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| 1 | One-step high-efficiency CRISPR/Cas9-mediated genome editing in Streptomyces显示文摘编辑技术 CRISPR 的指导 RNA 的 DNA 定期聚类 interspaced 短 palindromic repeats/Cas9 被用来介绍双 stranded 闯入染色体并且在细菌指导随后的地点特定的插入 / 删除或基因材料的代替例如 Escherichia coli,链球菌肺病,和乳杆菌 reuteri。在这研究,我们建立了在 Streptomyces 基因操作为使用编辑 plasmid pKCcas9dO 的一个高效率的 CRISPR/Cas9 染色体,它包括目标特定的指南 RNA,优化 codon 的 cas9,和二个指导相同的修理模板。由交付编辑 plasmids 进模型紧张 Streptomyces coelicolor M145 的 pKCcas9dO 系列,通过一步舞 intergeneric 转移,我们完成了与60%100%的高效率在不同层次编辑的染色体,包括单个基因删除,例如 actII-orf4 ,整顿,和 glnR ,并且单个大尺寸的基因簇删除,扮演 21.3 kb , undecylprodigiosin 红 31.6 kb ,和 Ca 2+-dependent 抗菌素例如 actinorhodin 的抗菌素 biosynthetic 簇 82.8 kb 。而且,我们也分别地与 54% 和 45% 的高效率认识到 actII-orf4 和整顿,并且 ACT 和红 biosynthetic 基因簇的同时的删除。最后,我们使用了这个系统介绍核苷酸点变化进 rpsL 基因,它与抵抗授与异种到链球菌。用这个系统,显著地,为一个轮染色体修正要求的时间被三分之一个减少或为常规方法的那些的一个一半。这些结果清楚地显示实质地编辑系统的确定的 CRISPR/Cas9 染色体改进与当前存在的方法相比编辑效率在的染色体 Streptomyces,和它在另外的放线菌种类为申请有诺言到染色体修正。 | He Huang Guosong Zheng Weihong Jiang Haifeng Hu Yinhua Lu | 2015 | Acta Biochimica et Biophysica Sinica2015，47，4： | 37 |
| 2 | Activation of the PI3K/AKT pathway mediates FSH-stimulated VEGF expression in ovarian serous cystadenocarclnoma显示文摘有证据建议那刺激滤泡的荷尔蒙(FSH ) 能由在癌症细胞增加脉管的 endothelial 生长因素(VEGF ) 表示便于卵巢的癌症的 neovascularization,尽管这个过程的内在的分子的机制不是众所周知的。因此,我们在卵巢的癌症房间线 SKOV-3 和 ES-2 在 VEGF 表示上调查了 FSH 的效果。有 FSH 的治疗显著地在一个剂量依赖者和时间依赖者举止增加了 VEGF 表示。另外, FSH 治疗提高了 survivin 和组织缺氧可诱导的 factor-1 (HIF-1 ) 的表示。survivin 或 HIF-1 击倒压制的 VEGF 表示,但是 survivin 仅仅击倒禁止的刺激 FSH 的 VEGF 表示。有 LY294002 的预告的处理,一个 phosphoinositide 3-kinase (PI3K )/AKT 禁止者,抵销 FSH,而是治疗与 U0126 导致的 survivin 的提高的表示,激活 mitogen 的蛋白质 kinase/extracellular 调整信号的 kinase 禁止者,没有如此的效果。我们进一步证明卵巢的浆液的 cystadenocarcinoma 样品有积极 AKT 和比的染色的 phosphorylated AKT (pAKT ) 蛋白质的许多更高的发生良性的卵巢的 cystadenoma 取样了(p < 0.01 ) 。5 年的幸存率仅仅在有卵巢的浆液的 cystadenocarcinoma 的病人是大约 15% 有 AKT 和 pAKT 表示,而它在没有 AKT 或 pAKT 表示的那些是大约 80% 。一起拿,这些结果显示 FSH 由 upregulating 增加 VEGF 的表示 survivin 的表示,它被发信号的 PI3K/AKT 激活小径。在 survivin 和 VEGF 的刺激 FSH 的表示理解 PI3K/AKT 小径的角色将为与卵巢的浆液的 cystadenocarcinoma 为病人评估预后并且为对这疾病追求有效治疗是有益的。 | Yan Huang Keqin Hua Xianrong Zhou Hongyan Jin Xiaojun Chen Xin Lu Yinhua Yu Xiliang Zha Youji Feng | 2008 | Cell Research2008，18，7： | 17 |
| 3 | Elimination of senescent cells byβ-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice显示文摘Cellular senescence,a persistent state of cell cycle arrest,accumulates in aged organisms,contributes to tissue dysfunction,and drives age-related phenotypes.The clearance of senescent cells is expected to decrease chronic,low-grade inflammation and improve tissue repair capacity,thus attenuating the decline of physical function in aged organisms.However,selective and effective clearance of senescent cells of different cell types has proven challenging.Herein,we developed a prodrug strategy to design a new compound based on the increased activity of lysosomalβ-galactosidase(β-gal),a primary characteristic of senescent cells.Our prodrug SSK1 is specifically activated byβ-gal and eliminates mouse and human senescent cells independently of senescence inducers and cell types.In aged mice,our compound effectively cleared senescent cells in different tissues,decreased the senescence-and age-associated gene signatures,attenuated low-grade local and systemic inflammation,and restored physical function.Our results demonstrate that lysosomalβ-gal can be effectively leveraged to selectively eliminate senescent cells,providing a novel strategy to develop anti-aging interventions. | Yusheng Cai Huanhuan Zhou Yinhua Zhu Qi Sun Yin Ji Anqi Xue Yuting Wang Wenhan Chen Xiaojie Yu Longteng Wang Han Chen Cheng Li Tuoping Luo Hongkui Deng | 2020 | Cell Research2020，30，7： | 12 |
