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| 1 | The Beishan underground research laboratory for geological disposal of high-level radioactive waste in China:Planning, site selection,site characterization and in situ tests显示文摘With the rapid development of nuclear power in China, the disposal of high-level radioactive waste(HLW) has become an important issue for nuclear safety and environmental protection. Deep geological disposal is internationally accepted as a feasible and safe way to dispose of HLW, and underground research laboratories(URLs) play an important and multi-faceted role in the development of HLW repositories. This paper introduces the overall planning and the latest progress for China's URL. On the basis of the proposed strategy to build an area-specific URL in combination with a comprehensive evaluation of the site selection results obtained during the last 33 years, the Xinchang site in the Beishan area,located in Gansu Province of northwestern China, has been selected as the final site for China's first URL built in granite. In the process of characterizing the Xinchang URL site, a series of investigations,including borehole drilling,geological mapping, geophysical surveying,hydraulic testing and in situ stress measurements, has been conducted. The investigation results indicate that the geological,hydrogeological, engineering geological and geochemical conditions of the Xinchang site are very suitable for URL construction. Meanwhile, to validate and develop construction technologies for the Beishan URL, the Beishan exploration tunnel(BET), which is a 50-m-deep facility in the Jiujing sub-area, has been constructed and several in situ tests, such as drill-and-blast tests, characterization of the excavation damaged zone(EDZ), and long-term deformation monitoring of surrounding rocks, have been performed in the BET. The methodologies and technologies established in the BET will serve for URL construction.According to the achievements of the characterization of the URL site, a preliminary design of the URL with a maximum depth of 560 m is proposed and necessary in situ tests in the URL are planned. | Ju Wang Liang Chen Rui Su Xingguang Zhao | 2018 | Journal of Rock Mechanics and Geotechnical Engineering2018，10，3： | 62 |
| 2 | Get effective polyclonal antisera in one month显示文摘According to the traditional immunization procedure, after the first injection of the sample A (emulsion of aimed antigen and Freund's complete adjuvant) to immunize rabbit, successive injections of the sample B (emulsion of aimed antigen and Freund's incomplete adjuvant) were followed every 2-4 weeks. In general,high titer of the corresponding polyclonal antisera will be observed after 4-5 injections of sample B in 3-4months. This report presents a simply modified procedure that was able to stimulate the antisera formation in one month and achieve enough avidity to satisfy either Western blot or immunohistochemistry analysis.It just applied an additional injection of the sample A to the rabbit at the 3rd day after the primary immunization injection. You could gain the high titer of the antisera right after the first sample B injection in one month. This method has produced the desired results in three different recombinant antigens with different molecular weight (5.9 KD-55 KD) expressed from prokaryotic or eukaryotic cells. | YUAN XIN HU, Ju YUAN QUO, Lu SHEN, YAN CHEN, Zu CHUAN ZHANG, YONG LIAN ZHANGState Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, | 2002 | Cell Research2002，12，2： | 45 |
| 3 | Effect of in-hospital medical complications on case fatality post-acute ischemic stroke: data from the China National Stroke Registry显示文摘 | WANG Peng-lian ZHAO Xing-quan YANG Zhong-hua WANG An-xin WANG Chun-xue LIU Li-ping WANGYi-long WANG Xin-gao JU Yi CHEN Sheng-yun CHEN Qi-dong QU Hui LU Jing-jing ZHANG Jing MA Rui-hua ZHANG Yu-mei WANG Yong-jun | 2012 | Chinese Medical Journal2012，，14： | 37 |
