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| 1 | IgG4-unrelated type 1 autoimmune pancreatitis显示文摘A 50-year-old male was referred to our hospital for the evaluation of hyperproteinemia.Fluorodeoxyglucose positron emission tomography revealed high fluorodeoxyglucose uptake in the pancreas,bilateral lacrimal glands,submandibular glands,parotid glands,bilateral pulmonary hilar lymph nodes,and kidneys.Laboratory data showed an elevation of hepatobiliary enzymes,renal dysfunction,and remarkably high immunoglobulin(Ig) G levels,without elevated serum IgG4.Abdominal computed tomography revealed swelling of the pancreatic head and bilateral kidneys.Endoscopic retrograde cholangiopancreatography showed an irregular narrowing of the main pancreatic duct in the pancreatic head and stricture of the lower common bile duct.Histological examination by endoscopic ultrasonography-guided fine-needle aspiration revealed findings of lymphoplasmacytic sclerosing pancreatitis without IgG4-positive plasma cells.Abnormal laboratory values and the swelling of several organs were improved by the treatment with steroids.The patient was diagnosed as having type 1 autoimmune pancreatitis(AIP) based on the International Consensus Diagnostic Criteria.Therefore,we encountered a case of compatible type 1 AIP without elevated levels of serum IgG4 or IgG4-positive plasma cells.This case suggests that AIP phenotypes are not always associated with IgG4. | Eriko Nakano Atsushi Kanno Atsushi Masamune Naoki Yoshida Seiji Hongo Shin Miura Tetsuya Takikawa Shin Hamada Kiyoshi Kume Kazuhiro Kikuta Morihisa Hirota Keisuke Nakayama Fumiyoshi Fujishima Tooru Shimosegawa | 2015 | World Journal of Gastroenterology2015，21，33： | 3 |
| 2 | Mucosa-associated lymphoid tissue lymphoma studied with FDG-PET: a comparison with CT and endoscopic findings显示文摘 | Keisuke Enomoto Kenichiro Hamada Hidenori Inohara Ichiro Higuchi Yasuhiko Tomita Takeshi Kubo Jun Hatazawa | 2008 | Annals of Nuclear Medicine2008，，4： | 1 |
| 3 | Recent progress and limitations of chemotherapy for pancreatic and biliary tract cancers显示文摘Gemcitabine chemotherapy has been the standard for advanced pancreatic cancer for more than a decade.New oral fluoropyrimidines such as S-1 and capecitabine are other key drugs.Gemcitabine plus erlotinib was the only combination therapy that significantly prolonged survival,although the effect was minimal.Little or no improvement in survival with recent moleculartargeted drugs might be attributed to the very high incidence of K-ras gene mutation in pancreatic cancer.Recently,the non-gemcitabine-based-regimen of FOLFIRINOX showed significantly greater overall survival compared with gemcitabine for the first time.For biliary tract cancer,gemcitabine plus cisplatin combination chemotherapy has been proved to significantly prolong survival and will become the standard therapy.Further improvement in survival is expected by the addition of cetuximab. | Minoru Tada Yousuke Nakai Takashi Sasaki Tsuyoshi Hamada Rie Nagano Dai Mohri Koji Miyabayashi Keisuke Yamamoto Hirofumi Kogure Kazumichi Kawakubo Yukiko Ito Natsuyo Yamamoto Naoki Sasahira Kenji Hirano Hideaki Ijichi Keishuke Tateishi Hiroyuki Isayama Masao Omata Kazuhiko Koike | 2011 | World Journal of Clinical Oncology2011，2，3： | 1 |
| 4 | Crosstalk between CYP2E1 and PPARα substrates and agonists modulate adipose browning and obesity显示文摘Although the functions of metabolic enzymes and nuclear receptors in controlling physiological homeostasis have been established, their crosstalk in modulating metabolic disease has not been explored.Genetic ablation of the xenobiotic-metabolizing cytochrome P450 enzyme CYP2 E1 in mice markedly induced adipose browning and increased energy expenditure to improve obesity. CYP2 E1 deficiency activated the expression of hepatic peroxisome proliferator-activated receptor alpha(PPARa) target genes,including fibroblast growth factor(FGF) 21, that upon release from the liver, enhanced adipose browning and energy expenditure to decrease obesity. Nineteen metabolites were increased in Cyp2 e1-null mice as revealed by global untargeted metabolomics, among which four compounds, lysophosphatidylcholine and three polyunsaturated fatty acids were found to be directly metabolized by CYP2 E1 and to serve as PPARa agonists, thus explaining how CYP2 E1 deficiency causes hepatic PPARa activation through increasing cellular levels of endogenous PPARa agonists. Translationally, a CYP2 E1 inhibitor was found to activate the PPARa-FGF21-beige adipose axis and decrease obesity in wild-type mice, but not in liver-specific Pparanull mice. The present results establish a metabolic crosstalk between PPARa and CYP2 E1 that supports the potential for a novel anti-obesity strategy of activating adipose tissue browning by targeting the CYP2 E1 to modulate endogenous metabolites beyond its canonical role in xenobiotic-metabolism. | Youbo Zhang Tingting Yan Tianxia Wang Xiaoyan Liu Keisuke Hamada Dongxue Sun Yizheng Sun Yanfang Yang Jing Wang Shogo Takahashi Qiong Wang Kristopher W.Krausz Changtao Jiang Cen Xie Xiuwei Yang Frank J.Gonzalez | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 1 |
| 5 | A retrospective analysis of early CA19-9 change in salvage chemotherapy for refractory pancreatic cancer显示文摘 | Yousuke Nakai Hiroyuki Isayama Takashi Sasaki Naminatsu Takahara Tsuyoshi Hamada Rie Uchino Suguru Mizuno Koji Miyabayashi Keisuke Yamamoto Dai Mohri Hirofumi Kogure Natsuyo Yamamoto Kenji Hirano Hideaki Ijichi Keisuke Tateishi Minoru Tada Kazuhiko Koike | 2013 | Cancer Chemotherapy and Pharmacology2013，，6： | 1 |
| 6 | Disease-specific mortality among patients with intraductal papillary mucinous neoplasm of the pancreas显示文摘 | Kazumichi Kawakubo Minoru Tada Hiroyuki Isayama Naoki Sasahira Yousuke Nakai Naminatsu Takahara Rie Uchino Tsuyoshi Hamada Koji Miyabayashi Keisuke Yamamoto Suguru Mizuno Dai Mohri Hirofumi Kogure Takashi Sasaki Natsuyo Yamamoto Kenji Hirano Hideaki Ijich | 2013 | Clinical Gastroenterology and Hepatology2013，，： | 1 |
| 7 | A retrospective study of S-1 and oxaliplatin combination chemotherapy in patients with refractory pancreatic cancer显示文摘 | Naminatsu Takahara Hiroyuki Isayama Yousuke Nakai Takashi Sasaki Tsuyoshi Hamada Rie Uchino Suguru Mizuno Koji Miyabayashi Hirofumi Kogure Natsuyo Yamamoto Naoki Sasahira Kenji Hirano Hideaki Ijichi Keisuke Tateishi Minoru Tada Kazuhiko Koike | 2013 | Cancer Chemotherapy and Pharmacology2013，，5： | 1 |
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