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| 1 | Activation of the PI3K/AKT pathway mediates FSH-stimulated VEGF expression in ovarian serous cystadenocarclnoma显示文摘有证据建议那刺激滤泡的荷尔蒙(FSH ) 能由在癌症细胞增加脉管的 endothelial 生长因素(VEGF ) 表示便于卵巢的癌症的 neovascularization,尽管这个过程的内在的分子的机制不是众所周知的。因此,我们在卵巢的癌症房间线 SKOV-3 和 ES-2 在 VEGF 表示上调查了 FSH 的效果。有 FSH 的治疗显著地在一个剂量依赖者和时间依赖者举止增加了 VEGF 表示。另外, FSH 治疗提高了 survivin 和组织缺氧可诱导的 factor-1 (HIF-1 ) 的表示。survivin 或 HIF-1 击倒压制的 VEGF 表示,但是 survivin 仅仅击倒禁止的刺激 FSH 的 VEGF 表示。有 LY294002 的预告的处理,一个 phosphoinositide 3-kinase (PI3K )/AKT 禁止者,抵销 FSH,而是治疗与 U0126 导致的 survivin 的提高的表示,激活 mitogen 的蛋白质 kinase/extracellular 调整信号的 kinase 禁止者,没有如此的效果。我们进一步证明卵巢的浆液的 cystadenocarcinoma 样品有积极 AKT 和比的染色的 phosphorylated AKT (pAKT ) 蛋白质的许多更高的发生良性的卵巢的 cystadenoma 取样了(p < 0.01 ) 。5 年的幸存率仅仅在有卵巢的浆液的 cystadenocarcinoma 的病人是大约 15% 有 AKT 和 pAKT 表示,而它在没有 AKT 或 pAKT 表示的那些是大约 80% 。一起拿,这些结果显示 FSH 由 upregulating 增加 VEGF 的表示 survivin 的表示,它被发信号的 PI3K/AKT 激活小径。在 survivin 和 VEGF 的刺激 FSH 的表示理解 PI3K/AKT 小径的角色将为与卵巢的浆液的 cystadenocarcinoma 为病人评估预后并且为对这疾病追求有效治疗是有益的。 | Yan Huang Keqin Hua Xianrong Zhou Hongyan Jin Xiaojun Chen Xin Lu Yinhua Yu Xiliang Zha Youji Feng | 2008 | Cell Research2008，18，7： | 17 |
| 2 | Activated carbon supported TiO_2 -photocatalysis doped with Fe ions for continuous treatment of dye wastewater in a dynamic reactor显示文摘Fe-doped TiO 2 coated on activated carbon (Fe-TiO 2 /AC, FTA) composites were prepared by an improved sol-gel method and characterized by scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, inductively coupled plasma mass spectrometry and BET surface area analysis. Obtained FTA composites were applied to the continuous treatment of dye wastewater in a dynamic reactor. The effects of Fe ion content, catalyst content, UV-lamp power and flowrate of the continuous treatment of dye wastewater on degradation efficiency were analyzed to determine the optimum operating conditions of dye wastewater degradation. Continuous photocatalytic experiments provided interesting results that FTA had a high chemical oxygen demand (COD) removal rate compared with TiO 2 , Fe doped TiO 2 (FT) and TiO 2 coated on activated carbon (TA). In particular, when using the FTA catalyst with a Fe ion content of 0.33%, the kinetic content (k = 0.0376) of COD removal was more than the sum of both TA (0.0205) and 0.33% FT (0.0166). FTA showed a high photoactivity because of a synergistic effect between Fe ions and AC on TiO 2 , which is higher than the individual effects of AC or Fe ions on TiO 2 . Additionally, for the photocatalytic degradation of dye wastewater, the optimum Fe ion content, catalyst content, UV-lamp power and flowrate were 0.33%, 6 g/L, 60 W (two lamps) and 300 mL/hr, respectively. An investigation of catalyst reuse revealed that the 0.33% FTA showed almost no deactivation in photocatalytic degradation of naturally treated wastewater. | Youji Li Jun Chen Jianben Liu Mingyuan Ma Wei Chen | 2010 | Journal of Environmental Sciences2010，22，8： | 13 |
| 3 | Inactivated properties of activated carbon-supported TiO_2 nanoparticles for bacteria and kinetic study显示文摘The activated carbon-supported TiO2 nanoparticles(TiO2/AC)were prepared by a properly controlled sol-gel method.The effects of activated carbons(AC)support on inactivated properties of TiO2 nanoparticles were evaluated by photocatalytic inactivation experiments of Escherichia coli.The key factors affecting the inactivation effciency were investigated,including electric power of lamp, temperature,and pH values.The results show that the TiO2/AC composites have high inactivation properties of E.coli in comparison with pure TiO2 powder.The kinetics of photocatalytic inactivation of E.coli was found to follow a pseudo-first order rate law for TiO2/AC composites,and kinetic behavior could be described in terms of a modified Langmuir-Hinshelwood model.The values of the adsorption equilibrium constants for the bacteria,Kc,and for the rate constants,kr,were certainly depended on TiO2 content.At 47 wt.%TiO2 coatings with the highest rate constant,the Kc and kr were 1.17×10 -8 L/cfu and 1.43×106 cfu/(L·min),respectively.The variety of parameters shows significant effects on inactivation rate.The outer layer of bacteria decomposed first resulting in inactivation of cell,and with further illumination,the cells nearly decomposed. | LI, Youji MA, Mingyuan WANG, Xiaohu WANG, Xiaohua | 2008 | Journal of Environmental Sciences2008，20，12： | 8 |
