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| 1 | Contribution of the Compass satellite navigation system to global PNT users显示文摘As one of the four global satellite navigation systems,Compass not only enhances satellite visibility and availability for positioning,navigation and timing (PNT) for users in China and the surrounding areas,but also improves PNT precision for global users.The improvements in satellite visibility and the dilution of precision are analyzed under GNSS compatibility and interoperation conditions.The contribution of the Compass satellite navigation system to global users,especially the benefits that users can acquire from the combination of Compass,GPS,GLONASS,and Galileo navigation systems,is analyzed using simulation data. | YANG YuanXi LI JinLong XU JunYi TANG Jing GUO HaiRong HE HaiBo | 2011 | Chinese Science Bulletin2011，56，26： | 90 |
| 2 | Preliminary assessment of the navigation and positioning performance of BeiDou regional navigation satellite system显示文摘BeiDou regional navigation satellite system(BDS)also called BeiDou-2 has been in full operation since December 27,2012.It consists of 14 satellites,including 5 satellites in Geostationary Orbit(GEO),5 satellites in Inclined Geosynchronous Orbit(IGSO),and 4 satellites in Medium Earth Orbit(MEO).In this paper,its basic navigation and positioning performance are evaluated preliminarily by the real data collected in Beijing,including satellite visibility,Position Dilution of Precision(PDOP)value,the precision of code and carrier phase measurements,the accuracy of single point positioning and differential positioning and ambiguity resolution(AR)performance,which are also compared with those of GPS.It is shown that the precision of BDS code and carrier phase measurements are about 33 cm and 2 mm,respectively,which are comparable to those of GPS,and the accuracy of BDS single point positioning has satisfied the design requirement.The real-time kinematic positioning is also feasible by BDS alone in the opening condition,since its fixed rate and reliability of single-epoch dual-frequency AR is comparable to those of GPS.The accuracy of BDS carrier phase differential positioning is better than 1 cm for a very short baseline of 4.2 m and 3 cm for a short baseline of 8.2 km,which is on the same level with that of GPS.For the combined BDS and GPS,the fixed rate and reliability of single-epoch AR and the positioning accuracy are improved significantly.The accuracy of BDS/GPS carrier phase differential positioning is about 35 and 20%better than that of GPS for two short baseline tests in this study.The accuracy of BDS code differential positioning is better than 2.5 m.However it is worse than that of GPS,which may result from large code multipath errors of BDS GEO satellite measurements. | YANG YuanXi LI JinLong WANG AiBing XU JunYi HE HaiBo GUO HaiRong SHEN JunFei DAI Xian | 2014 | Science China Earth Sciences2014，57，1： | 125 |
| 3 | Comparing the Diagnostic Criteria for Gestational Diabetes Mellitus of World Health Organization 2013 with 1999 in Chinese Population显示文摘INTRODUCTION Gestational diabetes mellitus (GDM) was earlier defined as 'hyperglycemia first recognized during pregnancy' and has more recently been described by American Diabetes Association (ADA) (2012) as diabetes diagnosed during pregnancy that is not clearly overt diabetes.[1] The hyperglycemia and adverse pregnancy outcomes study (HAPO) demonstrated that the risk of adverse maternal,fetal,and neonatal outcomes continuously increase as a function of maternal glycemia at 24-28 weeks,even within ranges previously considered normal for pregnancy.[2] After reviewing the results of the HAPO study,many international diabetes study groups,including the International Association of Diabetes and Pregnancy Study Groups and ADA have adopted the 75 g oral glucose tolerance test (OGTT) at 24-28 weeks as a screening and diagnostic test and defined new cut-off values for GDM diagnosis.The Ministry of Health of China published the criteria for GDM,that is the same as the ADA criteria on July 1,2011.World Health Organization (WHO) has recommended the 75 g OGTT with different cut-offvalues as a diagnostic test since 1999,changed its recommendation on 2013.In Hongkong and Yunnan province in China,most hospital adopted the WHO 1999 criteria,nevertheless,there is no evidence of multicenter and large sample to show that the GDM population within the same ethnic group diagnosed by the new WHO criteria matches those diagnosed by the old one and consistency between the two criteria has not been reported.Thus,we conducted this study to analyze the two criteria in Chinese pregnant women. | Weiwei Zhu Huixia Yang Yumei Wei Zilian Wang Xuelan Li Hairong Wu Nan Li Meihua Zhang Xinghui Liu Hua Zhang Yunhui Wang Jianmin Niu Yujie Gan Liruo Zhong Yunfeng Wang Anil Kapur | 2015 | Chinese Medical Journal2015，，1： | 42 |
