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| 1 | Hangzhou criteria as downstaging criteria in hepatocellular ca显示文摘Background:The downstaging of hepatocellular carcinoma(HCC)has been confirmed to benefit liver transplantation(LT)patients whose tumors are beyond the transplantation criteria.Milan criteria(MC),a tumor size and number-based assessment,is currently used as the endpoint in these patients.However,many studies believe that tumor biological behavior should be added to the evaluation criteria for downstaging efficacy.Hence,this study aimed to explore the feasibility of Hangzhou criteria(HC),which introduced tumor grading and alpha-fetoprotein in addition to tumor size and number,as an endpoint of downstaging.Methods:We performed a multicenter and retrospective study of 206 patients accepted locoregional therapy(LRT)as downstaging/bridge treatment prior to LT in three centers of China.Results:Recipients were divided into four groups:failed downstaging to the HC(group A,n=46),successful downstaging to the HC(group B,n=30),remained within the HC all the time(group C,n=113),and tumor progressed(group D,n=17).The 3-year HCC recurrence probabilities of groups B and C were not significantly different(10.3%vs.11.6%,P=0.87).The HCC recurrent rate was significantly higher in group A(52.3%)compared with that in group B/C(P<0.05).Seven patients(7/76,9.2%)whose tumor exceeded the the HC were successfully downstaged to the MC,and 39.5%(30/76)to the the HC.In group B,23 patients remained beyond the MC and their survivals were as well as those of patients within the MC.Conclusions:Compared to the MC,HC downstaging criteria can give more HCC patients access to LT and furthermore,the outcome of these patients is the same as those matching MC downstaging criteria.Hangzhou downstaging criteria therefore is applicable in clinical practice. | Qi-Fan Zhan Sun-Bin Ling Yi-Nan Deng Qiao-Nan Shan Qian-Wei Ye Sheng-Jun Xu Guang-Jiang Jiang Di Lu Xu-Yong Wei Li Zhuang Wu Zhang Tian Shen Bei-Ni Cen Hai-Yang Xie Ji-Min Liu Jian Wu Shu-Sen Zheng Yang Yang Xiao Xu | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，4： | 11 |
| 2 | Bile acid and receptors:biology and drug discovery for nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD),a series of liver metabolic disorders manifested by lipid accumulation within hepatocytes,has become the primary cause of chronic liver diseases worldwide.About 20%–30%of NAFLD patients advance to nonalcoholic steatohepatitis(NASH),along with cell death,inflammation response and fibrogenesis.The pathogenesis of NASH is complex and its development is strongly related to multiple metabolic disorders(e.g.obesity,type 2 diabetes and cardiovascular diseases).The clinical outcomes include liver failure and hepatocellular cancer.There is no FDA-approved NASH drug so far,and thus effective therapeutics are urgently needed.Bile acids are synthesized in hepatocytes,transported into the intestine,metabolized by gut bacteria and recirculated back to the liver by the enterohepatic system.They exert pleiotropic roles in the absorption of fats and regulation of metabolism.Studies on the relevance of bile acid disturbance with NASH render it as an etiological factor in NASH pathogenesis.Recent findings on the functional identification of bile acid receptors have led to a further understanding of the pathophysiology of NASH such as metabolic dysregulation and inflammation,and bile acid receptors are recognized as attractive targets for NASH treatment.In this review,we summarize the current knowledge on the role of bile acids and the receptors in the development of NAFLD and NASH,especially the functions of farnesoid X receptor(FXR)in different tissues including liver and intestine.The progress in the development of bile acid and its receptors-based drugs for the treatment of NASH including bile acid analogs and non-bile acid modulators on bile acid metabolism is also discussed. | Ting-ying Jiao Yuan-di Ma Xiao-zhen Guo Yun-fei Ye Cen Xie | 2022 | Acta Pharmacologica Sinica2022，43，5： | 7 |
