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| 1 | The Arabidopsis bZIP1 Transcription Factor Is Involved in Sugar Signaling, Protein Networking, and DNA Binding显示文摘糖发信号是种使用集成各种各样的内部、外部的暗示完成滋养的动态平衡的机制,调停发展节目,和清晰压力回答。许多 bZIP 抄写因素被知道涉及营养素或应力发信号。Arabidopsis S1 组 bZIP 基因, AtbZIP1,在介绍学习的以前的基因表情作为糖敏感的基因被识别(植物房间。16, 21282150 ) 。在这份报告,我们证明 AtbZIP1 的表示被糖以一个快、敏感、可逆的方法镇压。AtbZIP1 的糖压抑被表明部件的保存的糖影响, hexokinase。除是调整糖的基因以外, AtbZIP1 能调停糖发信号并且影响基因表示,植物生长,和开发。当碳营养素是有限的时, AtbZIP1 原因的功能的获得或损失处于早幼苗建立的率变化。phenotypic 分析的结果显示 AtbZIP1 充当早幼苗生长的一个否定管理者。用在 microarray 分析的 gain-of-function 和 loss-of-function 植物,通常认为的调整 AtbZIP1 的基因的二个集合被识别了。在他们之中,糖应答的基因是高度过去代表的,含有在调停糖的基因表示的 AtbZIP1 的一个角色。用酵母二混血儿(Y-2-H ) 屏蔽,双分子的荧光互补(BiFC ) 分析,我们能概括广泛的 C/S1 AtbZIP 蛋白质交往在生活房间的网络。最后,我们证明 AtbZIP1 能在 vitro 绑基于 ACGT 的主题并且有约束力的特征看起来被在 AtbZIP1 和 C 组 AtbZIPs 之间的 heterodimerization 影响,包括 AtbZIP10 和 AtbZIP63。 | Shin Gene Kang John Price Pei-Chi Lin Jong Chan Hong Jyan-Chyun Jang | 2010 | Molecular Plant2010，3，2： | 13 |
| 2 | A Novel Semiconductor CIGS Photovoltaic Material and Thin-Film ED Technology显示文摘In order to achieve low cost high efficiency thin film solar cells,a novel Semiconductor Photovoltaic (PV) active material CuIn 1-x Ga x Se 2 (CIGS) and thin film Electro Deposition (ED) technology is explored.Firstly,the PV materials and technologies is investigated,then the detailed experimental processes of CIGS/Mo/glass structure by using the novel ED technology and the results are reported.These results shows that high quality CIGS polycrystalline thin films can be obtained by the ED method,in which the polycrystalline CIGS is definitely identified by the (112),(204,220) characteristic peaks of the tetragonal structure,the continuous CIGS thin film layers with particle average size of about 2μm of length and around 1 6μm of thickness.The thickness and solar grade quality of CIGS thin films can be produced with good repeatability.Discussion and analysis on the ED technique,CIGS energy band and sodium (Na) impurity properties,were also performed.The alloy CIGS exhibits not only increasing band gap with increasing x ,but also a change in material properties that is relevant to the device operation.The beneficial impurity Na originating from the low cost soda lime glass substrate becomes one prerequisite for high quality CIGS films.These novel material and technology are very useful for low cost high efficiency thin film solar cells and other devices. | ZHENG Guang fu 1,YANG Hong xing 1,MAN Cheuk ho 1,WONG Wing lok 2, AN Da wei 1 and John BURNETT 1(1 Centre for Development of Solar Energy Technology,Department of Building Services Engineering, The Hong Kong Polytechnic University,Hong Kong,C | 2001 | Journal of Semiconductors2001，22，11： | 10 |
| 3 | 3-year Treatment of Tenofovir Alafenamide vs.Tenofovir Disoproxil Fumarate for Chronic HBV Infection in China显示文摘Background and Aims:Tenofovir alafenamide(TAF)has similar efficacy to tenofovir disoproxil fumarate(TDF)but with improved renal and bone safety in chronic hepatitis B patients studied outside of China.We report 3-year results from two phase 3 studies with TAF in China(Clinicaltrials.gov:NCT02836249 and NCT02836236).Methods:Chinese hepatitis B e antigen(HBeAg)-positive and-negative chronic hepatitis B patients with viremia and elevated alanine aminotransferase were randomized 2:1 to TAF or TDF treatment groups and treated in a double-blind fashion for 144 weeks(3 years).Efficacy responses were assessed by individual study while safety was assessed by a pooled analysis.Results:Of the 334 