| 4 | Application of a Quality Control Circle to Reduce the Wait Times between Continuous Surgeries显示文摘Purpose: To investigate how to shorten patient wait times between continuous ocular operations and to evaluate the influence of a quality control circle(QCC) on operating room management.Methods:.QCC management was established to conduct activities..Clinical data were collected to analyze the causes of long wait times between continuous surgeries. Effective measures were undertaken correspondingly.Results:.The staff from QCC actively undertook measures that would significantly shorten patient wait times between continuous ocular surgeries(P<0.05).Conclusion:.Multiple measures,.such as setting up a QCC,enhancing the arrangement of surgical procedures,.establishing effective communication channels,.optimizing human resources, and integrating the use of instruments, can effectively shorten patient wait times between continuous vitreous or retinal surgeries. | Hairong Zhang Li Wang Yueye Cai Ronghua Ye Jingyi Lin Dongdong Jiang | 2015 | Eye Science2015，30，2： | 45 |
| 5 | Late Miocene Red River submarine fan,northwestern South China Sea显示文摘A huge submarine fan is discovered through the research of the seismic and borehole data in the binding site of Yinggehai basin and Qiongdongnan basin in northwestern South China Sea.The fan,mainly formed during Late Miocene (Huangliu period) has an area over 10000 km 2 and maximum thickness of over 2000 m.It is characterized by a wedge-shaped oblique progradation configuration on the dip profile and a hummocky bidirectional progradation configuration on the strike profile.The core and Logging data from the well YC35-1-2 located in the front side of the fan indicate that sandy gravity flow deposits are predominant in lower Huangliu Formation and change to interbeds of sand and mud in upper Huangliu Formation.The fan is interpreted as a sand/mud-rich submarine fan in combination with the bathyal geological background of Huangliu period.A preliminary analysis of provenance indicates that neither the Guiren Uplift in the west nor the Hainan Uplift in the north can serve as the major provenance for the submarine fan.The provenance is considered to be from the Red River,based on the sedimentary facies study of the Huangliu Formation in Yinggehai basin.The fan is thus named as 'Red River submarine fan'.The Red River depositional system consists of the Red River submarine fan,the Red River delta,and associated submarine canyons.The discovery of the Red River submarine fan provides important information for the research of the uplift of Tibetan Plateau and the evolvement of Red River Fault Zone.Furthermore,it also points out a new direction for the deepwater hydrocarbon exploration in the northern South China Sea. | WANG YingMin XU Qiang LI Dong HAN JianHui LU Ming WANG YongFeng LI WeiGuo WANG HaiRong | 2011 | Chinese Science Bulletin2011，56，14： | 28 |
| 6 | Deep soil water infiltration and its dynamic variation in the shifting sandy land of typical deserts in China显示文摘Soil moisture is the key resource constraint in arid ecosystems, and has been a focus of research on restoration. However, quantitative studies on the contribution of rainfall to deep soil rainfall infiltration are lacking. In this study, we used the YWB-01 Deep Soil Infiltration Water Recorder which had been invented by ourselves to measure the quantity of rain infiltration into deep soil, 150 cm below ground, in four locations in China: Mu Us Sandy Land and Ulan Buh, Tengger, and Badan Jilin deserts over a 2-year period. We found:(1) Deep soil rainfall infiltration decreased progressively from east to west and from semiarid to arid areas, with two locations completely lacking rainfall infiltration. Heavy rain was important to deep soil infiltration in shifting sandy land of arid and semiarid areas.(2) Seasonal variation of infiltration was correlated with rainfall, with a time lag that was less apparent in areas with more rainfall.(3) For single intense rainfall events, infiltration maximums occurred 40–55 h after the rainfall, during which the infiltration rates increased rapidly before reaching a peak, and then decreased slowly. Continuous infiltration could last about 150 h. Rainfall infiltration was determined by the combined action of intensity, quantity and duration. Rainfall with low intensity, long duration, and large quantity was most favorable for deep soil infiltration. Our results can be used in water resource assessments and protection during eco-restoration in the arid and semiarid areas in China. | YANG WenBin TANG JinNian LIANG HaiRong DANG HongZhong LI Wei | 2014 | Science China Earth Sciences2014，57，8： | 21 |
