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| 1 | Microbiologically influenced corrosion behavior of S32654 super austenitic stainless steel in the presence of marine Pseudomonas aeruginosa biofilm显示文摘S32654 super austenitic stainless steel(SASS) is widely used in highly corrosive environments. However,its microbiologically influenced corrosion(MIC) behavior has not been reported yet. In this study, the corrosion behavior of S32654 SASS caused by a corrosive marine bacterium Pseudomonas aeruginosa was investigated using electrochemical measurements and surface analysis techniques. It was found that P. aeruginosa biofilm accelerated the corrosion rate of S325654 SASS, which was demonstrated by a negative shift of the open circuit potential(EOCP), a decrease of polarization resistance and an increase of corrosion current density in the culture medium. The largest pit depth of the coupons exposed in the P.aeruginosa broth for 14 days was 2.83 m, much deeper than that of the control(1.33 m) in the abiotic culture medium. It was likely that the P. aeruginosa biofilm catalyzed the formation of CrO_3, which was detrimental to the passive film, resulting in MIC pitting corrosion. | Huabing Li Chuntian Yang Enze Zhou Chunguang Yang Hao Feng Zhouhua Jiang Dake Xu Tingyue Gu Ke Yang | 2017 | Journal of Materials Science & Technology2017，33，12： | 10 |
| 2 | New electrochemical energy storage systems based on metallic lithium anode the research status,problems and challenges of lithium-sulfur,lithium-oxygen and all solid state batteries显示文摘Li-ion batteries have played a key role in the portable electronics and electrification of transport in modern society. Nevertheless,the limited highest energy density of Li-ion batteries is not sufficient for the long-term needs of society. Since lithium is the lightest metal among all metallic elements and possesses the lowest redox potential of.3.04 V vs. standard hydrogen electrode, it delivers the highest theoretical specific capacity of 3860 mA h g^(-1) and a high working voltage of full batteries which causes a great interest in electrochemical energy storage systems. Lithium-sulfur, lithium-oxygen and corresponding all solid state batteries based on metal lithium anode have received widely attention owing to their high energy densities. However, the problems in the cathode,electrolyte and anode of these three systems restrict their practical application. In this review, the research status and problems of these three energy storage systems are summarized and the challenges and future perspectives are also outlined. | Liangyu Li Chunguang Chen Aishui Yu | 2017 | Science China Chemistry2017，60，11： | 8 |
| 3 | Mutation of kri1l causes definitive hematopoiesis failure via PERK-dependent excessive autophagy induction显示文摘 | Xiao-E Jia Ke Ma Tao Xu Lei Gao Shuang Wu Cong Fu Wenjuan Zhang Zhizhang Wang Kaiyu Liu Mei Dong Changbin Jing Chunguang Ren Zhiwei Dong Yi Chen Yi Jin Qiuhua Huang Xing Chang Min Deng Li Li Lingfei Luo Jun Zhu Yongjun Dang Hung-Chun Chang Leonard I Zon Yi Zhou Saijuan Chen Weijun Pan | 2015 | Cell Research2015，25，8： | 8 |
| 4 | Microbiologically influenced corrosion of titanium caused by aerobic marine bacterium Pseudomonas aeruginosa显示文摘Microbiologically influenced corrosion(MIC) is a big threat to the strength and safety of many metallic materials used in different environments throughout the world. The metabolites and bioactivity of the microorganisms cause severe deterioration on the metals. In this study, MIC of pure titanium(Ti) was studied in the presence of a highly corrosive aerobic marine bacterium Pseudomonas aeruginosa. The results obtained from electrochemical test showed that Ti was corrosion resistant