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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Robust multiuser MIMO scheduling algorithms with imperfect CSI显示文摘Robust multiuser multiple-input-multiple-output (MIMO) scheduling algorithms are proposed in this paper.With imperfect channel state information (CSI),traditional scheduling algorithms for the multiuser MIMO system based on the zero forcing precoding scheme will lose some performance due to the multi-user interference (MUI).In order to improve the system average throughput,we study the robust multiuser MIMO scheduling problem with imperfect CSI.From the average capacity formula,we derive a robust factor which can transform the robust multiuser MIMO scheduling problem into the traditional one,thus most existing non-robust scheduling algorithms can be robust if this factor is adopted.Simulation results show that compared with the traditional algorithms,the proposed robust algorithms can improve the system average throughput significantly under the CSI error environment. | MAO JunLing GAO JinChun LIU YuanAn XIE Gang ZHANG Jian | 2012 | Science China(Information Sciences)2012，55，4： | 4 |
| 3 | A method for predicting consolidation settlements of floating column improved clayey subsoil显示文摘A method of predicting the consolidation settlement-time curve of floating soil-cement column on improved soft clayey subsoil has been proposed.The degree of the consolidation(U(t))of the system is calculated by the double soil-layer consolidation theory,and the methods for evaluating the equivalent hydraulic conductivity(k)and the coefficient of volume compressibility(mv)of the part of the column improved layer have been proposed.The effectiveness of the method was verified by comparing predictions with the results of finite element analysis(FEA)using a unit cell model.The consolidation settlement(s(t))can be calculated by the method of treating a part of the column improved layer as an unimproved layer and using the corresponding average U(t)value.By comparing the predicted results with the measurements of laboratory model tests and three case histories in Fukuoka,Japan,the effectiveness of the proposed methods has been verified.It is suggested that the method can be used for designing the soft clayey subsoil improvement using floating soil-cement columns. | Jinchun CHAI Supasit PONGSIVASATHIT | 2010 | Frontiers of Structural and Civil Engineering2010，4，2： | 4 |
| 4 | Benzene containing polyhydroxyalkanoates homo-and copolymers synthesized by genome edited Pseudomonas entomophila显示文摘Microbial synthesis of functional polymers has become increasingly important for industrial biotechnology.For the first time,it became possible to synthesize controllable composition of poly(3-hydroxyalkanoate)(P3HA)consisting of 3-hydroxydodecanoate(3HDD)and phenyl group on the side-chain when chromosome of Pseudomonas entomophila was edited to weaken itsβ-oxidation.Cultured in the presence of 5-phenylvaleric acid(PVA),the edited P.entomophila produced only homopolymer poly(3-hydroxy-5-phenylvalerate)or P(3HPhV).While copolyesters P(3HPhV-co-3HDD)of 3-hydroxy-5-phenylvalerate(3HPhV)and 3-hydroxydodecanoate(3HDD)were synthesized when the strain was grown on mixtures of PVA and dodecanoic acid(DDA).Compositions of 3HPhV in P(3HPhV-co-3HDD)were controllable ranging from 3%to 32%depending on DDDA/PVA ratios.Nuclear magnetic resonance(NMR)spectra clearly indicated that the polymers were homopolymer of P(3HPhV)and random copolymers of 3HPhV and 3HDD.Their mechanical and thermal properties varied dramatically depending on the monomer ratios.Our results demonstrated the possibility to produce tailor-made,novel functional PHA using the chromosome edited P.entomophila. | SHEN Rui CAI LongWei MENG DeChuan WU LinPing GUO Kai DONG GuoXing LIU Lei CHEN JinChun WU Qiong CHEN GuoQiang | 2014 | Science China(Life Sciences)2014，57，1： | 4 |
