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| 1 | Recent developments in HVDC transmission systems to support renewable energy integration显示文摘The demands for massive renewable energy integration, passive network power supply, and global energy interconnection have all gradually increased, posing new challenges for high voltage direct current(HVDC) power transmission systems, including more complex topology and increased diversity of bipolar HVDC transmission. This study proposes that these two factors have led to new requirements for HVDC control strategies. Moreover, due to the diverse applications of HVDC transmission technology, each station in the system has different requirements. Furthermore, the topology of the AC-DC converter is being continuously developed, revealing a trend towards hybrid converter stations. | Zhou Li Ruopei Zhan Yazhou Li Yan He Jinming Hou Xiaoling Zhao Xiao-Ping Zhang | 2018 | Global Energy Interconnection2018，1，5： | 11 |
| 2 | Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms显示文摘The infusion of coronavirus disease 2019(COVID-19)patients with mesenchymal stem cells(MSCs)potentially improves clinical symptoms,but the underlying mechanism remains unclear.We conducted a randomized,single-blind,placebo-controlled(29 patients/group)phase II clinical trial to validate previous findings and explore the potential mechanisms.Patients treated with umbilical cord-derived MSCs exhibited a shorter hospital stay(P=0.0198)and less time required for symptoms remission(P=0.0194)than those who received placebo.Based on chest images,both severe and critical patients treated with MSCs showed improvement by day 7(P=0.0099)and day 21(P=0.0084).MSC-treated patients had fewer adverse events.MSC infusion reduced the levels of C-reactive protein,proinflammatory cytokines,and neutrophil extracellular traps(NETs)and promoted the maintenance of SARS-CoV-2-specific antibodies.To explore how MSCs modulate the immune system,we employed single-cell RNA sequencing analysis on peripheral blood.Our analysis identified a novel subpopulation of VNN2+hematopoietic stem/progenitorlike(HSPC-like)cells expressing CSF3R and PTPRE that were mobilized following MSC infusion.Genes encoding chemotaxis factors—CX3CR1 and L-selectin—were upregulated in various immune cells.MSC treatment also regulated B cell subsets and increased the expression of costimulatory CD28 in T cells in vivo and in vitro.In addition,an in vivo mouse study confirmed that MSCs suppressed NET release and reduced venous thrombosis by upregulating kindlin-3 signaling.Together,our results underscore the role of MSCs in improving COVID-19 patient outcomes via maintenance of immune homeostasis. | Rongjia Zhu Tingdong Yan Yingmei Feng Yan Liu Hongcui Cao Gongxin Peng Yanlei Yang Zhen Xu Jingqi Liu Wei Hou Xiaoyue Wang Zhe Li Luchan Deng Shihua Wang Jing Li Qin Han Hongling Li Guangliang Shan Yinghao Cao Xingyan An Jianshe Yan Zhonghui Zhang Huafei Li Xuebin Qu Jiaqi Zhu Shumin Zhou Jiao Wang Fengchun Zhang Jinming Gao Ronghua Jin Dayong Xu Yan-Qing Ma Tao Huang Shuang Peng Zhi Zheng Ilia Stambler Eric Gilson Lee Wei Lim Alexey Moskalev Antonio Cano Sasanka Chakrabarti Brun Ulfhake Huanxing Su Haoying Xu Sihuan Xu Feng Wei Holly MBrown-Borg Kyung-Jin Min Georgina Ellison-Hughes Calogero Caruso Kunlin Jin Robert Chunhua Zhao | 2021 | Cell Research2021，31，12： | 5 |
| 3 | Climatology of Cloud-base Height from Long-term Radiosonde Measurements in China显示文摘Clouds are critical to the global radiation budget and hydrological cycle, but knowledge is still poor concerning the observed climatology of cloud-base height(CBH) in China. Based on fine-resolution sounding observations from the China Radiosonde Network(CRN), the method used to estimate CBH was modified, and uncertainty analyses indicated that the CBH is good enough. The accuracy of CBH estimation is verified by the comparison between the sounding-derived CBHs and those estimated from the micro-pulse lidar and millimeter-wave cloud radar. As such, the CBH climatology was compiled for the period 2006–16. Overall, the CBH exhibits large geographic