ningquan WENG Tao LUO Yinbo HUANG | 2022 | Science China Earth Sciences2022，65，7： | 0 |
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