| 4 | A predictive factor for the response to S-1 plus cisplatin in gastric cancer显示文摘AIM:To prove that the protein expression level of thymidylate synthase is a predictive factor for the response to S-1/cisplatin(CDDP)chemotherapy in gastric cancer.METHODS:We measured the protein expression levels of thymidylate synthase(TS),dihydropyrimidine dehydrogenase(DPD),and orotate phosphoribosyltrans-ferase(OPRT)in advanced gastric cancer.Before S-1/CDDP chemotherapy,tumor specimens from primary sites were obtained by endoscopic biopsy and analyzed by enzyme-linked immunosorbent assay.The chemo-therapeutic effects on the primary sites were evaluated by endoscopic biopsy performed more than once after S-1/CDDP chemotherapy.The effects are a predictive factor for the response to S-1/CDDP chemotherapy inpatients with advanced gastric cancer,as evaluated by endoscopic biopsy over time.RESULTS:The protein expression level of TS was significantly higher(P<0.05)in the tumor than in the normal tissue,and significantly lower(P<0.05)in the responders than in the non-responders.We were able to evaluate the correlation between changes in the protein expression levels of TS,DPD and OPRT and chemotherapeutic responses in 7 patients by assessing tumor tissues more than twice.In the responders,the protein expression level of TS was<40 ng/mg protein.However,there were significant increases in the protein expression levels of TS(P<0.01)and DPD(P<0.05)after chemotherapy in 3 patients.In these cases,the patient assessment changed from'responder'to'non-responder'.In the non-responders,the protein expression level of TS was>40 ng/mg protein.CONCLUSION:We have confirmed that the protein expression level of TS is a predictive factor for the response to S-1/CDDP chemotherapy in patients with advanced gastric cancer. | Ikuko Miyazaki Takashi Kawai Youji Harada Fuminori Moriyasu | 2010 | World Journal of Gastroenterology2010，16，36： | 8 |
| 5 | 慢性头晕患者的颈肌张力和静态平衡的客观评价显示文摘目的:头晕患者常诉有颈部僵硬的症状。本研究拟探讨颈部症状在头晕患者中的病理机制。方法:26例因单侧前庭病变导致慢性头晕的患者和24例健康对照者参与本次研究,通过客观测量慢性头晕患者双侧斜方肌的肌张力,探讨其与静态姿势干扰的关系。采用颈肌张力仪客观测量双侧斜方肌张力,计算双侧颈肌张力(ANT)和双侧颈肌张力比值(右/左)(RNT)。静态平衡仪测量重心移动轨迹的总长度(LNG)。结果:头晕患者闭眼状态下,ANT和LNG呈负相关(r=-0.44,P<0.05)。头晕患者和健康对照者在闭眼状态时,RNT和LNG呈正相关。结论:ANT平均值升高提示前庭代偿导致的维持静态姿势平衡的颈肌张力增加。颈肌张力的不对称和姿势不平衡有关。 | 张甦琳 孔维佳 YOUJI ASAMA FUMIYUKI GOTO TOMOKO TSUTSUMI KAORU OGAWA | 2013 | 临床耳鼻咽喉头颈外科杂志2013，27，3： | 5 |
| 6 | Nucleoprotein-based indirect enzyme-linked immunosorbent assay(indirect ELISA) for detecting antibodies specific to Ebola virus and Marbug virus显示文摘Full-length nucleoproteins from Ebola and Marburg viruses were expressed as His-tagged recombinant proteins in Escherichia coli and nucleoprotein-based enzyme-linked immunosorbent assays(ELISAs) were established for the detection of antibodies specific to Ebola and Marburg viruses. The ELISAs were evaluated by testing antisera collected from rabbit immunized with Ebola and Marburg virus nucleoproteins. Although little cross-reactivity of antibodies was observed in antiEbola virus nucleoprotein rabbit antisera, the highest reactions to immunoglobulin G(Ig G) were uniformly detected against the nucleoprotein antigens of homologous viruses. We further evaluated the ELISA's ability to detect antibodies to Ebola and Marburg viruses using human sera samples collected from individuals passing through the Guangdong port of entry. With a threshold set at the mean plus three standard deviations of average optical densities of sera tested, the ELISA systems using these two recombinant nucleoproteins have good sensitivity and specificity. These results demonstrate the usefulness of ELISA for diagnostics as well as ecological and serosurvey studies of Ebola and Marburg virus infection. | Yi Huang Youjie Zhu Mengshi Yang Zhenqing Zhang Donglin Song Zhiming Yuan | 2014 | Virologica Sinica2014，29，6： | 4 |