patients(180 HBeAg-positive and 154 HBeAg-negative)randomized and treated,baseline characteristics were similar between groups.The overall mean age was 38 years and 73%were male.The mean HBV DNA was 6.4 log10 IU/mL.The median alanine aminotransferase was 88 U/L,and 37%had a history of antiviral use.At week 144,the proportion with HBV DNA<29 IU/mL was similar among the two groups,with TAF at 83%vs.TDF at 79%,and TAF at 93%vs.TDF at 92%for the HBeAg-positive and-negative patients,respectively.In each study,higher proportions of TAF than TDF patients showed normalized alanine aminotransferase(via the American Association for the Study of Liver Diseases and the China criteria)and showed loss of HBsAg;meanwhile,the HBeAg seroconversion rates were similar.Treatment was well-tolerated among the TAF patients,who showed a smaller median decline in creatinine clearance(−0.4 vs.−3.2 mL/min;p=0.014)and less percentage change in bone mineral density vs.TDF at hip(−0.95%vs.−1.93%)and spine(+0.35%vs.−1.40%).Conclusions:In chronic hepatitis B patients from China,TAF treatment provided efficacy similar to TDF but with better renal and bone safety at 3 years. | Jinlin Hou Qin Ning Zhongping Duan You Chen Qing Xie Fu-Sheng Wang Lunli Zhang Shanming Wu Hong Tang Jun Li Feng Lin Yongfeng Yang Guozhong Gong John FFlaherty Anuj Gaggar Shuyuan Mo Cong Cheng Gregory Camus Chengwei Chen Yan Huang Jidong Jia Mingxiang Zhang GS-US-320-0110 and GS-US-320-0108 China Investigators | 2021 | Journal of Clinical and Translational Hepatology2021，9，3： | 7 |
| 4 | The clinical association of programmed cell death protein 4(PDCD4) with solid tumors and its prognostic significance:a meta-analysis显示文摘Background: Programmed cell death protein 4(PDCD4) is a novel tumor suppressor protein involved in pro?grammed cell death. Its association with cancer progression has been observed in multiple tumor models, but evidence supporting its association with solid tumors in humans remains controversial. This study aimed to determine the clinical signiicance and prognostic value of PDCD4 in solid tumors.Methods: A systematic literature review was performed to retrieve publications with available clinical informa?tion and survival data. The eligibility of the selected articles was based on the criteria of the Dutch Cochrane Centre proposed by the Meta?analysis Of Observational Studies in Epidemiology group. Pooled odds ratios(ORs), hazard ratios(HRs), and 95% conidence intervals(CIs) for survival analysis were calculated. Publication bias was examined by Begg's and Egger's tests.Results: Clinical data of 2227 cancer patients with solid tumors from 23 studies were evaluated. PDCD4 expression was signiicantly associated with the diferentiation status of head and neck cancer(OR 4.25, 95% CI 1.87–9.66) and digestive system cancer(OR 2.87, 95% CI 1.84–4.48). Down?regulation of PDCD4 was signiicantly associated with short overall survival of patients with head and neck(HR: 3.44, 95% CI 2.38–4.98), breast(HR: 1.86, 95% CI 1.36–2.54), digestive system(HR: 2.12, 95% CI 1.75–2.56), and urinary system cancers(HR: 3.16, 95% CI 1.06–9.41).Conclusions: The current evidence suggests that PDCD4 down?regulation is involved in the progression of several types of solid tumor and is a potential marker for solid tumor prognoses. Its clinical usefulness should be conirmed by large?scale prospective studies. | John Zeng Hong Li Wei Gao Wai-Kuen Ho Wen Bin Lei William Ignace Wei Jimmy Yu-Wai Chan Thian-Sze Wong | 2016 | Chinese Journal of Cancer2016，35，12： | 7 |