| 4 | Chinese Economic Structure and SDA Model | CHEN Xi\|kang 1,\ GUO Ju\|e 2 1. Academy of Machemation and Systems Science, Chinese Academy of Science Beijing 100080, China 2. Shaanxi Institute of Finance and Economics, Xi′an 710061, China | 2000 | Systems Science and Systems Engineering2000，10，2： | 40 |
| 5 | Spatio-temporal dynamics of vegetation and its relationship with climate factors Mongolia, China coverage in Inner显示文摘The vegetation coverage dynamics and its relationship with climate factors on different spatial and temporal scales in Inner Mongolia during 2001-2010 were analyzed based on MODIS-NDVI data and climate data.The results indicated that vegetation coverage in Inner Mongolia showed obvious longitudinal zonality,increasing from west to east across the region with a change rate of 0.2/10°N.During 2001-2010,the mean vegetation coverage was 0.57,0.4 and 0.16 in forest,grassland and desert biome,respectively,exhibiting evident spatial heterogeneities.Totally,vegetation coverage had a slight increasing trend during the study period.Across Inner Mongolia,the area of which the vegetation coverage showed extremely significant and significant increase accounted for 11.25% and 29.13% of the area of whole region,respectively,while the area of which the vegetation coverage showed extremely significant and significant decrease accounted for 7.65% and 26.61%,respectively.On inter-annual time scale,precipitation was the dominant driving force of vegetation coverage for the whole region.On inter-monthly scale,the change of vegetation coverage was consistent with both the change of temperature and precipitation,implying that the vegetation growth within a year is more sensitive to the combined effects of water and heat rather than either single climate factor.The vegetation coverage in forest biome was mainly driven by temperature on both inter-annual and inter-monthly scales,while that in desert biome was mainly influenced by precipitation on both the two temporal scales.In grassland biome,the yearly vegetation coverage had a better correlation with precipitation,while the monthly vegetation coverage was influenced by both temperature and precipitation.In grassland biome,the impacts of precipitation on monthly vegetation coverage showed time-delay effects. | MU Shaojie YANG Hongfei LI Jianlong CHEN Yizhao GANG Chengcheng ZHOU Wei JU Weimin | 2013 | Journal of Geographical Sciences2013，23，2： | 28 |
| 6 | The 1997-1998 warm event in the South China Sea显示文摘A strong warm event happens during spring 1997 to spring 1999 in the South China Sea. Its intensity and duration show that it is the strongest event on the record over the past decades. It also corresponds with the severe flood over the valley of the Yangtze River and a couple of marine environmental events. This note addressed the evolution process by using several data sets, such as sea surface temperature, height and wind stress in addition to subsurface temperature. The onset of the warm event almost tele-connects with the El Nino event in the tropical Pacific Ocean. Summer monsoon is stronger and winter monsoon is weaker in 1997 so that there are persistent westerly anomalies in the South China Sea. During the development phase, the warm advection caused by southerly anomalies is the major factor while the adjustment of the thermocline is not obvious. Subsequently, the southerly anomalies decay and even northerly anomalies appear in the summer of 1998 resulting from the weaker than normal summer | WANG Dongxiao XIE Qiang DU Yan WANG Weiqiang CHEN Ju | 2002 | Chinese Science Bulletin2002，47，14： | 24 |
| 7 | IL-17 response mediates acute lung injury induced by the 2009 Pandemic Influenza A (HIN1) Virus显示文摘 | Chenggang Li Penghui Yang Yang Sun Taisheng Li Chen Wang Zhong Wang Zhen Zou Yiwu Yan Wei Wang Chen Wang Zhongwei Chen Li Xing Chong Tang Xiangwu Ju Feng Guo Jiejie Deng Yan Zhao Peng Yang Jun Tang Huanling Wang Zhongpeng Zhao Zhinan Yin Bin Cao Xiliang Wang Chengyu Jiang | 2012 | Cell Research2012，22，3： | 22 |