| 7 | Preparation of TiO_2/activated carbon with Fe ions doping photocatalyst and its application to photocatalytic degradation of reactive brilliant red K2G显示文摘Titanium dioxide coated on activated carbon(AC) with Fe ions doping(Fe-TiO2/AC) composite was prepared by an improved sol-gel method.The photocatalytic activities were tested by photocatalytic degradation of reactive brilliant red K2G in solution.The results show that in comparison with the agglomeration of pure TiO2,the TiO2 nanoparticles are well dispersed in the AC matrix,of which sizes are decreased with Fe ions doping.Additionally,the iron species on TiO2 of composite are Fe2O3 and FeO,which do not affect the crystalline structures of TiO2 nanoparticles.The AC matrix and iron doping content influence the fluorescence intensity of composite due to their effects on recombination probability of hole-electron pairs.Compared with TiO2,0.3% Fe-TiO2,TiO2/AC,0.5% Fe-TiO2/AC and 0.1% Fe-TiO2/AC,the 0.3% Fe-TiO2/AC shows the highest photoactivity with the complete mineralization of K2G for finite time due to the optimum Fe ions content and AC matrix.Furthermore,the kinetic constant(k=0.0229 min-1) of 0.3% Fe-TiO2/AC composite is more than the sum of both TiO2/AC(0.0154 min-1) and 0.3% Fe-TiO2(0.0057 min-1) because coexistence of the AC and Fe ions has an enlarging effect on improving the photoactivity of TiO2. | LI YouJi,LI Jing,MA MingYuan,OUYANG YuZhu & YAN WenBin College of Chemistry and Chemical Engineering,Jishou University,Jishou 416000,China | 2009 | Science China Chemistry2009，52，8： | 4 |
| 8 | Exposure to persistent organic pollutants as potential risk factors for developing diabetes显示文摘Persistent organic pollutants(POPs),such as dioxins,polychlorinated biphenyls(PCBs) ,and organochlorine pesticides(OCPs),which are synthetic chemicals or by-products with an intrinsic resistance to natural degradation processes,are released into the environment,resulting in the widespread dispersal and accumulation in the environment,as well as in human and ecological food chains.Due to their ubiquity in the environment and lipophilic properties,there is emerging concern over the potential risks of human exposure to POPs.Extensive growing evidence indicated that exposure to POPs might be strongly associated with increased risk of a worldwide epidemic of diabetes,especially type 2 diabetes,suggesting that POPs might play a key role in their pathogenesis.Based on summary of the related studies,this paper reviews the epidemiologic and experimental data that addresses the association between increased risk of diabetes and POP exposure,including dioxins,PCBs,OCPs,polybrominated flame retardants(PBFRs),and some environmental estrogens.The potential mechanisms whereby POPs cause diabetes were discussed,such as alterations in lipid metabolism,in glucose transport,in insulin signaling pathway,in steroid metabolism,and disruption of endocrine system,induction of tumor necrosis factor-α(TNF-α) .However,with respect to diabetes,some of the evidence on POPs linked to risk of diabetes was suggestive of a direct or indirect association but was limited or inconclusive.Future research is urgently needed for determining the relative contribution of POPs to diabetes and elucidating the exact mechanisms. | WANG ChunXiang,XU ShunQing,LV ZiQuan,LI YuanYuan,WANG YouJie & CHEN Tian Key Laboratory of Environment and Health,Ministry of Education School of Public Health,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China | 2010 | Science China Chemistry2010，53，5： | 3 |
| 9 | Experimental and Numerical Investigation on Erosion Corrosion of the Air Cooler Tube Bundle in a Residue Hydrotreating Unit显示文摘Corrosion leakage occurred in the 14th tube bundle in the first row of a residual oil hydrotreating air cooler after operating for two years.The failure location was 0.5 m from the outlet header box.In this paper,the erosion corrosion of the air cooler tube bundle was investigated by experimental and numerical methods.Visual inspection,scanning electron microscopy(SEM),and X-ray diffraction(XRD)experiments were performed,and the failure morphology and material composition confirmed that the damage was caused by erosion corrosion.The shear stress transport k–ωturbulence model(SST-k–ω)was then used to investigate the flow and erosion corrosion characteristics,combined with mass transfer,corrosion rate,and ionization equilibrium models.The numerical simulation results revealed that the