| 5 | Effects of Huatan Tongluo decoction on vascular endothelial growth factor receptor 2 expression in synovial tissues of rats with collagen-induced arthritis显示文摘OBJECTIVE: To determine the therapeutic effect and potential mechanism of Huatan Tongluo decoction on rats with collagen-induced arthritis.METHODS: Forty specific pathogen-free Wistar rats were selected, and 10 were randomly selected as the control(group 1). The remaining rats were injected intradermally with emulsified type Ⅱ bovine collagen at the tail base and back, followed by a booster 7 d post first immunization. After establishing collagen-induced arthritis(CIA), rats were randomly divided into three groups(n = 10). The rats were treated orally for 30 d as follows: group 1, saline; group 2, model(saline); group 3, tripterygium polyglycoside(TP; 7.81 mg/kg, positive control);group 4, Huatan Tongluo decoction(HTTL; 7.5 g/kg). Body weight, ankle swelling and arthritis index were measured over the course of the study. The rats were sacrificed 30 d after treatment. Morphological changes in the synovium were observed by hematoxylin and eosin staining. Pannus formation and synovial thickness in the left ankle were observed by color Doppler ultrasoundVascular endothelial growth factor(VEGF) and VEGFR2 protein levels were measured by immunohistochemistry.VEGF/VEGFR2 mRNA levels were measured by real-time quantitative polymerase chain reaction.RESULTS: Compared with the model group, a significantly lower arthritis index was observed in the positive control group(P < 0.05) and HTTL group(P < 0.01), after treatment. Both positive control and HTTL reduced intra-articular pannus formation and synovial thickening. Furthermore, VEGF mRNA,and VEGFR2 protein and mRNA levels were significantly downregulated(P < 0.05) in the treatment groups.CONCLUSION: Inhibition of the expression of VEGF and VEGFR2 in synovial tissues and the formation of pannus and synovial hyperplasia may be part of the mechanism of HTTL for relieving the symptoms of rheumatoid arthritis in CIA rats. | Chen Jinchun Qiu Mingshan Li Yihan Zhang Qian Zhang Yiyan Lin Shuangjie Zhang Shaohong Qian Lixia Gao Hai Li Liang-cheng | 2019 | Journal of Traditional Chinese Medicine2019，39，2： | 4 |
| 6 | Flame Retardancy of Epoxy Resin/β-cyclodextrin@Resorcinol Bisdiphenylphosphate Inclusion Composites显示文摘In order to improve the efficiency of β-CD,the inclusion complex of β-CD and resorcinol bisdiphenylphosphate (RDP) (β-CD@RDP) was prepared,which β-CD was as the host component and RDP was as the guest.The structure and thermal stability property of β-CD@RDP was also characterized.EP/β-CD@RDP composites were prepared by adding β-CD@RDP into EP matrix.The results of thermogravimetric test showed that the flame retardant systems could effectively increase the corresponding temperature of EP matrix to reach the maximum thermal decomposition rate,and exhibited good char-forming property.When the amount of β-CD@RDP in EP was 20wt%,the limiting oxygen index (LOI) value of EP was increased to 26.5% from 19.8%,and the vertical burning test (UL-94) reached V-1 level.The cone calorimeter test indicated that 20wt% loading in EP could reduce the peak of heat release rate (PHRR) and the total heat release (THR) of EP by 94.7% and 93.4% respectively,and the peak of smoke production rate (PSPR) and the total smoke production (TSP) was reduced by 16.7% and 22.2%,respectively.Therefore,the addition of β-CD@RDP could reduce the fire risk of EP effectively. | SHAN Xueying HAN Ji SONG Yan XING Zhixiang LI Jinchun | 2020 | Journal of Wuhan University of Technology(Materials Science)2020，35，2： | 4 |
| 7 | Synthetic Process of Bio-Based Phenol Formaldehyde Adhesive Derived from Demethylated Wheat Straw Alkali Lignin and Its Curing Behavior显示文摘Lignin is a natural biopolymer with a complex three-dimensional network, commercially obtained from wasteliquid of paper pulp and bioethanol production, and could be a candidate for preparation of environment-friendlybio-based polyphenol material. In the present work, the demethylated wheat straw alkali lignin (D-Lig), preparedby demethylation of wheat straw alkali lignin (Lig) using an in-situ generated Lewis acid, was used to synthesizebio-based phenol formaldehyde resin adhesive (D-LPF) applied in plywood. Effects of synthetic process’s factors,including lignin substitution for phenol, NaOH concentration and molar ratio of formaldehyde