| 8 | Spatial and temporal variations of forest LAI in China during 2000-2010显示文摘Forests are crucial terrestrial ecosystems.Their leaf area index (LAI) is a key parameter determining the exchange of matter and energy between the atmosphere and the ground surface.In this study,MOD 09A1 and MCD 43A1 data were input into an inversion model based on the 4-scale geometric optical model to retrieve 8-d 500 m LAI products in China during the period 2000 to 2010.The resulting LAI product was validated using LAI measured in 6 typical areas.The spatial and temporal variations of forest LAI and its relationships with temperature and precipitation were analyzed.The results show that the accuracy of the 500 m LAI product was above 70% in the 6 typical areas,indicating the reliability of this product.From 2000 to 2010,forest LAI in northeast,north,and south central China showed increasing trends.However,forest LAI in southeast and parts of southwest China showed downward trends,mainly because of the significant decrease observed during the period 2008 to 2010.Annual mean forest LAI positively correlated with annual mean temperature (AMT) in northeastern China and negatively correlated with AMT in southwest China.It had positive correlations with annual total precipitation in central south and north China.The abnormal climate conditions in 2001 and 2009 caused forest LAI to be obviously lower than normal in regions south of the Qinling Mountains and Huaihe River.Annual mean LAI decreased by more than 1.0 in some areas. | LIU YiBo JU WeiMin CHEN JingMing ZHU GaoLong XING BaiLing ZHU JingFang HE MingZhu | 2012 | Chinese Science Bulletin2012，57，22： | 22 |
| 9 | Analysis of observations on the urban surface energy balance in Beijing显示文摘1 年(20092010 ) 大小从在一个 325-m 塔的三垂直的层位于闹市区北京的传感器获得的城市的表面精力平衡(SEB ) 被分析。结果显示出那:(1 ) 从 325-m 塔的大小代表位于半潮湿的温暖适度的大陆人季风气候地区的城市的 SEB 特征。在典型热、多雨的夏天,感冒和干燥冬季,测量鲍恩比率在冬季在夏天和最大值是最小的。在 140 m 测量春天,夏天,秋天,和冬季的鲍恩比率分别地是 2.86, 0.82, 1.17,和 4.16。(2 ) 在 140-m 的高度(在经常的流动层) ,中午反照率是 0.10 夏天, 0.12 为春天和秋天,并且 0.14 为冬季。白天的比率理智的热流动,潜伏的热流动,和捕捞放射的存储热流动是 0.25, 0.16,和 0.59 清楚天空的天,并且 0.33, 0.19,和 0.48 为多云的天分别地。(3 ) 在清楚天空的天下面,夜间理智的热流动是几乎零,但是潜伏的热流动比零大。为多云的天,夜间理智的热流动比在冬季的潜伏的热流动稍微大。向上的热流动是的夜间大概由于人为的版本(为夏天的主要潜伏的热,当时为冬季的潜伏、理智的热) 。 | MIAO ShiGuang DOU JunXia CHEN Fei LI Ju LI AiGuo | 2012 | Science China Earth Sciences2012，55，11： | 23 |
| 10 | Exosomes from Suxiao Jiuxin pill-treated cardiac mesenchymal stem cells decrease H3K27 demethylase UTX expression in mouse cardiomyocytes in vitro显示文摘Suxiao Jiuxin 药片(SJP ) 是为在中国的急性冠的症候群的处理的繁体中文药,它包含二个主要部件, tetramethylpyrazine (TMP ) 和龙脑(BOR ) 。因此远然而,在心脏的微型环境上位于 SJP 的有益的效果下面的分子的机制是未知的。心脏的间充质的干细胞(C-MSCs ) 通过 microvesicles (exosomes ) 的版本与 cardiomyocytes (厘米) 交流恢复心脏的动态平衡并且得到修理,部分地通过 epigenetic 规章的机制。在这研究,我们检验了 SJP 处理是否改变了 C-MSC-derived exosomes (SJP-Exos ) 引起 epigenetic 在接受者厘米的色彩的改变。从老鼠心孤立的 C-MSC 是有 SJP (SJP-Exos ) 的 pretreated, TMP (TMP-Exos ) 或 BOR (BOR-Exos ) 。然后, HL-1 房间,一根鼠标 cardiomyocyte 线,从控制与 exosomes 被对待 C-MSCs (Ctrl-Exos ) , SJP-Exos, TMP-Exos 或 BOR-Exos。有 SJP-Exos 的处理显著地增加了 histone 的蛋白质层次 3 离氨酸 27 trimethylation (H3K27me3 ) ,为心脏的 transcriptional 抑制的一个关键 epigenetic 染色质标记,在 HL-1 房间。为了推进,探索 SJP-Exo-mediated H3K27me3 upregulation 的机制,我们在对待 exosome 的 HL-1 房间估计了关键 histone methylases (EZH1, EZH2 和 EED ) 和 demethylases (JMJD3 和 UTX ) 的 mRNA 表示层次。有 SJP-Exo 的处理有选择地在接受者 HL-1 房间压制了 UTX 表示。而且, PCNA,房间复制的一个内长的标记,比在 Ctrl-Exo-treated HL-1 房间在 SJP-Exo-treated HL-1 房间是显著地更高的。这些结果证明 SJP-Exos 增加 cardiomyocyte 增长并且证明 SJP 能调制 C-MSC-derived exosomes 引起 epigenetic 染色质在接受者 cardiomyocytes 改变;因而, SJP-Exos 可能被用来支持 cardiomyocyte 增长。 | Xiao-fen RUAN Yongdun LI Cheng-wei JU Yan SHEN Wei LEI Can CHEN Yang LI Hong YU Yu-tao LIU II-man KIM Xiao-long WANG Neal L WEINTRAUB Yaoliang TANG | 2018 | Acta Pharmacologica Sinica2018，39，4： | 23 |