water phase volume fraction increased with flow and heat transfer in the fluid,which increased the mass flow rate and concentration of hydrogen sulfide.The mass transfer coefficient and corrosion rate were proposed as important parameters to characterize erosion corrosion.Moreover,the local concentration of wall shear stress was found to increase the risk of erosion corrosion.The predicted high-risk area was consistent with the actual failure area,which verified that this failure incident was attributable to erosion corrosion by the water phase. | Jin Haozhe Yu Chenyang Gu Youjie Qian Guangwei Liu Xiaofei Ou Guofu Jia Yongna | 2022 | China Petroleum Processing & Petrochemical Technology2022，24，4： | 2 |
| 10 | Preparation and photocatalytic activity of TiO_2-coated granular activated carbon composites by a molecular adsorption-deposition method显示文摘TiO2 nanoparticle-coated granular activated carbon (GAC) composite photocatalysts (CPs) were suc-cessfully prepared by a molecular adsorption-deposition (MAD) method. The CPs were detected by scanning electron microscopy (SEM), X-ray diffraction (XRD), X-ray Photoelectron Spectroscopy (XPS), BET surface area and UV-Vis adsorption spectroscopy, and their photoactivity was evaluated by methyl orange (MO) photodegradation. The results show that small-sized TiO2 nanoparticles were dispersed well, deposited on the surface of GAC, and showed slight blue shift in comparison with pure TiO2. With the increase in TiO2 content, the CPs showed band gaps in lower energy, smaller surface areas and the higher content of Ti3+ ions. Compared with pure TiO2 and others CPs samples, CPs-382 sample showed the highest photoactivity due to the optimum TiO2 content and surface area besides the synergic effect of photocatalytic degradation of TiO2 and adsorptive property of GAC. In addition, the CPs could be very easily reclaimed, recycled and reused for methyl orange removal while high photoactivity is pre-served. | LI YouJi, LI Jing, MA MingYuan, OUYANG YuZhu & YAN WenBin College of Chemistry and Chemical Engineering, Jishou University, Jishou 416000, China | 2008 | Science China Chemistry2008，51，11： | 2 |
| 11 | Comparative proteomics analyses of intraspecific differences in the response of Stipa purpurea to drought显示文摘Stipa purpurea is widely distributed along a large precipitation gradient on the Tibetan Plateau.This implies that S.purpurea from different populations may have different responses to drought stress.To explore this we compared the morphological and physiological changes of S.purpurea seedlings cultivated from seeds from Gar County and Nagqu County after 7 and 14 days of drought stress and subsequent rewatering.The results showed that S.purpurea plants from the more arid Gar area were more tolerant to drought stress than that from Nagqu.To investigate the potential mechanisms underlying this difference,we used i TRAQ quantitative proteomics technology to analyze protein dynamics in S.purpurea samples treated with 7 days of drought stress and subsequent re-watering.The results indicated that,during the process of drought and re-watering treatments,there were differentially expressed proteins in either or both S.purpurea populations.These differential proteins were divided into 24 functional categories that were mainly associated with stress response,the antioxidant system,photosynthesis,carbohydrate metabolism,and post-translational modifications.According to these results,we concluded that the molecular basis of stronger drought resistance likely lies in the specific up-regulation or higher expression of many proteins involved in stress response,the antioxidant system,post-translational modification and osmotic regulation in S.purpurea from Gar County compared with that from Nagqu.This study improves our understanding of the intraspecific differences in drought resistance within S.purpurea populations,which helps to understand the distribution of S.purpurea along the moisture gradient,as well as the effect of climate change on this species. | Xiong Li Yunqiang Yang Shihai Yang Xudong Sun Xin Yin Youjie Zhao Yongping Yang | 2016 | 植物分类与资源学报2016，38，2： | 2 |