| 4 | Forecasting Container Throughput of Qingdao Port with a Hybrid Model显示文摘This paper proposes a hybrid forecasting method to forecast container throughput of Qingdao Port.To eliminate the influence of outliers,local outlier factor(lof) is extended to detect outliers in time series,and then different dummy variables are constructed to capture the effect of outliers based on domain knowledge.Next,a hybrid forecasting model combining projection pursuit regression(PPR) and genetic programming(GP) algorithm is proposed.Finally,the hybrid model is applied to forecasting container throughput of Qingdao Port and the results show that the proposed method significantly outperforms ANN,SARIMA,and PPR models. | HUANG Anqiang LAI Kinkeung LI Yinhua WANG Shouyang | 2015 | Journal of Systems Science & Complexity2015，28，1： | 10 |
| 5 | SPEECH EMOTION RECOGNITION USING MODIFIED QUADRATIC DISCRIMINATION FUNCTION显示文摘Quadratic Discrimination Function (QDF) is commonly used in speech emotion recognition, which proceeds on the premise that the input data is normal distribution. In this paper, we propose a transformation to normalize the emotional features, then derivate a Modified QDF (MQDF) to speech emotion recognition. Features based on prosody and voice quality are extracted and Principal Component Analysis Neural Network (PCANN) is used to reduce dimension of the feature vectors. The results show that voice quality features are effective supplement for recognition, and the method in this paper could improve the recognition ratio effectively. | Zhao Yan Zhao Li Zou Cairong Yu Yinhua | 2008 | Journal of Electronics(China)2008，25，6： | 9 |
| 6 | Multicenter study of the clinicopathological features and recurrence risk prediction model of early-stage breast cancer with low-positive human epidermal growth factor receptor 2 expression in China (Chinese Society of Breast Surgery 021)显示文摘Background:Breast cancer with low-positive human epidermal growth factor receptor 2(HER2)expression has triggered further refinement of evaluation criteria for HER2 expression.We studied the clinicopathological features of early-stage breast cancer with low-positive HER2 expression in China and analyzed prognostic factors.Methods:Clinical and pathological data and prognostic information of patients with early-stage breast cancer with low-positive HER2 expression treated by the member units of the Chinese Society of Breast Surgery and Chinese Society of Surgery of Chinese Medical Association,from January 2015 to December 2016 were collected.The prognostic factors of these patients were analyzed.Results:Twenty-nine hospitals provided valid cases.From 2015 to 2016,a total of 25,096 cases of early-stage breast cancer were treated,7642(30.5%)of which had low-positive HER2 expression and were included in the study.After ineligible cases were excluded,6486 patients were included in the study.The median follow-up time was 57 months(4-76 months).The