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| 1 | A restoration-promoting integrated floating bed and its experimental performance in eutrophication remediation显示文摘Numerous studies on eutrophication remediation have mainly focused on purifying water first, then restoring submerged macrophytes. A restoration-promoting integrated floating bed(RPIFB) was designed to combine the processes of water purification and macrophyte restoration simultaneously. Two outdoor experiments were conducted to evaluate the ecological functions of the RPIFB. Trial 1 was conducted to compare the eutrophication purification among floating bed, gradual-submerging bed(GSB) and RPIFB technologies. The results illustrated that RPIFB has the best purification capacity. Removal efficiencies of RPIFB for TN, TP, NH+ 4-N, NO-3-N, CODCr, Chlorophyll-a and turbidity were 74.45%, 98.31%, 74.71%, 88.81%, 71.42%, 90.17% and 85%, respectively. In trial 2, influences of depth of GSB and photic area in RPIFB on biota were investigated. When the depth of GSB decreased and the photic area of RPIFB grew, the height of Potamogeton crispus Linn. increased, but the biomass of Canna indica Linn. was reduced. The mortalities of Misgurnus anguillicaudatus and Bellamya aeruginosa in each group were all less than 7%. All results indicated that when the RPIFB was embedded into the eutrophic water, the regime shift from phytoplankton-dominated to macrophyte-dominated state could be promoted. Thus, the RPIFB is a promising remediation technology for eutrophication and submerged macrophyte restoration. | Yiming Guo Yunguo Liu Guangming Zeng Xinjiang Hu Xin Li Dawei Huang Yunqin Liu Yicheng Yin | 2014 | Journal of Environmental Sciences2014，26，5： | 18 |
| 2 | The acidic tumor microenvironment: a target for smart cancer nano-theranostics显示文摘The acidic tumor microenvironment(TME), which mainly results from the high glycolytic rate of tumor cells, has been characterized as a hallmark of solid tumors and found to be a pivotal factor participating in tumor progression. Recently, due to the increasing understanding of the acidic TME, it has been shown that the acidic TME could be utilized as a multifaceted target during the design of various pH-responsive nanoscale theranostic platforms for the precise diagnosis and effective treatment of cancers. In this article,we will give a focused overview on the latest progress in utilizing this characteristic acidic TME as the target of nano-theranostics to enable cancer-specific imaging and therapy. The future perspectives in the development of acidic TME-targeting nanomedicine strategies will be discussed afterwards. | Liangzhu Feng Ziliang Dong Danlei Tao Yicheng Zhang Zhuang Liu | 2018 | National Science Review2018，5，2： | 14 |
| 3 | Rat model of cholelithiasis with human gallstones implanted in cholestasis-induced virtual gallbladder显示文摘AIM:To facilitate translational research on cholelithiasis,we have developed a rat model of human gallstones by exploiting the unique biliopancreatic features of this species.METHODS:Under anesthesia,16 adult rats of equal genders underwent two times of abdominal surgery.First,their common bile duct(CBD)was ligated to cause cholestasis by total biliary obstruction(TBO).On day 0,1,3,7,14,21 and 28 after TBO,magnetic resonance imaging(MRI)was conducted to monitor the dilatation of the CBD,and blood was sampled to analyze total serum bilirubin(TSB).Secondly,on day 30,the abdomen was re-opened and gallstone(s)collected from human patients were implanted in the dilated CBD asa virtual gallbladder(VGB),which was closed by suture ligation.This rat cholelithiasis model was examined by MRI,clinical observation,microcholangiography and histology.RESULTS:All rats survived two laparotomies.After ligation,the CBD was dilated to a stable size of 4 to30 mm in diameter on day 21-28,which became a VGB.The rats initially showed signs of jaundice that diminished over time,which paralleled with the evolving TSB levels from 0.6±0.3 mg/d L before ligation,through a peak of 10.9±1.9 mg/dL on day 14,until a nearly normalized value after day 28.The dilated CBD with thickened wall allowed an incision for implantation of human gallstones of 1-10 mm in diameter.The rat cholelithiasis was proven by in vivo MRI and postmortem microcholangiography and histomorphology.CONCLUSION:A rat model cholelithiasis with human gallstones has been established,which proves feasible,safe,reliable,nontoxic and cost-effective.Given the gallstones of human origin,applications of this model may be of help in translational research such as optical detection and lysis of gallstones by systemic drug administration. | Marlein Miranda Cona Yewei Liu Ting Yin Yuanbo Feng Feng Chen Stefaan Mulier Yue Li Jian Zhang Raymond Oyen Yicheng Ni | 2016 | World Journal of Methodology2016，6，2： | 7 |
