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| 1 | A partition-ligation-combination-subdivision EM algorithm for haplotype inference with multiallelic markers: update of the SHEsis (http://analysis.bio-x.cn)显示文摘 | Zhiqiang Li Zhao Zhang Zangdong He Wei Tang Tao Li Zhen Zeng Lin He Yongyong Shi | 2009 | Cell Research2009，19，4： | 122 |
| 2 | A nationwide survey of psychological distress among Chinese people in the COVID-19 epidemic:implications and policy recommendations显示文摘The Coronavirus Disease 2019(COVID-19)epidemic emerged in Wuhan,China,spread nationwide and then onto half a dozen other countries between December 2019 and early 2020.The implementation of unprecedented strict quarantine measures in China has kept a large number of people in isolation and affected many aspects of people's lives.It has also triggered a wide variety of psychological problems,such as panic disorder,anxiety and depression.This study is the first nationwide largescale survey of psychological distress in the general population of China during the COVID-19 epidemic. | Jianyin Qiu Bin Shen Min Zhao Zhen Wang Bin Xie Yifeng Xu | 2020 | General Psychiatry2020，33，2： | 69 |
| 3 | Multiple genetic alterations and behavior of cellular biology in gastric cancer and other gastric mucosal lesions:H.pylori infection,histological types and staging显示文摘AIM To investigate the expression of multiplegenes and the behavior of cellular biology ingastric cancer(GC)and other gastric mucosallesions and their relations to Helicobacter pylori(H.pylori)infection,tumor staging andhistological subtypes.METHODS Three hundred and twenty-sevenspecimens of gastric mucosa obtained viaendoscopy or surgical resection,and ABCimmunohistochemical staining were used todetect the expression of p53,p16,Bcl-2 andCOX-2 proteins.H.pylori was determined byrapid urea test combined with pathologicalstaining or14C urea breath test.Cellular image analysis was performed in 66 patients withintestinal metaplasia(IM)and/or dysplasia(Dys).In 30 of them,both cancer and theparacancerous tissues were obtained at the timeof surgery.Histological pattern,tumor staging,lymph node metastasis,grading ofdifferentiation and other clinical data werestudied in the medical records.RESULTS p16 expression of IM or Dys wassignificantly lower in positive H.pylori chronicatrophic gastritis(CAG)than those withnegative H.pylori(CAG:54.8% vs 88.0%,IM:34.4% vs 69.6%,Dys:23.8% vs 53.6%,allP<0.05),Bcl-2 or COX-2 expression of IM orDys in positive H.pylori cases was significantlyhigher than that without H.pylori(Bcl-2:68.8%vs23.9%,90.5% vs 60.7%;COX-2:50.0% vs10.8%,61.8% vs 17.8%;all P<0.05).Themean number of most parameters of cellularimage analysis in positive H.pylori group wassignificantly higher than that in negative H.pylori group(Ellipser:53±14,40±12μm,Area1:748±572,302±202 μm2,Area2:3050±1661,1681±1990 μm2,all P<0.05;Ellipseb:79±23,58±15 μm,Ratio1:22%±5%,13%±4%,Ratio2:79%±17%,53%±20%,all P<0.01).There was significant correlation between Bcl-2and histologic pattern of gastric carcinoma,andbetween COX-2 and tumor staging or lymph nodemetastasis(Bcl-2:75.0% vs 16.7%;COX-2:76.0% vs 20.0%,79.2% vs 16.7%;allP<0.05).CONCLUSION p1l6, Bcl-2, and COX-2 but not p53 gene may play a role in the early genesis/ progression of gastric carcinoma and are associated with H. pylori infection. p53 gene is relatively late event in gastric tumorigenesis and mainly relates to its progression. There is more cellular-biological behavior of malignant tumor in gastric mucosal lesions with H. pylori infection. Aberrant Bcl-2 protein expression appears to be preferentially associated with the intestinal type cancer. COX-2 seems to be related to tumor staging and lymph node metastasis. | Heng Jun Gao Lian Zhen Yu Jian Feng Bai Yan Shen Peng Gu Sun Han Lin Zhao Kun Miu Xiu Zhen Lü Xiao Yong Zhang Zhi Quan Zhao | 2000 | World Journal of Gastroenterology2000，6，6： | 52 |
| 4 | Combined detection tumor markers for diagnosis and prognosis of gallbladder cancer显示文摘AIM:To clarify the value of combined use of markers for the diagnosis of gallbladder cancer and prediction of its prognosis.METHODS:Serum cancer antigens(CA)199,CA242,carcinoembryonic antigen(CEA),and CA125 levels were measured in 78 patients with gallbladder cancer(GBC),78 patients with benign gallbladder diseases,and 78 healthy controls using electrochemiluminescence.CA199,CA242,CEA,and CA125 levels and positive rates were analyzed and evaluated pre-and postoperatively.Receiver operator characteristic curves were used to determine diagnostic sensitivity and specificity of GBC.Survival time analysis,including survival curves,and multivariate survival analysis of a Cox proportional hazards model was performed to evaluate independent prognostic factors.RESULTS:Serum CA242,CA125,and CA199 levels in the GBC group were significantly higher when compared with those in the benign gallbladder disease and healthy control groups(P<0.01).With a single tumor marker for GBC diagnosis,the sensitivity of CA199 was the highest(71.7%),with the highest specificity being in CA242(98.7%).Diagnostic accuracy was highest with a combination of CA199,CA242,and CA125(69.2%).CA242 could be regarded as a tumor marker of GBC infiltration in the early stage.The sensitivity of CA199 and CA242 increased with progression of GBC and advanced lymph node metastasis(P<0.05).The78 GBC patients were followed up for 6-12 mo(mean:8 mo),during which time serum CA199,CA125,and CA242 levels in the recurrence group were significantly higher than in patients without recurrence(P<0.01).The post-operative serum CA199,CA125,and CA242levels in the non-recurrence group were significantly lower than those in the GBC group(P<0.01).Multivariate survival analysis using a Cox proportional hazards model showed that cancer of the gallbladder neck and CA199 expression level were independent prognostic factors.CONCLUSION:CA242 is a marker of GBC infiltration in the early stage.CA199 and cancer of the gallbladder neck are therapeutic and prognostic markers. | Yun-Feng Wang Fei-Ling Feng Xu-Hong Zhao Zhen-Xiong Ye He-Ping Zeng Zhen Li Xiao-Qing Jiang Zhi-Hai Peng | 2014 | World Journal of Gastroenterology2014，20，14： | 37 |
| 5 | The Phenotypic Characterization of Naturally Occurring Regulatory CD4^+CD25^+T Cells显示文摘免疫系统的动态平衡取决于在对自我抗原的对入侵的病原体和有免疫力的忍耐的有免疫力的反应之间的平衡。中央、外部的忍耐是为 T 房间忍耐的正式就职和维护的重要机制。最近,许多注意对规章的 T 房间(Treg ) 被给予了,它在维持外部有免疫力的忍耐起一个重要作用。到目前为止,关于 Treg 房间的表面标记没有令人满意的进展,因为任何一个都不为 Treg 房间是唯一的。在这评论,我们总结在自然地发生的CD4+CD25+ Treg 房间( nTreg )表示的一些重要分子,包括 forkhead/winged-helix 家庭 transcriptional 抑压者 p3 ( Foxp3 ),肿瘤坏死因素受体( TNFR )家庭, CD28/CTLA4 分子, chemokine 受体,像使用费的受体( TLR ), membranebound TGF-和其它分子例如 neuropilin-1 ,淋巴细胞激活 gene-3 (落后) -3 和 granzyme.This 评论在 nTreg | Huanfa Yi Yu Zhen Lingling Jiang Jialin Zheng Yong Zhao | 2006 | Cellular & Molecular Immunology2006，3，3： | 31 |
