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| 1 | Diagnosis, treatment, and prevention of 2019 novel coronavirus infection in children: experts' consensus statement显示文摘Since the outbreak of 2019 novel coronavirus infection (2019-nCoV) in Wuhan City,China,by January 30,2020,a total of 9692 confirmed cases and 15,238 suspected cases have been reported around 31 provinces or cities in China.Among the confirmed cases,1527 were severe cases,171 had recovered and been discharged at home,and 213 died.And among these cases,a total of 28 children aged from 1 month to 17 years have been reported in China.For standardizing prevention and management of 2019-nCoV infections in children,we called up an experts' committee to formulate this experts' consensus statement.This statement is based on the Novel Coronavirus Infection Pneumonia Diagnosis and Treatment Standards (the fourth edition) (National Health Committee) and other previous diagnosis and treatment strategies for pediatric virus infections.The present consensus statement summarizes current strategies on diagnosis,treatment,and prevention of 2019-nCoV infection in children. | Kunling Shen Yonghong Yang Tianyou Wang Dongchi Zhao Yi Jiang Runming Jin Yuejie Zheng Baoping Xu Zhengde Xie Likai Lin Yunxiao Shang Xiaoxia Lu Sainan Shu Yan Bai Jikui Deng Min Lu Leping Ye Xuefeng Wang Yongyan Wang Liwei Gao | 2020 | World Journal of Pediatrics2020,16,3: | 56 |
| 2 | Effects of free ammonia on volatile fatty acid accumulation and process performance in the anaerobic digestion of two typical bio-wastes显示文摘The effect of free ammonia on volatile fatty acid(VFA)accumulation and process instability was studied using a lab-scale anaerobic digester fed by two typical bio-wastes:fruit and vegetable waste(FVW)and food waste(FW)at 35°C with an organic loading rate(OLR)of 3.0 kg VS/(m^3·day). The inhibitory effects of free ammonia on methanogenesis were observed due to the low C/N ratio of each substrate(15.6 and 17.2,respectively). A high concentration of free ammonia inhibited methanogenesis resulting in the accumulation of VFAs and a low methane yield. In the inhibited state,acetate accumulated more quickly than propionate and was the main type of accumulated VFA. The co-accumulation of ammonia and VFAs led to an 'inhibited steady state' and the ammonia was the main inhibitory substance that triggered the process perturbation. By statistical significance test and VFA fluctuation ratio analysis,the free ammonia inhibition threshold was identified as 45 mg/L. Moreover,propionate,iso-butyrate and valerate were determined to be the three most sensitive VFA parameters that were subject to ammonia inhibition. | Xuchuan Shi Jia Lin Jiane Zuo Peng Li Xiaoxia Li Xianglin Guo | 2017 | Journal of Environmental Sciences2017,29,5: | 24 |
| 3 | Regional features of the temperature trend in China based on Empirical Mode Decomposition显示文摘由实验模式分解方法,我们在超过 700 个车站分析了观察每月平均的温度从 1951 2001 在中国上。同时,每个车站的温度可变性被这个方法计算。 | SUN Xian LIN Zhenshan CHENG Xiaoxia JIANG Chuangye | 2008 | Journal of Geographical Sciences2008,18,2: | 8 |
| 4 | Comparison of the short-term and long-term outcomes of laparoscopic hysterectomies and of abdominal hysterectomies: a case study of 4,895 patients in the Guangxi Zhuang Autonomous Region, China显示文摘Background: To evaluate the short-term and long-term outcomes after laparoscopic hysterectomy(LH) compared with abdominal hysterectomy(AH) in case of benign gynecological disease. Methods: A multi-center cohort retrospective comparative study of population among 4,895 hysterectomies(3,539 LH vs.1,356 AH) between 2007 and 2013 was involved. Operative time(OT), estimated blood loss(EBL), intra-operative and post-operative complications, passing flatus; days with indwelling catheter, questionnaires covering pelvic floor functions and sexual functions were assessed.Results: The EBL(174.1±157.4 vs. 263.1±183.2 cc, LH and AH groups, respectively), passing flatus(38.7±14.1 vs. 48.1±13.2 hours), days with indwelling catheter(1.5±0.6 vs. 2.2±0.8 days), use of analgesics(6.5% vs. 73.1%), intra-operative complication rate(2.4% vs. 4.1%), post-operative complication rate(2.3% vs. 