| 4 | Amino Acid Composition and Functional Properties of Giant Red Sea Cucumber (Parastichopus californicus) Collagen Hydrolysates显示文摘Giant red sea cucumber (Parastichopus californicus) is an under-utilized species due to its high tendency to autolysis.The aim of this study was to evaluate the functional properties of collagen hydrolysates from this species.The degree of hydrolysis (DH),amino acid composition,SDS-PAGE,emulsion activity index (EAI),emulsion stability index (ESI),foam expansion (FE),and foam stability (FS) of hydrolysates were investigated.The effects of pH on the EAI,ESI FE and FS of hydrolysates were also inves-tigated.The results indicated that the β and α1 chains of the collagen were effectively hydrolyzed by trypsin at 50℃ with an En-zyme/Substrate (E/S) ration of 1:20 (w:w).The DH of collagen was up to 17.3% after 3 h hydrolysis with trypsin.The hydrolysates had a molecular weight distribution of 1.1 17 kDa,and were abundant in glycine (Gly),proline (Pro),glutamic acid (Glu),alanine (Ala) and hydroxyproline (Hyp) residues.The hydrolysates were fractionated into three fractions (< 3 kDa,3 10 kDa,and > 10 kDa),and the fraction of 3 10 kDa exhibited a higher EAI value than the fraction of > 10 kDa (P<0.05).The fraction of > 10 kDa had higher FE and FS values than other fractions (P<0.05).The pH had an important effect on the EAI,ESI,FE and FS.All the fractions showed undesirable emulsion and forming properties at pH 4.0.Under pH 7.0 and pH 10.0,the 3 10 kDa fraction showed higher EAI value and the fraction of > 10 kDa showed higher FE value,respectively.They are hoped to be utilized as functional ingredients in food and nutraceutical industries. | LIU Zunying SU Yicheng ZENG Mingyong | 2011 | Journal of Ocean University of China2011，10，1： | 5 |
| 5 | Autophagy receptor CCDC50 tunes the STING-mediated interferon response in viral infections and autoimmune diseases显示文摘DNA sensing and timely activation of interferon(IFN)-mediated innate immunity are crucial for the defense against DNA virus infections and the clearance of abnormal cells.However,overactivation of immune responses may lead to tissue damage and autoimmune diseases;therefore,these processes must be intricately regulated.STING is the key adaptor protein,which is activated by cyclic GMP-AMP,the second messenger derived from cGAS-mediated DNA sensing.Here,we report that CCDC50,a newly identified autophagy receptor,tunes STING-directed type I IFN signaling activity by delivering K63-polyubiquitinated STING to autolysosomes for degradation.Knockout of CCDC50 significantly increases herpes simplex virus 1(HSV-1)-or DNA ligand-induced production of type I IFN and proinflammatory cytokines.Ccdc50-deficient mice show increased production of IFN,decreased viral replication,reduced cell infiltration,and improved survival rates compared with their wild-type littermates when challenged with HSV-1.Remarkably,the expression of CCDC50 is downregulated in systemic lupus erythematosus(SLE),a chronic autoimmune disease.CCDC50 levels are negatively correlated with IFN signaling pathway activation and disease severity in human SLE patients.CCDC50 deficiency potentiates the cGAS-STING-mediated immune response triggered by SLE serum.Thus,our findings reveal the critical role of CCDC50 in the immune regulation of viral infections and autoimmune diseases and provide insights into the therapeutic implications of CCDC50 manipulation. | Panpan Hou Yuxin Lin Zibo Li Ruiqing Lu Yicheng Wang Tian Tian Penghui Jia Xi Zhang Liu Cao Zhongwei Zhou Chunmei Li Jieruo Gu Deyin Guo | 2021 | Cellular & Molecular Immunology2021，18，10： | 3 |
