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| 1 | Clinical features and the traditional Chinese medicine therapeutic characteristics of 293 COVID-19 inpatient cases显示文摘Coronavirus disease 2019 (COVID-19) is now pandemic worldwide and has heavily overloaded hospitals in Wuhan City, China during the time between late January and February. We reported the clinical features and therapeutic characteristics of moderate COVID-19 cases in Wuhan that were treated via the integration of traditional Chinese medicine (TCM) and Western medicine. We collected electronic medical record (EMR) data, which included the full clinical profiles of patients, from a designated TCM hospital in Wuhan. The structured data of symptoms and drugs from admission notes were obtained through an information extraction process. Other key clinical entities were also confirmed and normalized to obtain information on the diagnosis, clinical treatments, laboratory tests, and outcomes of the patients. A total of 293 COVID-19 inpatient cases, including 207 moderate and 86 (29.3%) severe cases, were included in our research. Among these cases, 238 were discharged, 31 were transferred, and 24 (all severe cases) died in the hospital. Our COVID-19 cases involved elderly patients with advanced ages (57 years on average) and high comorbidity rates (61%). Our results reconfirmed several well-recognized risk factors, such as age, gender (male), and comorbidities, as well as provided novel laboratory indications (e.g., cholesterol) and TCM-specific phenotype markers (e.g., dull tongue) that were relevant to COVID-19 infections and prognosis. In addition to antiviral/antibiotics and standard supportive therapies, TCM herbal prescriptions incorporating 290 distinct herbs were used in 273 (93%) cases. The cases that received TCM treatment had lower death rates than those that did not receive TCM treatment (17/273= 6.2% vs. 7/20= 35%, P = 0.0004 for all cases;17/77= 22% vs. 7/9= 77.7%, P = 0.002 for severe cases). The TCM herbal prescriptions used for the treatment of COVID-19 infections mainly consisted of Pericarpium Citri Reticulatae, Radix Scutellariae, Rhizoma Pinellia, and their combinations, which reflected the practical TCM principles (e.g., clearing heat and dampening phlegm). Lastly, 59% of the patients received treatment, including antiviral, antibiotics, and Chinese patent medicine, before admission. This situation might have some effects on symptoms, such as fever and dry cough. By using EMR data, we described the clinical features and therapeutic characteristics of 293 COVID-19 cases treated via the integration of TCM herbal prescriptions and Western medicine. Clinical manifestations and treatments before admission and in the hospital were investigated. Our results preliminarily showed the potential effectiveness of TCM herbal prescriptions and their regularities in COVID-19 treatment. | Zixin Shu Yana Zhou Kai Chang Jifen Liu Xiaojun Min Qing Zhang Jing Sun Yajuan Xiong Qunsheng Zou Qiguang Zheng Jinghui Ji Josiah Poon Baoyan Liu Xuezhong Zhou Xiaodong Li | 2020 | Frontiers of Medicine2020，14，6： | 7 |
| 2 | Preparation and Thermal Properties of Grafted CNTs Composites显示文摘Oleylamine(G18) and octanol(G8) were grafted onto the surfaces of the multi-walled carbon nanotubes(CNTs).The grafted CNTs were dispersed into palmitic acid(PA) and paraffin wax(PW) to prepare phase change composites.The heat storage/retrieval experiments showed that the composites kept stable after repeating melting and solidification for 80 times.The structure of the G18-CNT/PA and G8-CNT/PA was homogenous compared with the pristine CNT(P-CNT)/PA.The latent heat capacity(Ls) of solid liquid phase change of G18-CNT/PW was higher than that of PW while those of the G8-CNT/PW and P-CNT/PW were lower than that of PW.Compared with PA,all PA based composites with both P-CNTs and grafted CNTs decreased Ls evidently.The Ls values of G18-CNT composites in both matrices were higher than that of the counterparts of G8-CNT.The thermal conductivities of all the PA based composites in the study were higher than that of PA,as well as those of all the PW based composites.However,the thermal conductivities of the G18-CNT composites in both matrixes were lower than those of the G8-CNT composites in both matrixes at all measured temperatures. | Jifen Wang Huaqing Xie Zhong Xin | 2011 | Journal of Materials Science & Technology2011，27，3： | 4 |