| 7 | Biocompatibility of bio-Mg-Zn alloy within bone with heart, liver, kidney and spleen显示文摘A magnesium-zinc alloy rod was implanted into the marrow cavity of the distal femur in New Zealand rabbits. The femur with the implanted alloy was compared with the contralateral femur in which a bone tunnel without implant was formed as a control. Degradation of the magnesium-zinc alloy was analyzed via X-ray, scanning electron microscopy, and element energy spectrum analysis. Serum magnesium, liver and kidney function tests, and myocardial enzymes were measured. Heart, liver, kidney and spleen were sectioned for pathological analysis, and the effects of the implanted material on the histology and function of important organs were analyzed. Magnesium-zinc alloy was resorbed from the bone marrow cavity of the femur; 87% of the alloy was degraded within 14 weeks after the surgery. There were no significant differences in serum magnesium, liver or kidney function tests, or myocardial enzymes be- fore the surgery and after degradation of the magnesium-zinc alloy. Histology of the heart, liver, kidney, and spleen did not change. This study demonstrated that magnesium-zinc alloy can be resorbed in bone, and that the degradation products have good biocompatibility with heart, liver, kidney, and spleen. | HE YaoHua TAO HaiRong ZHANG Yan JIANG Yao ZHANG ShaoXiang ZHAO ChangLi LI JiaNan ZHANG BeiLei SONG Yang ZHANG XiaoNong | 2009 | Chinese Science Bulletin2009，54，3： | 18 |
| 8 | Indirect mineral carbonation of titanium-bearing blast furnace slag coupled with recovery of TiO_2 and Al_2O_3显示文摘Large quantities of CO_2 and blast furnace slag are discharged in the iron and steel industry. Mineral carbonation of blast furnace slag can offer substantial CO_2 emission reduction and comprehensive utilization of the solid waste.This paper describes a novel route for indirect mineral carbonation of titanium-bearing blast furnace(TBBF) slag,in which the TBBF slag is roasted with recyclable(NH_4)_2SO_4(AS) at low temperatures and converted into the sulphates of various valuable metals, including calcium, magnesium, aluminium and titanium. High value added Ti-and Al-rich products can be obtained through stepwise precipitation of the leaching solution from the roasted slag. The NH_3 produced during the roasting is used to capture CO_2 from flue gases. The NH_4HCO_3 and(NH_4)_2CO_3 thus obtained are used to carbonate the CaSO_4-containing leaching residue and MgSO_4-rich leaching solution, respectively. In this study, the process parameters and efficiency for the roasting, carbonation and Ti and Al recovery were investigated in detail. The results showed that the sulfation ratios of calcium,magnesium, titanium and aluminium reached 92.6%, 87% and 84.4%, respectively, after roasting at an AS-to-TBBF slag mass ratio of 2:1 and 350 °C for 2 h. The leaching solution was subjected to hydrolysis at 102 °C for 4 h with a Ti hydrolysis ratio of 95.7% and the purity of TiO_2 in the calcined hydrolysate reached 98 wt%.99.7% of aluminium in the Ti-depleted leaching solution was precipitated by using NH_3. The carbonation products of Ca and Mg were CaCO_3 and(NH_4)_2 Mg(CO_3)_2·4H_2O, respectively. The latter can be decomposed into MgCO_3 at 100–200 °C with simultaneous recovery of the NH_3 for reuse. In this process, approximately 82.1% of Ca and 84.2%of Mg in the TBBF slag were transformed into stable carbonates and the total CO_2 sequestration capacity per ton of TBBF slag reached up to 239.7 kg. The TiO_2 obtained can be used directly as an end product, while the Al-rich precipitate and the two carbonation products can act, respectively, as raw materials for electrolytic aluminium,cement and light magnesium carbonate production for the replacement of natural resources. | Lin Wang Weizao Liu Jingpeng Hu Qiang Liu Hairong Yue Bin Liang Guoquan Zhang Dongmei Luo Heping Xie Chun Li | 2018 | Chinese Journal of Chemical Engineering2018，26，3： | 14 |