| 6 | Growth inhibition and oxidative damage of Microcystis aeruginosa induced by crude extract of Sagittaria trifolia tubers显示文摘Aquatic macrophytes are considered to be promising in controlling harmful cyanobacterial blooms. In this research, an aqueous extract of Sagittaria trifolia tubers was prepared to study its inhibitory effect on Microcystis aeruginosa in the laboratory. Several physiological indices of M. aeruginosa, in response to the environmental stress, were analyzed. Results showed that S. trifolia tuber aqueous extract significantly inhibited the growth of M. aeruginosa in a concentration-dependent way. The highest inhibition rate reached 90% after 6 day treatment. The Chlorophyll-a concentration of M. aeruginosa cells decreased from 343.1 to314.2 μg/L in the treatment group. The activities of superoxide dismutase and peroxidase and the content of reduced glutathione in M. aeruginosa cells initially increased as a response to the oxidative stress posed by S. trifolia tuber aqueous extract, but then decreased as time prolonged. The lipid peroxidation damage of the cyanobacterial cell membranes was reflected by the malondialdehyde level, which was notably higher in the treatment group compared with the controls. It was concluded that the oxidative damage of M. aeruginosa induced by S.trifolia tuber aqueous extract might be one of the mechanisms for the inhibitory effects. | Jiang Li Yunguo Liu Pingyang Zhang Guangming Zeng Xiaoxi Cai Shaobo Liu Yicheng Yin Xinjiang Hu Xi Hu Xiaofei Tan | 2016 | Journal of Environmental Sciences2016，28，5： | 3 |
| 7 | Neutrophil-derived heparin binding protein triggers vascular leakage and synergizes with myeloperoxidase at the early stage of severe burns(With video)显示文摘Background:Burn shock caused by vascular leakage is one of the main causes of high mortality in severe burn injury.However,the pathophysiological mechanism of vascular leakage is still unclear.The purpose of this study was to explore the molecular mechanism of vascular leakage in the early stage of severe burn and provide a new target for the treatment of severe burns.Methods:Neutrophils were isolated from human peripheral blood by magnetic beads sorting.ELISA was used to detect neutrophil-derived granule proteins and glycocalyx injury products in plasma.The vascular leakage and neutrophil movement were assessed by in vivo laser confocal imaging in mice,and high-quality video were provided.Adhesion-related molecules were investigated by qRT-PCR.The damage to glycocalyx of mice vascular endothelial cellswas observed by transmission electron microscope and scanning electron microscope.Proteomic analysis,flow cytometry and immunofluorescence were used to further study the relationship between human peripheral blood neutrophil-derived hypochlorite(HOCl)and CD44 of human vascular endothelial cells.Results:In this study,we found that rapidly increasing activated neutrophils secrete heparin binding protein(HBP)andmyeloperoxidase(MPO)after severe burn injury.Increased HBP triggers vascular leakage with synergy of MPO,results in systemic edema and burn shock.Furthermore,we found that the MPO catalytic product HOCl but not MPO triggers CD44 extracellular domain shedding from vascular endothelial cells to damage the glycocalyx.Damage to the glycocalyx results in firm adhesion of neutrophils and increases vascular leakage.However,MPO inhibitors partially protect the glycocalyx of vascular endothelial cells.The combination of HBP and MPO inhibitors markedly reduces vascular leakage and systemic edema in the early stage of severe burns.Conclusions:Taken together,these data reveal that neutrophil-derived HBP and MPO play an important synergies role in triggering vascular leakage at the early stage of severe burns.Targeted intervention in these two biomolecules may introduce new strategies for helping to reduce large amount of fluid loss and subsequent burn shock. | Lu Liu Yiming Shao Yixuan Zhang Yunxi Yang Jiamin Huang Linbin Li Ran Sun Yuying Zhou Yicheng Su Bingwei Sun | 2021 | Burns & Trauma2021，9，1： | 3 |
