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| 1 | Mogroside V inhibits LPS-induced COX-2 expression/ROS production and overexpression of HO-1 by blocking phosphorylation of AKT1 in RAW264.7 cells显示文摘Momordica grosvenori is a valuable edible plant with medicinal purposes, and it is widely used in medicated diets and traditional Chinese medicine in Asia. Mogroside V (MV), the main bioactive component from M. grosvenori, is comm only used as a natural sweetener. M. grosvenori extracts have been reported to exert potent anti-inflammatory property, however the underlying molecular mechanism still remains unknown. In the present study, the biological effect of MV in inflammation was investigated in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. The ELISA and western blot analysis results showed that MV significantly inhibited LPS-induced prostaglandin E2 (PGE2) production and cyclooxygenase-2 (COX-2) expression. MV markedly decreased the phosphorylation of IxB-a, increased IkB-oc, and reduced nuclear p-65 and C/EBP6. Furthermore, MV attenuated LPS-induced phosphorylation of MAPKs and AKT1, and only the phosphorylation status of AKT1 was found to be consistent with the expression trend of COX-2. Moreover, MV reduced ROS level and restored overexpressed HO-1 and AP-1 to basal level, which can be markedly reversed by AKT1 inhibitor LY294002. These results revealed that AKT1 plays a key role in LPS-induced COX-2 expression, and acts as a mediator to keep the redox balance in LPS-stimulated RAW264.7 cells. MV exerts anti-inflammatory property by blocking AKT1-mediated NF-kB and C/EBP6 activation, ROS generation and AP-1/ HO-1 expression. Therefore, the present study indicated that MV has a significant chemopreventive effect on the inflammatory lesions and suggested that AKT1 is a potential specific target of MV for relieving inflammation. | Yong Li Luyan Zou Tao Li Dengni Lai Yanyang Wu Si Qin | 2019 | Acta Biochimica et Biophysica Sinica2019，51，4： | 14 |
| 2 | Effectiveness of Inactivated COVID-19 Vaccines Against Symptomatic,Pneumonia,and Severe Disease Caused by the Delta Variant:Real World Study and Evidence—China,2021显示文摘Summary What is already known about this topic?Effectiveness of China’s 2 inactivated vaccines(BBIBPCorV and CoronaVac)against pre-Delta severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)variants ranged from 47%to over 90%,depending on the clinical endpoint,and with greater effectiveness against more severe coronavirus disease 2019(COVID-19).During an outbreak in Guangdong,inactivated vaccine effectiveness(VE)against the Delta variant was 70%for symptomatic infection and 100%for severe COVID-19.However,separate or combined VE estimates for the two inactivated vaccines against Delta are not available.What is added by this report?In an outbreak that started in a hospital,VEs of completed primary vaccination with inactivated COVID-19 vaccines against symptomatic COVID-19,COVID-19 pneumonia,and severe COVID-19 caused by the Delta variant were 51%,61%,and 82%.Completed primary vaccination reduced the risk of progressing from mild to moderate or severe COVID-19 by 74%.VE estimates for BBIBP-CorV and CoronaVac or combined vaccination were similar,and partial vaccination was ineffective.What are the implications for public health practice?Completed primary vaccination with either of the 2 inactivated COVID-19 vaccines reduces risk of symptomatic COVID-19,COVID-19 pneumonia,and severe COVID-19 caused by the Delta variant.Completion of the completed primary vaccination with two doses is necessary for protection from Delta. | Dan Wu Yanyang Zhang Lin Tang Fuzhen Wang Ying Ye Chao Ma Hui Zheng Wenzhou Yu Lei Cao Yifan Song Abuduwaili Reyimu Xiaoxiao Zhang Haifeng Wang Yifei Nie Mingxia Lu Muge Qi Jun Li Ruolin Wang Kaichao Yang Changshuang Wang Lawrence Everett Rodewald Geroge Fu Gao Zhijie An Zundong Yin | 2022 | China CDC weekly2022，4，4： | 7 |
| 3 | Inductance calculation for 3D microsolenoids with single-layer coils显示文摘Three-dimensional(3D) single-layer microcoils have always been a key element for electromagnetic systems;but they lack an easy and accurate method to calculate the inductance value for their complex 3D micro-structures. This paper employed a curve-fitting process to obtain the associated equation for the inductance value and geometric parameters based on the simulation results. The correction factors regarding helical pitch and wire diameter were reviewed,which are used for compensation in the Nagaoka formula. The simulation process numerically simulated the performance of the 3D microcoils using a FEM electro-magnetic-coupled analysis method. Comparison of the simulated inductance value and the Nagaoka formula was undertaken,which shows that the helical pitch and wire diameter contribute a main role in the calculation error. The derived formula was expressed in a concise form to precisely calculate the inductance value of 3D microsolenoids with single-layer coils. | LIU Keyin YANG Qing CHEN Feng ZHAO Yulong MENG Xiangwei SHAN Chao LI Yanyang | 2014 | Instrumentation2014，1，2： | 6 |