| 5 | Neurological consequences of systemic inflammation in the premature neonate显示文摘Despite substantial progress in neonatal care over the past two decades leading to improved survival of extremely premature infants, extreme prematurity continues to be associated with long term neurodevelopmental impairments. Cerebral white matter injury is the predominant form of insult in preterm brain leading to adverse neurological consequences. Such brain injury pattern and unfavorable neurologic sequelae is commonly encountered in premature infants exposed to systemic inflammatory states such as clinical or culture proven sepsis with or without evidence of meningitis, prolonged mechanical ventilation, bronchopulmonary dysplasia, necrotizing enterocolitis and chorioamnionitis. Underlying mechanisms may include cytokine mediated processes without direct entry of pathogens into the brain, developmental differences in immune response and complex neurovascular barrier system that play a critical role in regulating the cerebral response to various systemic inflammatory insults in premature infants. Understanding of these pathologic mechanisms and clinical correlates of such injury based on serum biomarkers or brain imaging findings on magnetic resonance imaging will pave way for future research and translational therapeutic opportunities for the developing brain. | Aparna Patra Hong Huang John A.Bauer Peter J.Giannone | 2017 | Neural Regeneration Research2017，12，6： | 5 |
| 6 | Structural and mechanistic understanding of an active and durable graphene carbocatalyst for reduction of 4-nitrophenol at room temperature显示文摘能代替基于金属的催化剂的活跃、持久、没有金属的 carbocatalyst 的发展具有增加科学、工艺的重要性。如此的催化剂的使用将避免例如,包含金属的催化剂引起的问题由稀罕金属资源的重金属和弄空的环境污染。此处,活跃、持久的 graphene carbocatalyst 在周围的温度为 4-nitrophenol 的 carbocatalytic 变换被介绍给 4-aminophenol。carbocatalyst 经由在 L 维生素酸(AA ) 和 graphene 氧化物之间的温和、以水为基的反应被准备(去) 并且没包含任何另外的反应物。在结构和催化性质优化期间,一系列 carbocatalysts 在各种各样的反应温度和 AA/GO 比率被制作。用几种描述技术,详细说明了这些 carbocatalysts 的结构的特征被识别。carbocatalysts 上的可能的活跃种类和地点也被识别例如某些包含氧的组,结合的系统,和 graphene 表边。另外,在这些之间的 synergistic 效果结果上的活跃种类和地点催化活动被加亮。而且,我们澄清了高稳定性的起源和优化 carbocatalyst 的耐久性。这里介绍的工作为加氢反应帮助高效的 carbocatalysts 的设计,并且在分子的水平增加结构、机械学的方面的理解导致高催化剂活动和耐久性。 | Huawen Hu John H. Xin Hong Hu Xiaowen Wang | 2015 | Nano Research2015，8，12： | 5 |
| 7 | Testing reintroduction as a conservation strategy for the critically endangered Chinese alligator: Movements and home range of released captive individuals显示文摘The Chinese alligator (Alligator sinensis) is considered the most critically endangered crocodilian as a result of the near total loss of its habitat and its extremely small and fragmented wild populations. Plans for population recovery lie mostly with wetland res- toration and the reintroduction of captive-reared animals. We carried out a first-trial release of 3 adult Chinese alligators (1♂, 2♀) into a pond at the Hongxing conservation site, Xuancheng, southern Anhui Province; the animals were radio-tracked from May to October in 2003. We hypothesized that after a period of adaptation, the alligators would establish definable home ranges. Two (1♂, 1♀) of the 3 alligators were monitored for the whole of the tracking period. The male had an annual home-range size of 7.61 hm2, and the female 4.00 hm2. Water temperature and pond water level were two important factors influencing the alligators' distributions, and daily movements. The radio-tracked alligators had overlapping home ranges, which notably included the one substantial island in the pond; that island is the only known