| 8 | Targeting the ubiquitination/deubiquitination process to regulate immune checkpoint pathways显示文摘The immune system initiates robust immune responses to defend against invading pathogens or tumor cells and protect the body from damage,thus acting as a fortress of the body.However,excessive responses cause detrimental effects,such as inflammation and autoimmune diseases.To balance the immune responses and maintain immune homeostasis,there are immune checkpoints to terminate overwhelmed immune responses.Pathogens and tumor cells can also exploit immune checkpoint pathways to suppress immune responses,thus escaping immune surveillance.As a consequence,therapeutic antibodies that target immune checkpoints have made great breakthroughs,in particular for cancer treatment.While the overall efficacy of immune checkpoint blockade(ICB)is unsatisfactory since only a small group of patients benefted from ICB treatment.Hence,there is a strong need to search for other targets that improve the efficacy of ICB.Ubiquitination is a highly conserved process which participates in numerous biological activities,including innate and adaptive immunity.A growing body of evidence emphasizes the importance of ubiquitination and its reverse process,deubiquitination,on the regulation of immune responses,providing the rational of simultaneous targeting of immune checkpoints and ubiquitination/deubiquitination pathways to enhance the therapeutic efficacy.Our review will summarize the latest findings of ubiquitination/deubiquitination pathways for anti-tumor immunity,and discuss therapeutic significance of targeting ubiquitination/deubiquitination pathways in the future of immunotherapy. | Jiaxin Liu Yicheng Cheng Ming Zheng Bingxiao Yuan Zimu Wang Xinying Li Jie Yin Mingxiang Ye Yong Song | 2021 | Signal Transduction and Targeted Therapy2021，6，2： | 3 |
| 9 | Pancreatic imaging:Current status of clinical practices and small animal studies显示文摘Different causative factors acting on the pancreas can result in diseases such as pancreatitis, diabetes and pancreatic tumors. The high incidence and mortality of pancreatic diseases have placed diagnostic imaging in a crucial position in daily clinical practice. In this minireview article different pancreatic imaging techniques are discussed, from the standard clinical imaging modalities and state of the art clinical magnetic resonance imaging techniques to current situations in pre-clinical pancreatic imaging studies. In particular, the challenges of pre-clinical rodent pancreatic imaging are addressed, with both the image acquisition techniques and the post-processing methods for rodent pancreatic imaging elaborated. | Ting Yin Yewei Liu Ronald Peeters Yuanbo Feng Yicheng Ni | 2017 | World Journal of Methodology2017，7，3： | 2 |
| 10 | THz spectra of five borates crystals显示文摘Terahertz spectral responses have been studied for five borate crystals Na5[B2P3O13] (NBP), Zn3BPO (ZBP), SrB4O7 (SBO), Na3La9O3(BO 3)8 (NLBO) and PbB4O7 (PBO). It is found that the samples had good transmission in 0.25―1.5 THz region. Both SBO and NLBO have an absorption coefficient less than 10 cm1. Among them, SBO has not only the smallest absorption coefficient but also a very flat dispersion in the frequency region under investigation. Distinct resonance absorption peaks are observed for ZBP at ν1 = 1.4 THz, ν2 = 2.0 THz and SBO at ν = 2.4 THz. In the spectrum of PBO, two abnormal dispersions appear in the frequency regions 1.44―1.74 and 2.2―2.5 THz. The absorption coefficients and refraction indices of the five crystals are extracted from the THz time-domain (THz-TDS) spectra in 0.25―2.5 THz region. The properties and origins of the spectral responses are addressed. | HOU BiHui WANG YaLi WU YiCheng CHEN Hua WANG Li FU PengZhen LIU FengYan | 2008 | Chinese Science Bulletin2008，53，1： | 2 |
| 11 | A critical review on lead migration, transformation and emission control in Chinese coal-fired power plants显示文摘Coal is widely utilized as an important energy source,but coal-fired power plant was considered to be an important anthropogenic lead emission source.In the present study,the distribution characteristics of lead in coal and combustion by-products are reviewed.Specifically,lead is mainly transferred to ash particles and the formation and migration mechanisms of particulate lead are summarized.Also,targeted measures are proposed to control the formation of fine particulate lead as well as to increase the removal efficiency during the