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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Characteristics of SARS-CoV-2 Delta variant-infected individuals with intermittently positive retest viral RNA after discharge显示文摘SARS-CoV-2-infected patients will be discharged when viral ribonucleic acid(RNA)is consecutively negative at least twice over a 24-h interval.However,we have demonstrated that positive retest viral RNA,a particular clinical phenomenon initially observed in discharged SARS-CoV-2-infected patients in early 2020[1,2],is the occasional reoccurrence of Polymerase Chain Reaction(PCR)-detectable viral RNA but not reinfection[3]. | Lu Li Jingyan Tang Zhiwei Xie Qingxin Gan Guofang Tang Zhongwei Hu Huimin Zeng Jingrong Shi Jiaojiao Li Yan Li Changwen Ke Min Kang Dan Liang Huan Lu Yuwei Tong Xilong Deng Jinxin Liu Hongzhou Lu Fuxiang Wang Fengyu Hu Feng Li Nanshan Zhong Xiaoping Tang | 2022 | National Science Review2022，9，10： | 3 |
| 3 | Self-powered electronic paper with energy supplies and information inputs solely from mechanical motions显示文摘The electronic paper(E-paper)displays features such as flexibility,sunlight visibility,and low power consumption,which makes it ideal for Internet of Things(IoT)applications where the goal is to eliminate bulky power modules.Here,we report a unique self-powered E-paper(SPEP),where information inputs and energy supplies are all converted from mechanical motion by a triboelectric nanogenerator(TENG).The operation of an electrophoretic E-paper is first investigated,identifying the current density as a determinative parameter for driving pigment particle motion and color change.Electrical and optical responses of the E-paper driven by a slidingmode TENG are then found to be consistent with that under a current source mode.All-in-one monochromic and chromatic SPEPs integrated with a flexible transparent TENG are finally demonstrated,and a pixelated SPEP is discussed for future research.The sliding-driven mechanism of SPEP allows for a potential handwriting function,is free of an extra power supply,and promises undoubtedly a wide range of future applications. | YIFAN GU TINGTING HOU PENG CHEN JINXIN CAO CHONGXIANG PAN WEIGUO HU BO-RU YANG XIONG PU AND ZHONG LIN WANG | 2020 | Photonics Research2020，8，9： | 2 |
| 4 | Spatial Distribution Characteristics and Influencing Factors of Taobao Villages in Guangzhou显示文摘Through a case study on 24 Taobao villages in Guangzhou,this paper analyzes the relationship between the spatial distribution characteristics and influencing factors of Taobao villages using the online data mining methodology,and compares e-commerce-based industry clusters with traditional industry clusters.The result shows that Taobao villages in Guangzhou are mainly distributed in peripheral areas of the central city,with low population and employment density; villages running the same kind of business present the trend of concentration.And the formation of Taobao villages is highly relevant to the distribution of factories,wholesale markets,express services,and low-rent housing,as well as the learning and demonstration effect among subjects.It further proves that,under the influence of e-commerce,the importance of economies of scale and economies of scope brought by geographic proximity has been weakened,while the importance of interaction and communication effect among subjects have been obviously strengthened. | Hu Yao Liu Li Liu Jinxin | 2017 | China City Planning Review2017，26，4： | 2 |
| 5 | HY5-HDA9 orchestrates the transcription of HsfA2 to modulate salt stress response in Arabidopsis显示文摘Integration of light signaling and diverse abiotic stress responses contribute to plant survival in a changing environment.Some reports have indicated that light signals contribute a plant’s ability to deal with heat,cold,and stress.However,the molecular link between light signaling and the saltresponse pathways remains unclear.We demonstrate here that increasing light intensity elevates the salt stress tolerance of plants.Depletion of HY5,a key component of light signaling,causes Arabidopsis thaliana to become salinity sensitive.Interestingly,the small heat shock protein(sHsp)family genes are upregulated in hy5-215 mutant plants,and HsfA 2 is commonly involved in the regulation of these sH sps.We found that HY5directly binds to the G-box motifs in the HsfA2promoter,with the cooperation of HISTONE DEACETYLASE 9(HDA9),to repress its expression.Furthermore,the accumulation of HDA9 and the interaction between HY5 and HDA9 are significantly enhanced by salt stress.On the contrary,high temperature triggers HY5 and HDA9 degradation,which leads to dissociation of HY5-HDA9from the HsfA2 promoter,thereby reducing salt tolerance.Under salt and heat stress conditions,fine tuning of protein accumulation and an interaction between HY5 and HDA9 regulate HsfA2 expression.This implies that HY5,HDA9,and HsfA2play important roles in the integration of light signaling with salt stress and heat shock response. | Jiaheng Yang Xiao Qu Tao Li Yixiang Gao Haonan Du Lanjie Zheng Manchun Ji Paifeng Zhang Yan Zhang Jinxin Hu Liangyu Liu Zefu Lu Zijian Yang Huiyong Zhang Jianping Yang Yongqing Jiao Xu Zheng | 2023 | Journal of Integrative Plant Biology2023，65，1： | 1 |