| 3 | First Report of Botryosphaeria dothidea Causing Sweet Osmanthus Leaf Dieback in China显示文摘Sweet osmanthus is one of the ten traditional famous flowers in China.The occurrence of the diseases caused by fungi other than Botryosphaeria spp.has been reported mainly from China on sweet osmanthus.A leaf dieback of sweet osmanthus caused by Botryosphaeria sp.was found for the first time in 2007 in Nanning City,Guangxi,China.The objectives of the present study were to isolate and characterize the causal organism of sweet osmanthus leaf dieback.The fungus was isolated from the lesions of affected sweet osmanthus leaves and its pathogenicity to sweet osmanthus was confirmed using a detached-leaf-inoculation method.The identification of the pathogen was carried out mainly based on the morphological characters and molecular analysis of internal transcribed spacer (ITS) sequences.The morphological characters of the pathogenic isolate GHX6 were agreed with that of Botryosphaeria dothidea.The ITS sequence of the isolate was amplified with primers ITS1 and ITS4,and submitted to GenBank (accession no.GQ368251).Molecular analysis based on ITS sequence comparison between the isolate GHX6 and the other related fungi derived from GenBank supported that the causal agent of the sweet osmanthus leaf dieback belonged to Botryosphaeria dothidea.This is the first report of Botryosphaeria dothidea causing leaf dieback on sweet osmanthus in China. | XIE Ling HUANG Si-liang CEN Zhen-lu LU Wei-hong QIN Bi-xia TANG Chen-guang HU Chun-jin QIN Li-ping | 2010 | Agricultural Sciences in China2010，9，6： | 6 |
| 4 | Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model显示文摘Chaperone-mediated autophagy(CMA)is a lysosome-dependent selective degradation pathway implicated in the pathogenesis of cancer and neurodegenerative diseases.However,the mechanisms that regulate CMA are not fully understood.Here,using unbiased drug screening approaches,we discover Metformin,a drug that is commonly the first medication prescribed for type 2 diabetes,can induce CMA.We delineate the mechanism of CMA induction by Metformin to be via activation of TAK1-IKKα/β signaling that leads to phosphorylation of Ser85 of the key mediator of CMA,Hsc70,and its activation.Notably,we find that amyloid-beta precursor protein(APP)is a CMA substrate and that it binds to Hsc70 in an IKKα/β-dependent manner.The inhibition of CMA-mediated degradation of APP enhances its cytotoxicity.Importantly,we find that in the APP/PS1 mouse model of Alzheimer's disease(AD),activation of CMA by Hsc70 overexpression or Metformin potently reduces the accumulated brain Aβplaque levels and reverses the molecular and behavioral AD phenotypes.Our study elucidates a novel mechanism of CMA regulation via Metformin-TAK1-IKKα/β-Hsc70 signaling and suggests Metformin as a new activator of CMA for diseases,such as AD,where such therapeutic intervention could be beneficial. | Xiaoyan Xu Yaqin Sun Xufeng Cen Bing Shan Qingwei Zhao Tingxue Xie Zhe Wang Tingjun Hou Yu Xue Mengmeng Zhang Di Peng Qiming Sun Cong Yi Ayaz Najafov Hongguang Xia | 2021 | Protein & Cell2021，12，10： | 5 |
| 5 | C–C motif chemokine ligand 16 inhibits the progression of liver cirrhosis via inactivating hepatic stellate cells显示文摘Background:Liver cirrhosis results from many forms of chronic damage,characterized by accumulation of extracellular matrix.The present study aimed to explore a potential non-invasive biomarker and its mechanism in the progression of liver cirrhosis.Methods:Gene Expression Omnibus(GEO)dataset(GSE15654,n=216)was analyzed to screen genes associated with progression of liver cirrhosis.A total of 181 plasma samples,including healthy control(HC,n=20),chronic hepatitis B(CHB,n=77)and HBV-related liver cirrhosis(LC,n=84),were enrolled for validation.In vitro and in vivo experiments were employed for the mechanistic investigation.Results:GEO dataset analysis showed that relatively low mRNA-expression of C–C motif chemokine ligand 16(CCL16)was associated with elevated Child-Pugh score(P=0.034)and worse prognosis(P=0.025).Plasma CCL16 level decreased in a stepwise pattern,with a median concentration of 10.29,6.57 and 4.47 ng/mL in the HC,CHB and LC groups,respectively(P<0.001).Low plasma CCL16 was