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| 1 | The cGAS-STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapy显示文摘The cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING) signaling exert essential regulatory function in microbial-and onco-immunology through the induction of cytokines, primarily type I interferons. Recently, the aberrant and deranged signaling of the cGAS-STING axis is closely implicated in multiple sterile inflammatory diseases, including heart failure,myocardial infarction, cardiac hypertrophy, nonalcoholic fatty liver diseases, aortic aneurysm and dissection, obesity, etc. This is because of the massive loads of damage-associated molecular patterns(mitochondrial DNA, DNA in extracellular vesicles) liberated from recurrent injury to metabolic cellular organelles and tissues, which are sensed by the pathway. Also, the cGAS-STING pathway crosstalk with essential intracellular homeostasis processes like apoptosis, autophagy, and regulate cellular metabolism.Targeting derailed STING signaling has become necessary for chronic inflammatory diseases. Meanwhile, excessive type I interferons signaling impact on cardiovascular and metabolic health remain entirely elusive. In this review, we summarize the intimate connection between the cGAS-STING pathway and cardiovascular and metabolic disorders. We also discuss some potential small molecule inhibitors for the pathway. This review provides insight to stimulate interest in and support future research into understanding this signaling axis in cardiovascular and metabolic tissues and diseases. | Patrick Kwabena Oduro Xianxian Zheng Jinna Wei Yanze Yang Yuefei Wang Han Zhang Erwei Liu Xiumei Gao Mei Du Qilong Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 18 |
| 2 | Microstructure and corrosion behavior of the heat affected zone of a stainless steel 308L-316L weld joint显示文摘Microstructure of the heat affected zone(HAZ) of a 308 L-316 L stainless steel(SS) weld joint and its corrosion behavior in high temperature water were studied. Peak of the residual strain was observed to approach to the fusion boundary in the HAZ while the strain increased from the top to root areas of the HAZ. The root area of the HAZ shows a lower corrosion resistance in high temperature water than the top and middle areas of the HAZ. This is attributed to a higher level of residual strain in association with a higher density of tangled dislocations in the top area of the HAZ. The results suggest that the residual strain in the HAZ could also promote the SCC through its effect on corrosion, in addition to that on the local microstructure and mechanical property of the steel. | Cheng Ma Qunjia Peng Jinna Mei En-Hou Han Wei Ke | 2018 | Journal of Materials Science & Technology2018，34，10： | 5 |
| 3 | Estrogenic effect of the extract of Renshen(Radix Ginseng) on reproductive tissues in immature mice显示文摘OBJECTIVE: To evaluate the estrogenic efficacy of Renshen(Radix Ginseng)(GS) on reproductive target tissues in immature mice.METHODS: One hundred and ten female immature Kunming(KM) mice, 21-day-old, were randomly assigned to eleven groups, 10 for each; one served as control group treated with 0.154 mg/kg estradiol valerate(EV,n = 10), the rest were treated respectively with GS intragastrically at a daily dose of 0.5,1.0, 1.5, 3.0, 6.0, 12.0, 18.0, 24.0 and 30.0 g/kg(n =10 in per group) for 7 days. The estrous cycle, uterine weight, hormone levels in circulation and histomorphology changes of uterus and vagina were scrupulously examined. The estrogen receptor(ER)α and ERβ expressions in the uterus and vagina were detected by immunohistochemistry and western blotting.RESULTS: Treatment with GS at the dose of 12.0,18.0 and 24.0 g/kg resulted significant estrogenic activity in the mice, as indicated by advanced and prolonged estrous stage and increased uterine weight(all P < 0.05). GS treatment substantially promoted development of reproductive tissue by thickening the uterine endometrium and increasing vaginal epithelial layers. In addition, treatment