| 11 | Management of cytokine release syndrome related to CAR-T cell therapy显示文摘Chimeric antigen receptor T (CAR-T) cell therapy is a novel cellular immunotherapy that is widely used to treat hematological malignancies, including acute leukemia, lymphoma, and multiple myeloma. Despite its remarkable clinical effects, this therapy has side effects that cannot be underestimated. Cytokine release syndrome (CRS) is one of the most clinically important and potentially life-threatening toxicities. This syndrome is a systemic immune storm that involves the mass cytokines releasing by activated immune cells. This phenomenon causes multisystem damages and sometimes even death. In this study, we reported the management of a patient with recurrent and refractory multiple myeloma and three patients with acute lymphocytic leukemia who suffered CRS during CAR-T treatment. The early application of tocilizumab, an anti-IL-6 receptor antibody, according to toxicity grading and clinical manifestation is recommended especially for patients who suffer continuous hyperpyrexia, hypotensive shock, acute respiratory failure, and whose CRS toxicities deteriorated rapidly. Moreover, low doses of dexamethasone (5-10 mg/day) were used for refractory CRS not responding to tocilizumab. The effective management of the toxicities associated with CRS will bring additional survival opportunities and improve the quality of life for patients with cancer. | Hongli Chen Fangxia Wang Pengyu Zhang Yilin Zhang Yinxia Chen Xiaohu Fan Xingmei Cao Jie Liu Yun Yang Baiyan Wang Bo Lei Liufang Gu Ju Bai Lili Wei Ruili Zhang Qiuchuan Zhuang Wanggang Zhang Wanhong Zhao Aili He | 2019 | Frontiers of Medicine2019，13，5： | 21 |
| 12 | Transplantation of magnetically labeled mesenchymal stem cells improves cardiac function in a swine myocardial infarction model显示文摘背景:间充质的干细胞(MSC ) 移植为心肌的修理提供一条新途径。然而,关于 MSC 移植的许多重要基本问题仍然保持未答复。有迫切需要从跳动的心识别 MSC 并且分析这条新途径的功效。试图本地化有磁力地标记的 MSC (MR-MSCs ) 并且监视补药的这研究与磁性的回声(先生) MR-MSCs 完成成像。方法:尖锐心肌的梗塞(AMI ) 被左前面的下降冠的动脉的汽球吸藏在猪创造。房间在心肌的梗塞以后经由 intracoronary 注入被交付。梗塞尺寸变化和心脏的功能与 3.0T 先生扫描仪被估计。结果然后被组织学、西方的污点分析证实。所有统计过程与 Systat (社会科学统计套装软体版本 12.01 ) 被执行。结果:26 猪的一个总数被划分成四个组(假冒操作组, n=6;有 PBS 移植的 AMI 组, n=6;标记的 MSC 组, n=7;未标记的 MSC 组, n=7 ) 。MSC, MR-MSCs (10 (7 ) 房间) 或在 MI 和连续心脏的先生成像研究在移植以后在 0, 4 和 8 个星期被执行以后, PBS 被 intracoronary 注射交付。先生成像证明 MI 尺寸在 MSC 移植以后减少了在标记并且未标记的组然而,增加在 MI 以后在 8 个星期在 AMI 组被看见。左室的喷射部分( LVEF )稍微在 AMI 组被增加(( 41.87+/-2.45 )%对( 39.04+/-2.80 )%, P>0.05 ),但是显著地在 MR-MSCs 组改善了(( 56.85+/-1.29 )%对( 40.67+/-2.00 )%, P<0.05 )并且未标记的组(( 55.38+/-1.07 )%对( 41.78+/-2.08 )%, P<0.05 )在 8 星期术后疗法。MR-MSCs 被普鲁士的蓝色和免疫进一步证实荧光灯的染色。西方的污点分析证明在 MSC 处理组和矩阵 metalloproteinase 的比率有象肌浆球蛋白重链和 troponin T 那样的 cardiomyocyte 标记的增加的表情 2 到 metalloproteinase 的织物禁止者, 1 与 AMI 组和假冒操作组相比在标记的组和未标记的组减少了。结论:移植 MR-MSCs 能改革新心肌层并且在 2 月的后续在一个 MI 模型阻止 remolding 并且代表一个比较喜欢的方法更好在未来理解干细胞治疗的机制临床的研究。 | QI Chun-mei MA Gen-shan LIU Nai-feng SHEN Cheng-xing CHEN Zhong LIU Xiao-jun HU Yao-peng ZHANG Xiao-li TENG Gao-jun JU Sheng-hong MA Ming TANG Yao-liang | 2008 | Chinese Medical Journal2008，，6： | 19 |
| 13 | Research on in-situ condition preserved coring and testing systems显示文摘As shallow resources are increasingly depleted,the mechanics'theory and testing technology of deep insitu rock has become urgent.Traditional coring technologies obtain rock samples without retaining the in-situ environmental conditions,leading to distortion of the measured parameters.Herein,a coring and testing systems retaining in-situ geological conditions is presented:the coring system that obtains in-situ rock samples,and the transfer and testing system that stores and analyzes the rocks under a reconstructed environment.The ICP-Coring system mainly consists of the pressure controller,active insulated core reactor and insulation layer and sealing film.The ultimate bearing strength of 100 MPa for pressurepreservation,temperature control accuracy of 0.97%for temperature-retained are realized.CH_(4)and CO permeability of the optimized sealing film are as low as 3.85 and 0.33 ppm/min.The average tensile elongation of the film is 152.4%and the light transmittance is