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| 1 | Karyotype Stability and Unbiased Fractionation in the Paleo-Allotetraploid Cucurbita Genomes显示文摘 | Honghe Sun Shan WU Guoyu Zhang Chen Jiao Shaogui Guo Yi Ren Jie Zhang Haiying Zhang Guoyi Gong Zhangcai Jia Fan Zhang Jiaxing Tian William J. Lucas Jeff J. Doyle Haizhen Li Zhangjun Fei Yong Xu | 2017 | Molecular Plant2017，10，10： | 33 |
| 2 | Efficacy of Shenzhuo formula on diabetic kidney disease:a retrospective study显示文摘OBJECTIVE:To observe the efficacy of a traditional Chinese medicine,Shenzhuo formula,on patients with diabetic kidney disease(DKD).METHODS:Eighty-eight outpatients with DKD were enrolled.Changes in estimated glomerular filtration rate(eGFR),creatinine clearance,serum creatinine,blood-urea-nitrogen,albuminuria,glycosylated hemoglobin(Hb_(A1C)),blood pressure,and lipid profile were measured and analyzed before and after intervention with Shenzhuo formula for 1,3,6,9,12,and 18 months.RESULTS:Compared with the baseline amounts,serum creatinine decreased,and eGFR and creatinine clearance increased,significantly after intervention for 1,3,6,9,12,and 18 months(all P < 0.05).Mean eGFR increased by 2.11 mL/min per 1.73 m7 y after18-month treatment.Urinary protein at 24 h decreased significantly after 1,3,9,and 12 months(P < 0.05).Hb_(A1C) decreased significantly(P < 0.05) after 3,6,9,12,and 18 months,and systolic blood pressure decreased significantly(P < 0.05) after 1,3,and 6 months.Total cholesterol decreased significantly(P < 0.05) after 1,3,6,and 18 months.Triglyceride and low-density lipoprotein-cholesterol decreased significantly(P < 0.05) after 1 and 3 months.CONCLUSION:Shenzhuo formula can improve eGFR and possibly slow DKD progression.Shenzhuo formula can also lower Hb_(A1C),lipid levels and blood pressure. | Tian Jiaxing Zhao Linhua Zhou Qiang Liu Wenke Chen Xinyan Lian Fengmei Tong Xiaolin | 2015 | Journal of Traditional Chinese Medicine2015，35，5： | 8 |
| 3 | Xuefuzhuyu decoction for hyperlipidemia: a systematic review and Meta-analysis of randomized clinical trails显示文摘OBJECTIVE:To evaluate the efficacy and safety of Xuefuzhuyu decoction for hyperlipidemia.METHODS:Randomized clinical trials on hyperlipidemia treated by Xuefuzhuyu decoction,either alone or with Western Medicine,were searched in electronic databases.Databases searched were:MEDLINE,Allied and Complementary Medicine Database,EMBASE,The Cochrane Library 2013(Issue4),China National Knowledge Infrastructure Database,Chinese Biomedical Literature Database,and Wanfang Database up to 2 May,2013.Study selection,data extraction,quality assessment,and data analysis were conducted according to the Cochranestandards.RESULTS:Six randomized clinical trials involving748 patients(373 patients in the treatment group,375 patients in the control group)were included in the analysis.The studies were of low methodological quality.Meta-analysis indicated that the effect of Xuefuzhuyu decoction on hyperlipidemia was better than that in the control group[n=748,OR=5.07,95%CI(3.40,7.58),P<0.01].Weighted mean differencesin total cholesterol,low-densitylipoprotein cholesterol,triglycerides,and high-density lipoprotein cholesterol were﹣0.79,﹣0.74,﹣0.44,0.16,respectively,and Meta-analysis revealed that the treatment group was better than the control group with 95%CI(﹣1.21,﹣0.36),(﹣0.94,﹣0.55),(﹣0.77,﹣0.11),(0.04,0.27),respectively(all P<0.05).Some adverse events in evaluated studies wererecorded.CONCLUSION:Xuefuzhuyu decoction may be effective for treating hyperlipidemia.The studies we analyzed were of low methodological quality,which indicates that the above findings should be considered cautiously.Therefore,more strictly designed large-scale randomized clinical trials are needed to evaluate the efficacy of Xuefuzhuyu decoction in hyperlipidemia. | Jiangquan Liao Jiaxing Tian Tengfei Li Weijiang Song Weihan Zhao Jinhang Du | 2014 | Journal of Traditional Chinese Medicine2014，34，4： | 5 |