| 6 | Fine mapping and candidate gene analysis of a green-revertible albino gene gra(t) in rice显示文摘Green-revertible albino is a novel type of chlorophyll deficiency in rice(Oryza sativa L.), which is helpful for further research in chlorophyll synthesis and chloroplast development to illuminate their molecular mechanism.In the previous study, we had reported a single recessive gene, gra(t), controlling this trait on the long arm of chromosome 2.In this paper, we mapped the gra(t) gene using 1,936 recessive individuals with albino phenotype in the F2 population derived from the cross between themo-photoperiod-sensitive genic male-sterile(T/PGMS) line Pei'ai 64S and the spontaneous mutant Qiufeng M.Eventually, it was located to a confined region of 42.4 kb flanked by two microsatellite markers RM2-97 and RM13553.Based on the annotation results of RiceGAAS system, 11 open reading frames(ORFs) were predicted in this region.Among them, ORF6 was the most possible gene related to chloroplast development, which encoded the chloroplast protein synthesis elongation factor Tu in rice.Therefore, we designated it as the candidate gene of gra(t).Sequence analysis indicated that only one base substitution C to T occurred in the coding region, which caused a missense mutation(Thr to Ile) in gra(t) mutant.These results are very valuable for further study on gra(t) gene. | Tao Chen Yadong Zhang Ling Zhao Zhen Zhu Jing Lin Suobing Zhang Cailin Wang | 2009 | Journal of Genetics and Genomics2009，36，2： | 31 |
| 7 | Apoptosis induced by norcantharidin in human tumor cells显示文摘INTRODUCTIONThe antitumor activity of norcantharidin (NCTD),the demethylated analogue of cantharidin,wasstudied in the early 1980s in China.NCTD has noside effects on urinary organs which cantharidin hasshown and is easier to synthesize,and it can inhibitthe proliferation of several tumor cell lines as wellas transplanted tumors.Clinical trials with NCTD asa monotherapeutic agent indicated that NCTD hadbeneficial effects in patients with different kinds | Zhen Xiao Sun Qing Wen Ma Tian De Zhao Yu Lin Wei Guang Sheng Wang Jia Shi Li | 2000 | World Journal of Gastroenterology2000，6，2： | 31 |
| 8 | Direct reprogramming of Sertoli cells into multipotent neural stem cells by defined factors显示文摘Multipotent 神经干细胞为房间治疗保持大诺言。到导致的 pluripotent 干细胞以及成熟神经原的成纤维细胞的 reprogramming 建议可能性没有首先建立 pluripotency,把一个严重地区分的体的房间变换成一个 multipotent 状态。这里,我们证明房间从中层导出的那 Sertoli 能直接被变换成拥有神经干细胞性质的一个 multipotent 状态。导致的神经干细胞(iNSCs ) 表示多重 NSC 特定的标记,展出类似于正常 NSC 的全球基因表示侧面,并且能够自强并且区分功能的神经原进神经胶质并且 electrophysiologically。为酷氨酸 hydroxylase (TH ) 积极的导出 iNSC 的神经原污点, γ -aminobutyric 酸,和胆碱 acetyltransferase。另外, iNSCs 能熬过并且产生跟随移植进有牙齿的回转的触处。iNSCs 的产生可以为疾病建模和再生药有重要含意。 | Chao Sheng Qinyuan Zheng Jianyu Wu Zhen Xu Libin Wang Wei Li Haijiang Zhang Xiao-Yang Zhao Lei Liu Ziwei Wang Changlong Guo Hua-Jun Wu Zhonghua Liu Liu Wang Shigang He Xiu-Jie Wang Zhiguo Chen Qi Zhou | 2012 | Cell Research2012，22，1： | 31 |