| 9 | Scientific and Engineering Progress in CO_2 Minerali zation Using Industrial Waste and Natural Minerals显示文摘The issues of reducing CO_2 levels in the atmo-sphere, sustainably utilizing natural mineral resources,and dealing with indus trial waste offer challenging opportunities for sustainable development in energy and the environment. The latest advances in CO_2 mineralization technology involving natural minerals and industrial waste are summarized in this paper, with great emphasis on the advancement of fundamental science, economic evaluation, and engineering applications. We discuss several lead-ing large-scale CO_2 mineralization methodologies from a techn ical and engineering-science perspective. For each technology option, we give an overview of the technical parameters, reaction pathway, reactivity, procedural scheme, and laboratorial and pilot devices. Furthermore, we present a discussion of each technology based on experimental results and the literature. Finally, current gaps in knowledge are identified in the conclusion, and an overview of the challenges and opportunities for future research in this field is provided. | Heping Xie Hairong Yue Jiahua Zhu Bin Liang Chun Li Yufei Wang Lingzhi Xie Xiangge Zhou | 2015 | Engineering2015，1，1： | 12 |
| 10 | Wheat straw pretreatment with KOH for enhancing biomethane production and fertilizer value in anaerobic digestion显示文摘Wheat straw biodegradability during anaerobic digestion was improved by treatment with potassium hydroxide(KOH)to decrease digestion time and enhance biomethane production and fertility value.KOH concentrations of1%(K1),3%(K2),6%(K3)and 9%(K4)were tested for wheat straw pretreatment at ambient temperature with a C:N ratio of 25:1.86% of total solids(TS),89% of volatile solids(VS)and 22% of lignocellulose,cellulose and hemicellulose(LCH)(22%)were decomposed effectively with the wheat straw pretreated by 6% KOH.Enhanced biogas production and cumulative biomethane yield of 258 ml·(g VS)^(-1)were obtained increased by 45% and 41%respectively,compared with untreated wheat straw.Pretreated wheat straw digestion also yielded a digestate with higher fertilizer values potassium(138%),calcium(22%)and magnesium(16%).These results show that TS,VS and LCH can be effectively removed from wheat straw pretreated with KOH,improving biodegradability biomethane production and fertilizer value. | Muhammad Jaffar Yunzhi Pang Hairong Yuan Dexun Zou Yanping Liu Baoning Zhu Rashid Mustafa Korai Xiujin Li | 2016 | Chinese Journal of Chemical Engineering2016，24，3： | 11 |
| 11 | An efficient methodology for utilization of K-feldspar and phosphogypsum with reduced energy consumption and CO2 emissions显示文摘The issues of reducing CO_2 emissions, sustainably utilizing natural mineral resources, and dealing with industrial waste offer challenges for sustainable development in energy and the environment. We propose an efficient methodology via the co-reaction of K-feldspar and phosphogypsum for the extraction of soluble potassium salts and recovery of SO_2 with reduced CO_2 emission and energy consumption. The results of characterization and reactivity evaluation indicated that the partial melting of K-feldspar and phosphogypsum in the hightemperature co-reaction significantly facilitated the reduction of phosphogypsum to SO_2 and the exchange of K^+(K-feldspar) with Ca^(2+)(CaSO_4 in phosphogypsum). The reaction parameters were systematically investigated with the highest sulfur recovery ratio of ~ 60% and K extraction ratio of ~ 87.7%. This novel methodology possesses an energy consumption reduction of ~ 28% and CO_2 emission reduction of ~ 55% comparing with the present typical commercial technologies for utilization of K-feldspar and the treatment of phosphogypsum. | Zhixi Gan Zheng Cui Hairong Yue Siyang Tang Changjun Liu Chun Li Bin Liang Heping Xie | 2016 | Chinese Journal of Chemical Engineering2016，24，11： | 11 |
| 12 | Indirect mineral carbonation of blast furnace slag with(NH4)2SO4 as a recyclable extractant显示文摘Large quantities of CO_2 and blast furnace slag are discharged in the iron and steel industry. Mineral carbonation of blast furnace slag can offer substantial CO_2 emission reduction and comprehensive utilisation of the solid waste. In this study, a recyclable extractant,(NH_4)_2SO_4, was used to extract calcium and magnesium from blast furnace slag(main phases of gehlenite and akermanite) by using low-temperature roasting to fix CO_2 through aqueous carbonation. The process parameters and efficiency of the roasting extraction, mineralisation, and Al recovery were investigated in detail. The results showed that the extractions of Ca, Mg, and Al can reach almost 100% at an(NH4)_2SO_4-to-slag mass ratio of 3:1 and at 370°C in 1 