disease-free survival rate was 92.1%at 5 years,and the overall survival rate was 97.4%at 5 years.At the follow-up,506(7.8%)cases of metastasis and 167(2.6%)deaths were noted.Multivariate Cox regression analysis showed that tumor stage,lymphvascular invasion,and the Ki67 index were related to recurrence and metastasis(P<0.05).The recurrence risk prediction model was established using a machine learning model and showed that the area under the receiving operator characteristic curve was 0.815(95%confidence interval:0.750-0.880).Conclusions:Early-stage breast cancer patients with low-positive HER2 expression account for 30.5%of all patients.Tumor stage,lymphvascular invasion,and the Ki67 index are factors affecting prognosis.The recurrence prediction model for breast cancer with low-positive HER2 expression based on a machine learning model had a good clinical reference value for predicting the recurrence risk at 5 years.Trial registration:ChiCTR.org.cn,ChiCTR2100046766. | Ling Xin Qian Wu Chongming Zhan Hongyan Qin Hongyu Xiang Ling Xu Jingming Ye Xuening Duan Yinhua Liu Chinese Society of Breast Surgery(CSBrS) Chinese Society of Surgery of Chinese Medical Association | 2022 | Chinese Medical Journal2022，，6： | 9 |
| 7 | A retrospective prognostic evaluation analysis using the 8th edition of American Joint Committee on Cancer(AJCC)cancer staging system for luminal A breast cancer显示文摘Objective: We retrospectively analyzed the clinical prognostic value of the 8th edition of the American Joint Committee on Cancer(AJCC) staging system for luminal A breast cancer.Methods: Using both the anatomic and prognostic staging in the 8th edition of AJCC cancer staging system, we restaged patients with luminal A breast cancer treated at the Breast Disease Center, Peking University First Hospital from 2008 to 2014. Follow-up data including 5-year disease free survival(DFS), overall survival(OS) and other clinic-pathological data were collected to analyze the differences between the two staging subgroups.Results: This study included 421 patients with luminal A breast cancer(median follow-up, 61 months). The 5-year DFS and OS rates were 98.3% and 99.3%, respectively. Significant differences in 5-year DFS but not OS were observed between different anatomic disease stages. Significant differences were observed in both 5-year DFS and OS between different prognostic stages. Application of the prognostic staging system resulted in assignment of 175 of 421 patients(41.6%) to a different group compared to their original anatomic stages. In total, 102 of 103 patients with anatomic stage IIA changed to prognostic stage IB, and 24 of 52 patients with anatomic stage IIB changed to prognostic stage IB, while 1 changed to prognostic stage IIIB. Twenty-two of 33 patients with anatomic stage IIIA were down-staged to IIA when staged by prognostic staging system, and the other 11 patients were down-staged to IIB. Two patients with anatomic stage IIIB were down-staged to IIIA. Among seven patients with anatomic stage IIIC cancer, two were down-staged to IIIA and four were down-staged to stage IIIB.Conclusions: The 8th edition of AJCC prognostic staging system is an important supplement to the breast cancer staging system. More clinical trials are needed to prove its ability to guide selection of proper systemic therapy and predict prognosis of breast cancer. | jingming ye wenjun wang ling xu xuening duan yuanjia cheng ling xin hong zhang shuang zhang ting li yinhua liu | 2017 | Chinese Journal of Cancer Research2017，29，4： | 8 |