to phenol, on thebonding strength and free formaldehyde content of D-LPF were investigated in detail, and the optimum syntheticprocess of D-LPF was obtained as following: Lignin substitution for phenol 60%, NaOH concentration 5.0% andmolar ratio of formaldehyde to phenol 2.0, and under the optimum reaction condition, the D-LPF presented lower free formaldehyde content (0.18%) and higher bonding strength (2.19 MPa), which was better than those ofcontaining-lignin phenol formaldehyde resin adhesive (LPF). Additionally, the curing behavior of the adhesivewas studied by differential scanning calorimetry (DSC) combined with gel time. It can be obtained that D-LPFresin adhesive had the shortest gel time, and fastest curing rate, compared with those of PF and L-PF resin adhesives. The curing kinetics data was fitted well by Kissinger model using non-isothermal DSC method, and theaverage activation energy value was 85.3 kJ/mol, slightly higher than that of commercial PF resin, while lowerthan that of LPF (90.2 kJ/mol). Finally, based on the analytical results of high temperature fourier transform infrared spectroscopy (FTIR), a possible curing mechanism of D-LPF was proposed. | Yan Song Zhixin Wang Xin Zhang Rong Zhang Jinchun Li | 2021 | Journal of Renewable Materials2021，9，5： | 3 |
| 8 | Structure modification and constant remelting speed control of a 120-t three-phase electroslag furnace显示文摘The traditional large electroslag remelting furnaces have many shortages,such as high short-network impedance and inductance,long maintenance time for electrode replacement,low stiffness of driveline,and low control accuracy of remelting speed.The present research was aimed to solve these problems through structure modification and constant remelting speed control for a 120-t electroslag remelting(ESR) furnace.Based on the technique of three-phase double electrodes in series,the short-network system and the structure of the 120-t ESR furnace were improved;and a continuous feeding system for the self-consumption electrode was proposed.A selfdesigned fully hydraulic driveline system with three degrees of freedom was successfully applied to the 120-t ESR furnace.An electrode auto-replacement system and the S-style speed-control curve of electrode-feeding system were designed on the basis of the soft measurement/sensing model on the remaining electrode length so as to obtain a high accuracy control system for constant remelting speed.The experiment products showed good surface quality and cross-sectional results,indicating good system control,and verifying the effectiveness of the structure modification of the furnace. | Wang Changzhou Song Jinchun | 2012 | China Foundry2012，9，4： | 3 |
| 9 | Effect of Ningmitai capsule plus sertraline on patients with premature ejaculation and enlarged seminal vesicles:A randomized clinical trial显示文摘OBJECTIVE: To investigate the effects of Ningmitai capsule combined with sertraline on patients with premature ejaculation(PE) and an increased anterior-posterior diameter(APD) of the seminal vesicles(SVs).METHODS: Sixty men with acquired PE were enrolled and randomly divided into two groups. The combined group was treated with Ningmitai capsule and sertraline, while the control group was treated with sertraline alone. Main outcomes were measured using the premature ejaculation diagnostic tool(PEDT), APD of SVs, and Clinical Global Impression of Change questionnaire and compared before and after 3 months of treatment.RESULTS: Comparing after treatment with before treatment outcomes within each group, the PEDT score was significantly reduced in the combined group(12.1 ± 2.5 vs 8.6 ± 3.2, P < 0.001, respectively) and control group(12.9 ± 2.6 vs 10.3 ± 1.6, P <0.001, respectively). Furthermore, the PEDT score after treatment was significantly lower in the combined compared with control group(8.6 ± 3.2 vs10.3 ± 1.6, P = 0.011, respectively). The APD of SVs in the combined group was significantly decreased after treatment [(10.8 ± 2.4) vs(12.9 ± 2.2) mm, P =0.001], while the APD of SVs in the control group was equivalent before and after treatment. The treatment response rate was not significantly higher