5.7%), post-operative constipation(12.1% vs. 24.6%), mild and serious stress urinary incontinence(SUI) post-operative(P<0.001; P=0.014), and proportion of Female Sexual Functioning Index(FSFI) total score <26.55 post-operative(P<0.001) of the LH group were significantly less than those of AH group. There wereno significant differences in OT(106.5±34.5 vs. 106.2±40.3 min) between the two groups.Conclusions: LH is a safe and efficient operation for improving patients' long-term quality of life(Qo L), and LH is a cost-effectiveness procedure for treating benign gynecological disease. LH is superior to AH due to reduced EBL, reduced post-operative pain and earlier passing flatus. | Hongying He Zhijun Yang Dingyuan Zeng Jiangtao Fan Xiaoxia Hu Yuan Ye Hua Bai YanmingJiang Zhong Lin Zhiying Lei Xinlin Li Lian Li Jinghua Gan Ying Lan Xiongzhi Tang Danxia Wang Junsong Jiang Xiaoyan Wu Meiying Li Xiaoqing Ren Xiaomin Yang Mei Liu Qinmei Wang Fuyan jiang Li Li | 2016 | Chinese Journal of Cancer Research2016,28,2: | 6 |
| 5 | Metamorphic Manipulating Mechanism Design for MCCB Using Index Reduced Iteration显示文摘The present research on moulded case circuit breaker(MCCB) focuses on the enhancement of current-limiting interrupting performance during short circuit, overload, under voltage and phase failure, involving electrics, magnetic, mechanics, thermal, material, friction, arc extinguishing, impact vibration, skin effect, etc. The rigid-flexible coupling of the parts and components of the metamorphic manipulating mechanism in multi-fields leads to the non-rigid, high frequency, high damping, singularity of the Euler-Lagrange equations which represents the multi-body dynamics. The small step iteration which is used for obtaining the instantaneous and short time critical interrupting performance of metamorphic mechanism appears inaccuracy. It is difficult to realize top-down design by existing CAD systems. Therefore, a metamorphic manipulating mechanism design method for MCCB using index reduced iteration(IRI) is put forward. The metamorphic manipulating mechanism of MCCB is decomposed into three mechanisms: main switch connector mechanism, electromagnet-drawbar-jump buckle mechanism, and bimetallic strip-drawbar mechanism, which is respectively described by electro-dynamic force, electromagnet force, and bimetallic strip force. The dummy part(virtual rigid) without moment of inertia and mass is employed as intermediate to join the flexible body and rigid body. The model of rigid-flexible coupling metamorphic mechanism multi-body dynamics is built. The differential algebraic equations(DAEs) of the multibody dynamics model are converted to pure ordinary differential equations(ODEs) by coordinate partition. Order reduced integration with multi-step and variable step-size is preceded based on IRI. The non-linear algebraic equations are solved in each integration step by Newton-Rapson iteration. There is no ill-condition and singularity of Jacobian matrix when step size reduces to zero. The independent prototype design system using ACIS R13, HOOPS V11.0 and Visual C++.NET 2003 has been developed, which verifies the effectiveness of the proposed method. The proposed method enhances the current-limiting interrupting performance of MCCB, and has reference significance for multi-body dynamics design for similar flexible metamorphic mechanisms in multi-fields. | XU Jinghua ZHANG Shuyou ZHAO Zhen LIN Xiaoxia | 2013 | Chinese Journal of Mechanical Engineering2013,26,2: | 5 |
| 6 | Expression of a New hemA Gene from Agrobacterium radiobacter in Escherichia coli for 5-Aminolevulinate Production显示文摘A new hemA gene encoding 5-aminolevulinate (ALA) synthase was cloned from Agrobacterium ra- diobacter zju-0121. The ALA synthase catalyzes the pyridoxal phosphate-dependent condensation of succinyl coen- zyme A (succinyl-CoA) and glycine to produce ALA. Four plasmids carrying the A, radiobacter hemA gene were transformed into different E. coli strains. The effects of both genetic and physiological factors on the expression of ALA synthase and ALA production were studied. The results indicated that the final intracellular activity of ALA