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| 1 | Deep learning based classification of rock structure of tunnel face显示文摘The automated interpretation of rock structure can improve the efficiency,accuracy,and consistency of the geological risk assessment of tunnel face.Because of the high uncertainties in the geological images as a result of different regional rock types,as well as in-situ conditions(e.g.,temperature,humidity,and construction procedure),previous automated methods have limited performance in classification of rock structure of tunnel face during construction.This paper presents a framework for classifying multiple rock structures based on the geological images of tunnel face using convolutional neural networks(CNN),namely Inception-ResNet-V2(IRV2).A prototype recognition system is implemented to classify 5 types of rock structures including mosaic,granular,layered,block,and fragmentation structures.The proposed IRV2 network is trained by over 35,000 out of 42,400 images extracted from over 150 sections of tunnel faces and tested by the remaining 7400 images.Furthermore,different hyperparameters of the CNN model are introduced to optimize the most efficient algorithm parameter.Among all the discussed models,i.e.,ResNet-50,ResNet-101,and Inception-v4,Inception-ResNet-V2 exhibits the best performance in terms of various indicators,such as precision,recall,F-score,and testing time per image.Meanwhile,the model trained by a large database can obtain the object features more comprehensively,leading to higher accuracy.Compared with the original image classification method,the sub-image method is closer to the reality considering both the accuracy and the perspective of error divergence.The experimental results reveal that the proposed method is optimal and efficient for automated classification of rock structure using the geological images of the tunnel face. | Jiayao Chen Tongjun Yang Dongming Zhang Hongwei Huang Yu Tian | 2021 | Geoscience Frontiers2021，12，1： | 13 |
| 2 | Chinese herbal medicine reduces mortality in patients with severe and critical coronavirus disease 2019: a retrospective cohort study显示文摘This study aimed to evaluate the efficacy of Chinese herbal medicine(CHM)in patients with severe/critical coronavirus disease 2019(COVID-19).In this retrospective study,data were collected from 662 patients with severe/critical COVID-19 who were admitted to a designated hospital to treat patients with severe COVID-19 in Wuhan before March 20,2020.All patients were divided into an exposed group(CHM users)and a control group(non-users).After propensity score matching in a 1:1 ratio,156 CHM users were matched by propensity score to 156 non-users.No significant differences in seven baseline clinical variables were found between the two groups of patients.All-cause mortality was reported in 13 CHM users who died and 36 non-users who died.After multivariate adjustment,the mortality risk of CHM users was reduced by 82.2%(odds ratio 0.178,95%CI 0.076–0.418;P<0.001)compared with the non-users.Secondly,age(odds ratio 1.053,95%CI 1.023–1.084;P<0.001)and the proportion of severe/critical patients(odds ratio 0.063,95%CI 0.028–0.143;P<0.001)were the risk factors of mortality.These results show that the use of CHM may reduce the mortality of patients with severe/critical COVID-19. | Guohua Chen Wen Su Jiayao Yang Dan Luo Ping Xia Wen Jia Xiuyang Li Chuan Wang Suping Lang Qingbin Meng Ying Zhang Yuhe Ke An Fan Shuo Yang Yujiao Zheng Xuepeng Fan Jie Qiao Fengmei Lian Li Wei Xiaolin Tong | 2020 | Frontiers of Medicine2020，14，6： | 10 |
| 3 | In uence of Particle Size on Laser Absorption and Scanning Track Formation Mechanisms of Pure Tungsten Powder During Selective Laser Melting显示文摘A three-dimensional laser absorption model based on ray tracing was established to describe the coupled interaction of a laser beam with particles in the powder layers of pure tungsten(W)material processed by selective laser melting(SLM).The influence of particle size on the powder-to-laser absorptivity and underlying absorption behavior was investigated.An intrinsic relationship between the absorption,distribution of absorbed irradiance within the powder layers,and surface morphology and geometric characteristics(e.g.,contact angle,width and height of tracks,and remelted depth)of the laser scanning tracks is presented here.Simulation conclusions indicate that the absorptivity of the powder layers considerably exceeds the single powder particle value or the dense solid material value.With an increase in particle size,the powder layer absorbs less laser energy.The maximum absorptivity of theWpowder layers reached 0.6030 at the particle size of 5 lm.The distribution of laser irradiance on the particle surface was sensitive to particle size,azimuthal angle,and