| 9 | Relationship between Cognition Function and Hippocampus Structure after Long-term Microwave Exposure显示文摘Objective To analyze the effects of long-term microwave exposure on hippocampal structure and function in the rat.Methods Experiments were performed on 184 male Wistar rats(three exposure groups and a sham group).Microwaves were applied daily for 6 min over 1 month at average power densities of 2.5,5,and 10 mW/cm2.Learning and memory abilities were assessed by Morris water maze.High performance liquid chromatography was used to detect neurotransmitter concentrations in the hippocampus.Hippocampal structures were observed by histopathological analysis.Results Following long-term microwave exposure there was a significant decrease in learning and memory activity in the 7 d,14 d,and 1 m in all three microwave exposure groups.Neurotransmitter concentrations of four amino acids(glutamate,aspartic acid,glycine,and gamma-aminobutyric acid) in hippocampus were increased in the 2.5 and 5 mW/cm2 groups and decreased in the 10 mW/cm2 group.There was evidence of neuronal degeneration and enlarged perivascular spaces in the hippocampus in the microwave exposure groups.Further,mitochondria became swollen and cristae were disordered.The rough endoplasmic reticulum exhibited sacculated distension and there was a decrease in the quantity of synaptic vesicles.Conclusion These data suggest that the hippocampus can be injured by long-term microwave exposure,which might result in impairment of cognitive function due to neurotransmitter disruption. | ZHAO Li PENG Rui Yun WANG Shui Ming WANG Li Feng GAO Ya Bing DONG Ji LI Xiang SU Zhen Tao | 2012 | Biomedical and Environmental Sciences2012，25，2： | 27 |
| 10 | Suppression of Jasmonic Acid-Mediated Defense by Viral-Inducible MicroRNA319 Facilitates Virus Infection in Rice显示文摘MicroRNAs (miRNAs ) 是植物开发和主人病毒相互作用的枢轴的调节的人。然而,角色和涉及病毒的感染和主人危险性的特定的 miRNAs 的行动模式仍然保持大部分不清楚。在这研究,我们给那瑞斯看引起 miR319 的增加的累积,但是减少的破旧绝技病毒(RRSV ) 感染调整 miR319 的 TCP (TEOSINTE BRANCHED/CYCLOIDEA/PCF ) 的表示基因,特别 TCP21,在米饭植物。转基因的米饭植物 overexpressing miR319 或 downregulating TCP21 展出了像疾病的显型并且与野类型的植物比较显示出显著地更高的危险性到 RRSV。相反,仅仅温和的疾病症状在感染 RRSV 的线 overexpressing TCP21 并且特别在转基因的植物 overexpressing 被观察 miR319 抵抗的 TCP21。miR319 的 RRSV 感染和 overexpression 在米饭与 JA 生合成和信号相关的基因的 downregulated 表示一起引起了减少的内长的 jasmonic 酸(JA ) 层次。然而,有甲基 jasmonate 的米饭植物的治疗减轻了 RRSV 引起并且减少了病毒累积的疾病症状。一起拿,我们的结果建议由在米饭的 RRSV 感染的 miR319 的正式就职压制调停 JA 的防卫便于病毒感染和症状开发。 | Chao Zhang Zuomei Ding Kangcheng Wu Liang Yang Yang Li Zhen Yang Shan Shi Xiaojuan Liu Shanshan Zhao Zhirui Yang Yu Wang Luping Zheng Juan Wei Zhenguo Du Aihong Zhang Hongqin Miao Yi Li Zujian Wu Jianguo Wu | 2016 | Molecular Plant2016，9，9： | 27 |
| 11 | A nationwide survey of psychological distress among Chinese people in the COVID-19 epidemic: implications and policy recommendations显示文摘The Coronavirus Disease 2019(COVID-19)epidemic emerged in Wuhan,China,spread nationwide and then onto half a dozen other countries between December 2019 and early 2020.The implementation of unprecedented strict quarantine measures in China has kept a large number of people in isolation and affected many aspects of people’s lives.It has also triggered a wide variety of psychological problems,such as panic disorder,anxiety and depression.This study is the first nationwide largescale survey of psychological distress in the general population of China during the COVID-19 epidemic. | Jianyin Qiu Bin Shen Min Zhao Zhen Wang Bin Xie Yifeng Xu | 2020 | General Psychiatry2020，33，1： | 26 |
