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| 1 | Clinical features and the traditional Chinese medicine therapeutic characteristics of 293 COVID-19 inpatient cases显示文摘Coronavirus disease 2019 (COVID-19) is now pandemic worldwide and has heavily overloaded hospitals in Wuhan City, China during the time between late January and February. We reported the clinical features and therapeutic characteristics of moderate COVID-19 cases in Wuhan that were treated via the integration of traditional Chinese medicine (TCM) and Western medicine. We collected electronic medical record (EMR) data, which included the full clinical profiles of patients, from a designated TCM hospital in Wuhan. The structured data of symptoms and drugs from admission notes were obtained through an information extraction process. Other key clinical entities were also confirmed and normalized to obtain information on the diagnosis, clinical treatments, laboratory tests, and outcomes of the patients. A total of 293 COVID-19 inpatient cases, including 207 moderate and 86 (29.3%) severe cases, were included in our research. Among these cases, 238 were discharged, 31 were transferred, and 24 (all severe cases) died in the hospital. Our COVID-19 cases involved elderly patients with advanced ages (57 years on average) and high comorbidity rates (61%). Our results reconfirmed several well-recognized risk factors, such as age, gender (male), and comorbidities, as well as provided novel laboratory indications (e.g., cholesterol) and TCM-specific phenotype markers (e.g., dull tongue) that were relevant to COVID-19 infections and prognosis. In addition to antiviral/antibiotics and standard supportive therapies, TCM herbal prescriptions incorporating 290 distinct herbs were used in 273 (93%) cases. The cases that received TCM treatment had lower death rates than those that did not receive TCM treatment (17/273= 6.2% vs. 7/20= 35%, P = 0.0004 for all cases;17/77= 22% vs. 7/9= 77.7%, P = 0.002 for severe cases). The TCM herbal prescriptions used for the treatment of COVID-19 infections mainly consisted of Pericarpium Citri Reticulatae, Radix Scutellariae, Rhizoma Pinellia, and their combinations, which reflected the practical TCM principles (e.g., clearing heat and dampening phlegm). Lastly, 59% of the patients received treatment, including antiviral, antibiotics, and Chinese patent medicine, before admission. This situation might have some effects on symptoms, such as fever and dry cough. By using EMR data, we described the clinical features and therapeutic characteristics of 293 COVID-19 cases treated via the integration of TCM herbal prescriptions and Western medicine. Clinical manifestations and treatments before admission and in the hospital were investigated. Our results preliminarily showed the potential effectiveness of TCM herbal prescriptions and their regularities in COVID-19 treatment. | Zixin Shu Yana Zhou Kai Chang Jifen Liu Xiaojun Min Qing Zhang Jing Sun Yajuan Xiong Qunsheng Zou Qiguang Zheng Jinghui Ji Josiah Poon Baoyan Liu Xuezhong Zhou Xiaodong Li | 2020 | Frontiers of Medicine2020，14，6： | 7 |
| 2 | Dietary fatty acids and bioactive fatty acid metabolites in alcoholic liver disease显示文摘Alcoholic liver disease(ALD)comprises a spectrum of liver pathology,including steatosis,steatohepatitis,and cirrhosis.Previous work from our group and others suggests that dietary fat,both the amount and composition,plays a pivotal role in ALD development and progression;however,the impact of specific dietary fatty acids on ALD pathogenesis is not fully elucidated.Preclinical rodent models of ALD revealed the deleterious effects of omega-6 polyunsaturated fatty acids(n-6 PUFAs),specifically linoleic acid(LA),and this may be partially attributed to the increased levels of pro-inflammatory oxidized LA metabolites.There is limited understanding regarding the role of omega-3 polyunsaturated fatty acids(n-3 PUFAs,such as alpha-linolenic acid,eicosapentaenoic acid,and docosahexaenoic acid),and bioactive n-3 PUFAderived lipid molecules in ALD.Given that majority of n-6 and n-3 PUFAs-derived metabolites are potent endogenous signaling molecules,knowledge regarding the changes in these lipid mediators may shed new light on the mechanisms contributing to ALD pathogenesis and reveal novel therapeutic targets and biomarkers of this disease.The current review summarizes relevant scientific literature regarding the role of dietary fat,distinct fatty acids,and bioactive fatty acid metabolites in ALD,and highlights recent advances in the field. | Kara H.Zirnheld Dennis R.Warner Jeffrey B.Warner Josiah E.Hardesty Craig J.McClain Irina A.Kirpich | 2019 | Liver Research2019，3，3： | 2 |
