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| 1 | Spatio-temporal framework of tectonic uplift stages of the Tibetan Plateau in Cenozoic显示文摘Four intensive uplift periods, i.e., 60–35, 25–17 and 12–8 Ma (but 18–13 Ma in the Himalayas of the southern Tibet), and since about 5 Ma, can be determined on the Tibetan Plateau by synthetical analysis of low-temperature thermo-chronology data, sedimentary deposit records, and structural deformation records of different areas. The strong tectonic uplift periods in different areas on the Tibetan Plateau are penecontemporaneous, except for the Himalayan area of the southern Tibet, where a rapid uplift and exhumation period, controlled by the activity of the South Tibetan Detachment System faults, occurred during 18–13 Ma. These strong uplift and exhumation periods correspond well to intensive deformation activity periods, suggesting tectonically-controlled uplift and exhumation. The deposit records, such as the distribution of coarse clastic sediments, the distribution of tectonically-controlled basins, stratigraphic discontinuousness or unconformity, and fault-controlled geomorphologic evolution, also match well with the strong uplift and exhumation periods. Expanding processes of the plateau are also discussed. | WANG GuoCan CAO Kai ZHANG KeXin WANG An LIU Chao MENG YanNing XU YaDong | 2011 | Science China Earth Sciences2011，54，1： | 49 |
| 2 | Cenozoic sedimentary records and geochronological constraints of differential uplift of the Qinghai-Tibet Plateau显示文摘Geological mapping data (1:250000) in the Qinghai-Tibet Plateau and its adjacent regions reveal the sediment sequences, distribution and tectonic evolution of the 92 Tertiary remnant basins. Southern Tibet and the Yecheng area in Xinjiang, located at southern and northwestern margins of the Qinghai-Tibet Plateau, respectively, were parts of the Neo-Tethys remnant sea in the Paleogene. In southern Tibet, both the subabyssal and abyssal sequences occur at the Gyangze, Saga, Guoyala, and Sangmai areas. The deep-water facies successions outcrop in the west, whereas the shallow-water facies sequences in the east, indicating the east to the west retreat of the Neo-Tethys Ocean. The retreat of the Neo-Tethys Ocean in the east was contributed to the earlier tectonic uplift of the eastern Qinghai-Tibet Plateau. The uplift process of the Plateau from the Late Cretaceous to Pliocene is described as follows: During the Late Cretaceous, tectonic uplift of the Qinghai-Tibet Plateau occurred in the northeastern part and the configuration of the Qinghai-Tibet Plateau was characterized by rise in the northeast and depression in the west. In the Paleocene-Eocene interval, the Tengchong-Baingoin and Kuyake-Golmud areas experienced local tectonic uplifting, the West Kunlun uplift zone broadened easterly, the Qilian uplift zone broadened southerly, and the Songpan-Garzê uplift zone shrank easterly. The Oligocene configuration of the Qinghai-Tibet Plateau was characterized by mountain chains rising along its margins and sedimentary basins in the central part because of tectonic uplifts of the Gangdisê and the Himalaya blocks. Meanwhile, the Kunlun-Altyn-Qilian uplift zones have also broadened southerly and northerly. In contrast, the great uplift zones of the Gangdisê, the Himalaya, the Karakorum, and the Kunlun blocks characterize the paleogeographic contours of the Qinghai-Tibet Plateau during the Miocene-Pliocene. Additionally, the thermochronological data on tectonic uplift events in southern Tibet, West Kunlun Mountains, Altyn Tagh, eastern Tibet, and western Sichuan all suggest that the most intense deformation occurred at 13-8 Ma and since 5 Ma, respectively, corresponding to two great uplift periods in Neogene. As a result, turnover of paleogeographic configuration of the Qinghai-Tibet Plateau occurred during the Neogene, experiencing a change from high contours in the east in the pre-Oligocene to high contours in the west at the end-Pliocene. The uplift of the Qinghai-Tibet Plateau during the Cenozoic was episodic, and the uplifts of various blocks within the Plateau were spatially and chronologically different. | ZHANG KeXin WANG GuoCan CAO Kai LIU Chao XIANG ShuYuan HONG HanLie KOU XiaoHu XU YaDong CHEN FenNing MENG YanNing CHEN RuiMing | 2008 | Science China Earth Sciences2008，51，11： | 31 |