| 4 | Successful treatment of latent autoimmune diabetes in adults with Traditional Chinese Medicine: a case report显示文摘INTRODUCTION: Latent autoimmune diabetes in adults(LADA) is regarded as one of the Insulin-dependent diabetes mellitus that progress slowly. It gradually became understood since 1970s. The onset usually appears in adulthood, the islet autoantibodies are positive and the function of β cell is declined rapidly.The treatment is insulin injection. CASE PRESENTATION: The case reported followed is a 37-year-old male patient who was newly diagnosed with type 2 diabetes. He abandoned oral hypoglycemic agents since they caused stomach indisposed. Before visiting, his islet autoantibodies were detected positive and he had never injected insulin before. We treated him with traditional Chinese herbals under the guidance of Traditional Chinese Medicine and differentiation, and achieved fine efficacy. CONCLUSION: Because the initial presentation of LADA is similar to Type 2 Diabetes Mellitus and examination is not in common use, misdiagnosis is not rare. Once LADA is diagnosed, the therapy must be adjusted. This case report indicated that Traditional Chinese Medicine might be an alternative treatment for LADA. | Jiaxing Tian Wenke Liu Zhong Zhen Xiaolin Tong | 2013 | Journal of Traditional Chinese Medicine2013，33，6： | 2 |
| 5 | Distributed Stepping Motor Control System显示文摘The beam diagnostic devices used at RIBLL are driven by stepper motors, which are controlled by I/O modules based on ISA-bus in an industrial computer. The disadvantages of such mode are that a large number of long cables are used and one computer to control is unsafe. We have developed a distributed stepping motor control system for the remote, local and centralized control of the stepping motors. RS-485 bus is used for the connection between the remote control unit and the local control units. The con... | Bai Jie, Chen Zhiqiang, Xiao Guoqing, Zhan Wenlong, Guo Zhongyan, Wang Meng, Sun Zhiyu Li Jiaxing, Tian Wendong, Wang Jiansong, Wang Wusheng, Mao Ruishi, Chen Zhiqiang Hu Zhcngguo, Chen Lixin and Li Ch | 2001 | IMP & HIRFL Annual Report2001，，1： | 1 |
| 6 | Discretely-supported nanoimprint lithography for patterning the high-spatial-frequency stepped surface显示文摘Non-planar morphology is a common feature of devices applied in various physical fields,such as light or fluid,which pose a great challenge for surface nano-patterning to improve their performance.The present study proposes a discretely-supported nanoimprint.lithography(NIL)technique to fabricate nanostructures on the extremely non-planar surface,namely high-spatial-frequency stepped surface.The designed discretely imprinting template implanted a discretely-supported intermediate buffer layer made of sparse pillars arrays.This allowed the simultaneous generation of air-cushion-like buffer and reliable support to the thin structured layer in the template.The resulting low bending stiffness and distributed concentrated load of the template jointly overcome the contact difficulty with a stepped surface,and enable the template to encase the stepped protrusion as tight as possible.Based on the proposed discretely-supported NIL,nanostructures were fabricated on the luminous interface of light emitting diodes chips that covered with micrometer step electrodes pad.About 96%of the utilized indium tin oxide transparent current spreading layer surface on top of the light emitting diode(LED)chips was coated with nanoholes array,with an increase by more than 40%in the optical output power.The excellent ability of nanopatterning a non-planar substrate could potentially lead innovate design and development of high performance device based on discretely-supported NIL. | Chunhui Wang Yu Fan Jinyou Shao Zhengjie Yang Jiaxing Sun Hongmiao Tian Xiangming Li | 2021 | Nano Research2021，14，8： | 1 |