the position of the powder particles on the substrate.The maximum irradiance in the powder layers decreased from 1.117×10^–3 to 0.85×10^–3W·μm^-2 and the contour of the irradiance distribution in the center of the irradiated area gradually contracted when the particle size increased from 5 to 45 lm.An experimental study on the surface morphologies and cross-sectional geometric characteristics of SLM-fabricated W material was performed,and the experimental results validated the mechanisms of the powder-to-laser-absorption behavior that were obtained in simulations.This work provides a scientific basis for the application of the ray-tracing model to predict the wetting and spreading ability of melted tracks during SLM additive manufacturing in order to yield a sound laser processability. | Jiayao Zhang Dongdong Gu Ying Yang Hongmei Zhang Hongyu Chen Donghuai Dai Kaijie Lin | 2019 | Engineering2019，5，4： | 6 |
| 4 | Bio-Based Hyperbranched Toughener From Tannic Acid and Its Enhanced Solvent-Free Epoxy Resin with High Performance显示文摘It is essential to design economic and efficient tougheners to prepare high-performance epoxy resin;however,this has remained a huge challenge.Herein,an eco-friendly,low-cost,and facile-fabricated bio-based hyperbranched toughener,carboxylic acid-functionalized tannic acid(CATA),was successfully prepared and applicated to the preparation of solvent-free epoxy resins.The mechanical performance,morphology,structural characterization,and thermal characterization of toughened epoxy resin system were studied.The toughened epoxy resin system with only 1.0wt%CATA reached the highest impact strength,111%higher than the neat epoxy resin system.Notably,the tensile strength and elongation at break of toughened epoxy resin systems increased moderately with increasing CATA loading.Nonphase-separated hybrids with significant toughening effect were obtained.Additionally,the thermal stabilities of toughened epoxy resin systems decreased with increasing CATA loading.This study provides an eco-friendly,cost-effective,and facile approach for the preparation of high-performance,solvent-free epoxy resins with potential for practical applications in sealing integrated circuits and electrical devices fields. | Jie Xu Jiayao Yang Hengxu Wang Peng Lin Xiaohuan Liu Jinjie Zhang Shenyuan Fu Yuxun Tang | 2019 | Journal of Renewable Materials2019，7，12： | 5 |
| 5 | Additive manufacturing alumina components with lattice structures by digital light processing technique显示文摘Digital light processing technique was applied to manufacture alumina ceramic parts with two types of lattice structure units, i.e. vertex interconnect structure and edge structure. The internal porosity of the unit is 40%. The printed parts were sintered and the grain size is about 1.1 μm. The bending strength of the vertex interconnect structure is much larger than that of the edge structure. Materials genome initiative(MGI) aims to digital design and intelligent manufacture for advanced components. This research shows us an example to achieve this goal. | Qjngfeng Zeng Changhao Yang Dingyi Tang Jiayao Li Zhiqiang Feng Jiantao Liu Kang Guan | 2019 | Journal of Materials Science & Technology2019，35，12： | 5 |
| 6 | DPSIR Model-Based Evaluation Index System for Geographic National Conditions显示文摘Establishing a reasonable evaluation index system is the basis and premise for the scientific evaluation of geographic national conditions. By analyzing the DPSIR model and its correlation and relation with the evaluation index system, the indexes for geographic national conditions were selected from the aspects of resources, ecology, environment, economy, society, etc to build an evaluation index system for geographic national conditions that consists of three hierarchies: index, criterion, and target levels. Furthermore, the index system was analyzed in terms of index integrity, low overlapping of elements, non-existence of isolated indexes, hierarchy of index system, etc., for the purpose of demonstrating that the DPSIR model-based evaluation index system for geographic national conditions meets the principles of index system establishment. | XIE Mingxia WANG Jiayao YANG Aiming CHEN Ke | 2017 | Wuhan University Journal of Natural Sciences2017，22，5： | 3 |