synthase and the production of ALA in different expression systems varied largely. Among them, the recombinant E. coli BL21 (DE3) harboring the expression plasmid pET28-A. R-hemA was the most suitable one. The effects of isopropyl-β-D-thiogalactopyranoside (IPTG) addition time, IPTG concentration, culture temperature and the initial concentration of precursors and glucose on the ALA production were also evaluated. The expressed ALA synthase accounted for about 23.7% of the intracellular soluble protein. The highest specific activity of ALA syn- thase was 13.8nmol·min-1·mg-1 of intracellular soluble protein. In the batch culture of the recombinant E. coli, the extracellular ALA concentration reached 0.9 g·L-1. | LIU Xiaoxia(刘晓侠) LIN Jianping(林建平) QIN Gang(秦钢) CEN Peilin(岑沛霖) | 2005 | Chinese Journal of Chemical Engineering2005,13,4: | 4 |
| 7 | Synthesis and enhanced visible-light responsive of C,N,S-tridoped TiO_2 hollow spheres显示文摘C,N,S-tridoped TiO2hollow spheres(labeled as C,N,S-THs) were synthesized using carbon spheres as template and C,N,S-tridoped TiO2nanoparticles as building blocks. The structure and physicochemical properties of the catalysts were characterized by Xray difraction(XRD), scanning electron microscopy(SEM), UV-Vis difuse reflectance spectrum(DRS), N2adsorption-desorption isotherms, X-ray photoelectron spectroscopy(XPS) and Photoluminescence emission spectroscopy(PL). The results showed that the hollow spheres had average diameter of about 200 nm and the shell thickness was about 20 nm. The tridoped TiO2hollow spheres exhibited strong absorption in the visible-light region. C,N,S-tridoped could narrow the band gap of the THs by mixing the orbit O 2p with C 2p, N 2p and S 3p orbits and shift its optical response from ultraviolet(UV) to the visible-light region. PL analysis indicated that the electron-hole recombination rate of TiO2hollow spheres had been efectively inhibited when doped with C, N and S elements.The photocatalytic activities of the samples were evaluated for the degradation of X-3B(Reactive Brilliant Red dye, C.I. Reactive Red2) aqueous solution under visible-light(λ > 420 nm) irradiation. It was found that the C,N,S-tridoped TiO2hollow spheres indicated higher photocatalytic activity than commercial P25 and the undoped counterpart photocatalyst. | Xiaoxia Lin Degang Fu Lingyun Hao Zhen Ding | 2013 | Journal of Environmental Sciences2013,25,10: | 4 |
| 8 | De novo assembly of a new Olea europaea genome accession using nano pore seque ncing显示文摘Olive(Olea europaea L.)is internationally renowned for its high-end product,extra virgin olive oil.An incomplete genome of O.europaea was previously obtained using shotgun sequencing in 2016.To further explore the genetic and breeding utilization of olive,an updated draft genome of olive was obtained using Oxford Nanopore third-generation sequencing and Hi-C technology.Seven different assembly strategies were used to assemble the fi nal genome of 1.30 Gb,with contig and scaffold N50 sizes of4.67 Mb and 42.60 Mb,respectively.This greatly increased the quality of the olive genome.We assembled 1.1 Gb of sequences of the total olive genome to 23 pseudochromosomes by Hi-C,and 53,518 protein-coding genes were predicted in the current assembly.Comparative genomics analyses,including gene family expansion and contraction,whole-genome replication,phylogenetic analysis,and positive selection,were performed.Based on the obtained high-quality olive genome,a total of nine gene families with 202 genes were identi fi ed in the oleuropein biosynthesis pathway,which is twice the number ofgenes identi fi ed from the previous data.This new accession of the olive genome is of suf fi cient quality for genome-wide studies on gene function in olive and has provided a foundation for the molecular breeding of olive species. | Guodong Rao Jianguo Zhang Xiaoxia Liu Chunfu Lin Huaigen Xin Li Xue Chenhe Wang | 2021 | Horticulture Research2021,8,1: | 4 |