| 6 | Quantum dots-hydrogel composites for biomedical applications显示文摘Quantum dots-hydrogel composites are promising new materials that have attracted extensive attention due to their incomparable biocompatibility and acceptable biodegradability, leading to enormous potential applications for various fields. This review summarizes the recent advances in quantum dots-hydrogel composites with a focus on synthesis methods, including hydrogel gelation in quantum dots(QDs) solution, embedding prepared QDs into hydrogels after gelation, forming QDs in situ within the preformed gel and cross-linking via QDs to form hydrogels. In particularly, biomedical applications as bioimaging,biosensing and drug delivery are also reviewed, followed by a discussion on the inherent challenges of design optimization, biocompatibility and bimodal applications and the prospect of the future development. These results will guide the development of quantum dots-hydrogel composites and provide critical insights to inspire researchers in future. | Wenjie Zhou Zhe Hu Jinxin Wei Hanqing Dai Yuanyuan Chen Siyu Liu Zhongtao Duan Fengxian Xie Wanlu Zhang Ruiqian Guo | 2022 | Chinese Chemical Letters2022，33，3： | 1 |
| 7 | Association between the Apolipoprotein E4 and Postoperative Cognitive Dysfunction in Elderly Patients Undergoing Intravenous Anesthesia and Inhalation Anesthesia显示文摘 | Yingmin Cai Haitao Hu Pengbin Liu Gaifeng Feng Weijiang Dong Bing Yu Yulin Zhu Jinxin Song Minggang Zhao | 2012 | Anesthesiology2012，，1： | 1 |
| 8 | Aqueous synthesis of 79%efficient AgInGaS/ZnS quantum dots for extremely high color rendering white light-emitting diodes显示文摘Over the past few decades,I-III-VI quantum dots(QDs)have attracted considerable attention due to their large Stokes shifts,good eco-friendliness,and wide tunable emissions.In this work,a facile microwave-assisted aqueous route using glutathione(GSH)and citric acid(CA)as dual stabilizers is introduced to synthesize AgInGaS/ZnS(AIGS/ZnS)core/shell QDs.An exceptional photoluminescence quantum yield(PL QY)as high as 79%is successfully achieved,boosting the best performance of water-dispersible AIGS QDs.By varying the Ag/Ga ratio,the PL peak wavelength can be tuned from 547 to 616 nm,and luminescent hydrogel films with different colors are obtained by embedding AIGS/ZnS QDs in polyacrylamide/poly-vinyl alcohol(PAAm/PVA)hydrogels.The white light-emitting diode(WLED)with a high color rendering index(CRI)of 92.1(R_(9)=92.0)and a correlated color temperature(CCT)of 3022 K is fabricated using QDs-PAAm/PVA hydrogel films in combination with a blue InGaN LED chip,indicating that the as-prepared QDs are competitive color-conversion materials for WLEDs. | Zhe Hu Hanxu Lu Wenjie Zhou Jinxin Wei Hanqing Dai b Hong Liu Zhiyong Xiong Fengxian Xie Wanlu Zhang Ruiqian Guo | 2023 | Journal of Materials Science & Technology2023，，3： | 1 |
| 9 | Resistance to Salmonellosis in the Chicken is linked to NRAMP1 and TNC显示文摘 | JINXIN HU NAT BUMSTEAD PAUL BARROW | 1997 | Genome Research1997，7，7： | 1 |
| 10 | Tumor growth and metastasis can be inhibited by maintaining genomic stability in cancer cells显示文摘癌症干细胞,像茎的癌症房间(SLCC ) ,或开始肿瘤的房间的存在被看作肿瘤形成和复发的原因,显示学习指向 SLCC 的新奇治疗的重要性。因为二竞争假设, SLCC 的起源是争论的:SLCC 也从转变祖先房间从织物成年人干细胞或 dedifferentiated 被转变。我们的以前的研究证明 SLCC 由在癌症房间增加 genomic 不稳定性是可诱导的。在这研究,堵住 SLCC 的出现, aminoethyl isothiourea ( AET ),清除自由激进分子的混合物并且被用来保护病人免受放射性的暴露的伤害,被用作与 mitomycin C ( MMC )在联合维持 genomic 稳定性的一个代理人,损坏 DNA 的通常使用的化学疗法的药。用有 VX2 肝的癌的一个兔子肿瘤模型,我们发现 MMC 独自增加了肺转移和处于不利地位的幸存结果,但是 MMC 和 AET 的联合颠倒了这效果平延长全面幸存。而且在由 immunocompromised 老鼠的一个 VX2 异种皮移植模型, MMC 独自与 AET 在联合充实 MMC 的开始肿瘤的房间,而是管理有效地消除了肿瘤房间。而且, MMC 独自提高了 genomic 不稳定性,但是与 AET 相结合的 MMC 在主要 VX2 肿瘤织物稀释了 genomic 不稳定性的程度。一起拿,我们的数据建议 genomic 保护者 AET 能由 AET 禁止 SLCC,和这联合治疗的正式就职,细胞毒素的代理人应该为未来被看作有希望的策略临床的评估。 | Yi Liang | 2015 | Frontiers of Medicine2015，9，1： | 1 |