reduced to 0%.Additionally,the pressure and steady-state temperature accuracy for reconstructing the in-situ environment of transfer and storage system up to 1%and±0.2 is achieved.The error recorded of the noncontact sensor ring made of lowdensity polymer is less than 6%than that of the contact test.The system can provide technical support for the deep in-situ rock mechanics research,improving deep resource acquisition capabilities and further clarifying deep-earth processes. | He-Ping Xie Tao Liu Ming-Zhong Gao Ling Chen Hong-Wei Zhou Yang Ju Feng Gao Xiao-Bo Peng Xiong-Jun Li Rui-Dong Peng Ya-Nan Gao Cong Li Zhi-Qiang He Ming-Qing Yang Zhi-Yu Zhao | 2021 | Petroleum Science2021，18，6： | 19 |
| 14 | Field-observation for an anticyclonic mesoscale eddy consisted of twelve gliders and sixty-two expendable probes in the northern South China Sea during summer 2017显示文摘An intensive field observation experiment using 12 Chinese gliders equipped with conductivity-temperature-depth (CTD) sensors and 62 expendable CTD probes (XCTDs) was performed to investigate the 3-D structure and time evolution of an anticyclonic eddy in the northern South China Sea (NSCS). The observed results showed that the anticyclonic eddy had a horizontal radius of about 80 km at surface and a vertical depth of impact of more than 1000 m. The largest temperature and salinity anomalies compared with the averaged values of the temperature and salinity profiles were 3.5°C and 0.4 psu at 120 m depth, respectively. Combined analysis of altimeter sea level and water mass properties indicated that the anticyclonic eddy was shed from the Kuroshio loop current. The vertical axis of the anticyclonic eddy tilted from surface to the observed maximum depth (1000 m) along its translation direction against the 2000 m isobath. The center of the anticyclonic eddy remained in the region east of Dongsha Island for more than half a month. During this time, the long axis direction of the eddy changed from across the slope to along the slope. Then, the eddy moved southward along the 2000 m isobaths. Both the geostrophic current and temperature distribution revealed that the eddy intensity weakened during the observation period gradually. These observations indicated strong interaction between the anticyclonic eddy and the slope topography of Dongsha Island. | Yeqiang SHU Ju CHEN Shuo LI Qiang WANG Jiancheng YU Dongxiao WANG | 2019 | Science China Earth Sciences2019，62，2： | 19 |
| 15 | The development and function of follicular helper T cells in immune responses显示文摘小囊的助手 T 房间(Tfh ) 作为提供帮助让 B 房间增殖并且在幼芽的中心经历抗体亲密关系成熟的一个系被提交了。证据支持了那个 Tfh 子集开发象另外的系一样,依赖于一个特别 transcriptional 节目被开始的微型环境。它为 Tfh 房间的开发和函数作为主人管理者被看了那 Bcl-6 和 IL-21 行为。Tfh dysregulation 涉及自体免疫的病理的发展,例如全身的豺狼座 erythematosus,风湿性关节炎和另外的自体免疫的疾病。现在的评论在在他们的开发和函数的 Tfh 房间和焦点的域里加亮最近的进展。 | Maogen Chen Zhiyong Guo Weiqiang Ju Bernhard Ryffel Xiaoshun He Song Guo Zheng | 2012 | Cellular & Molecular Immunology2012，9，5： | 18 |
| 16 | Effectiveness of Different Waist Circumference Cut-off Values in Predicting Metabolic Syndrome Prevalence and Risk Factors in Adults in China显示文摘Objective To study the effectiveness of waist circumference cut-off values in predicting the prevalence of metabolic syndrome(MetS) and risk factors in adults in China. Methods A cross-sectional survey was condcuted in 14 provinces(autonomous region, municipality) in China. A total of 47 325 adults aged ≥20 years were selected by multistage stratified sampling, and questionnaire survey and physical and clinical examination were conducted among them. MetS was defined according to the International Diabetes Federation(IDF) criteria and modified IDF criteria.Results The age-standardized prevalence of MetS was 24.2%(22.1% in men and 25.8% in women) and 19.5%(22.1% in men and 18.0% in women) according to the IDF criteria and modified IDF criteria respectively. The age-standardized prevalence of pre-MetS was 8.1%(8.6% in men and 7.8% in women) according to the modified