| 12 | The South China Sea is not a mini-Atlantic: plate-edge rifting vs intra-plate rifting显示文摘The South China Sea,as‘a non-volcanic passive margin basin’in the Pacific,has often been considered as a small-scale analogue of the Atlantic.The recent ocean drilling in the northern South China Sea margin found,however,that the Iberian model of non-volcanic rifted margin from the Atlantic does not apply to the South China Sea.In this paper,we review a variety of rifted basins and propose to discriminate two types of rifting basins:plate-edge type such as the South China Sea and intra-plate type like the Atlantic.They not only differ from each other in structure,formation process,lifespan and geographic size,but also occur at different stages of the Wilson cycle.The intra-plate rifting occurred in the Mesozoic and gave rise to large oceans,whereas the plate-edge rifting took place mainly in the mid-Cenozoic,with three-quarters of the basins concentrated in the Western Pacific.As a member of the Western Pacific system of marginal seas,the South China Sea should be studied not in isolation on its origin and evolution,but in a systematic context to include also its neighboring counterparts. | Pinxian Wang Chi-Yue Huang Jian Lin Zhimin Jian Zhen Sun Minghui Zhao | 2019 | National Science Review2019，6，5： | 24 |
| 13 | Dynamic Modeling and Simulation of Multi-body Systems Using the Udwadia-Kalaba Theory显示文摘Laboratory experiments were conducted for falling U-chain,but explicit analytic form of the general equations of motion was not presented.Several modeling methods were developed for fish robots,however they just focused on the whole fish's locomotion which does little favor to understand the detailed swimming behavior of fish.Udwadia-Kalaba theory is used to model these two multi-body systems and obtain explicit analytic equations of motion.For falling U-chain,the mass matrix is non-singular.Second-order constraints are used to get the constraint force and equations of motion and the numerical simulation is conducted.Simulation results show that the chain tip falls faster than the freely falling body.For fish robot,two-joint Carangiform fish robot is focused on.Quasi-steady wing theory is used to approximately calculate fluid lift force acting on the caudal fin.Based on the obtained explicit analytic equations of motion(the mass matrix is singular),propulsive characteristics of each part of the fish robot are obtained.Through these two cases of U chain and fish robot,how to use Udwadia-Kalaba equation to obtain the dynamical model is shown and the modeling methodology for multi-body systems is presented.It is also shown that Udwadia-Kalaba theory is applicable to systems whether or not their mass matrices are singular.In the whole process of applying Udwadia-Kalaba equation,Lagrangian multipliers and quasi-coordinates are not used.Udwadia-Kalaba theory is creatively applied to dynamical modeling of falling U-chain and fish robot problems and explicit analytic equations of motion are obtained. | ZHAO Han ZHEN Shengchao CHEN Ye-Hwa | 2013 | Chinese Journal of Mechanical Engineering2013，26，5： | 22 |