nesting site of the local native wild alligators. Aggressive interactions between the released alligators and native wild alligators were observed during the breeding season around this island. All the three reintroduced alligators survived the winter of 2003 and were alive in the same pond in 2008. We concluded that the Hongxing conservation site provided a suitable habitat for the reintroduced alligators. However, the low water level in the pond resulting from farmland irrigation in August and September can be a substantial threat to the alligators' survival. Therefore, regu- lations on irrigation in summer and autumn are needed to balance the water needs of the alligators and agriculture. | WANG ZhengHuan YAO Hong DING YouZhong THORBJARNARSON John WANG XiaoMing | 2011 | Chinese Science Bulletin2011，56，24： | 5 |
| 8 | Accelerated flow softening and dynamic transformation of Ti-6Al-4V alloy in two-phase region during hot deformation via coarsening αgrain显示文摘The flow softening is an important phenomenon during hot deformation of metallic materials.In the present work,a more evident flow softening of Ti-6 Al-4 V alloy when deformed in two-phase region was observed in coarser a grain sample,which was attributed to an accelerated dynamic transformation from harder α phase into β phases.Notably,full β microstructure was observed in coarse grain samples at strain of 1.2,while retained a phase was observed in fine a grain specimens.In the views of thermodynamics and crystallographic analysis,the in-depth mechanisms of dynamic transformation were further investigated. | Xiankun Ji Baoqi Guo Fulin Jiang Hong Yu Dingfa Fu Jie Teng Hui Zhang John J.Jonas | 2020 | Journal of Materials Science & Technology2020，36，1： | 5 |
| 9 | Multifunctional organically modified graphene with super-hydrophobicity显示文摘 | Huawen Hu Chan C. K. Allan Jianhua Li Yeeyee Kong Xiaowen Wang John H. Xin Hong Hu | 2014 | Nano Research2014，7，3： | 5 |
| 10 | Polarization reversal via a transient relaxor state in nonergodic relaxors near freezing temperature显示文摘Among the unresolved issues in the study of relaxor ferroelectrics is the role of freezing temperature,across which the dynamics of polarization reversal in relaxor ferroelectrics changes.The presence of this freezing temperature is best manifested by the appearance of a double polarization hysteresis loop just above the freezing temperature.Given that the polarization pinching evolving into a double hysteresis starts well below the freezing temperature,there exists a transient temperature regime between the nonergodic and the ergodic relaxor states.To clarify the role of the freezing temperature on the pinching,the polarization reversal near the freezing temperature of relaxor(Pb_(1-x)La_(x))(Zr_(1-y)T_(y))_(1-x/4)O_(3)(PLZT)was monitored using three in situ electric field methods:electrocaloric effect,neutron diffraction,and transmission electron microscopy.We demonstrate that the pinching results from a two-step process,1)domain detexturization in the ferroelectric state and 2)miniaturization of domains.This observation explains the recently reported gap between the depolarization temperature T_(d) and the ferroelectric-torelaxor transition temperature T_(F-R) in lead-free relaxors.We further show that T_(d) and T_(F-R),which have long been considered identical in lead-based relaxors,are not the same.The current study suggests that the mismatch between T_(d) and TF-R is an inherent feature in both lead-based and lead-free relaxor ferroelectrics. | Chang-Hyo Hong Hanzheng Guo Xiaoli Tan John E.Daniels Wook Jo | 2019 | Journal of Materiomics2019，5，4： | 4 |