| 8 | Improvement of pristinamycin I(PI)production in Streptomyces pristinaespiralis by metabolic engineering approaches显示文摘Pristinamycin,produced by Streptomyces pristinaespiralis,which is a streptogramin-like antibiotic consisting of two chemically unrelated components:pristinamycin I(PI)and pristinamycin II(PII),shows potent activity against many antibiotic-resistant pathogens.However,so far pristinamycin production titers are still quite low,particularly those of PI.In this study,we constructed a PI single component producing strain by deleting the PII biosynthetic genes(snaE1 and snaE2).Then,two metabolic engineering approaches,including deletion of the repressor gene papR3 and chromosomal integration of an extra copy of the PI biosynthetic gene cluster(BGC),were employed to improve PI production.The final engineered strain DPIIDpapR3/PI produced a maximum PI level of 132 mg/L,with an approximately 2.4-fold higher than that of the parental strain S.pristinaespiralis HCCB10218.Considering that the PI biosynthetic genes are clustered in two main regions in the 210 kb“supercluster”containing the PI and PII biosynthetic genes as well as a cryptic polyketide BGC,these two regions were cloned separately and then were successfully assembled into the PI BGC by the transformation-associated recombination(TAR)system.Collectively,the metabolic engineering approaches employed is very efficient for strain improvement in order to enhance PI titer. | Jiali Meng Rongrong Feng Guosong Zheng Mei Ge Yvonne Mast Wolfgang Wohlleben Jufang Gao Weihong Jiang Yinhua Lu | 2017 | Synthetic and Systems Biotechnology2017，2，2： | 7 |
| 9 | Metabolic engineering of Streptomyces coelicolor for enhanced prodigiosins (RED) production显示文摘Bacterial prodigiosins are red-colored secondary metabolites with multiple activities,such as anticancer,antimalarial and immunosuppressive,which hold great potential for medical applications.In this study,dramatically enhanced prodigiosins(RED) production in Streptomyces coelicolor was achieved by combinatorial metabolic engineering,including inactivation of the repressor gene ohkA,deletion of the actinorhodin(ACT) and calcium-dependent antibiotic(CDA) biosynthetic gene clusters(BGCs) and multi-copy chromosomal integration of the RED BGC.The results showed that ohkA deletion led to a 1-fold increase of RED production over the wild-type strain M145.Then,the ACT and CDA BGCs were deleted successively based on the AohkA mutant(SBJ101).To achieve multi-copy RED BGC integration,artificial ΦC31 attB site(s) were inserted simultaneously at the position where the ACT and CDA BGCs were deleted.The resulting strains SBJ102(with a single deletion of the ACT BGC and insertion of one artificial attB site) and SBJ103(with the deletion of both BGCs and insertion of two artificial attB sites) produced 1.9-and 6-fold higher RED titers than M145,respectively.Finally,the entire RED BGC was introduced into mutants from SBJ101 to SBJ103,generating three mutants(from SBJ104 to SBJ106) with chromosomal integration of one to three copies of the RED BGC.The highest RED yield was from SBJ106,which produced a maximum level of 96.8 mg g^(-1) cell dry weight,showing a 12-fold increase relative to M145.Collectively,the metabolic engineering strategies employed in this study are very efficient for the construction of high prodigiosin-producing strains. | Panpan Liu Hong Zhu Guosong Zheng Weihong Jiang Yinhua Lu | 2017 | Science China(Life Sciences)2017，60，9： | 7 |