| 4 | The principle of second generation wavelet for milling cutter breakage detection显示文摘Performance degradation or failure of manufacturing equipment will badly influence machining quality.Because of discontinuousness of the milling process,dynamic signals produced in the milling process become non-stationary.This paper indicates that the essence of SGW(second generation wavelet) transform in non-stationary signal processing is the mathematics principle of inner product transform of a dynamic signal with basis functions.Namely,by means of the inner product operation of a signal with basis functions containing scale function and wavelet function,signal decomposition and reconstruction are obtained.Acoustic emission signals generated in the milling processes of a CNC machine were analyzed by using the basis functions of SGW which are oscillation,decay and compact support.The features of end milling cutter breakage have been extracted,and the influences on machining surface quality have been identified effectively,which provide scientific bases for fault diagnosis,error tracing and quality control. | HE ZhengJia CAO HongRui LI Zhen ZI YanYang CHEN XueFeng | 2009 | Science China(Technological Sciences)2009，52，5： | 5 |
| 5 | Modeling and optimization of a single-drive push–pull silicon Mach–Zehnder modulator显示文摘We present an equivalent circuit model for a silicon carrier-depletion single-drive push–pull Mach–Zehnder modulator(MZM)with its traveling wave electrode made of coplanar strip lines.In particular,the partialcapacitance technique and conformal mapping are used to derive the capacitance associated with each layer.The PN junction is accurately modeled with the fringe capacitances taken into consideration.The circuit model is validated by comparing the calculations with the simulation results.Using this model,we analyze the effect of several key parameters on the modulator performance to optimize the design.Experimental results of MZMs confirm the theoretical analysis.A 56 Gb/s on–off keying modulation and a 40 Gb/s binary phase-shift keying modulation are achieved using the optimized modulator. | Yanyang Zhou Linjie Zhou Haike Zhu Chiyan Wong Yida Wen Lei Liu Xinwan Li Jianping Chen | 2016 | Photonics Research2016，4，4： | 5 |
| 6 | Delphinidin-induced autophagy protects pancreatic β cells against apoptosis resulting from high-glucose stress via AMPK signaling pathway显示文摘Hyperglycemia,a diagnostic characteristic of diabetes mellitus,is detrimental to pancreatic 0 cells.Delphinidin,a member of the anthocyanin family,inhibits glucose absorption,increases glucagonlike peptide(GLP-1)secretion,and improves insulin secretion in diabetes.However,whether delphinidin plays a protective role in pancreatic p-cell mass and function is not clear.In this study,delphinidin was found to decrease the high-glucose-induced apoptosis of RIN-m5F pancreatic β cells.In addition,delphinidin induced autophagy in RIN-m5F cells under the normal and highglucose conditions,while 3-methyladenine(3-MA)inhibition of autophagy significantly diminished the protective role of delphinidin against high-glucose-induced apoptosis of pancreatic β cells.Delphinidin also decreased the level of cleaved caspase 3 and increased the phosphorylation level of AMP-activated protein kinase a(AMPKa)Thr172.Compound C,an AMPK inhibitor,was found to decrease the ratio of LC3-II/LC3-I,and the apoptotic rate of high-glucose-injured cells was in creased after treatme nt with delphinidin,in dicating that delphinidi n attenuated the n egative effects of high-glucose stress to cells.In con elusion,our data dem on strate that delphi nidin protects pancreatic B cells against high-glucose-induced injury by autophagy regulation via the AMPK signaling pathway.These findings might shed light on the underlying mechanisms of diabetes and help improve the prevention and therapy of this common disease. | Dengni Lai Mingyong Huang Lingyan Zhao Yan Tian Yong Li Dongpo Liu Yanyang Wu Fangming Deng | 2019 | Acta Biochimica et Biophysica Sinica2019，51，12： | 3 |