| 7 | A Humidity-Powered Soft Robot with Fast Rolling Locomotion显示文摘A range of soft robotic systems have recently been developed that use soft,flexible materials and respond to environmental stimulus.The greatest challenge in their design is the integration of the actuator,energy sources,and body of robots while achieving fast locomotion and well-defined programmable trajectories.This work presents such a design that operates under constant conditions without the need for an externally modulated stimulus.By using a humidity-sensitive agarose film and overcoming the isotropic and random bending of the film,the robot,which we call the Hydrollbot,harnesses energy from evaporation for spontaneous and continuous fast self-rolling locomotion with a programmable trajectory in a constant-humidity environment.Moreover,the geometric parameters of the film were fine-tuned to maximize the rolling speed,and the optimised hydrollbot is capable of carrying a payload up to 100%of its own weight.The ability to self-propel fast under constant conditions with programmable trajectories will confer practical advantages to this robot in the applications for sensors,medical robots,actuation,etc. | Lei Fu Weiqiang Zhao Jiayao Ma Mingyuan Yang Xinmeng Liu Lei Zhang Yan Chen | 2022 | Research2022，，4： | 3 |
| 8 | Theoretical connection from the dielectric constant of films to the capacitance of capacitors under high temperature显示文摘In the process of coping with energy and environmental protection issues,technologies such as energy materials,energy devices,and energy systems have made great progress.With excellent performance,film capacitors play an increasingly important role in energyrelated fields.With the increase of application scenarios and the continuous development of film material technology,it is urgent to establish a better theoretical connection from films to capacitors.First,the main components of the capacitor including the film and the positional relationships among them are given.Then,from the two perspectives of indirect calculation according to the volume and the direct calculation according to the winding process,the equation between the dielectric constant of films and the corresponding capacitance of capacitors is established.Further,the measurement data and error analysis results of the built test platform prove the accuracy and great potential of the proposed calculation methods.In addition,error sources,including film thickness uniformity,are listed.Finally,the challenges faced by the proposed calculation methods and the paths that can be referenced for future research are summarised and discussed. | Yongxin Zhang Qikun Feng Shaolong Zhong Jiayao Pei Fangyi Chen Lei Huang Zhe Yang Zhimin Dang | 2023 | High Voltage2023，8，4： | 3 |
| 9 | LilrB3 is a putative cell surface receptor of APOE4显示文摘The three isoforms of apolipoprotein E(APOE2,APOE3,and APOE4)only differ in two amino acid positions but exert quite different immunomodulatory effects.The underlying mechanism of such APOE isoform dependence remains enigmatic.Here we demonstrate that APOE4,but not APOE2,specifically interacts with the leukocyte immunoglobulin-like receptor B3(LilrB3).Two discrete immunoglobin-like domains of the LilrB3 extracellular domain(ECD)recognize a positively charged surface patch on the N-terminal domain(NTD)of APOE4.The atomic structure reveals how two APOE4 molecules specifically engage two LilrB3 molecules,bringing their intracellular signaling motifs into close proximity through formation of a hetero-tetrameric complex.Consistent with our biochemical and structural analyses,APOE4,but not APOE2,activates human microglia cells(HMC3)into a pro-inflammatory state in a LilrB3-dependent manner.Together,our study identifies LilrB3 as a putative immune cell surface receptor for APOE4,but not APOE2,and may have implications for understanding the biological functions as well as disease relevance of the APOE isoforms. | Jiayao Zhou Yumeng Wang Gaoxingyu Huang Min Yang Yumin Zhu Chen Jin Dan Jing Kai Ji Yigong Shi | 2023 | Cell Research2023，33，2： | 0 |
| 10 | Protective effects and mechanisms of Lizhong decoction(理中汤) against non-alcoholic fatty liver disease in a rat model显示文摘OBJECTIVE: To investigate the protective effects and molecular mechanisms of Lizhong decoction( 理中汤, LZD) against non-alcoholic fatty liver disease(NAFLD). METHODS: Male Wistar rats were fed a high-fat diet for four weeks to induce NAFLD, and were administered LZD by gavage for four weeks. Potential therapeutic targets for NAFLD were analyzed using network pharmacology. Liver pathology was evaluated using Oil Red O and hematoxylin-eosin staining. Furthermore, mitochondrial function, lipid metabolism, oxidative stress, and inflammatory response were examined. RESULTS: Rats with NAFLD exhibited high levels of hepatic damage and cholesterol deposition. Moreover, apoptosis was increased, superoxide dismutase and glutathione content were reduced, malondialdehyde content was increased, and the protein expression of inflammatory cytokines and p-c-Jun N-terminal kinase was increased. The LZD treatment ameliorated mitochondrial dysfunction, reduced liver damage,inhibited oxidative stress and inflammatory response, upregulated peroxisome proliferator-activated receptor(PPAR)-γ expression, and suppressed dipeptidyl peptidase 4(DPP4) expression in the liver. CONCLUSION: It was found that LZD alleviates NAFLD by activating PPAR-γ and inhibiting DPP4. | YANG Jiayao TAO Dongqing MA Wei LIU Song LIAO Yan SHU Lei ZHANG Shu LI Chenyu DU Nianlong | 2022 | Journal of Traditional Chinese Medicine2022，42，5： | 0 |