| 3 | Annual cost of illness of stomach and esophageal cancer patientsin urban and rural areas in China: A multi-center study显示文摘Objective: Stomach and esophageal cancer are imposing huge threats to the health of Chinese people whereas there were few studies on the financial burden of the two cancers.Methods: Costs per hospitalization of all patients with stomach or esophageal cancer discharged between September 2015 and August 2016 in seven cities/counties in China were collected, together with their demographic information and clinical details. Former patients in the same hospitals were sampled to collect information on annual direct non-medical cost, indirect costs and annual number of hospitalization. Annual direct medical cost was obtained by multiplying cost per hospitalization by annual number of hospitalization. Annual cost of illness(ACI)was obtained by adding the average value of annual direct medical cost, direct non-medical cost and indirect cost,stratified by sex, age, clinical stage, therapy and pathologic type in urban and rural areas. Costs per hospitalization were itemized into eight parts to calculate the proportion of each part. All costs were converted to 2016 US dollars(1 USD=6.6423 RMB).Results: Totally 19,986 cases were included, predominately male. Mean ages of stomach cancer and urban patients were lower than that of esophageal cancer and rural patients. ACI of stomach and esophageal cancer patients were $10,449 and $13,029 in urban areas, and $2,927 and $3,504 in rural areas, respectively. Greater ACI was associated with male, non-elderly patients as well as those who were in stage I and underwent surgeries.Western medicine fee took the largest proportion of cost per hospitalization.Conclusions: The ACI of stomach and esophageal cancer was tremendous and varied substantially among the population in China. Preferential policies of medical insurance should be designed to tackle with this burden and further reduce the health care inequalities. | Zhixun Yang Hongmei Zeng Ruyi Xia Qian Liu Kexin Sun Rongshou Zheng Siwei Zhang Changfa Xia He Li Shuzheng Liu Zhiyi Zhang Yuqin Liu Guizhou Guo Guohui Song Yigong Zhu Xianghong Wu Bingbing Song Xianzhen Liao Yanfang Chen Wenqiang Wei Guihua Zhuang Wanqing Chen | 2018 | Chinese Journal of Cancer Research2018，30，4： | 22 |
| 4 | Late Caledonian Ductile Thrusting Deformation in the Central East Kunlun Belt, Qinghai, China and Its Significance: Evidence from Geochronology显示文摘A high-angle ductile thrusting deformation with top-to-the-north movement penetratively developed in the Proterozoic-Early Paleozoic metamorphic rocks along the Central East Kunlun beR. The deformed rocks suffered epidote-amphibolite facies metamorphism. On the basis of our previous study, we present more data in this paper to further support that the ductile thrust deformation occurred in the later Caledonian and more detailed information about the deformation.A zircon U-Pb concordant age of 446±2.2 Ma of a deformed granodiorite in the ductile thrust zone was obtained and can be interpreted as the lower limit of the deformation. A syntectonically crystallized and also strongly deformed hornblende Ar/Ar dating gives an Ar/Ar plateau age of 426.5±3.8 Ma, which represents the deformation age. A strongly orientated muscovite gives an Ar/Ar plateau age of 408±1.6Ma, representing the cooling age after the peak temperature, constraining the upper limit of the ductile thrust deformation. This ductile thrust deformation can be interpreted as the result of the closing of the Central East Kunlun archipelago ocean. To the north, At/At plateau ages of 382.9±0.2 Ma and 386.8±0.8 Ma of muscovite in the deformed Xiaomiao Group represent the uplift cooling ages of deeper rocks after the thrusting movement. The original thrusting foliation has a low angle. A rotation model was put forward to explain the development of the foliation from the original low-angle to present high-angle dipping. | WANG Guocan, CHEN Nengsong, ZHU Yunhai and ZHANG Kexin Faculty of Earth Sciences, China University of Geosciences, Wuhan, Hubei 430074 E-mail: wgcan@cug.edu.cn Ren Xifei, Liu Ruixun and Xie Guanglian | 2003 | Acta Geologica Sinica(English Edition)2003，77，3： | 18 |