with GS induced significant up-regulation of ERαand ERβ expressions in reproductive tissues, and ERα up-regulation was stronger than that of ERβ.GS could raise levels of circulating estrogen, simultaneously decrease levels of luteinizing hormone and follicle-stimulating hormone(all P < 0.001)compared with the control group.CONCLUSION: Our findings suggest that GS had estrogenic effect on reproductive tissues in immature mice by stimulating biosynthesis of estrogen in circulation and up-regulating ERs. | Ding Jie Xu Ying Ma Xiaoping An Jinna Yang Xiudong Liu Zhiqiang Lin Na | 2015 | Journal of Traditional Chinese Medicine2015，35，4： | 3 |
| 4 | Study on the Microstructure of Human Articular Cartilage/Bone Interface显示文摘 | Yaxiong Liu Qin Lian Jiankang He Jinna Zhao Zhongmin Jin Dichen Li | 2011 | Journal of Bionic Engineering2011，8，3： | 3 |
| 5 | Graphic theory on interval stability of networked control systems显示文摘A new method on the interval stability of networked control systems (NCSs) with random delay and data packet dropout is studied.Combining interval systems and NCSs,a graphic condition on judging interval stabil- ity is presented in terms of the weighted diagraph theory in graph theory.Furthermore,utilizing the graph-theoretic algorithm,the delay-depended controller gains are obtained.Aiming at the same delay and data packed dropout, several controller gains are obtained,simultaneously.The example and simulation illustrate the effectiveness of the proposed method. | Li Jinna Zhang Qingling | 2008 | Journal of Systems Engineering and Electronics2008，19，6： | 3 |
| 6 | Increased Expression of EIF5A2 , via Hypoxia or Gene Amplification, Contributes to Metastasis and Angiogenesis of Esophageal Squamous Cell Carcinoma显示文摘 | Yan Li Li Fu Jian-biao Li Yanru Qin Ting-ting Zeng Jie Zhou Zhao-lei Zeng Jinna Chen Ting-Ting Cao Xiaojiao Ban Chaonan Qian Zongwei Cai Dan Xie Peng Huang Xin-Yuan Guan | 2014 | Gastroenterology2014，，： | 3 |
| 7 | Microstructure Characterization of the Fusion Zone of an Alloy 600-82 Weld Joint显示文摘Characterization of the microstructure of the fusion zone of an Alloy 600-82 weld joint was conducted,with focus on the weld residual strain distribution and the comparison of the microstructure of heat affected zone(HAZ) with that of cold worked alloy. Peak of the residual strain was observed to approach to the fusion boundary in HAZ while the strain increased from the top of the weld to the root. Strain distribution in the HAZ was found to be concentrated adjacent to grain boundaries(GBs), with a peak of approximately three times of that in grain. Further, triple junctions of the GB appear to cause a higher strain concentration than single GBs. The microstructure of HAZ consists of partially tangled dislocations, which is different from slip bands of high density dislocations in cold worked alloy. This may cause a relatively higher intergranular cracking resistance of HAZ due to the difficulty in transferring tangled dislocations to GB in HAZ under deformation. | Cheng Ma Jinna Mei Qunjia Peng Ping Deng En-Hou Han Wei Ke | 2015 | Journal of Materials Science & Technology2015，31，10： | 3 |
| 8 | Controllability and observability of networked control systems with time-varying delays显示文摘The controllability and observability of networked control systems are studied.Aiming at the networked control system with time-varying delay,the sufficient and necessary conditions for complete controllability and complete observability of the system are presented,respectively.Because of Markov characteristic of the network-induced delay,in terms of stochastic theory,a sufficient and necessary condition for completely mean value controllability of networked control systems is obtained.Further,the conditions that the controllability and observability of networked control systems are equivalent to the initial time-invariant system are given.Controllability and observability realization indexes are also discussed,respectively.The numerical example demonstrates the effectiveness of the proposed theory. | Li Jinna Zhang Qingling Li Yuan | 2009 | Journal of Systems Engineering and Electronics2009，20，4： | 2 |