| 9 | Molecular evolution and genetic diversity analysis of SFTS virus based on next-generation sequencing显示文摘SFTS virus(SFTSV)is a novel bunyavirus,which was discovered as the etiological agent of severe fever with thrombocytopenia syndrome(SFTS)in China in 2009,and was now prevalent in at least 25 provinces in China.SFTS was subsequently identified in South Korea and Japan in 2012.To explore themolecular evolution and genetic characteristics of this newly identified pathogen,we reported 72 whole genome sequences of SFTSV,and built a dataset of SFTSV genome sequences containing 292 L-segment,302 M-segment and 502 S-segment.We clearly divided SFTSV into six genotypes,Genotype A-F.It was found that genotype F was the dominant epidemic genotype of Japan,South Korea,and Zhejiang province of China.The coalescent analysis supported that SFTSV originated in the early 18th century from Zhejiang province,and Genotype F was the most primitive one.Henan,Hubei,and Anhui provinces which are located in Dabie Mountain area weremainly epidemic of Genotype A,which emerged relatively late but distributed widely.A total of 37 recombination events were identified,making SFTSV with a high recombination frequency(L segment 5.1%,Msegment 3.6%,S segment 0.8%)among negative-strand segmented RNA viruses.It was identified that 19 reassortant strains belonged to 12 reassortment forms of SFTSV genome containing 6 newly identified forms.The reassortment virus and recombination in tick were both found for the first time.We also found many of genotype-specific mutation sites,7 of which could be considered as potential molecular marker for genotype classification.This study promoted a more comprehensive understanding of the phylogeny and origin,and the genetic diversity of SFTSV,and it could help the studies of other newly discovered tick-borne bunyavirus as reference data and research ideas. | Aqian Li Lin Liu Wei Wu Yang Liu Xiaoxia Huang Chuan Li Di Liu Jiandong Li Shiwen Wang Dexin Li Mifang Liang | 2021 | Biosafety and Health2021,3,2: | 4 |
| 10 | A super pan-genomic landscape of rice显示文摘Pan-genomes from large natural populations can capture genetic diversity and reveal genomic complexity.Using de novo longread assembly,we generated a graph-based super pan-genome of rice consisting of a 251-accession panel comprising both cultivated and wild species of Asian and African rice.Our pan-genome reveals extensive structural variations(SVs)and gene presence/absence variations.Additionally,our pan-genome enables the accurate identification of nucleotide-binding leucine-rich repeat genes and characterization of their inter-and intraspecific diversity.Moreover,we uncovered grain weight-associated SVs which specify traits by affecting the expression of their nearby genes.We characterized genetic variants associated with submergence tolerance,seed shattering and plant architecture and found independent selection for a common set of genes that drove adaptation and domestication in Asian and African rice.This super pan-genome facilitates pinpointing of lineage-specific haplotypes for trait-associated genes and provides insights into the evolutionary events that have shaped the genomic architecture of various rice species. | Lianguang Shang Xiaoxia Li Huiying He Qiaoling Yuan Yanni Song Zhaoran Wei Hai Lin Min Hu Fengli Zhao Chao Zhang Yuhua Li Hongsheng Gao Tianyi Wang Xiangpei Liu Hong Zhang Ya Zhang Shuaimin Cao Xiaoman Yu Bintao Zhang Yong Zhang Yiqing Tan Mao Qin Cheng Ai Yingxue Yang Bin Zhang Zhiqiang Hu Hongru Wang Yang Lv Yuexing Wang Jie Ma Quan Wang Hongwei Lu Zhe Wu Shanlin Liu Zongyi Sun Hongliang Zhang Longbiao Guo Zichao Li Yongfeng Zhou Jiayang Li Zuofeng Zhu Guosheng Xiong Jue Ruan Qian Qian | 2022 | Cell Research2022,32,10: | 3 |