significantly related to hepatic dysfunction both in the CHB and LC groups(P<0.05).Combination of CCL16 and ALT showed improved distinguishing capability for LC compared to either alone.In vitro,CCL16 expression was downregulated by lipopolysaccharide and hypoxia.Overexpression of CCL16 from human normal liver cell line(LO2)reduced the extracellular matrix associated proteins(Col1 and Col4)in human hepatic stellate cell line(LX-2).In vivo,the pathological feature of cirrhosis was alleviated by the hepatocytespecific expression of CCL16.Conclusions:CCL16 could be a feasible plasma marker to predict the occurrence and progression of liver cirrhosis.CCL16 might impact liver cirrhosis through inactivating hepatic stellate cells. | Jian-Yong Zhuo Di Lu Zu-Yuan Lin Bei-Ni Cen Xu-Yong Wei Hai-Yang Xie Shu-Sen Zheng Xiao Xu | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，5： | 3 |
| 6 | Combined effects of a high-fat diet and chronic valproic acid treatment on hepatic steatosis and hepatotoxicity in rats显示文摘 | Li-fang ZHANG Ling-sheng LIU Xiao-man CHU Hao XIE Li-juan CAO Cen GUO Ji-ye A Bei CAO Meng-jie LI Guang-ji WANG Hai-ping HAO | 2014 | Acta Pharmacologica Sinica2014，35，3： | 3 |
| 7 | The circFASN/miR-33a pathway participates in tacrolimusinduced dysregulation of hepatic triglyceride homeostasis显示文摘Dyslipidemia exhibits a high incidence after liver transplantation,in which tacrolimus,a widely used immunosuppressant,plays a fundamental role.MicroRNAs and related circRNAs represent a class of noncoding RNAs that have been recognized as important regulators of genes associated with lipid metabolism.However,their transcriptional activities and functional mechanisms in tacrolimus-related dyslipidemia remain unclear.In this study,we observed that tacrolimus could induce triglyceride accumulation in hepatocytes by stimulating sterol response element-binding proteins(SREBPs)and miR-33a.Our in silico and experimental analyses identified miR-33a as a direct target of circFASN.Tacrolimus could downregulate circFASN and result in elevated miR-33a in vivo and in vitro.Overexpression of circFASN or silencing of miR-33a decreased the promoting effects of tacrolimus on triglyceride accumulation.Clinically,the incidence of dyslipidemia in liver transplant recipients with elevated serum miR-33a after liver transplantation was higher than that in patients without elevated serum miR-33a(46.3%vs.18.8%p=0.012,n=73).Our results showed that the circFASN/miR-33a regulatory system plays a distinct role in tacrolimus-induced disruption of lipid homeostasis.MiR-33a is likely a risk factor for tacrolimus-related dyslipidemia,providing a potential therapeutic target to combat tacrolimus-induced dyslipidemia after liver transplantation. | Chenzhi Zhang Kangchen Chen Rongli Wei Guanghan Fan Xuechun Cai Li Xu Beini Cen Jianguo Wang Haiyang Xie Shusen Zheng Xiao Xu | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 2 |
| 8 | Differentially Expressed microRNAs as Potential Markers for Vital Reaction of Burned Skin显示文摘The identification of antemortem burns and postmortem burns is essential in forensic practice.In this study,microRNA(miRNA)microarray analysis was conducted to identify differentially expressed miRNAs in the skin of an experimental burn model.Microarray analysis revealed 24 differentially expressed miRNAs in antemortem burned mice skin,with 19 miRNAs significantly upregulated and 5 downregulated.Based on the intersection predicted using three databases(Targetscan,microRNA.org,and PITA),293 potential miRNA targets were identified.These dysregulated miRNAs and their predicted targets were further analyzed using the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes databases.Several functional categories and signaling pathways were enriched,including the“fc epsilon ri signaling pathway,”“endometrial cancer,”and“mTOR signaling pathway.”Expression patterns of 10 differentially expressed miRNAs were verified by reverse transcription‑quantitative polymerase chain reaction in mice skins.The results agreed with the results of microarray analysis.These findings suggest that differentially expressed miRNAs revealed by microarray are potential markers for forensic molecular diagnosis of antemortem burns. | Hao‑Pin Lyu Ming Cheng Jin‑Cen Liu Ming‑Yuan Ye Di Xu Jie‑Tao He Xiao‑Li Xie Qi Wang | 2018 | Journal of Forensic Science and Medicine2018，4，3： | 2 |