variability across China, at both 0800 Local Standard Time(LST) and 2000 LST, irrespective of season. In addition, the summertime cloud base tends to be elevated to higher altitudes in dry regions [i.e., Inner Mongolia and the North China Plain(NCP)]. By comparison, the Tibetan Plateau(TP),Pearl River Delta(PRD) and Sichuan Basin(SCB) have relatively low CBHs(< 2.4 km above ground level). In terms of seasonality, the CBH reaches its maximum in summer and minimum in winter. A low cloud base tends to occur frequently(> 70%) over the TP, PRD and SCB. In contrast, at most sites over the Yangtze River Delta(YRD) and the NCP, about half the cloud belongs to the high-cloud category. The CBH does not exhibit marked diurnal variation in summer, throughout all CRN sites, probably due to the persistent cloud coverage caused by the East Asia Summer Monsson. To the best of our knowledge, this is the first CBH climatology produced from sounding measurements in China, and provides a useful reference for obtaining observational cloud base information. | Yong ZHANG Lejian ZHANG Jianping GUO Jinming FENG Lijuan CAO Yang WANG Qing ZHOU Liangxu LI Bai LI Hui XU Lin LIU Ning AN Huan LIU | 2018 | Advances in Atmospheric Sciences2018，35，2： | 2 |
| 4 | Effects of apoptosis?related proteins caspase?3, Bax and Bcl?2 on cerebralischemia rats显示文摘 | Guangyi Liu Tao Wang Tinging Wang Jinming Song Zhen Zhou | 2013 | Biomedical Reports2013，，6： | 2 |
| 5 | Advances of nanoparticles as drug delivery systems for disease diagnosis and treatment显示文摘Decades have passed since the first nanoparticles-base medicine was approved for human cancer treatment, and the research and development of nanoparticles for drug delivery are always undergoing.Nowadays, the significant advances complicate nanoparticles’ branches, including liposomes, solid lipid nanoparticles, inorganic nanoparticles, micelles, nanovaccines and nano-antibodies, etc. These nanoparticles show numerous capabilities in treatment and diagnosis of stubborn diseases like cancer and neurodegenerative diseases, emerging as novel drug carriers or therapeutic agents in future. In this review, the complicated branches of nanoparticles are classified and summarized, with their property and functions concluded. Besides, there are also some delivery strategies that make nanoparticles smarter and more efficient in drug delivery, and frontiers in these strategies are also summarized in this review. Except these excellent works in newly-produced drug delivery nanoparticles, some points of view and future expectations are made in the end. | Rui Liu Cong Luo Zhiqing Pang Jinming Zhang Shaobo Ruan Meiying Wu Lei Wang Tao Sun Nan Li Liang Han Jinjin Shi Yuanyu Huang Weisheng Guo Shaojun Peng Wenhu Zhou Huile Gao | 2023 | Chinese Chemical Letters2023，34，2： | 2 |
| 6 | Clinical Comparison of Airway Stent Placement in Intervention Room and Operating Room显示文摘Background and objective Airway stent placement is the effective regimen for central airway obstruction(CAO),while its application scenarios varied.This study aimed to make clinical comparison of airway stent placement in the intervention room and operating room.Methods Patients underwent airway stent placement between 2014 and 2018 were included in this retrospective case-control study.Clinical performance of airway stent placement in intervention room and operating room were compared.Results 82 patients were included in this study,including 39 in the intervention room and 43 in the operating room.Patients treated in the intervention room had lower Charlson comorbidity index(CCI)(P=0.018)and received less Y-shaped stents(P<0.001).Better clinical response(P=0.026),more stents placed(P<0.001)and longer length of stent(P<0.001)were observed in operating room,while there was no significantly statistical difference of stent-related complications and post-stent survival rate between the two groups.Extracorporeal membrane oxygenation(ECMO)supported airway stent placement procedures were performed in the operating room,which provided definitive safety support for high-risk intervention.Conclusion Patients with CAO could benefit from the operating room scenario,and airway stent placement in the operating room is more suitable for patients with higher CCI scores and receiving more complicated procedures. | Ying WANG Jinming XU Qi WU Yuqiong ZHOU Zhou AN Wang LV Jian HU | 2020 | 中国肺癌杂志2020，23，6： | 2 |