in the combined compared with control group.CONCLUSION: These results indicated that the effect of Ningmitai capsule combined with sertraline was better than that of sertraline alone for the treatment of PE patients exhibiting an increased APD of SVs. The therapeutic effect found for the combined treatment may be due to antibacterial and anti-inflammatory activity reported for Ningmitai capsule,and may suggest that seminal vesiculitis is a potential pathophysiological factor in acquired PE. | Peng Longping Hong Zhiwei Shen Jiaming Hu Xuechun Shao Yong Jing Jun Lu Jinchun Yao Bing | 2018 | Journal of Traditional Chinese Medicine2018，38，2： | 3 |
| 10 | Lifetime prediction of electrical connectors under multiple environment stresses of temperature and particulate contamination显示文摘Electrical connectors play a significant role in the electronic and communication systems.As they are often exposed in the atmosphere environment, it is extremely easy for them to cause electrical contact failure.It is essential to carry out the reliability modeling and predict the lifetime.In the present work, the accelerated lifetime testing method which is on account of the uniform design method was designed to obtain the degradation data under multiple environmental stresses of temperature and particulate contamination for electrical connectors.Based on the degradation data, the pseudo life can be acquired.Then the reliability model was established by analyzing the pseudo life.Accordingly, the reliability function and reliable lifetime function were set up, and the reliable lifetime of the connectors under the multiple environment stresses of temperature and particulate contamination could be predicted for electrical connectors. | Li Qingya Gao Jinchun Xie Gang Jin Qiuyan Ji Rui | 2016 | The Journal of China Universities of Posts and Telecommunications2016，23，5： | 3 |
| 11 | Multi-Objective Optimization Design through Machine Learning for Drop-on-Demand Bioprinting显示文摘Drop-on-demand (DOD) bioprinting has been widely used in tissue engineering due to its highthroughput efficiency and cost effectiveness. However, this type of bioprinting involves challenges such as satellite generation, too-large droplet generation, and too-low droplet speed. These challenges reduce the stability and precision of DOD printing, disorder cell arrays, and hence generate further structural errors. In this paper, a multi-objective optimization (MOO) design method for DOD printing parameters through fully connected neural networks (FCNNs) is proposed in order to solve these challenges. The MOO problem comprises two objective functions: to develop the satellite formation model with FCNNs;and to decrease droplet diameter and increase droplet speed. A hybrid multi-subgradient descent bundle method with an adaptive learning rate algorithm (HMSGDBA), which combines the multisubgradient descent bundle (MSGDB) method with Adam algorithm, is introduced in order to search for the Pareto-optimal set for the MOO problem. The superiority of HMSGDBA is demonstrated through comparative studies with the MSGDB method. The experimental results show that a single droplet can be printed stably and the droplet speed can be increased from 0.88 to 2.08 m·s^-1 after optimization with the proposed method. The proposed method can improve both printing precision and stability, and is useful in realizing precise cell arrays and complex biological functions. Furthermore, it can be used to obtain guidelines for the setup of cell-printing experimental platforms. | Jia Shi Jinchun Song Bin Song Wen F. Lu | 2019 | Engineering2019，5，3： | 2 |
| 12 | A Novel Anti-human DR5 Monoclonal Antibody with Tumoricidal Activity Induces Caspase-dependent and Caspase-independent Cell Death显示文摘 | Yabin Guo Caifeng Chen Yong Zheng Jinchun Zhang Xiaohui Tao Shilian Liu Dexian Zheng Yanxin Liu | 2006 | 中国生物学文摘2006，20，1： | 2 |
| 13 | Model tests on anomalous low friction and pendulum-type wave phenomena显示文摘异常低磨擦( ALF )和现象是的摆钟类型波浪(μ