| 5 | Finite-time adaptive consensus of a class of multi-agent systems显示文摘Multi-agent systems(MASs) are ubiquitous in natural and artificial systems. This paper aims to establish the finite-time adaptive consensus criterion for a class of MASs with nonlinear dynamics. Traditionally, the finite-time consensus criterion is often established based on the prior information on Lipschitz constants and the eigenvalues of Laplacian matrix. However, it is difficult to acquire the above prior information for most real-world engineering systems. To overcome the above difficulty, this paper develops the finite-time consensus criteria for a class of MASs with nonlinear dynamics via adaptive technique. In detail, we design the finite-time distributed node-based and edge-based adaptive consensus protocols for a class of MASs with fixed and switching topologies. Numerical simulations are also given to validate the proposed finite-time adaptive consensus criterion. | LIU KeXin WU LuLu Lü JinHu ZHU HengHui | 2016 | Science China(Technological Sciences)2016，59，1： | 16 |
| 6 | Prostate cancer in Asia:A collaborative report显示文摘The incidence of prostate cancer(PCa)within Asian population used to be much lower than in the Western population;however,in recent years the incidence and mortality rate of PCa in some Asian countries have grown rapidly.This collaborative report summarized the latest epidemiology information,risk factors,and racial differences in PCa diagnosis,current status and new trends in surgery management and novel agents for castration-resistant prostate cancer.We believe such information would be helpful in clinical decision making for urologists and oncologists,health-care ministries and medical researchers. | Rui Chen Shancheng Ren 无 Ming Kwong Yiu Ng Chi Fai Wai Sam Cheng Lap Hong Ian Seiji Naito Tadashi Matsuda Elijah Kehinde Ali Kural Jason Yichun Chiu Rainy Umbas Qiang Wei Xiaolei Shi Liqun Zhou Jian Huang Yiran Huang Liping Xie Lulin Ma Changjun Yin Danfeng Xu Kexin Xu Zhangqun Ye Chunxiao Liu Dingwei Ye Xin Gao Qiang Fu Jianquan Hou Jianlin Yuan Dalin He Tiejun Pan Qiang Ding Fengshuo Jin Benkang Shi Gongxian Wang Xiuheng Liu Dongwen Wang Zhoujun Shen Xiangbo Kong Wanhai Xu Yaoliang Deng Haibo Xia Alexa NCohen Xu Gao Chuanliang Xu Yinghao Sun | 2014 | Asian Journal of Urology2014，1，1： | 13 |
| 7 | Interpretation of breast cancer screening guideline for Chinese women显示文摘Breast cancer is the most common malignant tumor in Chinese women.Early screening is the best way to improve the rates of early diagnosis and survival of breast cancer patients.The peak onset age for breast cancer in Chinese women is considerably younger than those in European and American women.It is imperative to develop breast cancer screening guideline that is suitable for Chinese women.By summarizing the current evidence on breast cancer screening in Chinese women,and referring to the latest guidelines and consensus on breast cancer screening in Europe,the United States,and East Asia,the China Anti-Cancer Association and National Clinical Research Center for Cancer(Tianjin Medical University Cancer Institute and Hospital)have formulated population-based guideline for breast cancer screening in Chinese women.The guideline provides recommendations on breast cancer screening for Chinese women at average or high risk of breast cancer according to the following three aspects:age of screening,screening methods,and screening interval.This article provides more detailed information to support the recommendations in this guideline and to provide more direction for current breast cancer screening practices in China. | Yubei Huang Zhongsheng Tong Kexin Chen Ying Wang Peifang Liu Lin Gu Juntian Liu Jinpu Yu Fengju Song Wenhua Zhao Yehui Shi Hui Li Huaiyuan Xiao Xishan Hao | 2019 | Cancer Biology & Medicine2019，16，4： | 10 |