| 7 | Rotating machinery fauh diagnosis using signal-adapted lifting scheme 显示文摘 | Zhen Li Zhengjia He Yanyang Zi | 2008 | Mechanical Systems and Signal Processing2008，22，3： | 1 |
| 8 | Ginkgolide B inhibits platelet release by blocking Syk and p38 MAPK phosphorylation in thrombin-stimulated platelets显示文摘 | Xueqing Liu Yan Yan Li Bao Beidong Chen Yanyang Zhao Ruomei Qi | 2014 | Thrombosis Research2014，，5： | 1 |
| 9 | One-step preparation of polyimide-inlaid amine-rich porous organic block copolymer for efficient removal of chlorophenols from aqueous solution显示文摘A novel polyimide-inlaid amine-rich porous organic block copolymer(PI-b-ARPOP) was prepared via one-step polymerization by using different molar ratios of melamine(MA)/terephthalaldehyde(TA)/pyromellitic dianhydride(PMDA), at molar ratios of 4/3/1, 4/2/2 and 4/1/3. The copolymer contained both aminal groups belonging to ARPOP and imide groups belonging to PI, and the bonding styles of the monomers and growth orientations of the polymeric chains were diversiform, forming an excellent porous structure. Notably, MA/TA/PMDA(4/2/2) had a surface area and pore volume of 487.27 m^2/g and 1.169 cm^3/g,respectively. The adsorption performance of the materials towards 2,4-dichlorophenol(2,4-DCP) in ultra-pure water was systematically studied. The pH value of 7 was optimal in aqueous solution. Na^+ and Cl^-ions did not negatively affect the adsorption process, while humic acid(HA) slightly decreased the capacity. The equilibrium time was 40 sec, and the maximum adsorption capacity reached 282.49 mg/g at 298 K. The removal process was endothermic and spontaneous, and the copolymer could maintain its porous structure and consistent performance after regeneration by treatment with alkali. Moreover, to further assess the practical applicability of the material, the adsorption performance towards 2,4-DCP in river water was also investigated. This paper demonstrated that the PI-b-ARPOP can be an efficient and practical adsorbent to remove chlorophenols from aqueous solution. | Yanyang Liu Haijian Ou Shangqing Li Qingliang You Huixian Liu Guiying Liao Dongsheng Wang | 2019 | Journal of Environmental Sciences2019，31，4： | 1 |
| 10 | Evaluation of Cold Tolerance of Different Dendrobium Species in North China显示文摘T o investigate cold tolerance of different cultivars and species in Dendrobium Sw. in North China, 8 strains of Dendrobium officinal and other 5 Dendrobium species were used to compare their cold-hardiness index in this study. The content of electrolyte leakage was increasing in Dendrobium Sw. as the temperature decreasing, while the content of peroxidase(POD) activity and the soluble sugar showed a rising trend before a downward trend. Besides, external morphology was another evaluation standard of cold tolerance. Thus, there was a significant difference between Dendrobium officinal and other Dendrobium species in the cold tolerance, and their cold tolerance capacity was as follows: s1 > s100 >s13 > 1301 > s300 > Dendrobium nobile > s126 > s145 > s95 > Dendrobium lindleyi > Dendrobium chrysotoxum > Dendrobium thyrsiflorum > Dendrobium lohohense. | SHEN Yanyang JIA Jinshan LI Zhongjian ZOU Kai LI Zhenghong ZHAO Lanyong | 2017 | Journal of Landscape Research2017，9，2： | 1 |
| 11 | Acid and organic resistant nano-hydrated zirconium oxide (HZO)/polystyrene hybrid adsorbent for arsenic removal from water显示文摘 | Zhigang Li Yanyang Zhang Jingsheng Xu Bingcai Pan Liang Chen Haojie Dong Weiming Zhang | 2014 | Chemical Engineering Journal2014，，： | 1 |
| 12 | A QFD-BASED EXPLORATION ON THE MECHANISM OF IMPROVING THE SUPERVISING QUALITY IN SECURITY MARKET显示文摘 | YANYANG ZHU JINLIN LI | 2005 | Proceedings of the 4th International Conference on Quality and Reliability2005，，： | 1 |
| 13 | Sporadic meningioangiomatosis- associated atypical meninggioma mimickingparenchymal invasion of brain: a case report and review of the literature 显示文摘 | Chen Yanyang Tiang Xiaoying Li Zhi | 2011 | Pubmed Journal2011，14，5： | 1 |
| 14 | Modulatory effects of one polysaccharide from Acanthopanax senticosus in alloxan-induced diabetic mice显示文摘 | Jianfang Fu Jufang Fu Yang Liu Ruiyu Li Bin Gao Nanyan Zhang Boliang Wang Yizhan Cao Kaoshan Guo Yanyang Tu | 2011 | Carbohydrate Polymers2011，，3： | 1 |
| 15 | Expression of EphrinB2 and EphB4 in glioma tissues correlated to the progression of glioma and the prognosis of glioblastoma patients显示文摘 | Yanyang Tu Shiming He Jianfang Fu Gang Li Ruxiang Xu Hongliu Lu Jianping Deng | 2012 | Clinical and Translational Oncology2012，，3： | 1 |