| 14 | IL-17 response mediates acute lung injury induced by the 2009 Pandemic Influenza A (HIN1) Virus显示文摘 | Chenggang Li Penghui Yang Yang Sun Taisheng Li Chen Wang Zhong Wang Zhen Zou Yiwu Yan Wei Wang Chen Wang Zhongwei Chen Li Xing Chong Tang Xiangwu Ju Feng Guo Jiejie Deng Yan Zhao Peng Yang Jun Tang Huanling Wang Zhongpeng Zhao Zhinan Yin Bin Cao Xiliang Wang Chengyu Jiang | 2012 | Cell Research2012，22，3： | 22 |
| 15 | Generation of haploid embryonic stem cells from Macaca fascicularis monkey parthenotes显示文摘在从经由单性生殖和男性单性生殖的老鼠的胚胎的干细胞(haESCs ) 启用了在修改基因的动物的哺乳动物的房间和代的基因屏蔽的 haploid 的推导的最近的成功。然而, haESCs 是否能从首领被导出,仍然保持未知。这里,我们从 Macaca fascicularis 猴子的单性生殖的胚囊报导 haESCs 的推导。这些房间,作为 PG-haESCs 称为,是 pluripotent 并且能在 vitro 或在 vivo 区分到三胚胎的细菌层的房间。有趣地,一根猴子 PG-haESC 线(MPH1 ) 的 haploidy 与另一个(MPH2 ) 的相比是更稳定的,作为没有排序的激活荧光的房间(FACS ) ,由 haploid 房间的存在出现超过 140 天 haploid 房间的丰富。重要地,转基因的猴子 PG-haESC 线能被 lentivirus- 和 piggyBac 产生调停 transposon 的基因转移。而且,基因屏蔽在猴子 PG-haESCs 是可行的。我们的结果证明 PG-haESCs 能从猴子被产生,提供为在首领的基因分析的一个理想的工具。 | Hui Yang Zhen Liu Yu Ma Cuiqing Zhong Qi Yin Chikai Zhou Linyu Shi Yijun Cai Hanzhi Zhao Hui Wang Fan Tang Yan Wang Chenchen Zhang Xin-yuan Liu Dongmei Lai Ying Jin Qiang Sun Jinsong Li | 2013 | Cell Research2013，23，10： | 22 |
| 16 | Age-related rhesus macaque models of COVID-19显示文摘Background:Since December 2019,an outbreak of the Corona Virus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus(SARS-CoV-2)in Wuhan,China,has become a public health emergency of international concern.The high fatality of aged cases caused by SARS-CoV-2 was a need to explore the possible age-related phenomena with non-human primate models.Methods:Three 3-5 years old and two 15 years old rhesus macaques were intratracheally infected with SARS-CoV-2,and then analyzed by clinical signs,viral replication,chest X-ray,histopathological changes and immune response.Results:Viral replication of nasopharyngeal swabs,anal swabs and lung in old monkeys was more active than that in young monkeys for 14 days after SARS-CoV-2 challenge.Monkeys developed typical interstitial pneumonia characterized by thickened alveolar septum accompanied with inflammation and edema,notably,old monkeys exhibited diffuse severe interstitial pneumonia.Viral antigens were detected mainly in alveolar epithelial cells and macrophages.Conclusion:SARS-CoV-2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys.Rhesus macaque models infected with SARS-CoV-2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS-CoV-2 infection. | Pin Yu Feifei Qi Yanfeng Xu Fengdi Li Peipei Liu Jiayi Liu Linlin Bao Wei Deng Hong Gao Zhiguang Xiang Chong Xiao Qi Lv Shuran Gong Jiangning Liu Zhiqi Song Yajin Qu Jing Xue Qiang Wei Mingya Liu Guanpeng Wang Shunyi Wang Haisheng Yu Xing Liu Baoying Huang Wenling Wang Li Zhao Huijuan Wang Fei Ye Weimin Zhou Wei Zhen Jun Han Guizhen Wu Qi Jin Jianwei Wang Wenjie Tan Chuan Qin | 2020 | Animal Models and Experimental Medicine2020，3，1： | 22 |