| 8 | Percent free prostate-specific antigen for prostate cancer diagnosis in Chinese men with a PSA of 4.0-10.0 ng/mL:Results from the Chinese Prostate Cancer Consortium显示文摘Objective:To test the diagnostic performance of percent free prostate-specific antigen(%fPSA)in predicting any prostate cancer(PCa)and high-grade prostate cancer(HGPCa)in a retrospective multi-center biopsy cohort with a PSA level of 4.0e10.0 ng/mL in China.Methods:Consecutive patients with a PSA of 4.0-10.0 ng/mL who underwent transrectal ultrasound-guided biopsy were enrolled at 16 Chinese medical centers from January 1st,2010 to December 31st,2013.Total and free serum PSA determinations were performed using three types of electro-chemiluminescence immunoassays recalibrated to the World Health Organization(WHO)standard.The diagnostic accuracy of PSA,%fPSA,and %fPSA in combination with PSA(%fPSA t PSA)was determined using the area under the receiver operating characteristic(ROC)curve(AUC).Results:A total of 2310 consecutive men with PSA levels between 4.0 and 10.0 ng/mL were included,and the detection rate of PCa was 25.1%.The AUC of%fPSA and %fPSA t PSA in predicting any PCa was superior to PSA alone in men aged≥60 years(0.623 vs.0.534,p<0.0001)but not in men aged 40e59 years(0.517 vs.0.518,p=0.939).Similar result was yield in predicting HGPCa.Conclusion:In a clinical setting of Chinese men with 4.0e10.0 ng/mL PSA undergoing initial prostate biopsy,adding %fPSA to PSA can moderately improve the diagnostic accuracy for any PCa and HGPCa compared with PSA alone in patients≥60 but not in patients aged 40-59 years. | Rui Chen Liping Xie Xiaobing Cai Yiran Huang Liqun Zhou Lulin Ma Xu Gao Chuanliang Xu Shancheng Ren Pengfei Shao Danfeng Xu Kexin Xu Zhangqun Ye Chunxiao Liu Dingwei Ye Li Lu Qiang Fu Jianquan Hou Jianlin Yuan Dalin He Tie Zhou Fubo Wang Biming He Yinghao Sun | 2015 | Asian Journal of Urology2015，2，2： | 8 |
| 9 | Application of deep learning in ecological resource research:Theories, methods, and challenges显示文摘Ecological resources are an important material foundation for the survival,development,and self-realization of human beings.In-depth and comprehensive research and understanding of ecological resources are beneficial for the sustainable development of human society.Advances in observation technology have improved the ability to acquire long-term,cross-scale,massive,heterogeneous,and multi-source data.Ecological resource research is entering a new era driven by big data.Traditional statistical learning and machine learning algorithms have problems with saturation in dealing with big data.Deep learning is a method for automatically extracting complex high-dimensional nonlinear features,which is increasingly used for scientific and industrial data processing because of its ability to avoid saturation with big data.To promote the application of deep learning in the field of ecological resource research,here,we first introduce the relationship between deep learning theory and research on ecological resources,common tools,and datasets.Second,applications of deep learning in classification and recognition,detection and localization,semantic segmentation,instance segmentation,and graph neural network in typical spatial discrete data are presented through three cases:species classification,crop breeding,and vegetation mapping.Finally,challenges and opportunities for the application of deep learning in ecological resource research in the era of big data are summarized by considering the characteristics of ecological resource data and the development status of deep learning.It is anticipated that the cooperation and training of cross-disciplinary talents may promote the standardization and sharing of ecological resource data,improve the universality and interpretability of algorithms,and enrich applications with the development of hardware. | Qinghua GUO Shichao JIN Min LI Qiuli YANG Kexin XU Yuanzhen JU Jing ZHANG Jing XUAN Jin LIU Yanjun SU Qiang XU Yu LIU | 2020 | Science China Earth Sciences2020，63，10： | 7 |