| 11 | 肠上皮的营养感知通过Hes1的翻译调控协调粘膜抗菌防御显示文摘文章简介近年来许多研究发现,经典免疫细胞如T细胞和巨噬细胞能够整合多种营养介导的分子信号来调控细胞代谢,进而影响免疫功能。肠道上皮细胞作为肠道免疫防御系统的第一道防线,在抵抗肠道病原菌感染过程中发挥了重要作用。在生物体内,胃肠道最先感知营养波动,其中位于肠腔侧的单层肠道上皮细胞尤为关键。 | Shaonan Liang Xue-Kun Guo Jiayao Ou Rongyao Huang Qing Xue Bin Zhang Yeonseok Chung Wei Wu Chen Dong Xuerui Yang 胡小玉 | 2020 | 科学新闻2020，，2： | 0 |
| 12 | Studies of cocoa tea, a wild tea tree containing theobromine显示文摘Camellia ptilophylla Chang is a wild tea tree containing theobromine and is caffeine-free.Lots of researches have been conducted for its domestication since it was discovered to contain theobromine in its shoots.First,its pharmacological and physiological effects have been studied,demonstrating that it can be used as a new resource of tea as daily and healthy beverage.Cocoa tea differs from traditional tea in that it does not excite the nervous system.Second,various ways of propagation have been investigated,and sexless cutting has been the method adopted currently.Third,through selection and breeding,plantation of cocoa tea can be set up to cultivate new varieties,and cocoa tea of different flavors such as green cocoa tea,oolong cocoa tea,and black cocoa tea can be processed.Thus,cocoa tea will become a choice in the tea market. | Xiaohong SONG Xianggang SHI Yunqin LI Li PENG Chengren LI Xiaorong YANG Chuangxing YE Jiaxian LI Yumei HE Hualin HUANG Aiqing MIAO Chaoyi ZHAO Jiayao WU Caijin LIN | 2009 | Frontiers in Biology2009，4，4： | 0 |
| 13 | The spatial transcriptomic landscape of human gingiva in health and periodontitis显示文摘The gingiva is a key oral barrier that protects oral tissues from various stimuli.A loss of gingival tissue homeostasis causes periodontitis,one of the most prevalent inflammatory diseases in humans.The human gingiva exists as a complex cell network comprising specialized structures.To understand the tissue-specific pathophysiology of the gingiva,we applied a recently developed spatial enhanced resolution omics-sequencing(Stereo-seq)technique to obtain a spatial transcriptome(ST)atlas of the gingiva in healthy individuals and periodontitis patients.By utilizing Stereo-seq,we identified the major cell types present in the gingiva,which included epithelial cells,fibroblasts,endothelial cells,and immune cells,as well as subgroups of epithelial cells and immune cells.We further observed that inflammation-related signalling pathways,such as the JAK-STAT and NF-κB signalling pathways,were significantly upregulated in the endothelial cells of the gingiva of periodontitis patients compared with those of healthy individuals.Additionally,we characterized the spatial distribution of periodontitis risk genes in the gingiva and found that the expression of IFI16 was significantly increased in endothelial cells of inflamed gingiva.In conclusion,our Stereo-seq findings may facilitate the development of innovative therapeutic strategies for periodontitis by mapping periodontitis-relevant genes and pathways and effector cells. | Zongshan Shen Ran Zhang Yunjia Huang Jiayao Chen Mengjun Yu Chunhua Li Yong Zhang Lingling Chen Xin Huang Jichen Yang Zhengmei Lin Songlin Wang Bin Cheng | 2024 | Science China(Life Sciences)2024，67，4： | 0 |
| 14 | Novel STING-targeted PET radiotracer for alert and therapeutic evaluation of acute lung injury显示文摘Acute lung injury(ALI),as a common clinical emergency,is pulmonary edema and diffuse lung infiltration caused by inflammation.The lack of non-invasive alert strategy,resulting in failure to carry out preventive treatment,means high mortality and poor prognosis.Stimulator of interferon genes(STING)is a key molecular biomarker of innate immunity in response to inflammation,but there is still a lack of STING-targeted strategy.In this study,a novel STING-targeted PET tracer,[~(18)F]FBTA,was labeled with high radiochemical yield(79.7±4.3%)and molar activity(32.5±2.9 GBq/μmol).We confirmed that[~(18)F]FBTA has a strong STING binding affinity(K_d=26.86±6.79 nmol/L)and can be used for PET imaging in ALI mice to alert early lung inflammation and to assess the efficacy of drug therapy.Our STING-targeted strategy also reveals that[~(18)F]FBTA can trace ALI before reaching the computed tomography(CT)diagnostic criteria,and demonstrates its better specificity and distribution than[~(18)F]fluorodeoxyglucose([~(18)F]FDG). | Duo Xu Fan Yang Jiayao Chen Tianxing Zhu Fen Wang Yitai Xiao Zibin Liang Lei Bi Guolong Huang Zebo Jiang Hong Shan Dan Li | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 0 |
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