in the abiotic culture medium after 14 d, while the increased corrosion current density(i_(corr)) obtained from polarization curves and the decreased charge transfer resistance(R_(ct)) from electrochemical impedance spectroscopy(EIS)indicated the accelerated corrosion of Ti caused by P. aeruginosa biofilm. For further confirmation of the above results, the surface of Ti was investigated using scanning electron microscopy(SEM), confocal laser scanning microscopy(CLSM) and X-ray photoelectron spectroscopy(XPS). According to the XPS results, TiO_2 was formed in both abiotic and biotic conditions, while unstable oxide Ti_2O_3 was detected in the presence of P. aeruginosa, leading to the defects in the passive film and localized corrosion. Pitting corrosion was investigated with the help of CLSM, and the largest pit depth found on Ti surface immersed in P. aeruginosa was 1.2 μm. Ti was not immune to MIC caused by P. aeruginosa. | M.Saleem Khan Zhong Li Ke Yang Dake Xu Chunguang Yang Dan Liu Yassir Lekbach Enze Zhou Phuri Kalnaowakul | 2019 | Journal of Materials Science & Technology2019，35，1： | 8 |
| 5 | FBW7 regulates endothelial functions by targeting KLF2 for ubiquitination and degradation显示文摘F 盒子和 WD 重复包含域 7 (FBW7 ) , E3 ubiquitin ligase SCF FBW7 (SKP1, cullin-1 和 FBW7 的建筑群) ,在各种各样的生理、病理学的过程起重要作用。尽管 FBW7 为脉管的开发被要求,它在内皮细胞层的函数尚待被调查。在这研究,我们证明 FBW7 是 endothelial 功能的一个重要管理者,包括 angiogenesis,白血球粘附和 endothelial 障碍正直。用 RNA 干扰,我们发现 FBW7 的弄空显著地在 vitro 并且在 vivo 损害 angiogenesis。我们识别了锌手指抄写因素 Krü象 ppel 一样因素 2 (KLF2 ) 作为在 endothelial 房间的 FBW7 的一个生理的目标。FBW7 击倒表示在 endothelial 房间导致了内长的 KLF2 蛋白质的累积。调停 FBW7 的 KLF2 破坏被显示在二保存 phosphodegrons 经由肝糖 synthase kinase-3 (GSK3 ) 取决于 KLF2 的 phosphorylation。变异这些 phosphodegron 主题废除了 KLF2 的调停 FBW7 的降级和 ubiquitination。调停 siRNA 显示出的 FBW7 击倒 KLF2 是在 endothelial 的规定的 FBW7 的一个必要目标,这工作。而且,调停 FBW7 的 KLF2 降级被显示为在 teratomas 并且在 zebrafish 开发的 angiogenesis 批评。一起拿,我们的学习在 endothelial 房间移植, angiogenesis,发炎和障碍完整的进程为 FBW7 建议一个角色,并且在 vivo 提供新奇卓见进 KLF2 稳定性的规定。 | Rui Wang Yah Wang Ning Liu Chunguang Ren Cong Jiang Kai Zhang Su Yu Yunfei Chen Hui Tang Qi Deng Cong Fu Yingcong Wang Rong Li Mingyao Liu Weijun Pan Ping Wang | 2013 | Cell Research2013，23，6： | 7 |
| 6 | Using a mesoscale ensemble to predict forecast error and perform targeted observation显示文摘Using NCEP short range ensemble forecast(SREF)system,demonstrated two fundamental on-going evolutions in numerical weather prediction(NWP)are through ensemble methodology.One evolution is the shift from traditional single-value deterministic forecast to flow-dependent(not statistical)probabilistic forecast to address forecast uncertainty.Another is from a one-way observation-prediction system shifting to an interactive two-way observation-prediction system to increase predictability of a weather system.In the first part,how ensemble spread from NCEP SREF predicting ensemble-mean forecast error was evaluated over a period of about a month.The result shows that the current capability of predicting forecast error by the 21-member NCEP SREF has reached to a similar or even higher level than that of current state-of-the-art NWP models in predicting precipitation,e.g.,the spatial correlation between ensemble spread and absolute forecast error has reached 0.5 or higher at 87 h(3.5 d)lead time on average for some meteorological variables.This demonstrates that the current operational ensemble system has already had preliminary capability of predicting the forecast error with usable skill,which is a remarkable achievement as of today.Given the good spread-skill relation,the probability derived from the ensemble was also statistically reliable,which is the most important feature a useful probabilistic forecast should have.The second part