| 10 | Crystalline boron nitride nanosheets by sonication-assisted hydrothermal exfoliation显示文摘A simple method to prepare two-dimensional hexagonal boron nitride(h-BN) scalably is essential for practical applications. Despite intense research in this area, high-yield production of two-dimensional h-BN with large size and high crystallinity is still a key challenge. In the present work, we propose a simple exfoliation process for boron nitride nanosheets(BNNSs) with high crystallinity by sonication-assisted hydrothermal method, via the synergistic effect of the high pressure, and cavitation of the sonication. Compared with the method only by sonication, the sonication-assisted hydrothermal method can get the fewer-layer BNNSs with high crystallinity.Meanwhile, it can reach higher yield of nearly 1.68%, as the hydrothermal method with the yield of only 0.12%. The simple sonication-assisted hydrothermal method has potential applications in exfoliating other layered materials, thus opening new ways to produce other layered materials in high yield and high crystallinity. | Zhaobo TIAN Kexin CHEN Siyuan SUN Jie ZHANG Wei CUI Zhipeng XIE Guanghua LIU | 2019 | Journal of Advanced Ceramics2019，8，1： | 7 |
| 11 | Regional Δ~14C patterns and fossil fuel derived CO_2 distribution in the Beijing area using annual plants显示文摘The level of atmosphericΔ14C and the fossil fuel derived CO 2 concentration in the Beijing area from May to September,2009, were systematically analyzed based on radiocarbon(14C)measurements of annual plants by accelerator mass spectrometry(AMS). The results show that the maximumΔ14C in Beijing was 29.6‰±2.2‰,and the minimum was–28.2‰±2.5‰,with a trend of decreasingΔ14C from the outer suburbs to inner suburbs to the urban center.This trend correlates well with increases in fossil fuel derived CO2 caused by human activities such as population density,industrial emissions and traffic,with lower values of atmosphericΔ14C associated with more intensive human activities.The fossil fuel derived CO 2 concentrations from May to September, 2009,ranged from 3.9±1.0 ppm to 25.4±1.0 ppm.It was calculated that each additional 1 ppm of CO2 from fossil fuels depleted the atmosphericΔ14C by approximately 2.70‰.This study suggests that 14C measurements of annual plants by AMS provide an effective method to rapidly trace fossil fuel derived CO2. | XI XianTing DING XingFang FU DongPo ZHOU LiPing LIU KeXin | 2011 | Chinese Science Bulletin2011，56，16： | 7 |
| 12 | Methods of computed tomography screening and management of lung cancer in Tianjin: design of a population-based cohort study显示文摘Objective: European lung cancer screening studies using computed tomography(CT) have shown that a management protocol based on measuring lung nodule volume and volume doubling time(VDT) is more specific for early lung cancer detection than a diameter-based protocol. However, whether this also applies to a Chinese population is unclear. The aim of this study is to compare the diagnostic performance of a volume-based protocol with a diameter-based protocol for lung cancer detection and optimize the nodule management criteria for a Chinese population.Methods: This study has a population-based, prospective cohort design and includes 4000 participants from the Hexi district of Tianjin, China. Participants will undergo low-dose chest CT at baseline and after 1 year. Initially, detected lung nodules will be evaluated for diameter and managed according to a routine diameter-based protocol(Clinical Practice Guideline in Oncology for Lung Cancer Screening, Version 2.2018). Subsequently, lung nodules will be evaluated for volume and management will be simulated according to a volume-based protocol and VDT(a European lung nodule management protocol). Participants will be