| 10 | Multicenter prospective study of magnetic resonance imaging prior to breast-conserving surgery for breast cancer显示文摘 | Liu Qian Liu Yinhua Xu Ling Duan Xuening Li Ting Qin Naishan Kang Hua Jiang Hongchuan Yang Deqi Qu Xiang Jiang Zefei Yu Chengze | 2014 | Chinese Medical Journal2014，，13： | 6 |
| 11 | Detection of periodontal pathogens in the patients with aortic aneurysm显示文摘 | Ding Fang Lyu Yalin Han Xiao Zhang Hai Liu Dongyu Hei Wei Liu Yinhua | 2014 | Chinese Medical Journal2014，，23： | 6 |
| 12 | A Contact Force Model Considering Meshing and Collision States for Dynamic Analysisin Helical Gear System显示文摘The current research on gear system dynamics mainly utilizes linear spring damping model to calculate the contact force between gears. However, this linear model cannot correctly describe the energy transfer process of collision that often occurs in gear system. Focus on the contact-impact events, this paper proposes an improved gear contact force model for dynamic analysis in helical gear transmission system. In this model, a new factor associated with hysteresis damping is developed for contact-impact state, whereas the traditional linear damping factor is utilized for normal meshing state. For determining the selection strategy of these two damping factors, the fundamental contact mechanics of contact-impact event affected by supporting forces are analyzed. During this analysis, an effect factor is proposed for evaluating the influence of supporting forces on collision. Meanwhile, a new restitution of coefficient is deduced for calculating hysteresis damping factor, which suitable for both separation and non-separation states at the end of collision. In addition, the time-varying meshing stiffness (TVMS) is obtained based on the potential energy approach and the slice theory. Finally, a dynamic analysis of a helical gear system is carried out to better understand the contact force model proposed in this paper. The analysis results show that the contribution of supporting forces to the dynamic response of contact-impact event within gear pair is important. The supporting forces and dissipative energy are the main reasons for gear system to enter a steady contact state from repeated contact-impact state. This research proposes an improved contact force model which distinguishes meshing and collision states in gear system. | Dong Xiang Yinhua Shen Yaozhong Wei | 2019 | Chinese Journal of Mechanical Engineering2019，32，3： | 5 |