波浪)在深块的岩石质量中的二典型、非线性、geo机械、动态的回答从在 situ 观察发现了,它在外部脉搏的影响下面从geo块的运动发生了,例如深限制的爆炸,地震,和岩石爆炸。与目的到证实上述二现象的存在并且试验性地学习他们的变化法律,臼连续统和块建模的花岗石和水泥上的实验室测试分别地在自我独立地发达的多种用途的严峻的系统上被进行。ALF 现象在二装载下面被认识到计划,块模型和工作的块被扮演在之上由象有不同时间间隔的垂直、水平的影响的联合行动一样的垂直影响和水平静态的力量的联合行动。它表明相应于工作的水平排水量堵住的水平排水量振幅和剩余的本地最大值和最小的分离时间延期满足了正规序列与其大多数满足了量的表示多重。而且,一个维的影响实验在水泥臼分别地建模的块花岗石模型,连续统,和块上被执行。在上述模型基于 1D 压力波浪的繁殖性质(振幅和块的加速时间历史的 Fourier 系列) 的比较和分析,在岩石质量中的破裂在加速振幅和高周波的波浪的变细上有巨大的效果,这被显示。由模型测试数据与的比较在里面 situ 测量结论,μ
波浪的存在在块与更大的尺寸建模的水泥臼试验性地被证实,并且相应于本地最大值的频率光谱亚块的三方向性的加速时间历史的密度曲线也满足了几个正规序列与多重。 | Hao Wu Qin Fang Yusheng Lu Yadong Zhang Jinchun Liu | 2009 | Progress in Natural Science:Materials International2009，19，12： | 2 |
| 14 | Experimental investigation on the wave-induced pore pressure around shallowly embedded pipelines显示文摘A series of regular wave experiments have been done in a large-scale wave flume to investigate the wave-induced pore pressure around the submarine shallowly embedded pipelines.The model pipelines are buried in three kinds of soils,including gravel,sand and silt with different burial depth.The input waves change with height and period.The results show that the amplitudes of wave-induced pore pressure increase as the wave period increase,and decay from the surface to the bottom of seabed.Higher pore pressures are recorded at the pipeline top and the lower pore pressures at the bottom,especially in the sand seabed.The normalized pressure around pipeline decreases as the relative water depth,burial depth or scattering parameters increase.For the silt seabed,the wavelet transform has been successfully used to analyze the signals of wave-induced pore pressure,and the oscillatory and residual pore pressure can be extracted by wavelet analysis.Higher oscillatory pressures are recorded at the bottom and the lower pressures at the top of the pipeline.However,higher residual pressures are recorded at the top and the lower pressures at the bottom of the pipeline. | PAN Dongzi WANG Lizhong PAN Cunhong HU Jinchun | 2007 | Acta Oceanologica Sinica2007，26，5： | 2 |
| 15 | Determination of subnanomolar levels of hydrogen peroxide in seawater by reagent-Injection chemiluminescence detection显示文摘 | YUAN Jinchun SHILLER A M | 1999 | Anal Chem1999，71，10： | 1 |
| 16 | Energy Efficiency Optimization for OFDM-Based Cognitive Radio Systems: A Water-Filling Factor Aided Search Method 显示文摘 | MAO Junling XIE Gang GAO Jinchun | 2013 | IEEE Transactions on Wireless Communications2013，12，5： | 1 |
| 17 | The method of feed-in energy on disc brake squeal显示文摘 | GUAN Dihua HUANG Jinchun | 2003 | Journal of Sound and Vibration2003，261，： | 1 |
| 18 | Sort-based relay selection algorithm for decode-and-forward relay system显示文摘In this paper, a sort-based relay selection algorithm is proposed for decode-and-forward wireless relay systems. The proposed algorithm can reduce computational complexity and system overhead in the relay selection for practical decode-and-forward wireless relay systems with multiple sources and multiple relays. This would be a very important improvement. Firstly, the sufficient and necessary conditions for a relay to be feasible to a source are derived. By adopting relay transmission via its feasible relay, the source can improve channel capacity compared to direct transmission. Then, a sort-based relay selection algorithm is proposed based on the sufficient and necessary conditions. In the proposed algorithm, each relay makes decision on its feasibility individually, but the final source-relay paring decision is made in a centralized manner. Simulation results show that the proposed algorithm can provide considerable system performance improvement over the existing algorithm. Especially at low signal-to-noise (SNR) region, the performance of the proposed algorithm almost reaches the optimal one. | XIE Gang LIU YuanAn GAO JinChun LI XingZheng | 2013 | Science China(Information Sciences)2013，56，2： | 1 |
| 19 | Modeling of Automotive Drum Brakes for Squeal and Parameter Sensitivity Analysis显示文摘 | Huang Jinchun Charles M Anil K | 2006 | Journal of Sound and Vibration2006，289，： | 1 |
| 20 | Biomimetic synthesis silver crystallite by peptide AYSSGAPPMPPF immobilized on PET film in vitro 显示文摘 | Zhang Xu Chert Jinchun Yang Peng | 2005 | Journal of Inorganic Biochemistry2005，99，： | 1 |
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