followed up for 4 years to evaluate lung cancer incidence and mortality. The primary outcome is the diagnostic performance of the European volume-based protocol compared to diameter-based management regarding lung nodules detected using low-dose CT.Results: The diagnostic performance of volume-and diameter-based management for lung nodules in a Chinese population will be estimated and compared.Conclusions: Through the study, we expect to improve the management of lung nodules and early detection of lung cancer in Chinese populations. | Yihui Du Yingru Zhao Grigory Sidorenkov Geertruida H.de Bock Xiaonan Cui Yubei Huang Monique D.Dorrius Mieneke Rook Harry J.M.Groen Marjolein A.Heuvelmans Rozemarijn Vliegenthart Kexin Chen Xueqian Xie Shiyuan Liu Matthijs Oudkerk Zhaoxiang Ye | 2019 | Cancer Biology & Medicine2019，16，1： | 7 |
| 13 | Characteristics of microfauna and their relationships with the performance of an activated sludge plant in China显示文摘微动物志组织的出现和许多与在中国的 Baoding Lugang 污水处理工厂的物理化学、运作的参数相比。属于并且爬行纤毛虫类是纤毛虫类的主导的组。爬行纤毛虫类和留有遗嘱的阿米巴与自河 BOD5 (生物化学的氧需求) 显示出一个强壮的协会。因此,自从他们的数字减少了,当这个过程生产了差的优秀自河,这二个组是可能的是有用简历指示物。留有遗嘱的阿米巴也有重要负相关与自河 TN (总氮) , NH4+-N, SS (推迟的固体) 和 SVI (污泥容量的索引) ,它意味着这组纤毛虫类可以是活性污泥系统的好性能的指示物。食肉的纤毛虫类和 flagellates 与 SVI 有重要正相关,建议这二个组可以是污泥的坏解决条件的指示物。因为微动物志种类的鉴定困难、费时间,我们用微动物志建议功能的组评估活性污泥系统的性能。 | ZHOU Kexin XU Muqi LIU Biao CAO Hong | 2008 | Journal of Environmental Sciences2008，20，4： | 5 |
| 14 | Cilastatin protects against imipenem-induced nephrotoxicity via inhibition of renal organic anion transporters(OATs)显示文摘Imipenem is a carbapenem antibiotic. However, Imipenem could not be marketed owing to its instability and nephrotoxicity until cilastatin, an inhibitor of renal dehydropeptidase-I(DHP-I),was developed. In present study, the potential roles of renal organic anion transporters(OATs) in alleviating the nephrotoxicity of imipenem by cilastatin were investigated in vitro and in rabbits. Our results indicated that imipenem and cilastatin were substrates of h OAT1 and h OAT3. Cilastatin inhibited h OAT1/3-mediated transport of imipenem with IC50 values comparable to the clinical concentration, suggesting the potential to cause a clinical drug–drug interaction(DDI). Moreover,imipenem exhibited h OAT1/3-dependent cytotoxicity, which was alleviated by cilastatin and probenecid. Furthermore, cilastatin and probenecid ameliorated imipenem-induced rabbit acute kidney injury, and reduced the renal secretion of imipenem. Cilastatin and probenecid inhibited intracellular accumulation of imipenem and sequentially decreased the nephrocyte toxicity in rabbit primary proximal tubule cells. Renal OATs, besides DHP-I, was also the target of interaction between imipenem and cilastatin, and contributed to the nephrotoxicity of imipenem. This therefore gives in part the explanation about the mechanism by which cilastatin protected against imipenem-induced nephrotoxicity. Thus, OATs can potentially be used as a therapeutic target to avoid the renal adverse reaction of imipenem in clinic. | Xiaokui Huo Qiang Meng Changyuan Wang Yanna Zhu Zhihao Liu Xiaodong Ma Xiaochi Ma Jinyong Peng Huijun Sun Kexin Liu | 2019 | Acta Pharmaceutica Sinica B2019，9，5： | 5 |
| 15 | ^(10)Be/~7Be implies the contribution of stratosphere-troposphere transport to the winter-spring surface O_3 variation observed on the Tibetan Plateau显示文摘10Be/7Be is a stratospheric sensitive tracer.In this paper,measurements of 10Be/7Be and surface O3 from October 2005 to May 2006 at Mt.Waliguan (hereafter WLG,100.898°E,39.287°N,3810 m,a.s.l.),China global atmospheric watch (GAW) observatory,are introduced and used to investigate the stratosphere-troposphere transport (STT) and its impact on surface O3 on the Tibetan Plateau.The results show that the magnitude of STT is weak in winter,followed by strengthening from the end of winter to the middle of spring (from mid February to mid April) with large increases in 10Be,7Be,10Be/7Be and surface O3.At the end of spring (from the end of April to mid May in this paper),the STT weakened,and the continuous increase of surface O3 at WLG is produced by tropospheric photochemistry reactions. | ZHENG XiangDong SHEN ChengDe WAN GuoJiang LIU KeXin TANG Jie XU XiaoBin | 2011 | Chinese Science Bulletin2011，56，1： | 5 |
