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| 1 | Characterization and Evaluation of OsLCT1 and OsN ramp5 Mutants Generated Through CRISPR/Cas9-Mediated Mutagenesis for Breeding Low Cd Rice显示文摘To explore how rice(Oryza sativa L.) can be safely produced in Cd-polluted soil, OsLCT1 and OsNramp5 mutant lines were generated by CRISPR/Cas9-mediated mutagenesis. One of OsLCT1 mutant(lct1×1) and two of OsNramp5 mutants(nramp5×7 and nramp5×9) were evaluated for grain Cd accumulation and agronomic performances. In paddy field soil containing approximately 0.9 mg/kg Cd, lct1×1 grains contained approximately 40%(0.17 mg/kg) of the Cd concentration of the wild type parental line, less than the China National Food Safety Standard(0.20 mg/kg). Both OsNramp5 mutants showed low grain Cd accumulation(< 0.06 mg/kg) in the paddy(approximately 0.9 mg/kg Cd) or in pots in soil spiked with 2 mg/kg Cd. However, only nramp5×7 showed normal growth and yield, whereas the growth of nramp5×9 was severely impaired. The study showed that lct1×1 could be used to produce rice grains safe for human consumption in lightly contaminated paddy soils and nramp5×7 used in soils contaminated by much higher levels of Cd. | LIU Songmei JIANG Jie LIU Yang MENG Jun XU Shouling TAN Yuanyuan LI Youfa SHU Qingyao HUANG Jianzhong | 2019 | Rice science2019，26，2： | 15 |
| 2 | Ultra-sensitive Nanoprobe Modified with Tumor Cell Membrane for UCL/MRI/PET Multimodality Precise Imaging of Triple-Negative Breast Cancer显示文摘Triple-negative breast cancer(TNBC)is a subtype of breast cancer in which the estrogen receptor and progesterone receptor are not expressed,and human epidermal growth factor receptor 2 is not amplified or overexpressed either,which make the clinical diagnosis and treatment very challenging.Molecular imaging can provide an effective way to diagnose TNBC.Upconversion nanoparticles(UCNPs),are a promising new generation of molecular imaging probes.However,UCNPs still need to be improved for tumor-targeting ability and biocompatibility.This study describes a novel probe based on cancer cell membrane-coated upconversion nanoparticles(CCm-UCNPs),owing to the low immunogenicity and homologous-targeting ability of cancer cell membranes,and modified multifunctional UCNPs.This probe exhibits excellent performance in breast cancer molecular classification and TNBC diagnosis through UCL/MRI/PET tri-modality imaging in vivo.By using this probe,MDA-MB-231 was successfully differentiated between MCF-7 tumor models in vivo.Based on the tumor imaging and molecular classification results,the probe is also expected to be modified for drug delivery in the future,contributing to the treatment of TNBC.The combination of nanoparticles with biomimetic cell membranes has the potential for multiple clinical applications. | Hanyi Fang Mengting Li Qingyao Liu Yongkang Gai Lujie Yuan Sheng Wang Xiao Zhang Min Ye Yongxue Zhang Mingyuan Gao Yi Hou Xiaoli Lan | 2020 | Nano-Micro Letters2020，12，5： | 5 |
| 3 | Ultrasonic-assisted pyrolyzation fabrication of reduced SnO2-x/g-C3N4 heterojunctions: Enhance photoelectro- chemical and photocatalytic activity under visible LED light irradiation显示文摘新奇 SnO 2x /g-C3 N 4 异质接面 nanocomposites 减少的 SnO 2x nanoparticles 和 exfoliated g-C 3 N 4 nanosheets 被一个方便一步舞热分解方法准备。同样准备的 nanocomposites 的结构、词法、光的性质详细被描绘,显示 g-C 3 N 4 nanosheets 被小、分散得好的 SnO 2x nanoparticles 阻止。nanocomposites 的紫外可见的光谱学吸收乐队比纯 SnO 2 或 g-C 3 N 4 。发生在 nanocomposites 的费用转移和再结合过程用线性扫描 voltammetry 和电气化学的阻抗光谱学被调查。在 30-W visible-light-emitting 二极管照耀下面,包含 27.4 wt.% SnO 2x 的异质接面展出了 0.0468 妈牴捡牡潢祸楬?楤湡票牤摩?倨?的最高的光电流密度??圠?敤潭獮牴瑡?桴瑡?湵楬敫倠??映汩?倠??渠湡牯摯?硥楨楢獴漠瑰捩污眠癡来極敤映慥畴敲?攠桮湡散?L潳灲楴湯?湡?牆湥敫?硥楣慴楴湯攠業獳潩?湩琠敨瘠獩扩敬爠来潩??摤瑩潩慮汬?眠?敭獡牵摥琠敨攠敬瑣楲慣?牰灯牥楴獥漠?呐??慮潮潲獤?湩汣摵湩?桴?潣摮'讟N楶祴愠潬杮琠敨朠潲瑷?楤敲瑣潩?景琠敨渠湡牯摯?桷捩?獩爠畯桧祬??? | Kai Li Xiaoqiao Zeng Shanmin Gao Lu Ma Qingyao Wang Hui Xu Zeyan Wang Baibiao Huang Ying Dai Jun Lu | 2016 | Nano Research2016，9，7： | 5 |