| 11 | 二十世纪九十年代中美电视广告中的文化价值比较显示文摘这篇文章对1993年中美两国1105个电视广告的内容进行了分析,并得出了八种在中美两国居于主导地位的文化价值。总体而言,美国的电视广告中,对于象征性和实用性的价值都有所体现,而中国则更多地诉诸于象征性的文化价值。研究结果表明,如今的中国广告业既是一个融会东西方文化的“大熔炉”,又是一面“双重扭曲的镜子”。中国的广告业以一种适应中国社会现实特质的强劲发展态势,体现着广告所具有的商业属性。而熔炉的开放性以及扭曲的双面镜日益闭合的趋势,对于整个行业发展及广告研究都有着深远的影响。研究还发现,中国电视广告中所描述的文化价值,大多与产品类别和产品起源有关。传递西方文化价值的主要是进口产品以及一些合资企业产品的广告。 | HONG CHENG JOHN C. SCHWEITZER 崔彤彦 | 2006 | 广告大观(理论版)2006，0，4： | 4 |
| 12 | The Shenzhen Declaration on Plant Sciences Uniting plant sciences and society to build a green, sustainable Earth显示文摘 | Peter R. Crane Song Ge De-Yuan Hong Hong-Wen Huang Gen-Lin Jiao Sandra Knapp W. John Kress Harold Mooney Peter H. Raven Jun Wen Wei-Hua Wu Huan-Ming Yang Wei-Hua Zhu Yu-Xian Zhu | 2017 | Journal of Systematics and Evolution2017，55，5： | 3 |
| 13 | Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma显示文摘Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer(NSCLC)risk,biological mechanisms of these variants remain largely unknown.By integrating a large-scale genotype data of 15581 lung adenocarcinoma(AD)cases,8350 squamous cell carcinoma(SqCC)cases,and 27355 controls,as well as multiple transcriptome and epigenomic databases,we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibility variants.We identified 3064 credible risk variants for NSCLC,which were overrepresented in enhancer-like and promoter-like histone modification peaks as well as DNase I hypersensitive sites.Transcription factor enrichment analysis revealed that USF1 was AD-specific while CREB1 was SqCC-specific.Functional annotation and genebased analysis implicated 894 target genes,including 274 specifics for AD and 123 for SqCC,which were overrepresented in somatic driver genes(ER=1.95,P=0.005).Pathway enrichment analysis and Gene-Set Enrichment Analysis revealed that AD genes were primarily involved in immune-related pathways,while SqCC genes were homologous recombination deficiency related.Our results illustrate the molecular basis of both wellstudied and new susceptibility loci of NSCLC,providing not only novel insights into the genetic heterogeneity between AD and SqCC but also a set of plausible gene targets for post-GWAS functional experiments. | Na Qin Yuancheng Li Cheng Wang Meng Zhu Juncheng Dai Tongtong Hong Demetrius Albanes Stephen Lam Adonina Tardon Chu Chen Gary Goodman Stig EBojesen Maria Teresa Landi Mattias Johansson Angela Risch H-Erich Wichmann Heike Bickeboller Gadi Rennert Susanne Arnold Paul Brennan John KField Sanjay Shete Loic Le Marchand Olle Melander Hans Brunnstrom Geoffrey Liu Rayjean JHung Angeline Andrew Lambertus AKiemeney Shan Zienolddiny Kjell Grankvist Mikael Johansson Neil Caporaso Penella Woll Philip Lazarus Matthew BSchabath Melinda CAldrich Victoria LStevens Guangfu Jin David CChristiani Zhibin Hu Christopher IAmos Hongxia Ma Hongbing Shen | 2021 | Frontiers of Medicine2021，15，2： | 3 |
| 14 | Heart Disease and Stroke Statistics—2006 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee显示文摘 | Thomas Thom Nancy Haase Wayne Rosamond Virginia J. Howard John Rumsfeld Teri Manolio Zhi-Jie Zheng Katherine Flegal Christopher O’Donnell Steven Kittner Donald Lloyd-Jones David C. Goff Yuling Hong Robert Adams Gary Friday Karen Furie Philip Gorelick Bret | 2006 | Circulation2006，，6： | 3 |
| 15 | Vascular Complications of Orthotopic Liver Transplantation: Experience in More than 4,200 Patients显示文摘 | John P. Duffy Johnny C. Hong Douglas G. Farmer Rafik M. Ghobrial Hasan Yersiz Jonathan R. Hiatt Ronald W. Busuttil | 2009 | Journal of the American College of Surgeons2009，，5： | 3 |