| 13 | Recent progress in organic solar cells(PartⅠmaterial science)显示文摘During past several years,the photovoltaic performances of organic solar cells(OSCs)have achieved rapid progress with power conversion efficiencies(PCEs)over 18%,demonstrating a great practical application prospect.The development of material science including conjugated polymer donors,oligomer-like organic molecule donors,fused and nonfused ring acceptors,polymer acceptors,single-component organic solar cells and water/alcohol soluble interface materials are the key research topics in OSC field.Herein,the recent progress of these aspects is systematically summarized.Meanwhile,the current problems and future development are also discussed. | Yahui Liu Bowen Liu Chang-Qi Ma Fei Huang Guitao Feng Hongzheng Chen Jianhui Hou Lingpeng Yan Qingya Wei Qun Luo Qinye Bao Wei Ma Wei Liu Weiwei Li Xiangjian Wan Xiaotian Hu Yanchun Han Yaowen Li Yinhua Zhou Yingping Zou Yiwang Chen Yongfang Li Yongsheng Chen Zheng Tang Zhicheng Hu Zhi-Guo Zhang Zhishan Bo | 2022 | Science China Chemistry2022，65，2： | 5 |
| 14 | Histo-and clinico-pathological analysis of a large series of triple-negative breast cancer in a single center in China:Evidences on necessity of histological subtyping and grading显示文摘Objective: To investigate histo-pathological distribution and clinico-pathological significance in a large Chinese triple-negative breast cancer(TNBC) patients serials based on the latest understanding of its clinico-pathological diversity, and to provide more information to clinicians to improve precision of individualized treatment of TNBC.Methods: A retrospective analysis was performed on patients with TNBC at Breast Disease Center, Peking University First Hospital between January 2010 and December 2019. Histo-and clinico-pathological characteristics were analyzed by Chi-square test and Student's t-test, and prognoses were calculated using KaplanMeier method and a Cox proportionate hazards model. Bonferroni correction was used to correct for multiple comparison.Results: Conventional type of TNBC(c TNBC) were identified in 73.7% of 582 TNBC, while special type of TNBC(s TNBC) were 26.3%, including 71 apocrine carcinoma, 20 medullary carcinoma, 31 metaplastic carcinoma, 18 invasive lobular carcinoma, 7 invasive micropapillary carcinoma, 5 adenoid cystic carcinoma and 1 acinic cell carcinoma. Compared to s TNBC, c TNBC was associated with high histologic grade(P<0.001) and lower androgen receptor(AR) expression(P<0.001). TNM stage of low-grade c TNBC was significantly lower than that of high-grade c TNBC(P=0.002). Although no significant difference, there was a trend that the rate of 5-year disease-free survival(DFS) and 5-year overall survival(OS) were longer in high-grade c TNBC than in high-grade s TNBC(P=0.091 and 0.518), and were longer in low-grade s TNBC than in high-grade s TNBC(P=0.051 and0.350). Metaplastic carcinomas showed larger tumor size(P=0.008) and higher proliferative Ki67 index(P=0.004)than c TNBCs.Conclusions: Results from our cohort imply that sub-categorization or subtyping and histological grading could be meaningful in pathological evaluation of TNBC, and need to be clarified in more large collections of TNBC. | Shuang Zhang Sixia Huang Hong Zhang Dong Li Xin Li Yuanjia Cheng Qian Liu Ling Xu Yue Wang Yinhua Liu Ting Li | 2020 | Chinese Journal of Cancer Research2020，32，5： | 5 |