of this research tested an ensemble-based interactive targeting(E-BIT)method.Unlike other mathematically-calculated objective approaches,this method is subjective or human interactive based on information from an ensemble of forecasts.A numerical simulation study was performed to eight real atmospheric cases with a 10-member,bred vector-based mesoscale ensemble using the NCEP regional spectral model(RSM,a sub-component of NCEP SREF)to prove the concept of this E-BIT method.The method seems to work most effective for basic atmospheric state variables,moderately effective for convective instabilities and least effective for precipitations.Precipitation is a complex result of many factors and,therefore,a more challenging field to be improved by targeted observation. | DU Jun LI Jun YU Rucong CUI Chunguang | 2014 | Acta Oceanologica Sinica2014，33，1： | 7 |
| 7 | A 23 GHz high-temperature superconducting microstrip filter for radio astronomy显示文摘This paper reports a 6-pole high-temperature superconducting (HTS) microstrip bandpass filter for radio astronomy applications. The filter has a center frequency of 23 GHz and a bandwidth the 2 GHz. We have made many efforts, such as adopting 0.25-mm-thick substrate, carefully designing the housing box and filter layout, to solve the problems in realizing a K-band planar filter. A special straight-line half-wavelength resonator (center-widen resonator) was also designed to reduce the insertion loss of the filter. The measured results showed a midband insertion loss of 0.11 dB with a ripple of 0.4 dB, and a return loss better than 11.5 dB. Good agreement was obtained between simulated and measured results. | GAO Lu GUO Jin WANG YueHui YU Tao ZHANG Qiang LI ChunGuang ZHANG XueQiang LI Hong LI JunJie LI WuXia GU ChangZhi MENG JiBao FENG Ji HE YuSheng | 2009 | Chinese Science Bulletin2009，54，19： | 6 |
| 8 | A high-performance narrowband high temperature superconducting filter显示文摘Recent development of a high-performance narrowband high-temperature superconducting (HTS) filter is presented. A 10-pole quasi-elliptic function response filter with two pairs of transmission zeros (for high selectivity), which has a center frequency of 2.185 GHz and a 3 dB bandwidth of 10 MHz (a fractional bandwidth of 0.45%), is introduced. The filter was fabricated on a 40 mm×16 mm×0.5 mm MgO wafer with double-sided YBCO films. The measured results show that the filter has 0.15 dB insertion loss at the center of the passband and a return loss better than -22.5 dB at a temperature of 67 K.Band edge steepness reaches over 28.3 dB/MHz at both the low and high frequency edges. The out-of-band rejection is over 78 dB at 8 MHz away from the center frequency and close to 100 dB in a wideband range. | CUI Bin ZHANG XueQiang SUN Liang BIAN YongBo GUO Jin WANG Jia LI ChunGuang LI Hong ZHANG Qiang HE YuSheng | 2010 | Chinese Science Bulletin2010，55，14： | 6 |
| 9 | Automatic Method for Synchronizing Workpiece Frames in Twin-robot Nondestructive Testing System显示文摘The workpiece frames relative to each robot base frame should be known in advance for the proper operation of twin-robot nondestructive testing system. However, when two robots are separated from the workpieces, the twin robots cannot reach the same point to complete the process of workpiece frame positioning. Thus, a new method is proposed to solve the problem of coincidence between workpiece frames. Transformation between two robot base frames is initiated by measuring the coordinate values of three non-collinear calibration points. The relationship between the workpiece frame and that of the slave robot base frame is then determined according to the known transformation of two robot base frames, as well as the