| 4 | Distribution Features of the Nanhua-Sinian Rifts and their Significance to Hydrocarbon Accumulation in the Tarim Basin显示文摘On the basis of reprocessing 34 new two-dimensional spliced long sections(20,191 km) in the Tarim Basin, the deep structure features of the Tarim Basin were analyzed through interpreting 30,451 km of two-dimensional seismic data and compiling basic maps. Seismic interpretation and geological analysis conclude that the Nanhua-Sinian strata are a set of rift-depression depositional systems according to their tectonic and depositional features. The rift valley formed in the Nanhua Period, and the transformation became weaker during the late Sinian Period, which eventually turned into depression. From bottom to top, the deposited strata include mafic igneous, tillite, mudstone, and dolomite. Three major depocenters developed inside this basin during the rift stage and are distributed in the eastern Tarim Basin, the Awati area, and the southwestern Tarim Basin. Among them, the rift in the eastern Tarim Basin strikes in the near east-west direction on the plane and coincides with the aeromagnetic anomaly belt. This represents a strong magnetic zone formed by upwelling basic volcanic rock along high, steep normal faults of the Nanhua Period. Controlled by the tectonic background, two types of sedimentary systems were developed in the rift stage and depression stage, showing two types of sequence features in the Sinian depositional stage. The Nanhua System appears as a wedge-shaped formation, with its bottom in unconformable contact with the base. The rifting event has a strong influence on the current tectonic units in the Tarim Basin, and affects the distribution of source rock in the Yuertus Formation and reservoir beds in the Xiaoerbulake Formation in Lower Cambrian, as well as the gypseous cap rock in Middle Cambrian. The distribution features of the rifts have important and realistic significance for determining the direction of oil and gas exploration in the deep strata of the Tarim Basin. Comprehensive analysis suggests that the Tazhong region is the most favorable zone, and the Kalpin-Bachu region is the optimal potential zone for exploring sub-salt oil and gas in deep Cambrian strata. | BAI Zhongkai CHENG Minghua CHEN Cheng HUO Junzhou ZHANG Junfeng ZHOU Xingui GAO Yongjin ZHAO Bo QIU Haijun HAN Miao YANG Youxing SUN Zhichao MIAO Miaoqing ZHANG Jinhu LI Qingyao | 2020 | Acta Geologica Sinica(English Edition)2020，94，2： | 3 |
| 5 | Unknown Chinese word extraction based on variety of overlapping strings显示文摘 | YE Yunming WU Qingyao LI Yan | 2013 | Information Processing and Management2013，49，2： | 1 |
| 6 | Unknown Chinese word extraction based on variety of overlapping strings显示文摘 | YE Yunming WU Qingyao LI Yan | 2013 | Information Processing & Management2013，49，2： | 1 |
| 7 | CURRENT STATUS OF ENDOSCOPIC RESECTION IN CHINA显示文摘 | MING‐YANCAI PING‐HONGZHOU LI‐QINGYAO | 2012 | Digestive Endoscopy2012，，： | 1 |
| 8 | CURRENT STATUS OF ENDOSCOPIC RESECTION IN CHINA显示文摘 | MING‐YANCAI PING‐HONGZHOU LI‐QINGYAO | 2012 | Digestive Endoscopy2012，，： | 1 |
| 9 | Ultrasound:The Potential Power for Cardiovascular Disease Therapy显示文摘Ultrasound can be considered a mechanical wave for both clinical diagnostic and therapeutic purposes on the basis of its good penetrability and directivity while spreading in solid organs or tissues without any ionizing radiation.As a powerful form of energy,ultrasound,is used for deep-tissue therapy with different sonication parameters.The feasibility of minimally invasive or noninvasive acoustic treatment of a variety of diseases,such as hypertension,arrhythmia,hypertrophic cardiomyopathy,and myocardial infraction,is being explored in animal experiments and clinical trials.In this review,we summarize the biomedical effects of acoustic intervention in experimental and clinical studies,current challenges,and the potential of ultrasound for cardiovascular disease therapy. | Xiaoyu Zheng Qingyao Liao Yue Wang Hua Li Xiaodong Wang Yaohui Wang Wentao Wu Junlin Wang Ling Xiao Jing Huang | 2019 | Cardiovascular Innovations and Applications2019，，B07： | 0 |