| 3 | Intracellular uptake of nanocrystals:Probing with aggregation-induced emission of fluorescence and kinetic modeling显示文摘Nanocrystal formulations have been explored to deliver poorly water-soluble drug molecules.Despite various studies of nanocrystal formulation and delivery,much more understanding needs to be gained into absorption mechanisms and kinetics of drug nanocrystals at various levels,ranging from cells to tissues and to the whole body.In this study,nanocrystals of tetrakis(4-hydroxyphenyl)ethylene(THPE)with an aggregation-induced emission(AIE)property was used as a model to explore intracellular absorption mechanism and dissolution kinetics of nanocrystals.Cellular uptake studies were conducted with KB cells and characterized by confocal microscopy,fow cytometry,and quantitative analyses.The results suggested that THPE nanocrystals could be taken up by KB cells directly,as well as in the form of dissolved molecules.The cellular uptake was found to be concentration-and timedependent.In addition,the intracellular THPE also could be exocytosed from cells in forms of dissolved molecules and nanocrystals.Kinetic modeling was conducted to further understand the cellular mechanism of THPE nanocrystals based on frst-order ordinary differential equations(ODEs).By ftting the kinetic model against experimental measurements,it was found that the initial nanocrystal concentration had a great infuence on the dynamic process of dissolution,cellular uptake,and exocytosis of THPE nanocrystals.As the nanocrystal concentration increased in the culture media,dissolution of endocytosed nanocrystals became enhanced,subsequently driving the effux of THPE molecules from cells. | Jifen Zhang Clairissa DCorpstein Tonglei Li | 2021 | Acta Pharmaceutica Sinica B2021，11，4： | 3 |
| 4 | Thermal properties of paraffin based composites containing multi-walled carbon nanotubes显示文摘 | Jifen Wang Huaqing Xie Zhong Xin | 2009 | Thermochimica Acta2009，，1： | 2 |
| 5 | Alterations in cell adhesion proteins and cardiomyopathy显示文摘Cell adhesive junction is specialized intercellular struc-ture composed of cell adhesion proteins. They are essential to connect adjacent heart muscle cell and make heart contraction effectively and properly. Clini-cal and genetic studies have revealed close relationship between cell adhesive proteins and the occurrence of various cardiomyopathies. Here we will review recent development on the disease phenotype, potential cel-lular and molecular mechanism related to cell adhesion molecules, with particular disease pathogenesis learned from genetic manipulated murine models. | Jifen Li | 2014 | World Journal of Cardiology2014，6，5： | 2 |
| 6 | Ultimate Evaluation of the Alkali/Polymer Combination Flooding Pilot Test in XingLongTai Oil Field显示文摘 | Jifen Zhang Keliang Wang Fengyun He | 1999 | SPE572911999，，： | 1 |
| 7 | Preparation and tribo- logical properties of tungsten disuLfide hollow spheres assisted by methyltrioctylammonium chloride 显示文摘 | WU Jifen ZHAI Wensheng JIE Guifen | 2010 | Tribology International2010，43，9： | 1 |
| 8 | Thermal properties of heat storage composites containing multiwalled carbon nanotubes显示文摘 | WANG Jifen XIE Huaqing XIN Zhong | 2008 | Journal of Applied Physics2008，1135，： | 1 |
| 9 | Thermal properties of heat storage composites containing multiwalled carbon nanotubes 显示文摘 | Jifen Wang Huaqing Xie Zhong Xin | 2008 | Journal of applied physics2008，，： | 1 |
| 10 | IL-27 subunits and its recePtor (WSX-l) mRNAs are markedly upregulated in inflammatory cells in the CNS during exPerimental autoimmune encePhalomyelitis显示文摘 | Jifen L Bruno G Xianzhang G | 2005 | J Neurol Sci2005，232，： | 1 |
| 11 | Strain selection of metarrhizium anisopliae by image analysis of colony morphology for consistency of steroid biotransformation显示文摘 | Yang Kui Wang Jifen Li Xiaojing | 2001 | Biotechnology and Bioengineering2001，75，1： | 1 |
| 12 | Thermal properties of heat storage composites containing multiwalled carbon nanotubes显示文摘 | Wang Jifen Xie Huaqing Xin Zhong | 2008 | Journal of Applied Physics2008，104，11： | 1 |
| 13 | On the Adsorption Vohanmmetry of the Lanthanum(Ⅲ) -alizarin Complexone-fluoride System 显示文摘 | Wenrui Jin Jifen Wang Xiaoli Zhang | 1990 | Elctroanal Chem1990，281，： | 1 |
| 14 | On Mechanism of the Electrochemical of the La(Ⅲ)-Aliabrin Complexone Complex with and without F-IN ( CH2 )6N4-HNO3 显示文摘 | Wenrui Jin Jifen Wang Xiaoli Zhang | 1990 | Elecreochimica Acta1990，35，： | 1 |
| 15 | IL-27 subunits and its receptor (WSX-1) mRNAs are markedly up-regulated in inflammatory cells in the CNS during experimental autoimmune encephalomyelitis显示文摘 | Jifen L Bruno G Zhang GX | 2005 | J Neurol Scien2005，232，： | 1 |
| 16 | Theoretical studies of the absorption and emission properties of the fluorene-based conjugated polymers 显示文摘 | WANG JIFEN FENG JIKANG REN AIM1N etal | 2004 | Macromolecules2004，37，： | 1 |
| 17 | Thermal properties of heat storage composites containing multiwalled carbon nanotubes显示文摘 | Wang Jifen Xie Huaqing Xin Zhong | 2008 | Journal of Applied Physics2008，104，11： | 1 |
| 18 | PW based phase change nanocomposites containing γ -Al 2 O 3显示文摘 | Jifen Wang Huaqing Xie Yang Li Zhong Xin | 2010 | Journal of Thermal Analysis and Calorimetry2010，，2： | 1 |
| 19 | N-cadherin haploinsufficiency affects cardiac gap junctions and arrhythmic susceptibility显示文摘 | Jifen Li Mark D. Levin Yanming Xiong Nataliya Petrenko Vickas V. Patel Glenn L. Radice | 2007 | Journal of Molecular and Cellular Cardiology2007，，3： | 1 |
| 20 | Thermal properties of paraffin based composites containing multi-walled carbon nanotubes显示文摘 | Jifen Wang Huaqing Xie Zhong Xin | 2009 | Thermochimica Acta2009，，1： | 1 |
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