| 16 | Paleoenvironmental implications of high-density records in Co-rich seamount crusts from the Pacific Ocean显示文摘Co-rich seamount crusts have been shown to possess great potential for providing information on paleoceanographic and paleoclimatic changes. High resolution data are essential to decipher and correctly understand such high-density records. With the development of modern microprobe techniques, detailed sampling of crusts can be performed and it is possible to retrieve detailed information about envi- ronmental changes recorded in the seamount crusts. We report here geochemical results of more than 40 elements (including all rare earth elements) of four Co-rich seamount crust samples, which were collected from seamounts in the central and western Pacific Ocean. These data were obtained with two micro-probe techniques: Electron Probe Micro Analyzer and Laser Ablation Inductively Coupled Plasma Mass Spectrometry. The chronological framework of the seamount crust samples was determined using the cos- mogenic 10Be and the Co-chronometer. Records of elemental composition, P, and Al/(Fe + Mn) and Y/Ho ratios across the sections of the four samples are used to identify paleoceanographic and paleoclimatic events over the past ~30 Ma. These data show that: (1) Al/(Fe + Mn) in the western Pacific seamount crust is a useful proxy for the assessment of changes of source materials related to the variability of the Asian monsoon; (2) P and Y/Ho can be used as proxies to infer biogenic episodes. Finally we discuss the methodology related to dating and micro-probe analysis used in crust study. | WANG XiaoHong ZHOU LiPing WANG YiMin ZHANG XueHua LIU XiaoMing FAN XingTao LIU KeXin ZHOU JianXiong | 2008 | Science China Earth Sciences2008，51，10： | 5 |
| 17 | Nanomedicine for acute respiratory distress syndrome: The latest application, targeting strategy, and rational design显示文摘Acute respiratory distress syndrome(ARDS)is characterized by the severe inflammation and destruction of the lung aireblood barrier,leading to irreversible and substantial respiratory function damage.Patients with coronavirus disease 2019(COVID-19)have been encountered with a high risk of ARDS,underscoring the urgency for exploiting effective therapy.However,proper medications for ARDS are still lacking due to poor pharmacokinetics,non-specific side effects,inability to surmount pulmonary barrier,and inadequate management of heterogeneity.The increased lung permeability in the pathological environment of ARDS may contribute to nanoparticle-mediated passive targeting delivery.Nanomedicine has demonstrated unique advantages in solving the dilemma of ARDS drug therapy,which can address the shortcomings and limitations of traditional anti-inflammatory or antioxidant drug treatment.Through passive,active,or physicochemical targeting,nanocarriers can interact with lung epithelium/endothelium and inflammatory cells to reverse abnormal changes and restore homeostasis of the pulmonary environment,thereby showing good therapeutic activity and reduced toxicity.This article reviews the latest applications of nanomedicine in pre-clinical ARDS therapy,highlights the strategies for targeted treatment of lung inflammation,presents the innovative drug delivery systems,and provides inspiration for strengthening the therapeutic effect of nanomedicine-based treatment. | Qi Qiao Xiong Liu Ting Yang Kexin Cui Li Kong Conglian Yang Zhiping Zhang | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 5 |