| 11 | Giant nonlinear Hall effect in twisted bilayer WSe_(2)显示文摘The recently discovered nonlinear Hall effect(NHE)in a few non-interacting systems provides a novel mechanism for generating second-harmonic electrical Hall signals under time-reversal-symmetric conditions.Here,we introduce a new approach to engineering an NHE by using twisted moiréstructures.We found that the twisted WSe_(2)bilayer exhibited an NHE when the Fermi level was tuned to the moiréflat bands.When the first moiréband was half-filled,the nonlinear Hall signal exhibited a sharp peak with a generation efficiency that was at least two orders of magnitude greater than those obtained in previous experiments.We discuss the possible origins of the diverging generation efficiency in twisted WSe_(2)based on resistivity measurements,such as moiré-interface-induced correlation effects and mass-diverging-type continuous Mot transition.This study demonstrates not only how interaction effects can combine with Berry curvature dipoles to produce novel quantum phenomena,but also the potential of NHE measurements as a new tool for studying quantum criticality. | Meizhen Huang Zefei Wu Jinxin Hu Xiangbin Cai En Li Liheng An Xuemeng Feng Ziqing Ye Nian Lin Kam Tuen Law Ning Wang | 2023 | National Science Review2023，10，4： | 0 |
| 12 | Molecular basis of Spns2-facilitated sphingosine-1-phosphate transport显示文摘Dear Editor,As one of the critical sphingolipid metabolites in eukaryotes,sphingosine-1-phosphate(S1P)acts as a bioactive lipid mediator in the immune and vascular systems.S1P prompts its physiological roles through two mechanisms,binding to its intracellular targets or extracellular secretion.Intracellular S1P promotes cellular proliferation,whereas plasma S1P facilitates immune cell trafficking,regulates angiogenesis,and helps to maintain vascular integrity.1 Due to the amphipathic property,S1P cannot diffuse freely but has to be transported across the cell membrane through active transport.1 In the past two decades,several S1P transporters have been identified,including two major facilitator superfamily(MFS)members:Spinster homolog 2(Spns2)and Mfsd2b,and some ATP-binding cassette family transporters.Among these transporters,Spns2 is the first identified and the most extensively studied.2 Here,we reported two cryo-electron microscopy(EM)structures of human Spns2 in inward-open conformations bound to S1P or inhibitor 16d. | Bin Pang Leiye Yu Tong Li Haizhan Jiao Xiaomei Wu Jinxin Wang Ruiping He Yurou Zhang Juan Wang Hongli Hu Wei Dai Li Chen Ruobing Ren | 2024 | Cell Research2024，34，2： | 0 |
| 13 | Strategic Guidance & Rigid Control: Innovation of Urban Master Planning in the New Period by Taking Shanghai 2040 Master Plan as an Example显示文摘The reform of urban master planning should make continuous progress to meet the requirements of urban and rural spatial resource control in the urbanization transformation period, considering its role of both strategic guidance and rigid control. As urban development in Shanghai is entering the era of stock-based development, it is important for the Shanghai 2040 Master Plan to upgrade urban strategies to adapt to the transformation environment of urban development, and to adjust the master planning system in line with Shanghai's reality. This article analyzes the development environment and challenges faced by the Shanghai 2040 Master Plan and reflects on the limitations of traditional master planning. To facilitate the spatial development transformation and spatial governance, the article summarizes the innovation ideas of the Shanghai 2040 Master Plan from aspects of functions, outcome framework, control system, organization format, etc. | Zhang Shangwu Jin Zhongmin Wang Xinzhe Zheng Degao Hu Guojun Fang Lan Shi Tingting Wu Kexin Wang Lili Sun Ye Liu Jinxin | 2018 | China City Planning Review2018，27，2： | 0 |
| 14 | Characteristics of photosynthesis and vertical canopy architecture of citrus trees under two labor-saving cultivation modes using unmanned aerial vehicle (UAV)-based LiDAR data in citrus orchards显示文摘Analyzing and comparing the effects of labor-saving cultivation modes on photosynthesis,as well as studying their vertical canopy architecture,can improve the tree structure of high-quality and high-yield citrus and selection of labor-saving cultivation modes.The photosynthesis of 1080 leaves of two labor-saving cultivation modes(wide-row and narrow-plant mode and fenced mode)comparing with the traditional mode were measured,and nitrogen content of all leaves and photosynthetic nitrogen use efficiency(PNUE)were determined.Unmanned aerial vehicle(UAV)-based light detection and ranging(LiDAR)data were used to assess the vertical architecture of three citrus cultivation modes.Results showed that for the wide-row and narrow-plant