| 9 | Electricity generation from bio-treatment of sewage sludge with microbial fuel cell显示文摘 | Junqiu Jiang Qingliang Zhao Jinna Zhang Guodong Zhang Duu-Jong Lee | 2009 | Bioresource Technology2009，，23： | 2 |
| 10 | Lead (Pb) isotopes as a tracer of Pb origin in Yangtze River intertidal zone显示文摘 | Zhang Weiguo Feng Huan Chang Jinna | 2008 | Chemical Geology2008，257，34： | 1 |
| 11 | Stability analysis in a delayed prey- predator- resource model with harvest effort and stage structure 显示文摘 | Liu Chao Zhang Qingling Li Jinna | 2014 | Applied Mathematics and Computation2014，238，： | 1 |
| 12 | Designing afforestation subsidies that account for the benefits of carbon sequestration: A case study using data from China’s Loess Plateau显示文摘 | Jinna Yu Shunbo Yao Bisheng Zhang | 2013 | Journal of Forest Economics2013，，： | 1 |
| 13 | Analysis of errors of handwrittendigits made by a multitude of classifiers 显示文摘 | CHING Y SUEN JINNA TAN | 2005 | Pattern RecognitionLetters archive2005，，： | 1 |
| 14 | Low Back Pain显示文摘 | G. Swink Hicks David N. Duddleston Lori D. Russell Honey E. Holman Jinna M. Shepherd C. Andrew Brown | 2002 | The American Journal of the Medical Sciences2002，，4： | 1 |
| 15 | A sensitive liquid chromatography mass spectrometry method for simultaneous determination of two active chromones from Saposhnikovia root in rat plasma and urine显示文摘 | Jinna Dai Xiaohui Chen Weiming Cheng | 2008 | Journal of Chromatography B2008，8，68： | 1 |
| 16 | Preoperative Staging of PapillaryThyroid Carcinoma : Comparison of Ultrasound Imaging and CT显示文摘 | Soo C J Jinna K Young K J | 2009 | AmericanJournal of Roentgenology2009，193，3： | 1 |
| 17 | Electricitygeneration from bio-treatment of sewage sludge with microbialfuel cell显示文摘 | Jiang Junqiu Zhao Qingliang Zhang Jinna | 2009 | Bioresource Technology2009，100，： | 1 |
| 18 | Heavy metal contamination in surface sediments of Yangtze River intertidal zone: An assessment from different indexes 显示文摘 | Zhang Weiguo Feng Huan Chang Jinna | 2009 | Environmental Pollution2009，157，： | 1 |
| 19 | Efficacy of integrative medicine in deficiency of both qi and yin in the rat model of type 2 diabetes显示文摘Objective:To establish a rat model of type 2 diabetes(T2DM)manifesting the Chinese medicine syndrome pattern of both qi and yin deficiency for evaluating the efficacy of a Chinese herbal formula(CHF),integrative medicine(IM),and pioglitazone(PIO)on T2DM indicators in the animal model.Methods:The rat model was induced by a high-fat diet(HFD)and streptozotocin(STZ,30 mg/kg).CHF(3.4 g/kg),PIO(2.7 mg/kg),and IM(3.4 g CHF+2.7 mg PIO)were administered to rats once daily for 14 days.Related laboratory parameters were observed.Results:Diabetic rats showed unsmooth fur,alopecia,reduced activity,huddling,somnolence,depression,pale or reddened tongue,damp/dark red tail,and high levels of water and food intake,urine volume,and stool weight,but weakened grip strength.Low levels of serum SOD,Nat-Kt-ATPase,cAMP/cGMP,and a high level of iNOS were observed.Hyperglycemia,hyperinsulinemia,insulin resistance,high levels of serum glucagon/IDE and pancreatic amylin,and low serum and pancreatic SS levels were evident as well.Conclusions:A rat model of T2DM with both qi and yin deficiency was successfully replicated.CHF appeared to be more efficacious than IM and PIO in the rat model of qi and yin deficiency pattern of T2DM,though IM and PIO were each found to have their merits and drawbacks in attenuating T2DM indicators in the rat model. | Jing Zhao Jinna Liu Bangzhong Wang Yuanchao Yao Guangxia Zhang Biyuan Liu Yuanfeng Zhang Tian Xie Ming Xie | 2015 | Journal of Traditional Chinese Medical Sciences2015，2，4： | 1 |
| 20 | Heavy metal contamination in surface sediments of Yangtze River intertidal zone: An assessment from different indexes显示文摘 | Weiguo Zhang Huan Feng Jinna Chang Jianguo Qu Hongxia Xie Lizhong Yu | 2009 | Environmental Pollution2009，，5： | 1 |
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