| 18 | Cenozoic Environmental Changes in the Northern Qaidam Basin Inferred from n-alkane Records显示文摘Cenozoic climatic and environmental changes in the arid Asian interior, and their possible relations with global climatic changes and the Tibetan Plateau uplift, have been intensively investigated and debated over past decades. Here we present 40-Myr(million years)-long n-alkane records from a continuous Cenozoic sediment sequence in the Dahonggou Section, Qaidam Basin, northern Tibetan Plateau, to infer environmental changes in the northern basin. A set of n-alkane indexes, including ACL, CPI and Paq, vary substantially and consistently throughout the records, which are interpreted to reflect relative contributions from terrestrial vascular plants vs. aquatic macrophytes, and thus indicate depositional environments. ACL values vary between 21 and 30; CPI values range from 1.0 to 8.0; and Paq values change from <0.1 to 0.8 over the past 40-Myr. We have roughly identified two periods, at 25.8–21.0 Ma(million years ago) and 13.0–17.5 Ma, with higher ACL and CPI and lower Paq values indicating predominant lacustrine environments. Lower ACL and CPI values, together with higher Paq values, occurred at >25.8 Ma, 17.5–21.0 Ma, and <13.0 Ma, corresponding to alluvial fan/river deltaic deposits and shallow lacustrine settings, consistent with the observed features in sedimentological facies. The inferred Cenozoic environmental changes in the northern Qaidam Basin appear to correspond to global climatic changes. | LIU Zhonghui ZHANG Kexin SUN Yuanyuan LIU Weiguo LIU Yusheng(Christopher) QUAN Cheng | 2014 | Acta Geologica Sinica(English Edition)2014，88，5： | 4 |
| 19 | Carbon isotopic composition and its implications on paleoclimate of the underground ancient forest ecosystem in Sihui,Guangdong显示文摘We present the carbon isotopic composition of the total organic carbon(TOC) and fine roots in the sedimentary profile from the underground ancient forest in Sihui to study the climatic and environmental changes from 4.5 ka BP to 0.6 ka BP.Results show that C3 plant was the main vegetation from 4.5 ka BP to 0.6 ka BP in this region.The ancient forest began to develop in the wetland at around 4 ka BP and disappeared together with the wetland at about 3.0 ka BP,implying that the climate had changed greatly at around 3.0 ka BP.As indicated by the simulation results,the content of atmospheric CO2 increased slightly during 3.5 ka BP and 3.0 ka BP,implying climate warming during that period.The interval of radiocarbon age between 3.0 ka BP and 1.2 ka BP was possibly caused by the strong erosion when the block was lifted in the neotectonic movement.From 1.2 ka BP to 0.6 ka BP,the region remained in terrestrial sedimentary environment,and the surface plant biomass declined gradually.Drought caused by the climate change was the likely cause for the disappearance of the ancient forest.South transition of Intertropical Convergence Zone(ITCZ) was probably the main mechanism for the climate change. | Ping Ding ChengDe Shen Ning Wang WeiXi Yi KeXin Liu XingFang Ding DongPo Fu | 2009 | Science China Earth Sciences2009，52，5： | 4 |
| 20 | Ionic liquids for high performance lithium metal batteries显示文摘The pursuit of high energy density has promoted the development of high-performance lithium metal batteries.However,it faces a serious security problem.Ionic liquids have attracted great attention due to their high ionic conductivity,non-flammability,and the properties of promoting the formation of stable SEI films.Deeply understanding the problems existing in lithium metal batteries and the role of ionic liquids in them is of great significance for improving the performance of lithium metal batteries.This article reviews the effects of the molecular structure of ionic liquids on ionic conductivity,Li^(+)ion transference number,electrochemical stability window,and lithium metal anode/electrolyte interface,as well as the application of ionic liquids in Li-high voltage cathode batteries,Li-O_(2) batteries and Li-S batteries.The molecular design,composition and polymerization will be the main strategies for the future development of ionic liquid-based electrolytes for high performance lithium metal battery. | Kexin Liu Zhuyi Wang Liyi Shi Siriporn Jungsuttiwong Shuai Yuan | 2021 | Journal of Energy Chemistry2021，30，8： | 4 |
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