relationship between the workpiece frame and that of the master robot base frame. Only one robot is required to actually measure the coordinate values of the calibration points on the workpiece. This requirement is beneficial when one of the robots cannot reach and measure the calibration points. The coordinate values of the calibration points are derived by driving the robot hand to the points and recording the values of top center point(TCP) coordinates. The translation and rotation matrices relate either the two robot base frames or the workpiece and master robot. The coordinated are solved using the measured values of the calibration points according to the Cartesian transformation principle. An optimal method is developed based on exponential mapping of Lie algebra to ensure that the rotation matrix is orthogonal. Experimental results show that this method involves fewer steps, offers significant advantages in terms of operation and time-saving. A method used to synchronize workpiece frames in twin-robot system automatically is presented. | LU Zongxing XU Chunguang PAN Qinxue MENG Fanwu LI Xinliang | 2015 | Chinese Journal of Mechanical Engineering2015，28，4： | 6 |
| 10 | mrle, a conotoxin from Conus marmoreus with a novel disulfide pattern显示文摘 | Yanfang Wang Xiaoxia Shao Min Li Sumin Wang Chengwu Chi Chunguang Wang | 2008 | Acta Biochimica et Biophysica Sinica2008，40，5： | 5 |
| 11 | Two Potent α3/5 Conotoxins from Piscivorous Conus achatinus显示文摘每个锥蜗牛生产不同 conotoxins 的混合物并且分泌他们使他们的猎物和食肉动物不能调动。α 3 /5 Conotoxins,从狩猎鱼的锥蜗牛孤立,目标肌肉烟碱的醋胆素受体。从食鱼的 Conus achatinus 的α 3 /5 conotoxin 的结构和功能没被学习。我们综合了二 pentadecamer 肽, Ac1.1a 和 Ac1.1b 与适当二硫化物结合,基于α 3 /5 conotoxinsfrom C 的 cDNA 序列。achatinus。Ac1.1a 和 Ac1.1b 由一仅仅氨基酸残余不同。他们分别地在堵住在 Xenopus laevisoocytes 表示的 recombinant 老鼠肌肉醋胆素受体上有类似的力量,与 36 nM 和 26 nM 的 IC_(50 ) 价值。为 Ac1.1b,开始的三 N 终端氨基酸的删除没改变它的活动,显示 N 终点不涉及和它的受体的相互作用。而且,我们的实验显示两毒素强烈在老鼠肌肉上比较喜欢α _1- δ子单元接口而不是α _1- γ结合部位烟碱的醋胆素受体。这些肽为结构的学习和烟碱的受体的功能提供另外的工具。 | Li LIU Geoffrey CHEW Edward HAWROT Chengwu CHI Chunguang WANG | 2007 | Acta Biochimica et Biophysica Sinica2007，39，6： | 5 |
| 12 | Effect of Cu Addition to 2205 Duplex Stainless Steel on the Resistance against Pitting Corrosion by the Pseudomonas aeruginosa Biofilm显示文摘The effect of copper addition to 2205 duplex stainless steel(DSS) on its resistance against pitting corrosion by the Pseudomonas aeruginosa biofilm was investigated using electrochemical and surface analysis techniques. Cu addition decreased the general corrosion resistance, resulting in a higher general corrosion rate in the sterile medium. Because DSS usually has a very small general corrosion rate, its pitting corrosion resistance is far more important. In this work, it was shown that 2205-3%Cu DSS exhibited a much higher pitting corrosion resistance against the P. aeruginosa biofilm compared with the 2205 DSS control, characterized by no significant change in the pitting potential and critical pitting temperature(CPT) values. The strong pitting resistance ability of 2205-3%Cu DSS could be attributed to the copper-rich phases on the surface and the release of copper ions, providing a strong antibacterial ability that inhibited the attachment and growth of the corrosive P. aeruginosa biofilm. | Ping Li Yang Zhao Yuzhi Liu Ying Zhao Dake Xu Chunguang Yang Tao Zhang Tingyue Gu Ke Yang | 2017 | Journal of Materials Science & Technology2017，33，7： | 5 |