| 3 | In vitro antioxidant capacity and free radical scavenging evaluation of active metabolite constituents of Newbouldia laevis ethanolic leaf extract显示文摘 | Josiah Bitrus Habu Ban:holomew Okechukwu Ibeh | 2015 | Biol Res2015，48，1： | 1 |
| 4 | Some new principles to rosin sizing显示文摘 | Josiah Marton Terazia Matron | 1982 | Tappi1982，65，11： | 1 |
| 5 | Peer-mediated social skills training program for young children with high-functioning autism显示文摘 | Kyong-Mee Chung Shaye Reavis Matt Mosconi Josiah Drewry Todd Matthews Marc J. Tassé | 2006 | Research in Developmental Disabilities2006，，4： | 1 |
| 6 | Composting and phytoremediation treatment of petro- leum sludge 显示文摘 | Ayotamuno Josiah M Kogbara Reginald B Agele Eriye A | 2010 | Soil Sediment Contain2010，19，6： | 1 |
| 7 | School-based participatory health education for malaria control in Ghana= engaging children as health messengers显示文摘 | Irene A Daisuke N Josiah KA | 2010 | Malar J2010，9，： | 1 |
| 8 | Biostimulation supplemented with phytoremediation in the reclamation of a petroleum contaminated soil显示文摘 | Josiah M A Reginald B K Onozemini S A | 2009 | World J Mierobiol Biotechnol2009，25，： | 1 |
| 9 | White - Tailed ceer browsing and rubbing preferences for trees and shrubs that pro- duce nontimber forest products 显示文摘 | Hygnstrom S E Skehon P D Josiah S J | 2009 | Horttechnology2009，19，1： | 1 |
| 10 | Superior Sagittal Sinus Thrombosis:Subtle Signs on Neuroimaging显示文摘 | Phua Hwee Tang Josiah Chai Yiong Huak Chan | 2008 | Ann Acad Med Singapore2008，37，5： | 1 |
| 11 | Fouling and predation;how do they affect growth and survival of the blacklip pearl oyster, Pinctada margaritifera, during nursery culture?显示文摘 | Pit Josiah H Southgate Paul C | 2003 | Aquaculture international2003，11，6： | 1 |
| 12 | Design and implementation of FROST: Digital forensic tools for the OpenStack cloud computing platform显示文摘 | Josiah Dykstra Alan T. Sherman | 2013 | Digital Investigation2013，，： | 1 |
| 13 | Fouling and predation:how do they affect growth and survival o f the blacklip pearl oyster,Pinctada margaritifera,during nursery culture显示文摘 | Josiah H P Southgate P C | | 0，，： | 1 |
| 14 | Laboratory testing for infection with the human immunodeficiency virus: established and novel approaches显示文摘 | Eleftherios Mylonakis Maria Paliou Michelle Lally Timothy P Flanigan Josiah D Rich | 2000 | The American Journal of Medicine2000，，7： | 1 |
| 15 | Acquiring forensic evidence from infrastructure-as-a-service cloud computing: Exploring and evaluating tools, trust, and techniques显示文摘 | Josiah Dykstra Alan T. Sherman | 2012 | Digital Investigation2012，，： | 1 |
| 16 | Extracellular functions of galectin-3显示文摘 | Josiah Ochieng Vyacheslav Furtak Pavel Lukyanov | 2002 | Glycoconjugate Journal (-)2002，，7： | 1 |
| 17 | Differential evolution algorithm for solving multi-objective crop planning model 显示文摘 | JOSIAH A FRED O | 2010 | Agricultural Wa- ter Management2010，97，6： | 1 |
| 18 | Release Point Determination and Dispersion Reduction for Ballistic Air-Drops 显示文摘 | Josiah T VanderMey David B Doman Adam R Gerlach | 2015 | Journal of Guidance Control and Dynamics2015，38，： | 1 |
| 19 | Measurement and calculation of forces in a magnetic journal bearing actuator显示文摘 | Josiah Knight Edwad McCaul Zule Xia | 1990 | NASA Workshop On Aerospace Applications of Magnetic Suspension Langley Research Center1990，，： | 1 |
| 20 | Being, the world, and appearance in early Stoicism and some other Greek philosophies显示文摘 | Gould Josiah B | 1974 | The Review of Metaphysics1974，，： | 1 |
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