| 9 | Caffeic acid phenethyl ester suppresses intestinal FXR signaling and ameliorates nonalcoholic fatty liver disease by inhibiting bacterial bile salt hydrolase activity显示文摘Propolis is commonly used in traditional Chinese medicine.Studies have demonstrated the therapeutic effects of propolis extracts and its major bioactive compound caffeic acid phenethyl ester(CAPE)on obesity and diabetes.Herein,CAPE was found to have pharmacological activity against nonalcoholic fatty liver disease(NAFLD)in diet-induced obese mice.CAPE,previously reported as an inhibitor of bacterial bile salt hydrolase(BSH),inhibited BSH enzymatic activity in the gut microbiota when administered to mice.Upon BSH inhibition by CAPE,levels of tauro-β-muricholic acid were increased in the intestine and selectively suppressed intestinal farnesoid X receptor(FXR)signaling.This resulted in lowering of the ceramides in the intestine that resulted from increased diet-induced obesity.Elevated intestinal ceramides are transported to the liver where they promoted fat production.Lowering FXR signaling was also accompanied by increased GLP-1 secretion.In support of this pathway,the therapeutic effects of CAPE on NAFLD were absent in intestinal FXR-deficient mice,and supplementation of mice with C16-ceramide significantly exacerbated hepatic steatosis.Treatment of mice with an antibiotic cocktail to deplete BSH-producing bacteria also abrogated the therapeutic activity of CAPE against NAFLD.These findings demonstrate that CAPE ameliorates obesity-related steatosis at least partly through the gut microbiota-bile acid-FXR pathway via inhibiting bacterial BSH activity and suggests that propolis enriched with CAPE might serve as a promising therapeutic agent for the treatment of NAFLD. | Xian-chun Zhong Ya-meng Liu Xiao-xia Gao Kristopher W.Krausz Bing Niu Frank J.Gonzale Cen Xie | 2023 | Acta Pharmacologica Sinica2023，44，1： | 2 |
| 10 | First Principle Calculation of Electromagnetic Mechanism for Fe_2Si Bulk Material显示文摘The electronic structure and the magnetic properties of Fe_2Si bulk have been calculated by the first-principle density function theory method. The band structure shows that the hexagonal Fe^2 Si bulk is ferromagnetic which is a metal structure under spin-up, and a semiconductor with the band gap of 0.518 eV under spin-down. The density of states shows the Fe^1 3d–spin and Fe^3 3d–spin in the electronic system are the main factors that is the source of the ferromagnetic properties of Fe_2Si bulk. The electronic structure Si-ions is 3s23p6 and that of Fe-ions is e_g^2↑e_g^(*1)↓t_(2g)~3↑. The molecular magnetic moment of Fe_2Si is 2.00 μB. The potential diagram of Fe_2Si bulk shows the formation of covalent and ionic bonds between the Fe atom and the Si atom, it leads to the center charge of Fe is polarized and off center position. These special properties of Fe_2Si bulk are mainly caused by d-d exchange and p-d hybridization. The results offer a certain reference for the magnetic semiconductor Fe_2Si material. | 李瑞杰 CEN Weifu 杨吟野 Lü Lin XIE Quan | 2019 | Journal of Wuhan University of Technology(Materials Science)2019，34，1： | 2 |
| 11 | Genetic analysis of SPG4 and SPGaA genes in a cohort of Chinese patients with hereditary spastic paraplegia显示文摘 | Lu XJ Cen ZD Xie F | 2014 | J Neurol Sei2014，347，： | 1 |
| 12 | Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease显示文摘 | Jiang Changtao Xie Cen Li Fei Zhang Limin Nichols Robert G Krausz Kristopher W Cai Jingwei Qi Yunpeng Fang Zhong-Ze Takahashi Shogo Tanaka Naoki Desai Dhimant Amin Shantu G Albert Istvan Patterson Andrew D Gonzalez Frank J | 2015 | Journal of Clinical Investigation2015，，1： | 1 |
| 13 | Highly Selective Gas-phase Synthesis of 1,1-Dichloroethylene from 1,1,2-Trichloroethane over Supported Amine Catalysts显示文摘 | TANG Cen JIN Yanxia WANG Xiaoxia HU Gengshen XIE Guanqun LI Xiaonian LUO Mengfei | 2015 | Chemical Research in Chinese Universities2015，31，5： | 1 |