| 13 | TCP7 functions redundantly with several Class Ⅰ TCPs and regulates endoreplication in Arabidopsis显示文摘TCP(TEOSINTE BRANCHED1/CYCLOIDEA/PROLIFERATING CELL FACTOR) proteins, a family of plantspecific transcription factors, play important roles in many developmental processes. However, genetic and functional redundancy among class I TCP limits the analysis of their biological roles. Here, we identified a dominantnegative mutant of Arabidopsis thaliana TCP7 named leaf curling-upward(lcu), which exhibits smaller leaf cells and shorter hypocotyls than the wild type, due to defective endoreplication. A septuple loss-of-function mutant of TCP7, TCP8, TCP14, TCP15, TCP21, TCP22, and TCP23 displayed similar developmental defects to those of lcu.Genome-wide RNA-sequencing showed that lcu and the septuple mutant share many misexpressed genes.Intriguingly, TCP7 directly targets the CYCLIN D1;1 (CYCD1;1) locus and activates its transcription. We determined that the C-terminus of TCP7 accounts for its transcriptional activation activity. Furthermore, the mutant protein LCU exhibited reduced transcriptional activation activity due to the introduction of an EAR-like repressive domain at its C-terminus. Together, these observations indicate that TCP7 plays important roles during leaf and hypocotyl development, redundantly, with at least six class I TCPs, and regulates the expression of CYCD1;1 to affect endoreplication in Arabidopsis. | Guofang Zhang Hongtao Zhao Chunguang Zhang Xiaoyun Li Yuanyuan Lyu Dongmei Qi Yanwei Cui Lin Hu Zhenjie Wang Zheng Liang Sujuan Cui | 2019 | Journal of Integrative Plant Biology2019，61，11： | 5 |
| 14 | Enhanced resistance of 2205 Cu-bearing duplex stainless steel towards microbiologically influenced corrosion by marine aerobic Pseudomonas aeruginosa biofilms显示文摘An antibacterial 2205-Cu duplex stainless steel(DSS)was shown to inhibit the formation and growth of corrosive marine biofilms by direct contact with copper-rich phases and the release of Cu^(2+)ions from the2205-Cu DSS surface.In this work,the microbiologically influenced corrosion(MIC)resistance of 2205-Cu DSS in the presence of the corrosive marine bacterium Pseudomonas aeruginosa was investigated.The addition of copper improved the mechanical properties such as the yield strength,the tensile strength and the hardness of 2205 DSS.Electrochemical test results from linear polarization resistance(LPR),electrochemical impedance spectroscopy(EIS)and critical pitting temperature(CPT)measurements showed that 2205-Cu DSS possessed a larger polarization resistance(R_p),charge transfer resistance(R_(ct))and CPT values,indicating the excellent MIC resistance of 2205-Cu DSS against the corrosive P.aeruginosa biofilm.The live/dead staining results and the SEM images of biofilm confirmed the strong antibacterial ability of 2205-Cu DSS.The largest pit depth of 2205-Cu DSS was considerably smaller than that of 2205 DSS after 14 d in the presence of P.aeruginosa(2.2μm vs 12.5μm).2205-Cu DSS possessed a superior MIC resistance to regular 2205 DSS in the presence of aerobic P.aeruginosa. | Dake Xu Enze Zhou Ying Zhao Huabing Li Zhiyong Liu Dawei Zhang Chunguang Yang Hai Lin Xiaogang Li Ke Yang | 2018 | Journal of Materials Science & Technology2018，34，8： | 4 |
| 15 | Space qualification mechanical tests of HTS filters for satellite application显示文摘High performance high-temperature superconducting (HTS) filters have been designed and constructed for satellite application. The filters are actually a superconducting integration of an 8-pole band-pass filter with an adjustable band-stop filter onto a single piece of LaAlO3 substrate (with dimension of 0.5×45×20 mm3). Typical results of the filters, i.e., Filters A (made by YBCO) & B (made by TBCCO) will be reported. The measured responses of Filter A showed excellent specifications, e.g., an insertion loss less than 0.1 dB, a return loss better than -22.5 dB in pass-band, band-edge steepness greater than 12 dB/MHz and out-of-band rejection at a certain band deeper than -110 dB. To satisfy the