| 11 | Neuroimaging diagnosis for cerebral infarction An 8-year bibliometric analysis显示文摘OBJECTIVE: To identify global research trends in neuroimaging diagnosis for cerebral infarction using a bibliometric analysis of the Web of Science. DATA RETRIEVAL: We performed a bibliometric analysis of data retrieval for neuroimaging diagnosis for cerebral infarction containing the key words 'CT, magnetic resonance imaging, MRI, transcranial Doppler, transvaginal color Doppler, digital subtraction angiography, and cerebral infarction' using the Web of Science. SELECTION CRITERIA: Inclusion criteria were: (a) peer-reviewed articles on neuroimaging diagnosis for cerebral infarction which were published and indexed in the Web of Science; (b) original research articles and reviews; and (c) publication between 2004-2011. Exclusion criteria were: (a) articles that required manual searching or telephone access; and (b) corrected papers or book chapters. MAIN OUTCOME MEASURES: (1) Annual publication output; (2) distribution according to country; (3) distribution according to institution; (4) top cited publications; (5) distribution according to journals; and (6) comparison of study results on neuroimaging diagnosis for cerebral infarction. RESULTS: Imaging has become the predominant method used in diagnosing cerebral infarction. The most frequently used clinical imaging methods were digital subtraction angiography, CT, MRI, and transcranial color Doppler examination. Digital subtraction angiography is used as the gold standard. However, it is a costly and time-consuming invasive diagnosis that requires some radiation exposure, and is poorly accepted by patients. As such, it is mostly adopted in interventional therapy in the clinic. CT is now accepted as a rapid, simple, and reliable non-invasive method for use in diagnosis of cerebrovascular disease and preoperative appraisal. Ultrasonic Doppler can be used to reflect the hardness of the vascular wall and the nature of the plaque more clearly than CT and MRI. CONCLUSION: At present, there is no unified standard of classification of cerebral infarction imaging. Detection of clinical super-acute cerebral infarction remains controversial due to its changes on imaging, lack of specificity, and its similarity to a space-occupying lesion. Neuroimaging diagno- sis for cerebral infarction remains a highly active area of research and development. | Yan Du Xiaoxia Yang Hong Song Bo Chen Lin Li Yue Pan Qiong Wu Jia Li | 2012 | Neural Regeneration Research2012,7,30: | 3 |
| 12 | The monitoring and analysis of the coastal lowland subsidence in the southern Hangzhou Bay with an advanced time-series InSAR method显示文摘Time-series InSAR analysis(e.g., permanent scatterers(PSInSAR)) has been proven as an effective technology in monitoring ground deformation over urban areas. However, it is a big challenge to apply this technology in coastal regions due to the lack of man-made targets. An distributed scatterers interferometric synthetic aperture radar(DSInSAR) is developed to solve the problem of insufficient samples and low reliability in monitoring coastal lowland subsidence, by applying a spatially adaptive filter and an eigendecomposition algorithm to estimating the optimal phase of statistically homogeneous distributed scatterers(DSs). Twenty-four scenes of COSMO-Sky Med images acquired between 2013 and 2015 are used to retrieve the land subsidence over the Shangyu District on south coast of the Hangzhou Bay, Zhejiang Province, China. The spatial pattern of the land subsidence obtained by the PS-InSAR and the DSInSAR coincides with each other, but the density of the DSs is three point five times higher than the permanent scatterers(PSs). Validated by precise levelling data over the same period, the DSInSAR method achieves an accuracy of ±5.0 mm/a which is superior to the PS-InSAR with±5.5 mm/a. The land subsidence in the Shangyu District is mainly distributed in the urban areas, industrial towns and land reclamation zones, with a maximum subsidence rate –30.2 mm/a. The analysis of geological data, field investigation and historical reclamation data indicates that human activities and natural compaction of reclamation material are major causes of the detected land subsidence. The results demonstrate that the DSInSAR method has a great potential in monitoring the coastal lowland subsidence and can be used to further investigate subsidence-related environmental issues in coastal regions. | HAN Peng YANG Xiaoxia BAI Lin SUN Qishi | 2017 | Acta Oceanologica Sinica2017,36,7: | 3 |
| 13 | Facet-dependent electro-optical properties of cholesteric liquid crystals doped with Cu2O nanocrystals显示文摘 | Dongyu Zhao Lihong Xu Yang Shang Xiaoxia Li Lin Guo | 2018 | Nano Research2018,11,9: | 2 |