IDF criteria. The prevalence of MetS was higher in urban residents than rural residents and in northern China residents than in southern China residents. The prevalence of central obesity was about 30% in both men and women according to the ethnicity-specific cut-off values of waist circumference for central obesity(90 cm for men and 85 cm for women). Multivariate regression analysis revealed no significant difference in risk factors between the two MetS definitions. Conclusion Using both the modified IDF criteria and ethnicity-specific cut-off values of waist circumference can provide more useful information about the prevalence of MetS in China. | ZHOU Hai Cheng LAI Ya Xin SHAN Zhong Yan JIA Wei Ping YANG Wen Ying LU Ju Ming WENG Jian Ping JI Li Nong LIU Jie TIAN Hao Ming JI Qiu He ZHU Da Long CHEN Li GUO Xiao Hui ZHAO Zhi Gang Li Qiang ZHOU Zhi Guang GE Jia Pu SHAN Guang Liang | 2014 | Biomedical and Environmental Sciences2014，27，5： | 17 |
| 17 | Consensus on the application of negative pressure wound therapy of diabetic foot wounds显示文摘Because China is becoming an aging society,the incidence of diabetes and diabetic foot have been increasing.Diabetic foot has become one of the main health-related killers due to its high disability and mortality rates.Negative pressure wound therapy(NPWT)is one of the most effective techniques for the treatment of diabetic foot wounds and great progress,both in terms of research and its clinical application,has been made in the last 20 years of its development.However,due to the complex pathogenesis and management of diabetic foot,irregular application of NPWT often leads to complications,such as infection,bleeding and necrosis,that seriously affect its treatment outcomes.In 2020,under the leadership of Burns,Trauma and Tissue Repair Committee of the Cross-Straits Medicine Exchange Association,the writing group for‘Consensus on the application of negative pressure wound therapy of diabetic foot wounds’was established with the participation of scholars from the specialized areas of burns,endocrinology,vascular surgery,orthopedics and wound repair.Drawing on evidence-based practice suggested by the latest clinical research,this consensus proposes the best clinical practice guidelines for the application and prognostic evaluation of NPWT for diabetic foot.The consensus aims to support the formation of standardized treatment schemes that clinicians can refer to when treating cases of diabetic foot. | Shizhao Ji Xiaobin Liu Jie Huang Junmin Bao Zhaohong Chen Chunmao Han Daifeng Hao Jingsong Hong Dahai Hu Yufeng Jiang Shang Ju Hongye Li Zongyu Li Guangping Liang Yan Liu Gaoxing Luo Guozhong Lv Xingwu Ran Zhongmin Shi Juyu Tang Aiping Wang Guangyi Wang Jiangning Wang Xin Wang Bing Wen Jun Wu Hailin Xu Maojin Xu Xiaofei Ye Liangxi Yuan Yi Zhang Shichu Xiao Zhaofan Xia | 2021 | Burns & Trauma2021，9，1： | 17 |
| 18 | Value of circulating cell-free DNA in diagnosis of hepatocelluar carcinoma显示文摘AIM:To investigate the value of combined detection of circulating cell-free DNA(cfDNA),a-fetal protein(AFP) and a L-fucosidase(AFU) for diagnosis of hepatocellular carcinoma(HCC).METHODS:Serum samples from 39 HCC patients and 45 normal controls were collected.Branched DNA(bDNA) was used to detect the level of cfDNA,and a receiver operating characteristic curve was employed to evaluate the diagnostic sensitivity,specificity,accuracy,positive predictive value,negative predictive value,positive likelihood ratio,negative likelihood ratio and Youden index,and to assess the diagnostic efficiency and their correlations with the clinicopathological features.AFP and AFU were detected by chemiluminescence and colorimetry,respectively.The significance of combined detection of the three biomarkers was discussed.RESULTS:cfDNA level was increased in 22 of the 39 HCC samples and in 2 of the 45 normal controls.cfDNA level in HCC samples was significantly higher than that in normal controls(P < 0.05).There were