requirement of rocket launch and space operation, three filters of the above design have undergone mechanical environmental simulation tests for space qualification. Detailed analysis of the response curves of Filter B measured before and after the tests showed that no noticeable change in the per-formance can be found. All the filters passed the rigorous ground simulation tests, which is the first time in China for HTS devices and provided a solid foundation for satellite applications of high-temperature superconductors in the near future. | HUANG JianDong SUN Liang LI ShunZhou MENG QingDuan ZHANG Qiang LI Fei ZHANG XueQiang LI ChunGuang HE AiSheng LI Hong GU ChangZhi LUO Qiang SUN QinFen WANG XiaoLin SUN YiFan WANG ZhiBing WANG YunFei LUO Sheng HE YuSheng | 2007 | Chinese Science Bulletin2007，52，13： | 3 |
| 16 | High-Resolution Mesoscale Analysis Data from the South China Heavy Rainfall Experiment (SCHeREX): Data Generation and Quality Evaluation显示文摘In this study, the observational data acquired in the South China Heavy Rainfall Experiment (SCHeREX) from May to July 2008 and 2009 were integrated and assimilated with the US National Oceanic and Atmospheric Administration's (NOAA) Local Analysis and Prediction System (LAPS; information available online at http://laps.fsl.noaa.gov). A high-resolution mesoscale analysis dataset was then generated at a spatial resolution of 5 km and a temporal resolution of 3 h in four observational areas: South China, Central China, Jianghuai area, and Yangtze River Delta area. The quality of this dataset was evaluated as follows. First, the dataset was qualitatively compared with radar reflectivity and TBB image for specific heavy rainfall events so as to examine its capability in reproduction of mesoscale systems. The results show that the SCHeREX analysis dataset has a strong capability in capturing severe mesoscale convective systems. Second, the mean deviation and root mean square error of the SCHeREX mesoscale analysis fields were analyzed and compared with radiosonde data. The results reveal that the errors of geopotential height, temperature, relative humidity, and wind of the SCHeREX analysis were within the acceptable range of observation errors. In particular, the average error was 45 m for geopotential height between 700 and 925 hPa, 1.0-1.1°C for temperature, less than 20% for relative humidity, 1.5-2.0 m s-1 for wind speed, and 20-25° for wind direction. The above results clearly indicate that the SCHeREX mesoscale analysis dataset is of high quality and sufficient reliability, and it is applicable to refined mesoscale weather studies. | NI Yunqi CUI Chunguang LI Hongli PENG Juxiang QIU Xuexing ZHANG Yanxia XU Xiaolin GAO Mei JIE Lianshu ZHANG Wenhua | 2011 | Acta meteorologica Sinica2011，25，4： | 2 |
| 17 | An L-band HTS duplexer with improved performance显示文摘An L-band HTS duplexer with improved performance for communication applications has been developed.This is an improved version of the duplexer previously developed by our group.The duplexer was composed of a T-junction and two channels.Each channel has a 10-pole quasi-elliptic function bandpass HTS filter with a bandwidth of 27 MHz,and center frequencies at 1200 MHz and 1260 MHz.To achieve higher performance,especially a good balance between selectivity and flat group delay,the two pairs of transmission zeros from the two filters were reassigned so that one pair is used for high selectivity and the other for flat group delay.To reduce the influence of parasitical coupling,new coupling structures were developed in the simulation process.The duplexer was fabricated on a 2 inch diameter,0.5 mm thick LaAlO3 wafer with a double-sided YBCO film.The measured results showed a very high performance:a mid-band insertion loss of 0.2 dB,a return loss better than-14 dB,a shape factor better than 1.4:1,an out-of-band rejection of better than 70 dB in a wide frequency range up to 3 GHz and excellent isolation(higher than 80 dB) between the two channels.In addition,the frequency band 5 ns group delay variation is over 10.5 MHz(38.7% of 1 dB bandwidth). | Jia Wang Qiang Zhang Bin Cui Jin Guo YongBo Bian XiaoFeng He ChunGuang Li XueQiang Zhang Hong Li WuXia Li et al. | 2010 | Chinese Science Bulletin2010，55，31： | 2 |