| 15 | Development of polymer–fullerene solar cells显示文摘Global efforts and synergetic interdisciplinary collaborations on solution-processed bulk-heterojunction polymer solar cells(PSCs or OPVs) made power conversion efficiencies over 10%possible.The rapid progress of the field is credited to the synthesis of a large number of novel polymers with specially tunable optoelectronic properties,a better control over the nano-morphology of photoactive blend layers,the introduction of various effective interfacial layers,new device architectures and a deeper understanding of device physics.We will review the pioneering materials for polymer-fullerene solar cells and trace the progress of concepts driving their development.We discuss the evolution of morphology control,interfacial layers and device structures fully exploring the potential of photoactive materials.In order to guide a further increase in power conversion efficiency of OPV,the current understanding of the process of free charge carrier generation and the origin of the photovoltage is summarized followed by a perspective on how to overcome the limitations for industrializing PSCs. | Fengling Zhang Olle Ingans Yinhua Zhou Koen Vandewal | 2016 | National Science Review2016，3，2： | 4 |
| 16 | Recent progress in organic solar cells(PartⅡdevice engineering)显示文摘1 Introduction Organic solar cells(OSCs)belong to a multidisciplinary field composed of chemistry,materials science,physics,engineering,etc.For a better reviewing of this field,we briefly divide the research field of OSCs into two parts:material science and device engineering.In our previous review,the material science part of OSCs,including conjugated polymer donors and acceptors,small molecular donors and acceptors. | Yahui Liu Bowen Liu Chang-Qi Ma Fei Huang Guitao Feng Hongzheng Chen Jianhui Hou Lingpeng Yan Qingya Wei Qun Luo Qinye Bao Wei Ma Wei Liu Weiwei Li Xiangjian Wan Xiaotian Hu Yanchun Han Yaowen Li Yinhua Zhou Yingping Zou Yiwang Chen Yuqiang Liu Lei Meng Yongfang Li Yongsheng Chen Zheng Tang Zhicheng Hu Zhi-Guo Zhang Zhishan Bo | 2022 | Science China Chemistry2022，65，8： | 3 |
| 17 | Pilose antler polypeptides ameliorates hypoxic- ischemic encephalopathy by activated neurotrophic factors and SDF1/CXCR4 axis in rats显示文摘Hypoxic-ischemic encephalopathy (催促) 是与高死亡和病态被联系的一个复杂条件。然而,很少有希望的处理为催促存在。在现在的学习,中央目的是识别覆有毛的鹿角多肽(奶头) 的治疗学的效果在上在老鼠催促。Sprague-Dawley (SD ) 老鼠(14 天旧) 被使用并且把组划分了成三包括控制组, hypoxic 局部缺血(嗨) 组和奶头组。在 21 天处理以后,运动活动在对待奶头的老鼠被改进,大脑萎缩被减少,服的浮肿被减轻到某程度。实时量的聚合酶链反应(RT-qPCR ) 分析显示奶头管理减少了在马头鱼尾的怪兽的煽动性的 cytokines 和 apoptosis 基因的表情与相比嗨组。而且,与神经营养的因素有关的基因的 mRNA 表情显著地在马头鱼尾的怪兽被增加。另外,氧化压力标记的表情都在奶头管理以后是下面调整的。而且,奶头起来调整 mRNA 和 SDF1 和 CXCR4 的蛋白质层次,它可以激活 SDF1/CXCR4 轴到节制大脑损害。这些结果建议那个奶头可以潜在地在处理被使用催促。 | Tao Wu Luna Yang Yan Chen Yinhua Ni Jianguo Jiang Wanjing Zhang Qianchen Zhou Xiaojun Zheng Qi Wang Zhengwei Fu Haifeng Li | 2018 | Acta Biochimica et Biophysica Sinica2018，50，3： | 3 |
| 18 | 关于中澳自由贸易协议潜在优势的分析模型——一份为中澳自由贸易协议可行性研究作准备的独立报告显示文摘1.2002年,为了促进双边贸易和投资,中国和澳大利亚建立了一个经济贸易框架。在这个框架下,一项关于未来中澳自由贸易协定(FTA)的联合可行性研究已经出炉。2.受澳大利亚外交贸易部委任,莫纳什大学的政策研究中心对关于中澳自由贸易协定所带来的潜在利益进行模型分析,并与来自中国社科院和南开大学的专家共同着手这项研究。3.在这项研究中,我们从三个方面对自由贸易协定进行模拟:消除商品贸易中的边境保护主义、投资自由化以及消除服务贸易壁垒。分析框架为一个多国家、多部门的可计算的一般均衡模型,即'莫纳什的多国家模型'。在我们的模拟中,假设基于自由贸易协定下的政策调整是于2006年开始贯彻落实的。4.在模拟FTA下政策调整所带来的冲击方面,我们首先模拟了一个常规发展模式(或称'基准模式'),基准模式描述了在中澳没有签订FTA情况下中国和澳大利亚经济的发展进程。与基准假设相比,其改变程度将被视为FTA下政策调整所带来的效应。5.从模型中,我们可以得出这样的结论:FTA使得中澳两国的产出增加并使得福利提高。据估计,FTA将提高中澳两国2006年至2015年期间的实际国内生产总值(GDP)和实际国民生产总值(GNP)的现值(见42页图表7.1),数值如下:澳大利亚实际GDP:180亿美元中国实际GDP:640亿美元澳大利亚实际GNP:220亿美元中国实际GNP:520亿美元6.从2005年至2015年期间的年均增长率方面来讲,FTA估计将使澳大利亚的实际GDP年均增长0.039个百分点,使中国的实际GDP年均增长0.042个百分点。7.两国实际GDP的增长主要归功于不断增加的资本、不断提高的生产率水平和得到优化利用的资源。澳大利亚实际GDP增长的一个潜在的重要因素就是贸易条件的改善。8.