| 10 | A comparison of in vitro anticancerous activity and mechanism of ethanolic extracts from different Ganoderma genus显示文摘Five ethanolic extracts from the mycelia of Ganoderma lucidum,G.tsugae,G.oerstedii,G.subamboinense,and G.resinaceum were respectively studied on their anticancerous activities against leukemic HL-60 cell line in vitro.Results showed that all five extracts potently inhibited HL-60 proliferation.The extract from G.lucidum mycelia exerted the highest activity.Annexin V/PI bivariate flow cytometric analysis further revealed that the five extracts significantly induced early apoptosis in HL-60 cells.The results illustrate that not only G.lucidum but also other Ganoderma species can inhibit cancer cells,and their mechanisms are related to induction of apoptosis. | ZHOU Yueqin YANG Xiaotong LI Xuquan FENG Huiqin MI Ke YANG Qingyao | 2006 | Frontiers in Biology2006，1，3： | 0 |
| 11 | Characterization and prediction of tailpipe ammonia emissions from in-use China 5/6 light-duty gasoline vehicles显示文摘On-road tailpipe ammonia (NH3) emissions contribute to urban secondary organic aerosol formation and have direct or indirect adverse impacts on the environment and human health. To understand the tailpipe NH3 emission characteristics, we performed comprehensive chassis dynamometer measurements of NH3 emission from two China 5 and two China 6 light-duty gasoline vehicles (LDGVs) equipped with three-way catalytic converters (TWCs). The results showed that the distance-based emission factors (EFs) were 12.72 ± 2.68 and 3.18 ± 1.37 mg/km for China 5 and China 6 LDGVs, respectively. Upgrades in emission standards were associated with a reduction in tailpipe NH3 emission. In addition, high NH3 EFs were observed during the engine warm-up period in cold-start cases owing to the intensive emissions of incomplete combustion products and suitable catalytic temperature in the TWCs. Notably, based on the instantaneous NH3 emission rate, distinct NH3–emitting events were detected under high/extra high velocity or rapid acceleration. Furthermore, NH3 emission rates correlated well with engine speed, vehicle specific power, and modified combustion efficiency, which were more easily accessible. These strong correlations were applied to reproduce NH3 emissions from China 5/6 LDGVs. The predicted NH3 EFs under different dynamometer and real-world cycles agreed well with existing measurement and prediction results, revealing that the NH3 EFs of LDGVs in urban routes were within 8.55–11.62 mg/km. The results presented here substantially contribute to improving the NH3 emission inventory for LDGVs and predicting on-road NH3 emissions in China. | Lewei Zeng Fengbin Wang Shupei Xiao Xuan Zheng Xintong Li Qiyuan Xie Xiaoyang Yu Cheng Huang Qingyao Hu Yan You Ye Wu | 2024 | Frontiers of Environmental Science & Engineering2024，18，1： | 0 |
| 12 | Derivation of Benzothiadiazine-1,1-dioxide Scaffolds via Transition Metal-Catalyzed C-H Activation/Annulation显示文摘Comprehensive Summary Benzothiadiazine-1,1-dioxide scaffold is bioactive framework with wild utility and applications.Synthesis of benzothiadiazine-fused isoquinoline derivatives and spiro benzothiadiazine derivatives through transition metal-catalyzed C—H activation/annulation was reported.3-Phenyl-2H-benzothiadiazine-1,1-dioxide was used as the reaction substrate,and vinylene carbonate and 4-diazopyrazolone were used as the coupling reagents,respectively.This strategy provides straightforward access to complex N-heterocycles in a highly efficient and simple manner. | Ruizhi Lai Shuran Xu Qingyao Zhang Hui Zhou Cankun Luo Yuerong Wang Li Hai Yong Wu | 2023 | Chinese Journal of Chemistry2023，41，16： | 0 |