| 16 | Long-Term Patient Outcome and Quality of Life After Liver Transplantation: Analysis of 20-Year Survivors显示文摘 | John P. Duffy Kenneth Kao Clifford Y. Ko Douglas G. Farmer Sue V. McDiarmid Johnny C. Hong Robert S. Venick Susan Feist Leonard Goldstein Sammy Saab Jonathan R. Hiatt Ronald W. Busuttil | 2010 | Annals of Surgery2010，，4： | 3 |
| 17 | Autonomic responses to blast overpressure can be elicited by exclusively exposing the ear in rats显示文摘Blast overpressure has become an increasing cause of brain injuries in both military and civilian populations. Though blast's direct effects on the cochlea and vestibular organs are active areas of study, little attention has been given to the ear's contribution to the overall spectrum of blast injury. Acute autonomic responses to blast exposure, including bradycardia and hypotension, can cause hypoxia and contribute to blast-induced neurotrauma. Existing literature suggests that these autonomic responses are elicited through blast impacting the thorax and lungs. We hypothesize that the unprotected ear also provides a vulnerable locus for blast to cause autonomic responses. We designed a blast generator that delivers controlled overpressure waves into the ear canal without impacting surrounding tissues in order to study the ear's specific contribution to blast injury. Anesthetized adult rats' left ears were exposed to a single blast wave ranging from 0 to 110 PSI(0-758 kPa). Blast exposed rats exhibited decreased heart rates and blood pressures with increased blast intensity, similar to results gathered using shock tubes and whole-body exposure in the literature. While rats exposed to blasts below 50 PSI(345 kPa) exhibited increased respiratory rate with increased blast intensity, some rats exposed to blasts higher than 50 PSI(345 kPa) stopped breathing immediately and ultimately died. These autonomic responses were significantly reduced in vagally denervated rats, again similar to whole-body exposure literature. These results support the hypothesis that the unprotected ear contributes to the autonomic responses to blast. | David S.Sandlin Yue Yu Jun Huang Chunming Zhang Alberto A.Arteaga John K.Lippincott Erin O.H.Peeden Ryan R.Guyton Lan Chen Laura L.S.Beneke Jerome C.Allison Hong Zhu Wu Zhou | 2018 | Journal of Otology2018，13，2： | 2 |
| 18 | A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial of Retinol Palmitate (Vitamin A) for Symptomatic Chronic Radiation Proctopathy显示文摘 | Eli D. Ehrenpreis Ashesh Jani Josh Levitsky Joseph Ahn John Hong | 2005 | Diseases of the Colon & Rectum2005，，1： | 2 |
| 19 | A novel tool to assess systolic asynchrony and identify responders of cardiac resynchronization therapy by tissue synchronization imaging显示文摘 | Cheuk-Man Yu Qing Zhang Jeffrey Wing-Hong Fung Hamish Chi-Kin Chan Yat-Sun Chan Gabriel Wai-Kwok Yip Shun-Ling Kong Hong Lin Yan Zhang John E. Sanderson | 2005 | Journal of the American College of Cardiology2005，，5： | 2 |
| 20 | Tissue Doppler Imaging Is Superior to Strain Rate Imaging and Postsystolic Shortening on the Prediction of Reverse Remodeling in Both Ischemic and Nonischemic Heart Failure After Cardiac Resynchronization Therapy显示文摘 | Cheuk-Man Yu Jeffrey Wing-Hong Fung Qing Zhang Chi-Kin Chan Yat-Sun Chan Hong Lin Leo C.C. Kum Shun-Ling Kong Yan Zhang John E. Sanderson | 2004 | Circulation: Journal of the American Heart Association2004，，1： | 2 |
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