| 17 | Semi-rigid thoracoscopy for undiagnosed exudative pleural effusions: a comparative study显示文摘背景 Thoracoscopy 为检测肋膜的流出高度敏感、精确。然而,很呼吸的医生不熟悉更普通的僵硬 thoracoscope 或灵活气管镜的使用,它是困难的在肋膜的洞以内操作。半硬的 thoracoscope 联合灵活、僵硬的仪器的最好的特征。因为有这台仪器的实践在中国是有限的,在为 undiagnosed exudative 的本地麻醉下面的半硬的 thoracoscopy (也就是医药的 thoracoscopy )的诊断用途肋膜的流出是在有 undiagnosed 的 50 个病人的 evaluated.Methods 肋膜的流出回顾地被学习,在2004年7月和2005年6月和剩余的之间的 23 收到的平淡的考试 27 个病人在2005年7月和2006年6月期间经历了医药 thoracoscopy 。肋膜的流出的平淡的考试包含了生物化学和细胞学,唾沫细胞学,和 thoracentesis。在诊断敏感的差别,与肋膜的液体检查和复杂并发症有关的费用在医药 thoracoscopy 揭示了的二 groups.Results 之间直接被比较在 6 个病人,的有结节的胸膜炎在 7 的腺癌,在 2 的有鳞房间的癌,在 3 的变形的癌,在 2 的间皮瘤, non-Hodgkin 在 1 的淋巴瘤,并且其它在 4 。仅仅 2 个病人不能变得明确诊断。医药 thoracoscopy 的诊断效率是 93%(25/27 ) 。仅仅 21% 病人在平淡的考试以后被诊断,包括在在 1 的 2 个病人,在 2 的肺癌症和未经决定的变形恶意的 parapneumonic 流出。有有结节的胸膜炎的 12 个病人被平淡的检查怀疑。与肋膜的流出测试有关的费用没显示出二个组(P=0.114 ) 之间的差别。在平淡的考试组的 23 个病人经历了 97 次 thoracentesis。二个肋膜的感染病人和 2 个气胸病人被鉴别并且接受抗菌素治疗和排水。医药 thoracoscopy 能被所有病人很好容忍。半硬的 thoracoscope 能被胸医生 casily 控制。最普通的复杂并发症从存在于的胸试管是短暂的胸疼痛(27 个病人中的 20 个) ,它将与常规止痛剂被管理。下的肺气肿的一个盒子和手术后的发烧的 2 个盒子是自我限制的。没有严重复杂并发症 occurred.Conclusions 医药 thoracoscopy 是一个简单、安全、划算的工具,与高积极的率。如果为医药 thoracoscopy 的设备是可得到的,医生们应该把它的存取递合适的病人。 | WANG Zhen TONG Zhao-hui LI Hong-jie ZHAO Ting-ting LI Xu-yan XU Li-li LUO Jing JIN Mu-lan LI Rui-sheng WANG Chen | 2008 | Chinese Medical Journal2008，，15： | 21 |
| 18 | Serum thymosin β4 levels in patients with hepatitis B virus-related liver failure显示文摘AIM:To investigate whether serum thymosinβ4 can provide diagnostic or prognostic information in liver failure patients caused by chronic hepatitis B virus(HBV) infection. METHODS:Serum thymosinβ4 levels were measured in 30 patients with acute-on-chronic liver failure(ACLF), 31 patients with chronic liver failure(CLF),30 patients with compensated liver cirrhosis(CR)and 32 patients with chronic hepatitis B and 30 healthy controls.Serum thymosinβ4 levels were measured by enzyme-linked immunosorbent assay and Child-Pugh and model for end-stage liver disease(MELD)scores were calculated for each patient on admission.RESULTS:Compared with healthy controls,serum thymosinβ4 levels in ACLF,CLF,CR and chronic hepatitis B patients were significantly lower,6.5047 (4.7879-10.5314)μg/mL vs 0.4632(0.2759-0.8768) μg/mL,0.6981(0.5209-1.2008)μg/mL,1.8053 (0.8110-2.3397)μg/mL,3.7803(1.8570-6.4722)μg/mL, respectively(P<0.001).The levels of thymosinβ4 in liver failure(ACLF or CLF)patients were markedly lower than that in CR(P<0.001),and a difference was also found between CLF and ACLF patients(P=0.038).In patients with chronic liver disease,there was a positive relationship between thymosinβ4 levels and albumin, choline esterase,and platelet(P<0.001),and negative relationship with alanine aminotransferase(P=0.020), aspartate aminotransferase,total bilirubin,international normalized ratio of prothrombin time,and Child-Pugh and MELD scores(P<0.001).Of the 61 liver failure patients,the thymosinβ4 levels of non-survivors were significantly lower than that of survivors(P=0.007). Receiver operating characteristics analysis identified a thymosinβ4 cutoff level of 0.5708μg/mL for predicting poor prognosis in all liver failure patients.The serial thymosinβ4 values were observed in 13 liver failure inpatients.Lower initial values were observed in the death.While greater improvement in thymosinβ4 value was found in those who recovered from the disease. CONCLUSION:Serum thymosinβ4 can be used as an important potential predictor for liver failure caused by chronic HBV infection. | Tao Han,Ying Liu,Huan Liu,Zheng-Yan Zhu,Yan Li,Shi-Xiang Xiao,Zhen Guo,Zhen-Gang Zhao,Department of Hepatology,Tianjin Institute of Hepatobiliary Disease,Tianjin Key Laboratory of Artificial Cells,Tianjin Third Central Hospital,Tianjin Medical University,83 Jintang Road,Tianjin 300170, China | 2010 | World Journal of Gastroenterology2010，16，5： | 20 |