| 7 | Novel mutation c.1210-3C>G in cis with a poly-T tract of 5T affects CFTR mRNA splicing in a Chinese patient with cystic fibrosis显示文摘Cystic fibrosis(CF)is a rare autosomal recessive disease with only one pathogenic gene cystic fibrosis transmembrane conductance regulator(CFTR).To identify the potential pathogenic mutations in a Chinese patient with CF,we conducted Sanger sequencing on the genomic DNA of the patient and his parents and detected all 27 coding exons of CFTR and their flanking intronic regions.The patient is a compound heterozygote of c.2909G>A,p.Gly970Asp in exon 18 and c.1210-3C>G in cis with a poly-T of 5T(T5)sequence,3 bp upstream in intron 9.The splicing effect of c.1210-3C>G was verified via minigene assay in vitro,indicating that wild-type plasmid containing c.1210-3C together with T7 sequence produced a normal transcript and partial exon 10-skipping-transcript,whereas mutant plasmid containing c.1210-3G in cis with T5 sequence caused almost all mRNA to skip exon 10.Overall,c.1210-3C>G,the newly identified pathogenic mutation in our patient,in combination with T5 sequence in cis,affects the CFTR gene splicing and produces nearly no normal transcript in vitro.Moreover,this patient carries a p.Gly970Asp mutation,thus confirming the high-frequency of this mutation in Chinese patients with CF. | Xinyue Zhao Keqiang Liu Wenshuai Xu Meng Xiao Qianli Zhang Jiaxing Song Keqi Chen Yaping Liu Xinlun Tian Kai-Feng Xu Xue Zhang | 2022 | Frontiers of Medicine2022，16，1： | 1 |
| 8 | Polarization assisted self-powered GaN-based UV photodetector with high responsivity显示文摘In this work, a self-powered GaN-based metal-semiconductor-metal photodetector(MSM PD) with high responsivity has been proposed and fabricated. The proposed MSM PD forms an asymmetric feature by using the polarization effect under one electrode, such that we adopt an AlGaN/GaN heterojunction to produce the electric field,and by doing so, an asymmetric energy band between the two electrodes can be obtained even when the device is unbiased. The asymmetric feature is proven by generating the asymmetric current-voltage characteristics both in the dark and the illumination conditions. Our results show that the asymmetric energy band enables the selfpowered PD, and the peak responsivity wavelength is 240 nm with the responsivity of 0.005 A/W. Moreover, a high responsivity of 13.56 A/W at the applied bias of 3 V is also achieved. Thanks to the very strong electric field in the charge transport region, when compared to the symmetric MSM PD, the proposed MSM PD can reach an increased photocurrent of 100 times larger than that for the conventional PD, even if the illumination intensity for the light source becomes increased. | JIAXING WANG CHUNSHUANG CHU KANGKAI TIAN JIAMANG CHE HUA SHAO YONGHUI ZHANG KE JIANG ZI-HUI ZHANG XIAOJUAN SUN DABING LI | 2021 | Photonics Research2021，9，5： | 1 |
| 9 | High carrier mobility and strong fluorescence emission: Toward highly sensitive single-crystal organic phototransistors显示文摘Organic single crystals(OSCs)offer a unique combination of both individual and collective properties of the employed molecules,but it remains highly challenging to achieve OSCs with both high mobilities and strong fluorescence emissions for their potential applications in multifunctional optoelectronics.Herein,we demonstrate the design and synthesis of two novel triphenylamine-functionalized thienoacenes-based organic semiconductors,4,8-distriphenylamineethynylbenzo[1,2-b:4,5-b′]dithiophene(4,8-DTEBDT)and 2,6-distriphenylamineethynylbenzo[1,2-b:4,5-b′]dithiophene(2,6-DTEBDT),with high-mobility and strong fluorescence emission.The two compounds show the maximum mobilities up to 0.25 and 0.06 cm^(2) V^(-1) s^(-1),the photoluminescence quantum yields(PLQYs)of 51% and 45%,and the small binding energies down to 55.13 and 58.79 meV.The excellent electrical and optical properties ensured the application of 4,8-DTEBDT and 2,6-DTEBDT single crystals in ultrasensitive UV phototransistors,achieving high photoresponsivity of 9.60×105 and 6.43×10^(4) AW^(-1),and detectivity exceeding 5.68×10^(17) and 2.99×10^(16) Jones. | Jingwei Tao Zhaoyang Liu Dan Liu Huanli Dong Jiangbo Jing Jiaxing Song Leijing Liu Bin Xu Wenjing Tian | 2023 | Aggregate2023，4，2： | 0 |