and traditional modes leaf photosynthetic CO_(2) assimilation rate,stomatal conductance,and transpiration rate of the upper layer were significantly higher than those of the middle layer,and values of the middle layer were markedly higher than those of the lower layer.In the fenced mode,a significant difference in photosynthetic factors between the upper and middle layers was not observed.A vertical canopy distribution had a more significant effect on PNUE in the traditional mode.Leaves in the fenced mode had distinct photosynthetic advantages and higher PNUE.UAV-based LiDAR data effectively revealed the differences in the vertical canopy architecture of citrus trees by enabling calculating the density and height percentile of the LiDAR point cloud.The point cloud densities of three cultivation modes were significantly different for all LiDAR density slices,especially at higher canopy heights.The labor-saving modes,particularly the fenced mode,had significantly higher height percentile data. | Yuanyong Dian Xiaoyang Liu Lei Hu Jinzhi Zhang Chungen Hu Yongzhong Liu Jinxin Zhang Wenbo Zhang Qingqing Hu Yahao Zhang Yanni Fang Jingjing Zhou | 2023 | Horticulture Research2023，10，3： | 0 |
| 15 | Android Malware Detection Using Local Binary Pattern and Principal Component Analysis显示文摘Nowadays,analysis methods based on big data have been widely used in malicious software detection.Since Android has become the dominator of smartphone operating system market,the number of Android malicious applications are increasing rapidly as well,which attracts attention of malware attackers and researchers alike.Due to the endless evolution of the malware,it is critical to apply the analysis methods based on machine learning to detect malwares and stop them from leakaging our privacy information.In this paper,we propose a novel Android malware detection method based on binary texture feature recognition by Local Binary Pattern and Principal Component Analysis,which can visualize malware and detect malware accurately.Also,our method analyzes malware binary directly without any decompiler,sandbox or virtual machines,which avoid time and resource consumption caused by decompiler or monitor in this process.Experimentation on 5127 benigns and 5560 malwares shows that we obtain a detection accuracy of 90%. | Qixin Wu Zheng Qin Jinxin Zhang Hui Yin Guangyi Yang Kuangsheng Hu | 2017 | 国际计算机前沿大会会议论文集2017，，1： | 0 |
| 16 | Prognostic nomogram incorporating radiological features for predicting overall survival in patients with AIDS-related non-Hodgkin lymphoma显示文摘Background: Acquired immune deficiency syndrome (AIDS)-related non-Hodgkin lymphoma (AR-NHL) is a high-risk factor for morbidity and mortality in patients with AIDS. This study aimed to determine the prognostic factors associated with overall survival (OS) and to develop a prognostic nomogram incorporating computed tomography imaging features in patients with acquired immune deficiency syndrome-related non-Hodgkin lymphoma (AR-NHL).Methods: A total of 121 AR-NHL patients between July 2012 and November 2019 were retrospectively reviewed. Clinical and radiological independent predictors of OS were confirmed using multivariable Cox analysis. A prognostic nomogram was constructed based on the above clinical and radiological factors and then provided optimum accuracy in predicting OS. The predictive accuracy of the nomogram was determined by Harrell C-statistic. Kaplan-Meier survival analysis was used to determine median OS. The prognostic value of adjuvant therapy was evaluated in different subgroups.Results: In the multivariate Cox regression analysis, involvement of mediastinal or hilar lymph nodes, liver, necrosis in the lesions, the treatment with chemotherapy, and the CD4 ≤100 cells/μL were independent risk factors for poor OS (allP < 0.050). The predictive nomogram based on Cox regression has good discrimination (Harrell C-index = 0.716) and good calibration (Hosmer-Lemeshow test,P = 0.620) in high- and low-risk groups. Only patients in the high-risk group who received adjuvant chemotherapy had a significantly better survival outcome.Conclusion: A survival-predicting nomogram was developed in this study, which was effective in assessing the survival outcomes of patients with AR-NHL. Notably, decision-making of chemotherapy regimens and more frequent follow-up should be considered in the high-risk group determined by this model. | Xueqin Li Ziang Pan Xing Wang Tianli Hu Wen Ye Dongmei Jiang Wen Shen Jinxin Liu Yuxin Shi Shuang Xia Hongjun Li | 2022 | Chinese Medical Journal2022，，1： | 0 |
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