| 18 | Polarization-sensitive and wide-spectrum photovoltaic detector based on quasi-1D ZrGeTe_(4)nanoribbon显示文摘Low-dimensional semiconductors with in-plane anisotropy and narrow bandgap have been extensively applied to polarized detection in the near-infrared(NIR)region.However,the narrow bandgap can cause noise owing to the high dark current in photodetectors.This article reports quasi-1D ZrGeTe_(4)nanoribbonbased photodetectors with low dark current and broadband polarization detection.The photodetector was fabricated by evaporating 50-nm-thick Au electrodes on a ZrGeTe_(4)nanoribbon.Benefiting from the photovoltaic characteristics in the ZrGeTe_(4)nanoribbon and Au electrodes,these photodetectors can operate without bias voltage,with decreased dark current,and improved device performance.Furthermore,the quasi-1D ZrGeTe_(4)nanoribbon-based photodetectors demonstrate a polarization sensitivity in a broadband from visible(VIS)to the NIR region,such as a high photoresponsivity of 625.65 mA W1,large external quantum efficiency of 145.9%at 532 nm,and photocurrent anisotropy ratio of 2.04 at 1064 nm.They exhibit a novel perpendicular optical reversal of 90in polarization-sensitive photodetection,angle-resolved absorption spectra,and azimuth-dependent reflectance difference microscopy(ADRDM)from VIS to the NIR region,as opposed to other nanoribbon-based polarization-sensitive photodetectors.This work paves the way for utilizing photovoltaic photodetectors based on low-dimensional materials for broad-spectrum polarized photodetection. | Ruixue Bai Tao Xiong Jinshu Zhou Yue-Yang Liu Wanfu Shen Chunguang Hu Faguang Yan Kaiyou Wang Dahai Wei Jingbo Li Juehan Yang Zhongming Wei | 2022 | InfoMat2022，4，3： | 2 |
| 19 | 转录因子EB在运动适应骨骼肌表型变化中的作用显示文摘转录因子EB(transcription factor EB,TFEB)是一种对骨骼肌糖、脂代谢、线粒体生物发生发挥作用的蛋白质,因其在物质代谢和生物发生等表型变化中表现出的重要作用而备受生物科学领域的关注。在正常生理状态下,TFEB主要存在于细胞浆中,并处于失活状态;在急性运动和耐力运动时发生转位,从细胞浆进入细胞核,诱导线粒体生物发生;参与调控糖代谢相关的一系列信号途径如葡萄糖转运体基因的表达、葡萄糖的摄取和利用、糖原合成等;还可调节脂肪酸氧化和氧化磷酸化等相关基因的表达,其结果增强了机体的运动能力。梳理TFEB在运动适应骨骼肌表型变化中的可能作用机制,为运动防治糖尿病、高脂血症和代谢综合症等胰岛素抵抗相关疾病的发生、发展提供新靶点,同时也可能为运动适应骨骼肌表型变化分子机制的研究提供新视角。 | 王平 LI Chunguang 丁树哲 | 2019 | 体育科学2019，39，5： | 2 |
| 20 | 急性递增负荷运动对小鼠骨骼肌SOD同工酶活性和mRNA表达的影响显示文摘目的:通过建立急性递增负荷小鼠运动模型,探讨小鼠急性跑台运动后骨骼肌抗氧化防御系统的反应。方法:30只6周龄清洁级雄性ICR小鼠,体重20.81±2.31g,随机分为安静对照组(C组,6只)、急性递增负荷运动45min组(E1组,6只)、90min组(E2,6只)、120min组(E3组,6只)和150min组(E4组,6只)组。正式运动按以下程序:第1级负荷:0°,8.2m/min(相当于53%VO2max),15min;第2级负荷:5°,15m/min(相当于64%VO_2max),15min;第3级负荷:10°,19.3m/min(相当于76%VO2max)。各组分别运动至所设相应时间及安静对照组,取出左、右侧腓肠肌,采用硝酸还原酶法测定线粒体NO含量,采用化学比色法测定eNOS活性,采用黄嘌呤氧化酶法测定线粒体MnSOD、Cu Zn SOD的活性;实时荧光定量PCR(Real-time PCR)检测骨骼肌MnSOD、CuZnSOD基因表达水平。结果:(1)与安静对照组相比,小鼠骨骼肌线粒体NO含量在急性递增负荷运动45min、90min、120min和150min均出现显著增加(P<0.05),且90min达到峰值(P<0.01);小鼠骨骼肌线粒体eNOS活性在急性递增负荷运动45min、90min和120min均出现显著增加(P<0.05),且90min达到峰值(P<0.01),但150min未出现显著性变化(P>0.05);(2)线粒体Mn SOD活性在急性运动45min后明显增加(P<0.05),急性运动90、120min和150min均出现极显著增加(P<0.01),且在120min达到峰值;(3)与安静对照组相比,MnSODmRNA在急性运动45min出现显著性增加(P<0.05),急性运动90min、120min和150min均出现极显著性增加(P<0.01),且在150min达到峰值(P<0.01)。结论:线粒体MnSOD对急性递增负荷运动具有较好的应答反应,是运动刺激-反应-适应的主要SOD机制。 | 王平 LI Chunguang 漆正堂 丁树哲 | 2016 | 成都体育学院学报2016，42，3： | 1 |
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