| 14 | A Multicenter Application and Evaluation of the Oxford Classification of IgA Nephropathy in Adult Chinese Patients显示文摘 | Cai-Hong Zeng Weibo Le Zhaohui Ni Minfang Zhang Lining Miao Ping Luo Rong Wang Zhimei Lv Jianghua Chen Jiong Tian Nan Chen Xiaoxia Pan Ping Fu Zhangxue Hu Lining Wang Qiuling Fan Hongguang Zheng Dewei Zhang Yaping Wang Yanhong Huo Hongli Lin Shuni Chen Sh | 2012 | American Journal of Kidney Diseases2012,,5: | 2 |
| 15 | Molecular functions of nitric oxide and its potential applications in horticultural crops显示文摘Nitric oxide(NO)regulates plant growth,enhances nutrient uptake,and activates disease and stress tolerance mechanisms in most plants,making NO a potential tool for use in improving the yield and quality of horticultural crop species.Although the use of NO in horticulture is still in its infancy,research on NO in model plant species has provided an abundance of valuable information on horticultural crop species.Emerging evidence implies that the bioactivity of NO can occur through many potential mechanisms but occurs mainly through S-nitrosation,the covalent and reversible attachment of NO to cysteine thiol.In this context,NO signaling specifically affects crop development,immunity,and environmental interactions.Moreover,NO can act as a fumigant against a wide range of postharvest diseases and pests.However,for effective use of NO in horticulture,both understanding and exploring the biological significance and potential mechanisms of NO in horticultural crop species are critical.This review provides a picture of our current understanding of how NO is synthesized and transduced in plants,and particular attention is given to the significance of NO in breaking seed dormancy,balancing root growth and development,enhancing nutrient acquisition,mediating stress responses,and guaranteeing food safety for horticultural production. | Chengliang Sun Yuxue Zhang Lijuan Liu Xiaoxia Liu Baohai Li Chongwei Jin Xianyong Lin | 2021 | Horticulture Research2021,8,1: | 2 |
| 16 | Enhanced photocatalytic activity of fluorine doped TiO 2 by loaded with Ag for degradation of organic pollutants显示文摘 | Xiaoxia Lin Fei Rong Degang Fu Chunwei Yuan | 2011 | Powder Technology2011,,: | 2 |
| 17 | Recent progress in hydrocarbon biofuel synthesis:Pathways and enzymes显示文摘Biofuels derived from hydrocarbon biosynthetic pathways have attracted increasing attention.Routes to hydrocarbon biofuels are emerging and mainly fall into two categories based on the metabolic pathways utilized:Fatty acid pathway-based alkanes/alkenes and isoprenoid biosynthetic pathway based terpenes.The primary focus of this review is on recent progress in the application of hydrocarbon biosynthetic pathways for hydrocarbon biofuel production,together with studies on enzymes,including efforts to engineering them for improved performance. | Feng-Ming Lin E.Neil G.Marsh Xiaoxia Nina Lin | 2015 | Chinese Chemical Letters2015,26,4: | 2 |
| 18 | HEP quantification strategy based on modified CREAM显示文摘The accurate quantification of human error probability(HEP) has long been a main pursuit for most human reliability analysis(HRA) methods. This paper proposes a strategy to analyzeand predict human error on the basis of a further modification of theexisting cognitive reliability and error analysis method (CREAM)in HRA. Through providing a broader definition for the key parametersused in the quantification method, this paper produces arelatively flexible strategy to determine the nominal HEP (HEP0).Basing on this strategy, the actual quantification of HEP in CREAMis able to be applied to more verified conditions. To prove the validityof the method proposed, a case study of spacecraft launch isalso introduced, in which the prediction derived from the method isproved consistent with real field data. | PAN Xing WANG Huixiong LIN Ye LIU Tun WANG Xiaoxia | 2019 | Journal of Systems Engineering and Electronics2019,30,4: | 2 |
| 19 | Carbon-doped mesoporous TiO 2 film and its photocatalytic activity显示文摘 | Xiaoxia Lin Fei Rong Xiang Ji Degang Fu | 2010 | Microporous and Mesoporous Materials2010,,1: | 1 |
| 20 | 查看详情显示文摘 | Lin Xiaoxia Xiang Feirong Ji Xiang | | 0,,: | 1 |