significant differences in sex and extra-and intrahepatic metastasis(P < 0.05).There was no significant correlation between cfDNA,AFP and AFU in the detection of HCC.The sensitivity of combined detection of cfDNA with one marker(AFP or AFU) and cfDNA with two markers(AFP and AFU) was 71.8%,87.2% and 89.7% vs 56.4%,53.8% and 66.7% for cfDNA,AFP and AFU used alone,respectively,the difference being statistically significant(P < 0.05).CONCLUSION:Quantitative analysis of cfDNA is sensitive and feasible,and the combined detection of cfDNA with AFP or AFU or both could improve the diagnostic sensitivity for HCC. | Ken Chen Hong Zhang Li-Na Zhang Shao-Qing Ju Jing Qi Dong-Feng Huang Feng Li Qun Wei Jing Zhang | 2013 | World Journal of Gastroenterology2013，19，20： | 16 |
| 19 | Statistical estimations of atmospheric duct over the South China Sea and the Tropical Eastern Indian Ocean显示文摘In 2010-2012 spring, atmospheric duct observation experiments were performed throughout three open cruises over the South China Sea and the Tropical Eastern Indian Ocean. The data used for ducting analysis were measured by high resolution balloon-borne GPS radiosondes. Through data quality control and diagnostic analysis, the probability of ducting occurrence and characteristic quantities of the three typical ducts were given. The total percentage occurrence of evaporation duct, surface-based duct and elevated duct were 75.3%, 5% and 43.7%, respectively. The mean evaporation duct height was 15.3 m. The mean values of duct height, thickness and magnitude were 84.1 m, 14.9 m and 10 M-units for surfaced-based duct, and 1003.6 m, 62.2 m and 7.9 M-units for elevated duct. These preliminary statistical results can serve as a basis for future comprehensive and comparative studies of atmospheric duct for the research region. | ZHAO XiaoFeng WANG DongXiao HUANG SiXun HUANG Ke CHEN Ju | 2013 | Chinese Science Bulletin2013，58，23： | 16 |
| 20 | Technology and Experiments of 42CrMo Bearing Ring Forming Based on Casting Ring Blank显示文摘Bearing ring is the crucial component of bearing. With regard to such problems as material waste, low efficiency and high energy consumption in current process of producing large bearing ring, a new process named 'casting-rolling compound forming technology' is researched by taking the typical 42CrMo slew bearing as object. Through theoretical analysis, the design criteria of the main casting-rolling forming parameters are put forward at first. Then the constitutive relationship model of as-cast 42CrMo steel and its mathematical model of dynamic recrystallization are obtained according to the results of the hot compression experiment. By a coupled thermal-mechanical finite element model for radial-axial rolling of bearing ring, the fraction of dynamic recrystallization is calculated and recrystallized grains size are predicated. Meanwhile, the effects of the initial rolling temperature and feed rate of idle roll on material microstructure evolution are analyzed. Finally, the industrial rolling experiment is designed and performed, based on the simulation results. In addition, mechanical and metallographic tests are conducted on rolled bearing ring to get the mechanical parameters and metallographic structure. The experimental data and results show that the mechanical properties of bearing ring produced by casting-rolling compound forming technology are up to industrial standard, and a qualified bearing ring can be successfully formed by employing this new technology. Through the study, a process of forming large bearing ring directly by using casting ring blank is obtained, which could provide an effective theoretical guidance for manufacturing large ring parts. It also has an edge in saving material, lowering energy and improving efficiency. | LI Yongtang JU Li QI Huiping ZHANG Feng CHEN Guozhen WANG Mingli | 2014 | Chinese Journal of Mechanical Engineering2014，27，2： | 16 |
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