| 16 | MicroRNA-218 Inhibits Glioma Invasion, Migration, Proliferation, and Cancer Stem-like Cell Self-Renewal by Targeting the Polycomb Group Gene Bmi1显示文摘 | Yanyang Tu Xingchun Gao Gang Li Hualin Fu Daxiang Cui Hui Liu Weilin Jin Yongsheng Zhang | 2013 | Cancer Research2013，，19： | 1 |
| 17 | Numerical modeling of transverse mode competition in strongly pumped multimode fiber lasers and amplifiers显示文摘 | Gong Mali Yuan Yanyang Li Chen | 2007 | Optics Express2007，15，6： | 1 |
| 18 | Customized wavelet denoising using intra-and inter-scale depen- dency for bearing fault detection显示文摘 | Li Zhen He Zhengjia Zi Yanyang | 2008 | Journal of Sound and Vibration2008，313，12： | 1 |
| 19 | Progress in building clinically relevant patient-derived tumor xenograft models for cancer research显示文摘Patient-derived tumor xenograft(PDX)models,a method involving the surgical extraction of tumor tissues from cancer patients and subsequent transplantation into immunodeficient mice,have emerged as a pivotal approach in translational research,particularly in advancing precision medicine.As the first stage of PDX development,the patient-derived orthotopic xenograft(PDOX)models implant tumor tissue in mice in the corresponding anatomical locations of the patient.The PDOX models have several advantages,including high fidelity to the original tumor,heightened drug sensitivity,and an elevated rate of successful transplantation.However,the PDOX models present significant challenges,requiring advanced surgical techniques and resourceintensive imaging technologies,which limit its application.And then,the humanized mouse models,as well as the zebrafish models,were developed.Humanized mouse models contain a human immune environment resembling the tumor and immune system interplay.The humanized mouse models are a hot topic in PDX model research.Regarding zebrafish patient-derived tumor xenografts(zPDX)and patient-derived organoids(PDO)as promising models for studying cancer and drug discovery,zPDX models are used to transplant tumors into zebrafish as novel personalized medical animal models with the advantage of reducing patient waiting time.PDO models provide a cost-effective approach for drug testing that replicates the in vivo environment and preserves important tumor-related information for patients.The present review highlights the functional characteristics of each new phase of PDX and provides insights into the challenges and prospective developments in this rapidly evolving field. | Weijing Wang Yongshu Li Kaida Lin Xiaokang Wang Yanyang Tu Zhenjian Zhuo | 2023 | Animal Models and Experimental Medicine2023，6，5： | 1 |
| 20 | Formable porous biochar loaded with La-Fe(hydr)oxides/montmorillonite for efficient removal of phosphorus in wastewater:process and mechanisms显示文摘The development of biochar-based granule-like adsorbents suitable for scaled-up application has been attracting increasing attention in the field of water treatment.Herein,a new formable porous granulated biochar loaded with La-Fe(hydr)oxides/montmorillonite(LaFe/MB)was fabricated via a granulation and pyrolysis process for enhanced phosphorus(P)removal from wastewater.Montmorillonite acted as a binder that increased the size of the granulated biochar,while the use of Fe promoted the surface charge and facilitated the dispersion of La,which was responsible for selective phosphate removal.LaFe/MB exhibited rapid phosphate adsorption kinetics and a high maximum adsorption capacity(Langmuir model,52.12 mg P g^(−1)),which were better than those of many existing granulated materials.The desorption and recyclability experiments showed that LaFe/MB could be regenerated,and maintained 76.7%of its initial phosphate adsorption capacity after four adsorption cycles.The high hydraulic endurance strength retention rate of the developed material(91.6%)suggested high practical applicability in actual wastewater.Electro-static attraction,surface precipitation,and inner-sphere complexation via ligand exchange were found to be involved in selective P removal over a wide pH range of 3-9.The thermodynamic parameters were determined,which revealed the feasibility and spontaneity of adsorption.Based on approximate site energy distribution analyses,high distribution frequency contributed to efficient P removal.The research results provide a new insight that LaFe/MB shows great application prospects for advanced phosphate removal from wastewater. | Enhui Sun Yanyang Zhang Qingbo Xiao Huayong Li Ping Qu Cheng Yong Bingyu Wang Yanfang Feng Hongying Huang Linzhang Yang Charles Hunter | 2022 | Biochar2022，4，1： | 1 |
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