| 7 | A polyphenol-assisted IL-10 mRNA delivery system for ulcerative colitis显示文摘With the development of synthesis technology, modified messenger RNA(mRNA) has emerged as a novel category of therapeutic agents for a broad of diseases. However, effective intracellular delivery of mRNA remains challenging, especially for its sensitivity to enzymatic degradation. Here, we propose a polyphenol-assisted handy delivery strategy for efficient in vivo delivery of IL-10 mRNA.IL-10 mRNA binds to polyphenol ellagic acid through supramolecular binding to yield a negatively charged core, followed by complexing with linear polyetherimide and coating with bilirubin-modified hyaluronic acid to obtain a layer-by-layer nanostructure. The nanostructure specifically up-regulated the level of IL-10, effectively inhibited the expression of inflammatory factors, promoted mucosal repair, protected colonic epithelial cells against apoptosis, and exerted potent therapeutic efficacy in dextran sulfate sodium salt-induced acute and chronic murine models of colitis. The designed delivery system without systemic toxicity has the potential to facilitate the development of a promising platform for mRNA delivery in ulcerative colitis treatment. | Zhejie Chen Wei Hao Caifang Gao Yangyang Zhou Chen Zhang Jinming Zhang Ruibing Wang Yitao Wang Shengpeng Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，8： | 2 |
| 8 | Studies on frictional pressure drop of gas-non-Newtonian fluid two-phase flow in the vacuum sewers 显示文摘 | Duan Jinming Zhou Jingxuan | 2006 | Civil Eng Environ Sys2006，23，1： | 1 |
| 9 | Orbital polarization, surface enhancement and quantum confinement in nanocluster magnetism 显示文摘 | Wan Xiangang Zhou Lei Dong Jinming Lee T K Wang Ding-sheng | 2004 | Phys Rev2004，69，17： | 1 |
| 10 | Effects of apoptosis?related proteins caspase?3, Bax and Bcl?2 on cerebralischemia rats显示文摘 | Guangyi Liu Tao Wang Tinging Wang Jinming Song Zhen Zhou | 2013 | Biomedical Reports2013，，6： | 1 |
| 11 | Monodispersed Au nanoparticles decorated graphene as an enhanced sensing platform for ultrasensitive stripping vohammetric detection of mercury(II)显示文摘 | GONG JINMING ZHOU TING SONG DANDAN | 2010 | Sensors and Actuators B: Chemical2010，150，1： | 1 |
| 12 | Identification and characterization of loop7 motif and its role in regulating biological function of human APOBEC3G through molecular modeling and biological assay显示文摘Human APOBEC3G(h A3G) is a cytidine deaminase which inhibits HIV-1 replication. The HIV-1 accessory protein viral infectivity factor(Vif) counteracts with hA3G by targeting it for proteasomal degradation. In this work, we constructed and optimized molecular models of the hA3G dimer and the h A3G–Vif complex. The molecular modeling study revealed that the loop7 motif of hA3G appears on the interfaces of both the h A3G–Vif complex and the hA3G dimer. Biochemical analysis provided evidence suggesting that binding of Vif to hA3G results in steric blocking of hA3G dimerization, implying that monomeric hA3G serves as a substrate for Vif-mediated degradation.Furthermore, we presented evidence for the important roles of the loop7 motif, especially the central residues within the region, in hA3G dimerization, h A3G–Vif interaction, Vif-mediated hA3G degradation as well as subcellular localization of hA3G. This work highlights a multiple-task interface formed by loop7 motif, which regulates biological function of hA3G, thus providing the feasibility of the strategy of blocking Vif-mediated A3 G degradation by targeting the putative site around loop7. | Congjie Zhai Ling Ma Zhixin Zhang Jiwei Ding Jing Wang Yongxin Zhang Xiaoyu Li Fei Guo Liyan Yu Jinming Zhou Shan Cen | 2017 | Acta Pharmaceutica Sinica B2017，7，5： | 1 |