| 14 | Cogeneration of H 2 and CH 4 from water hyacinth by two-step anaerobic fermentation显示文摘 | Jun Cheng Binfei Xie Junhu Zhou Wenlu Song Kefa Cen | 2009 | International Journal of Hydrogen Energy2009，，7： | 1 |
| 15 | COVID-19 reinfection in the presence of neutralizing antibodies显示文摘Due to the high transmissibility of the SARS-CoV-2 virus,it continues to infect over 300000 people worldwide per day(WHO statistics,December 2020),even almost one year after the first COVID-19 cases were confirmed[1,2].One of the most important public health discussions being undertaken currently concerns the protective nature of the immune response and the possibility of reinfection in recovered individuals. | Ju Zhang Nan Ding Lili Ren Rui Song Danying Chen Xuesen Zhao Budong Chen Junyan Han Jiarui Li Yangzi Song Lin Di Kai Han Fengting Yu Ruming Xie Zhihai Chen Wen Xie Jingyuan Liu Shan Cen Yuhai Bi Angela R.Wu Fujie Zhang Chen Chen Hui Zeng | 2021 | National Science Review2021，8，4： | 1 |
| 16 | Using log mining to analyze user behavior on search engine显示文摘用户行为分析成为了最重要的研究话题之一,特别以性能优化,体系结构分析,和系统维护,由于搜索引擎用户的快速的生长。由足够地在木头数据上执行分析,研究人员和因特网公司能得到指导到更好的搜索引擎。在这篇论文,我们基于从一个真实商业搜索引擎的木头获得的搜索请求的约 7.5 亿个条目执行我们的分析。用户行为的几个方面被学习,包括询问长度,询问精制的比率,建议存取等等。不同信息需要可以导致不同行为,并且我们在这篇论文探讨这讨论。我们坚定地相信这些分析将与改进搜索引擎的有效性和效率的尊重是有用的。 | Ke XIE Huijia YU Rongwei CEN | 2012 | Frontiers of Electrical and Electronic Engineering in China2012，7，2： | 1 |
| 17 | Bioassay of Mildiomycin and a Rapid, Cost-Effective Agar Plug Method for Screening High-yielding Mutants of Mildiomycin显示文摘 | Zhi-Peng Xie Zhi-Nan Xu Wen-He Shen Pei-Lin Cen | 2005 | World Journal of Microbiology and Biotechnology (-)2005，，8： | 1 |
| 18 | Dysregulations of UDP-glucuronosyltransferases in rats with valproic acid and high fat diet induced fatty liver显示文摘 | Lifang Zhang Xiaoman Chu Hong Wang Hao Xie Cen Guo Lijuan Cao Xueyan Zhou Guangji Wang Haiping Hao | 2013 | European Journal of Pharmacology . 2013 (1-3)2013，，1： | 1 |
| 19 | Crosstalk between CYP2E1 and PPARα substrates and agonists modulate adipose browning and obesity显示文摘Although the functions of metabolic enzymes and nuclear receptors in controlling physiological homeostasis have been established, their crosstalk in modulating metabolic disease has not been explored.Genetic ablation of the xenobiotic-metabolizing cytochrome P450 enzyme CYP2 E1 in mice markedly induced adipose browning and increased energy expenditure to improve obesity. CYP2 E1 deficiency activated the expression of hepatic peroxisome proliferator-activated receptor alpha(PPARa) target genes,including fibroblast growth factor(FGF) 21, that upon release from the liver, enhanced adipose browning and energy expenditure to decrease obesity. Nineteen metabolites were increased in Cyp2 e1-null mice as revealed by global untargeted metabolomics, among which four compounds, lysophosphatidylcholine and three polyunsaturated fatty acids were found to be directly metabolized by CYP2 E1 and to serve as PPARa agonists, thus explaining how CYP2 E1 deficiency causes hepatic PPARa activation through increasing cellular levels of endogenous PPARa agonists. Translationally, a CYP2 E1 inhibitor was found to activate the PPARa-FGF21-beige adipose axis and decrease obesity in wild-type mice, but not in liver-specific Pparanull mice. The present results establish a metabolic crosstalk between PPARa and CYP2 E1 that supports the potential for a novel anti-obesity strategy of activating adipose tissue browning by targeting the CYP2 E1 to modulate endogenous metabolites beyond its canonical role in xenobiotic-metabolism. | Youbo Zhang Tingting Yan Tianxia Wang Xiaoyan Liu Keisuke Hamada Dongxue Sun Yizheng Sun Yanfang Yang Jing Wang Shogo Takahashi Qiong Wang Kristopher W.Krausz Changtao Jiang Cen Xie Xiuwei Yang Frank J.Gonzalez | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 1 |
| 20 | Cogeneration of H 2 and CH 4 from water hyacinth by two-step anaerobic fermentation显示文摘 | Jun Cheng Binfei Xie Junhu Zhou Wenlu Song Kefa Cen | 2009 | International Journal of Hydrogen Energy2009，，7： | 1 |
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