h. Adjusting the p H value of the leaching solution of the roasted slag to 5.5 with the NH_3 released during the roasting resulted in 99% Al precipitation, while co-precipitation of Mg was lower than 2%. The Mg-rich leachate after the depletion of Al and the leaching residue(main phases of CaSO_4 and SiO_2) were carbonated using(NH_4)_2CO_3 and NH_4HCO_3 solutions, respectively, under mild conditions. Approximately 99% of Ca and 89% of Mg in the blast furnace slag were converted into CaCO_3 and(NH_4)_2 Mg(CO_3)_2·4 H_2O,respectively. The latter can be selectively decomposed to magnesium carbonate at 100-200 °C to recover the NH_3 for reuse. In the present route, the total CO_2 sequestration capacity per tonne of blast furnace slag reached up to 316 kg, and 313 kg of Al-rich precipitate, 1000 kg of carbonated product containing CaCO_3 and SiO_2, and 304 kg of carbonated product containing calcium carbonate and magnesium carbonate were recovered simultaneously. These products can be used, respectively, as raw materials for the production of electrolytic aluminium, cement, and light magnesium carbonate to replace natural resources. | Jinpeng Hu Weizao Liu Lin Wang Qiang Liu Fang Chen Hairong Yue Bin Liang Li Lü Ye Wang Guoquan Zhang Chun Li | 2017 | Journal of Energy Chemistry2017，26，5： | 9 |
| 13 | Integrity analysis of COMPASS and other GNSS combined navigation显示文摘The integrity requirement should be satisfied when GNSS is used in aviation.There are now two ways for integrity monitoring,that is,receiver autonomous integrity monitoring(RAIM) and GNSS integrity channel(GIC) based on augmentation system.The rapid development of the Beidou satellite navigation system(COMPASS) will significantly improve the satellite geometry.Besides,the effects of first order ionosphere delay will be mitigated by the combination of GNSS multi-frequency signals.The availability of RAIM will be enhanced,which makes it possible to provide a worldwide seamless integrity service for aviation by using RAIM.The contribution of COMPASS to the availability of RAIM is analyzed by simulation;and the integrity requirement of which aviation approaching phrase can be satisfied when using COMPASS single system and its combination with other satellite navigation system is analyzed.Moreover,the influence of user range accuracy(URA) of COMPASS on integrity performance is discussed. | XU JunYi YANG YuanXi LI JinLong HE HaiBo GUO HaiRong | 2013 | Science China Earth Sciences2013，56，9： | 8 |
| 14 | High-quality de novo assembly of the Eucommia ulmoides haploid genome provides new insights into evolution and rubber biosynthesis显示文摘We report the acquisition of a high-quality haploid chromosome-scale genome assembly for the first time in a tree species,Eucommia ulmoides,which is known for its rubber biosynthesis and medicinal applications.The assembly was obtained by applying PacBio and Hi–C technologies to a haploid that we specifically generated.Compared to the initial genome release,this one has significantly improved assembly quality.The scaffold N50(53.15 MB)increased 28-fold,and the repetitive sequence content(520 Mb)increased by 158.24 Mb,whereas the number of gaps decreased from 104,772 to 128.A total of 92.87%of the 26,001 predicted protein-coding genes identified with multiple strategies were anchored to the 17 chromosomes.A new whole-genome duplication event was superimposed on the earlierγpaleohexaploidization event,and the expansion of long terminal repeats contributed greatly to the evolution of the genome.The more primitive rubber biosynthesis of this species,as opposed to that in Hevea brasiliensis,relies on the methylerythritol-phosphate pathway rather than the mevalonate pathway to synthesize isoprenyl diphosphate,as the MEP pathway operates predominantly in trans-polyisoprene-containing leaves and central peels.Chlorogenic acid biosynthesis pathway enzymes were preferentially expressed in leaves rather than in bark.This assembly with higher sequence contiguity can foster not only studies on genome structure and evolution,gene mapping,epigenetic analysis and functional genomics but also efforts to improve E.ulmoides for industrial and medical uses through genetic engineering. | Yun Li Hairong Wei Jun Yang Kang Du Jiang Li Ying Zhang Tong Qiu Zhao Liu Yongyu Ren Lianjun Song Xiangyang Kang | 2020 | Horticulture Research2020，7，1： | 7 |