| 13 | A decision method for existence of vector-valued osculatory rational interpolants显示文摘 | Tao Youtian Zhu Xiaolin Zhou Jinming | 2007 | Journal of Hefei University of Technology (Natural Science)2007，30，1： | 1 |
| 14 | Effect of Low Temperature on Germination Characteristics of Rice Cultivars显示文摘The effects of low temperature on germination characteristics of rice seeds were studied,using three rice varieties as materials.The results showed that the germination rate,germination energy,germination index,vigor index,shoot length and root length all reduced with the decrease of temperature.When the treatment temperature was 10 ℃,whether or not cold-resistant varieties,the values of all parameters showed an extremely significant difference from the control's.When the stress temperature was 15 ℃,compared with the normal condition,the parameter values of the non-tolerant variety( Changbai 9) had an extremely significant difference and the germination rate,germination potential,seedling length and root length of two cold-tolerance varieties( Jisheng 202 and Tongjing 9) had little difference from the control.Therefore,the above four indicators at 15 ℃ can be considered as the evaluation indices of cold tolerance at early stage. | Yadong ZHAO Dianfa ZHOU Xiuyun LIN Qiang SUN Pengzhi Li Ding Zaisong Jinming WANG | 2018 | Agricultural Biotechnology2018，7，6： | 1 |
| 15 | Study of Surface Quality in High Speed Turning of Inconel 718 with Uncoated and Coated CBN Tools显示文摘 | ZHOU Jinming BUSHLYA Volodymyr AVDOVIC Pajazit | 2012 | The International Journal of Advanced Manufacturing Technology2012，58，14： | 1 |
| 16 | Strain-induced ferromagnetism in zigzag edge graphene nanoribbon with a topological line defeet显示文摘 | Ting Hu Jian Zhou Jinming Dong etc | 2012 | Physical Review B2012，86，12： | 1 |
| 17 | A novel TIR-NBS-LRR gene regulates immune response to Phytophthora root rot in soybean显示文摘Phytophthora root rot(PRR),caused by Phytophthora sojae,is a devastating disease of soybean.The NBSLRR gene family is a class of plant genes involved in disease resistance.miRNA mediates plant response to biotic stresses by regulating the expression of target genes at the transcriptional or post-translational level.Glyma.16G135500,encoding an NBS-LRR-type protein,is a target of gma-miR1510 that responds to pathogen infections.We cloned and overexpressed Glyma.16G135500(naming it GmTNL16)and knocked down mi R1510 using short tandem target mimic technology to identify the roles of the GmTNL16/gma-mi R1510 pair in the interaction of soybean and the oomycete.By overexpressing GmTNL16 in transgenic hairy roots of soybean,we showed that biomass of P.sojae was lower in overexpressing hairy roots than in control roots.Thus,miR1510 expression was reduced upon P.sojae infection,reflecting the induced expression of GmTNL16 conferring resistance to P.sojae in soybean.Differentially expressed genes were enriched in plant-pathogen interaction,plant hormone signal transduction,and secondary metabolism by RNA sequencing analyze.In particular,jasmonate and salicylic acid pathway-associated genes,including JAZ,COI1,TGA,and PR,responded to P.sojae infection.All of these results indicate that the GmTNL16/gma-miR1510 pair participates in soybean defense response via the JA and SA pathways. | Li Zhou Sushuang Deng Huidong Xuan Xingxing Fan Ruidong Sun Jinming Zhao Haitang Wang Na Guo Han Xing | 2022 | The Crop Journal2022，10，6： | 1 |
| 18 | Synthesis and in vitro characterization of ionone-based ehalcones as novel antiandrosens effective against multiple clinically relevant androgen receptor mutants 显示文摘 | Jinming Zhou Guoyan Geng Jianhui Wu | 2010 | Invest New Drugs2010，28，： | 1 |
| 19 | Synthesis of NaA zeolite from kaolin source显示文摘 | Qian Miao Zhihui Zhou Jianhua Yang Jinming Lu Shiwei Yan Jinqu Wang | 2009 | Frontiers of Chemical Engineering in China2009，，1： | 1 |
| 20 | Separation of stable oil–water emulsion by the hydrophilic nano-sized ZrO 2 modified Al 2 O 3 microfiltration membrane显示文摘 | Jian-er Zhou Qibing Chang Yongqing Wang Jinming Wang Guangyao Meng | 2010 | Separation and Purification Technology2010，，3： | 1 |
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