| 19 | Dihydromyricetin protects neurons in an MPTPinduced model of Parkinson's disease by suppressing glycogen synthase kinase-3 beta activity显示文摘瞄准:它是相信的将军那个 mitochondrial 机能障碍和氧化应力在 Parkinsons 疾病(PD ) 的病理起关键作用。Dihydromyricetin (DHM ) ,从白蔹属 grossedentata 提取的自然 flavonoid,最近被发现得到有势力抗氧化效果。在现在的学习,我们在保护 dopaminergic neurons.Methods 探索了 DHM 的角色:男 C57BL/6 老鼠 intraperitoneally 与 1-methyl4-phenyl-1,2,3,6-tetrahydropyridine (MPTP ) 被注射让 7 d 导致 PD。另外,老鼠为 13 d 的一个总数与 5 或 10 mg/kg DHM 被对待(在 MPTP 的开始前的 3 d,在 MPTP 管理(7 d ) 和在 MPTP 的结束以后的 3 d 期间) 。为盐或 DHM 独自一个的处理组,老鼠被注射与盐或为 13 d 的 DHM。在 d 上 14,行为的测试(运动活动, rotarod 测试和杆测试) 被管理。在行为的测试以后,老鼠被牺牲,并且大脑织物为 immunofluorescence 染色并且西方的弄污是镇定的。另外, MES23.5 细胞与 MPP + 和 DHM 被对待,并且评估了使用细胞生存能力试金,反应的氧种(ROS ) 大小, apoptosis 分析和西方的 blotting.Results:DHM 显著地稀释了导致 MPTP 的老鼠行为的缺陷和 dopaminergic 神经原损失。在 MES23.5 房间, DHM 以一种剂量依赖者方式稀释了 MPP +-induced 房间损害和 ROS 生产。另外, DHM 在一个剂量依赖者和时间依赖者举止增加了肝糖 synthase kinase-3 贝它 phosphorylation,它可以与导致 DHM 的 dopaminergic neuronal protection.Conclusion 被联系:现在的学习证明 DHM 是为由 modulating 的 DA 神经原的一个有势力 neuroprotective 代理人 Akt/GSK-3β小径,它建议那 DHM 可以是 PD 的一个有希望的治疗学的候选人。 | Zhao-xiang REN Ya-fei ZHAO Ting CAO Xue-chu ZHEN | 2016 | Acta Pharmacologica Sinica2016，37，10： | 19 |
| 20 | Comparison of Undernutrition Prevalence of Children under 5 Years in China between 2002 and 2013显示文摘Objective To describe the undernutrition status of children under 5-year in China, and study the trend between 2002 and 2013. Methods The study was based on two national surveys. Undernutrition was determined against WHO's 2006 growth standards. The prevalence in 2013 and 2002 was weighted by China sixth National Population Census(2010). The relationship between undernutrition and gender/age groups/different areas use weighted logistic regression. Results The results indicated the overall prevalence of stunting, underweight, and wasting of Chinese children under 5-year was 8.1%, 2.4%, and 1.9% in 2013, respectively. The prevalence of stunting was higher for children aged 12-47 month, while underweight was higher for children aged 48-59 month. The prevalence of undernutrition was higher in rural areas than in urban areas, especially in poor rural areas. There was a decline of stunting, underweight, and wasting between 2002 and 2013 among the children, with greater reduction in rural areas than in urban areas. Conclusion The prevalence of undernutrition of children under 5-year remains high in rural areas especially in poor rural areas in China. It is urgent to take action to control undernutrition in the vulnerable areas and subgroups. | YU Dong Mei ZHAO Li Yun YANG Zhen Yu CHANG Su Ying YU Wen Tao FANG Hong Yun WANG Xun YU Dan GUO Qi Ya XU Xiao Li FANG Yue Hui ZHAO Wen Hua YANG Xiao Guang DING Gang Qiang LIANG Xiao Feng | 2016 | Biomedical and Environmental Sciences2016，29，3： | 18 |
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