| 15 | Formation and evolution mechanisms of large-clusters during rapid solidification process of liquid metal Al显示文摘A molecular dynamics simulation study has been performed for the formation and evolution characteristics of nano-clusters in a large-scale system consisting of 400000 atoms of liquid metal Al. The center-atom method combined with pair-bond analysis technique and cluster-type index method (CTIM) has been applied here to describe the structural configurations of various basic clusters. It is demonstrated that both the 1551 bond-type and the icosahedral cluster (12 0 12 0) constructed by 1551 bond-types are dominant among all the bond-types and cluster-types, respectively, in the system and play a critical role in the microstructure transitions of liquid metal Al. The nano-clusters (containing up to 150 atoms) are formed by the combination of some middle and small clusters with distinctly different sizes, through mutual competition by unceasing annex and evolution in a seesaw manner (in turn of obtaining and losing),which do not occur as the multi-shell structures accumulated with an atom as the center and the surrounding atoms are arranged according to a certain rule. This is the essential distinction of nano-cluster in liquid metal from those obtained by gaseous deposition, ionic spray methods, and so on. Though the nano-clusters differ from each other in shape and size, all of them possess protruding corners that could become the starting points of various dendrite structures in the solidification processes of liquid metals. | LIU Rangsu, DONG Kejun, LIU Fengxiang, ZHENG Caixing, LIU Hairong & LI Jiyong Department of Applied Physics, Hunan University, Changsha 410082, China College of Materials Science and Engineering, Hunan University, Changsha 410082, China College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China | 2005 | Science China(Physics,Mechanics & Astronomy)2005，48，1： | 7 |
| 16 | Simultaneous preparation of TiO2 and ammonium alum,and microporous SiO2 during the mineral carbonation of titanium-bearing blast furnace slag显示文摘In this study,a route for simultaneous mineralization of CO2 and production of titanium dioxide and ammonium alum,and microporous silicon dioxide from titanium-bearing blast furnace slag(TBBF slag)was proposed,which is comprised of(NH4)2 S04 roasting,acid leaching,ammonium alum crystallization,silicic acid flocculation and Ti hydrolysis.The effects of relevant process parameters were systematically investigated.The re sults showed that under the optimal roasting and leaching conditions about 85%of titanium and 84.6%of aluminum could be extracted while only 30%of silicon entered the leachate.84%of Al^3+was crystallized from the leachate in the form of ammonium aluminum sulfate dodecahydrate with a purity up to 99.5 wt%.About 85%of the soluble silicic acid was flocculated with the aid of secondary alcohol polyoxyethylene ether 9(AEO-9)to yield a microporous SiO2 material(97.4 wt%)from the crystallized mother liquor.The Al-and Si-depleted solution was then hydrolyzed to generate a titanium dioxide(99.1 wt%)with uniform particle size distribution.It was figured out that approximately 146 kg TiO2 could be produced from 1000 kg of TBBF slag.Therefore,the improved process is a promising method for industrial application. | Yingjie Xiong Tahani Aldahri Weizao Liu Guanrun Chu Guoquan Zhang Dongmei Luo Hairong Yue Bin Liang Chun Li | 2020 | Chinese Journal of Chemical Engineering2020，28，9： | 7 |
| 17 | Characteristics of distribution of Mycobacterium tuberculosis lineages in China显示文摘The genotyping methods of Mycobacterium tuberculosis would dramatically improve our understanding of the molecular epidemiology of tuberculosis. 3,929 isolates, from a National Survey of Drug-Resistant Tuberculosis in 2007 in China, were successfully genotyped by large sequence polymorphisms and 15 loci variable number tandem repeats. We found that 2,905(2,905/3,929, 73.9%) cases belonged to Lineage 2, dominated in the east and central regions, 975 cases(975/3,929, 24.8%) were Lineage 4, highly prevailed in the west regions, and 36 and 13 cases were Lineage 3 and Lineage 1, respectively. We also explored the associations between lineages(Lineage 2 vs. Lineage 4) and clinical characteristics by logistic regression. For Lineage 2, the risk factors were Han-ethnicity population and fever. However, for Lineage 4, they were occupation(farmer), and degree of education(non-literate). Fully understanding of the distribution of Mycobacterium tuberculosis lineage and its risk factors would play a critical role in tuberculosis prevention, control, and treatment. | Haixia Chen Li He Chao Cai Jingyi Liu Junnan Jia Liang Ma Hairong Huang Lixia Wang Xumin Ni Jimin Gao Weimin Li | 2018 | Science China(Life Sciences)2018，61，6： | 7 |