通过不断增长的双边贸易和投资,FTA强化了中澳双方的经济合作伙伴关系;就整体而言,它也在世界范围内创造了贸易:由于中澳FTA的签订,世界进口量相较于基线水平也相应增长。9.为了更好地利用资源,两国实现了各部门之间的劳动力调整,这主要是为了消除商品贸易边境保护主义。然而,由于两国之间的互补性,部门间的这种劳动力再分配还是更倾向于促进两国间已发生的自然调整进程。而且,与中澳两国在还没有自由贸易协定时的全球化中已发生的合作相比,这种调整只能属于小规模范畴的调整。10.澳大利亚从自由贸易协定获利最大的产业有谷物、羊毛织品、绒线、矿物和有色金属。中国获利最大的产业则是制造业,特别是纺织品、服装和其它杂项制成品(如玩具和体育用品等);而两国的服务部门则都能从FTA中获益。11.如果2006年至2010年期间,政策调整能够逐步实施,则至2015年FTA所带来的长期效应将和在2006年完全贯彻执行FTA的效果没有区别。然而,越早实施FTA将会使两国更早获益,而相比较而言,如果采取不急不愠的措施,那么其导致实际GDP和实际GNP获益的现值将减少。 | Yinhua MAI Philip ADAMS Mingtai FAN Ronglin LI Zhaoyang ZHENG 黄姗姗 郑秀莲 王思婷 熊爱宗 洪冬梅 | 2007 | 经济资料译丛2007，，3： | 3 |
| 19 | Green production of sugar by membrane technology:How far is it from industrialization?显示文摘Application of membrane filtration in sugar production is attractive because it can reduce the usage of chemicals,produce high-quality clarified juice,and obtain various high value-added products.However,some technical problems,such as insufficient membrane performance,high sucrose loss in membrane retentate,severe membrane fouling,and incomplete cleaning protocols,limit its industrial applications.In order to facilitate the development of membrane technology for sugar production,this review summarizes recent progress on the applications of membrane filtration in different stages of sugar production as well as the integrated membrane processes for various purposes.Moreover,some important issues including membrane fouling,membrane cleaning,economic feasibility and engineering problems of the membrane-based sugar production process are discussed.Finally,the existing challenges and future research prospects for the industrialization of this green technique are pointed out. | Hao Zhang Jianquan Luo Lulu Liu Xiangrong Chen Yinhua Wan | 2021 | Green Chemical Engineering2021，2，1： | 3 |
| 20 | AgBF_4/[emim][BF_4] supported ionic liquid membrane for carbon monoxide/nitrogen separation显示文摘In this paper,AgBF_4/[emim][BF_4] supported ionic liquid membranes(SILMs) were prepared successfully for CO/N_2 separation using nitrogen pressure immobilization procedures.The incorporation of AgBF_4 could decrease membrane weight loss,improve the pressure-resistant ability,and keep the critical pressure(0.45 MPa) of the SILMs.The high viscosity and undissolved Ag BF_4 solids in membrane liquid would disturb gas molecular transport through membrane and give rise to the gas transport resistance.Therefore,the gas permeability decreased remarkably with increasing AgBF_4 carrier content in the membrane.When the molar ratio of AgBF_4 to [emim][BF_4] increased from 0:1 to 0.3:1,the CO/N_2 selectivity of the SILMs showed a great increase from ~1 to ~9 at 20 °C and 0.4 MPa,suggesting that AgBF_4 was an effective carrier for CO facilitated transport.The permeabilities of N_2 and CO increased at higher transmembrane pressure,indicating that molecular transport would dominate the transport process at high pressure.The temperature-dependent gas permeability followed the Arrhenius equation.Moreover,the differences between the activation energies of CO and N_2 became larger after introducing AgBF_4,resulting in more obvious decrease in the CO/N_2 selectivity at higher operating temperature. | Shichao Feng Yuanyuan Wu Jianquan Luo Yinhua Wan | 2019 | Journal of Energy Chemistry2019，28，2： | 2 |
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