| 13 | VALORIZATION OF BIOGAS THROUGH SIMULTANEOUS CO_(2) AND H_(2)S REMOVAL BY RENEWABLE AQUEOUS AMMONIA SOLUTION IN MEMBRANE CONTACTOR显示文摘Upgrading biogas into biomethane not only improves the biogas utilization as vehicle fuel or natural gas substitute,but also reduces the greenhouse gases emissions.Considering the principle of engineering green energy process,the renewable aqueous ammonia(RAA)solution obtained from biogas slurry was used to remove H_(2)S and CO_(2) simultaneously in the hollow fiber membrane contactor.RAA was mimicked in this study using the ammonia aqueous solution mixed with some typical impurities including ethanol,acetic acid,propionic acid,butyric acid and NH4HCO_(3).Compared with the typical physical absorption(i.e.,pure water)removing 48%of H_(2)S from biogas,RAA with 0.1 mol·L^(−1) NH_(3) could remove 97%of H_(2)S.Increasing the NH3 concentration from 0.1 to 0.5 mol·L^(−1) could elevate the CO_(2) absorption flux from 0.97 to 1.72 mol·m^(−2)·h^(−1) by 77.3%.Among the impurities contained in RAA,ethanol has a less impact on CO_(2) absorption,while other impurities like CO_(2) and acetic acid have significant negative impacts on CO_(2) absorption.Fortunately,the impurities have a less influence on H_(2)S removal efficiency,with more than 98%of H_(2)S could be removed by RAA.Also,the influences of operating parameters on acid gases removal were investigated to provide some engineering suggestions. | Tao SUN Wenlong LI Jiandong WEI Long JI Qingyao HE Shuiping YAN | 2023 | Frontiers of Agricultural Science and Engineering2023，10，3： | 0 |
| 14 | Melatonin activates the OsbZIP79–OsABI5 module that orchestrates nitrogen and ROS homeostasis to alleviate nitrogen-limitation stress in rice显示文摘Melatonin(Mel)has previously been reported to effectively alleviate nitrogen-limitation(N-L)stress and thus increase nitrogen-use efficiency(NUE)in several plants,but the underlying mechanism remains obscure.Here,we revealed that OsbZIP79(BASIC LEUCINE ZIPPER 79)is transcriptionally activated under N-L conditions,and its expression is further enhanced by exogenous Mel.By the combined use of omics,genetics,and biological techniques,we revealed that the OsbZIP79–OsABI5(ABSCISIC ACID INSENSITIVE 5)module stimulated regulation of reactive oxygen species(ROS)homeostasis and the uptake and metabolismof nitrogen under conditions of indoor nitrogen limitation(1/16 normal level).OsbZIP79 activated the transcription of OsABI5,and OsABI5 then bound to the promoters of target genes,including genes involved in ROS homeostasis and nitrogen metabolism,activating their transcription.This module was also indispensable for upregulation of several other genes involved in abscisic acid catabolism,nitrogen uptake,and assimilation under N-L and Mel treatment,although these genes were not directly transactivated by OsABI5.Field experiments demonstrated that Mel significantly improved rice growth under low nitrogen(L-N,half the normal level)by the same mechanism revealed in the nitrogen-limitation study.Mel application produced a 28.6%yield increase under L-N and thus similar increases in NUE.Also,two OsbZIP79-overexpression lines grown in L-N field plots had significantly higher NUE(+13.7%and+21.2%)than their wild types.Together,our data show that an OsbZIP79–OsABI5 module regulates the rice response to N insufficiency(N limitation or low N),which is important for increasing NUE in rice production. | Meng Jiang Yue Song Ruifang Yang Chenfan Zheng Yunchao Zheng Huali Zhang Shan Li Yuanyuan Tan Jianzhong Huang Qingyao Shu Ruiqing Li | 2023 | Plant Communications2023，4，6： | 0 |
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