| 18 | Characterization of a LAL-type regulator NemR in nemadectin biosynthesis and its application for increasing nemadectin production in Streptomyces cyaneogriseus显示文摘Nemadectin, a macrocyclic lactone antibiotic, is produced by Streptomyces cyaneogriseus ssp. noncyanogenus. A methoxime derivative of nemadectin, moxdectin, has been widely used to control insect and helminth in animal health. Despite the importance of nemadectin, little attention has been paid to the regulation of nemadectin biosynthesis, which has hindered efforts to improve nemadectin production via genetic manipulation of regulatory genes. Here, we characterize the function of nemR, the cluster-situated regulatory gene encoding a LAL-family transcriptional regulator, in the nemadectin biosynthesis gene cluster of S. cyaneogriseus ssp. noncyanogenus NMWT1. NemR is shown to be essential for nemadectin production and found to directly activate the transcription of nemA1-1/A1-2/A2, nemC and nemA4/A3/E/D operons, but indirectly activate that of nemG and nemF. A highly conserved sequence 5′-TGGGGTGKATAGGGGGTA-3′(K=T/G) is verified to be essential for NemR binding.Moreover, four novel targets of NemR, including genes encoding an SsgA-like protein(TU94_12730), a methylmalonyl-CoA mutase(TU94_19950), a thioesterase of oligomycin biosynthesis(TU94_22425) and a MFS family transporter(TU94_24835)are identified. Overexpression of nemR significantly increased nemadectin production by 79.9%, in comparison with NMWT1,suggesting that nemR plays an important role in the nemadectin biosynthesis. | Chuang Li Hairong He Jiabin Wang Hui Liu Haiyan Wang Yajie Zhu Xiangjing Wang Yanyan Zhang Wensheng Xiang | 2019 | Science China(Life Sciences)2019，62，3： | 6 |
| 19 | Improvements on radiation-hardened performance of static induction transistor显示文摘The radiation-hardened performances of static induction transistor (SIT) have been studied in depth in this paper. The effects of radiation of electron beam on the I-V characteristics, carrier distribution and potential distribution in the channel of SIT have been represented. A large number of electron-hole pairs are generated in the depletion region of reversely biased gate-channel PN junction. The radiation-generated electrons drift towards the drain region at high positive potential, while generated holes flow into gate region biased to the lowest potential. With the accumulation of holes in gate region, the gate potential is boosted, resulting in a decrease in the height of potential barrier in channel, and an increase in drain current. I-V characteristics of SIT in the presence of radiation have been theoretically derived, and compared with experimental results. With the increase in thickness of epitaxial layer, the radiation-hardened capability of SIT is continuously improved until the optimum thickness of 26 μm is reached. The optimum matching relationship among geometric, material and technological parameters has been represented to acquire excellent radiation-hardened performances of SIT. | WANG YongShun LUO XianLiang LI HaiRong WANG ZiTing WU Rong ZHANG CaiZhen LI SiYuan | 2010 | Science China(Information Sciences)2010，53，5： | 6 |
| 20 | Combined pretreatment using CaO and liquid fraction of digestate of rice straw: Anaerobic digestion performance and electron transfer显示文摘To improve anaerobic digestion(AD)efficiency of rice straw,solid alkaline CaO and the liquid fraction of digestate(LFD)were used as pretreatment agents of rice straw.The results showed that AD performance of rice straw with CaOLFD pretreatment was optimal in different pretreatment methods of the CaO+LFD,CaOLFD,LFD+CaO,CaO,and LFD.The maximum methane yield(314 ml(g VS)^(-1))and the highest VFAs concentration(14851 mg·L^(-1) on day 3)of the CaOLFD pretreatment group were 81%and 118%higher than that of the control group,respectively.Under the action of solid alkaline CaO,the bacteria of Clostridium,Atopostipes,Sphaerochaeta,Tissierella,Thiopseudomonas,Rikenellaceae,and Sedimentibacter could build up co-cultures with the archaeal of Methanosaeta,Methanobacterium,and Methanosarcina performing direct interspecies electron transfer(DIET)and improving AD performance of rice straw.Therefore,the combined pretreatment using CaO and LFD could not only pretreat rice straw but also stimulate co-cultures of microorganism to establish DIET enhancing AD efficiency. | Ruolin Guan Hairong Yuan Liang Zhang Xiaoyu Zuo Xiujin Li | 2021 | Chinese Journal of Chemical Engineering2021，34，8： | 5 |
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