| 10 | Application of synthetic biology in bladder cancer显示文摘Bladder cancer(BC)is the most common malignant tumor of the genitourinary system.The age of individuals diagnosed with BC tends to decrease in recent years.A variety of standard therapeutic options are available for the clinical management of BC,but limitations exist.It is difficult to surgically eliminate small lesions,while radiation and chemotherapy damage normal tissues,leading to severe side effects.Therefore,new approaches are required to improve the efficacy and specificity of BC treatment.Synthetic biology is a field emerging in the last decade that refers to biological elements,devices,and materials that are artificially synthesized according to users’needs.In this review,we discuss how to utilize genetic elements to regulate BC-related gene expression periodically and quantitatively to inhibit the initiation and progression of BC.In addition,the design and construction of gene circuits to distinguish cancer cells from normal cells to kill the former but spare the latter are elaborated.Then,we introduce the development of genetically modified T cells for targeted attacks on BC.Finally,synthetic nanomaterials specializing in detecting and killing BC cells are detailed.This review aims to describe the innovative details of the clinical diagnosis and treatment of BC from the perspective of synthetic biology. | Mengting Ding Jiaxing Lin Caipeng Qin Ping Wei Jiahe Tian Tianxin Lin Tao Xu | 2022 | Chinese Medical Journal2022，135，18： | 0 |
| 11 | Electric-driven flexible-roller nanoimprint lithography on the stress-sensitive warped wafer显示文摘Surface nanopatterning of semiconductor optoelectronic devices is a powerful way to improve their quality and performance.However,photoelectric devices’inherent stress sensitivity and inevitable warpage pose a huge challenge on fabricating nanostructures large-scale.Electric-driven flexible-roller nanoimprint lithography for nanopatterning the optoelectronic wafer is proposed in this study.The flexible nanoimprint template twining around a roller is continuously released and recovered,controlled by the roller’s simple motion.The electric field applied to the template and substrate provides the driving force.The contact line of the template and the substrate gradually moves with the roller to enable scanning and adapting to the entire warped substrate,under the electric field.In addition,the driving force generated from electric field is applied to the surface of substrate,so that the substrate is free from external pressure.Furthermore,liquid resist completely fills in microcavities on the template by powerful electric field force,to ensure the fidelity of the nanostructures.The proposed nanoimprint technology is validated on the prototype.Finally,nano-grating structures are fabricated on a gallium nitride light-emitting diode chip adopting the solution,achieving polarization of the light source. | Yu Fan Chunhui Wang Jiaxing Sun Xiaogang Peng Hongmiao Tian Xiangming Li Xiaoliang Chen Xiaoming Chen Jinyou Shao | 2023 | International Journal of Extreme Manufacturing2023，5，3： | 0 |
| 12 | ZnO/ZnS core-shell composites for low-temperature-processed perovskite solar cells显示文摘Electron transport layers(ETLs)in perovskite solar cells(PSCs)are a key factor to determine the photovoltaic performance.Herein,we demonstrate preparation of Zn O/ZnS core-shell composites through directly synthesizing ZnS on the ZnO nanoparticles in solution.We confirmed the formation of ZnO/ZnS core-shell composites by the uses of X-ray diffraction patterns and the Fourier transform infrared spectroscopy.ZnO/ZnS composites exhibit much homogeneous surface morphology as compared with the bare Zn O as revealed in the scanning electronic microscopy.Moreover,the upper shift of conduction band level upon composition of the Zn O/Zn S film results in a better alignment of energy level,which facilitates cascade charge extraction and thus improves the current density of perovskite solar cell.The shift of conduction band also improves the voltage of the PSCs.The photoluminescence(PL)spectroscopies measured in both steady and transient states were carried out to characterize the charge extraction at the interface between CH_3NH_3PbI_3and the electron transport layers of either ZnO or ZnO/ZnS composite.The ZnO/ZnS composite can more efficiently quench the PL signal of perovskite absorber than bare Zn O resulting in enhanced photocurrent generation in PSCs. | Enqiang Zheng Yaqin Wang Jiaxing song Xiao-Feng Wang Wenjing Tian Gang Chen Tsutomu Miyasaka | 2018 | Journal of Energy Chemistry2018，27，5： | 0 |
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