| 12 | Photoactivity of titanium dioxide/carbon felt composites prepared with the assistance of supercritical carbon dioxide: Effects of calcination temperature and supercritical conditions显示文摘TiO2-coated carbon felt(TCF)composite catalysts have been prepared via a supercritical treatment of titanium tetraisopropoxide(TTIP)as the precursor.The physical properties of the catalysts were characterized by means of thermogravimetric and differential thermal analysis(TG–DTA),X-ray diffraction(XRD),fluorescence spectroscopy,scanning electron microscopy (SEM),and BET surface areas techniques.The photocatalytic activities of the materials were evaluated using the degradation of Congo red(CR)as a probe reaction.All the composites showed much higher photocatalytic activity than commercial P25 due to significant synergistic effects.Reused TCF retained high photocatalytic activity for degradation of CR.The photocatalytic efficiency in CR degradation was found to be strongly dependent on the TiO2-coating ratio and calcination temperature.A possible mechanism for the enhanced reactivity involves shuttling of electrons from TiO2 particles to the carbon felt(CF)as a result of an optimal arrangement in TCF that stabilizes charge separation and reduces charge recombination.In addition to the significant synergistic effects,the abundant spaces between adjacent carbon fibers allow UV light to penetrate into the felt-like photocatalyst to a considerable depth,so that a three-dimensional environment is available for the photocatalytic reaction. | LI YouJi CHEN Wei LI LeiYong MA MingYuan | 2011 | Science China Chemistry2011，54，3： | 2 |
| 13 | Two-dimensional numerical simulation of hydrodynamic behaviors of drop covered with vapor film显示文摘The breakup of drop covered with vapor film is numerically simulated. The moving particle semi-implicit method is used to solve the 2-dimensional unsteady Navier-Stokes equations for drop, vapor and ambient fluid. The results show that vapor film suppresses the drop breakup and hence the critical Weber number increases with the increasing thickness of vapor film. The breakup process can be divided into two stages. The drop deformation and breakup mainly occur in the later stage. Three breakup mechanisms are unveiled, which are almost the same as that of drop breakup without vapor film except for the stronger Rayleigh-Taylor instability for drop with vapor film. Our simulation results are comparable with the previous experiments. | DUAN Riqiang, JIANG Shengyao, ZHANG Youjie, JIA Haijun & YANG Xingtuan Institute of Nuclear and New Energy Technology, Tsinghua University Advanced Reactor Engineering and Safety, Key Laboratory of MOE of China, Beijing 102201, China | 2005 | Science China(Technological Sciences)2005，48，2： | 2 |
| 14 | A Fast New Algorithm for Training Feed-forward Networks显示文摘 | HIDEAKI SAKAI | 1992 | IEEE Trains SP1992，49，1： | 1 |
| 15 | Link betweenHelicobacter pylori-associated gastritis and duodenal ulcer显示文摘 | Hiroshi Saita Dr. Motonobu Murakami Jung Kenn Yoo Sanae Teramura Hiroshi Dekigai Youji Takahashi Toru Kita | 1993 | Digestive Diseases and Sciences1993，，1： | 1 |
| 16 | A novel Notch3 deletion mutation in a Chinese patient with cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL)显示文摘 | Weiming F Yuliang W Youjie L | 2013 | J Clin Neurosci2013，20，2： | 1 |
| 17 | Thermal behavior of coal-tar pitch modified with BMI resin 显示文摘 | Lin Qilang Li Jintu Yang Youjie | 2010 | Journal of Analytical and Applied Pyrolysis2010，87，1： | 1 |
| 18 | Tea catechins decrease micellar solubility andintestinal absorption of cholesterol in rots显示文摘 | Ikuo I Youji I Eiji S | 1992 | Biochimica et Biophysica Acta (BBA)-lipids and lipid MetaboLism1992，1127，2： | 1 |
| 19 | CXCL12 secreted from glioma stem cells regulates their proliferation显示文摘 | Youji Uemae Eiichi Ishikawa Satoru Osuka Masahide Matsuda Noriaki Sakamoto Shingo Takano Kei Nakai Tetsuya Yamamoto Akira Matsumura | 2014 | Journal of Neuro-Oncology2014，，1： | 1 |
| 20 | Gankyrin plays an essential role in estrogen-driven and GPR30-mediated endometrial carcinoma cell proliferation via the PTEN/PI3K/AKT signaling pathway显示文摘 | Jiawen Zhang Yongbin Yang Zhenbo Zhang Yinyan He Zhiqiang Liu Yinhua Yu Sufang Wu Bin Cai Youji Feng | 2012 | Cancer Letters2012，，： | 1 |
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