low-temperature flue gas clean process.In detail,interactions between gaseous lead and some coal-bearing minerals or added adsorbents could obviously suppress the formation of fine particulate lead.On the other hand,some efforts(including promoting capture of fine particles,reducing resistivity of particles and strengthening the gas-liquid contact)could be made to improve the fine particulate lead removal capacity.Notably,the formation mechanism of fine particulate lead is still unclear due to the limitations of research methods.Some differences in the removal principles of fine particles and particulate lead make the lead emission precisely control a great challenge.Finally,the environmental potential risk of lead emission from flue gas and ash residues is addressed and further discussed. | Yicheng Wang Hongyun Hu Xinye Wang Huimin Liu Lu Dong Guangqian Luo Yongchun Zhao Hong Yao | 2023 | Journal of Environmental Sciences2023，，2： | 2 |
| 12 | Two-step Optimal Allocation of Stationary and Mobile Energy Storage Systems in Resilient Distribution Networks显示文摘Energy storage systems (ESSs) are acknowledged to be a promising option to cope with issues in high penetration of renewable energy and guarantee a highly reliable power supply. In this paper, a two-step optimal allocation model is proposed to obtain the optimal allocation (location and size) of stationary ESSs (SESSs) and mobile ESSs (MESSs) in the resilient distribution networks (DNs). In the first step, a mixed-integer linear programming (MILP) problem is formulated to obtain the preselected location of ESSs with consideration of different scenarios under normal operation conditions. In the second step, a two-stage robust optimization model is established to get the optimal allocation results of ESSs under failure operation conditions which are solved by column-and-constraint generation (C&CG) algorithm. A hybrid ESS allocation strategy based on the subjective and objective weight analysis is proposed to give the final allocation scheme of SESSs and MESSs. Finally, the proposed two-step optimal allocation model is demonstrated on a modified IEEE 33-bus system to show its effectiveness and merits. | Xinyi Jiang Jian Chen Qiuwei Wu Wen Zhang Yicheng Zhang Jie Liu | 2021 | Journal of Modern Power Systems and Clean Energy2021，9，4： | 2 |
| 13 | Energy-efficient and security-optimized AES hardware design for ubiquitous computing显示文摘Ubiquitous computing must incorporate a certain level of security.For the severely resource con-strained applications,the energy-efficient and small size cryptography algorithm implementation is a critical prob-lem.Hardware implementations of the advanced encryption standard (AES) for authentication and encryption are presented.An energy consumption variable is derived to evaluate low-power design strategies for battery-powered devices.It proves that compact AES architectures fail to optimize the AES hardware energy,whereas reducing invalid switching activities and implementing power-optimized sub-modules are the reasonable methods.Implemen-tations of different substitution box (S-Boxes) structures are presented with 0.25 μm 1.8 V CMOS (complementary metal oxide semiconductor) standard cell library.The comparisons and trade-offs among area,security,and power are explored.The experimental results show that Galois field composite S-Boxes have smaller size and highest security but consume considerably more power,whereas decoder-switch-encoder S-Boxes have the best power char-acteristics with disadvantages in terms of size and security.The combination of these two type S-Boxes instead of homogeneous S-Boxes in AES circuit will lead to optimal schemes.The technique of latch-dividing data path is analyzed,and the quantitative simulation results demonstrate that this approach diminishes the glitches effectively at a very low hardware cost. | Chen Yicheng Zou Xuecheng Liu Zhenglin Han Yu Zheng Zhaoxia | 2008 | Journal of Systems Engineering and Electronics2008，19，4： | 2 |
| 14 | Advanced glycation end-product N ? -carboxymethyl-Lysine accelerates progression of atherosclerotic calcification in diabetes显示文摘 | Zhongqun Wang Yicheng Jiang Naifeng Liu Liqun Ren Yinghong Zhu Yanli An Dengyu Chen | 2012 | Atherosclerosis2012，，2： | 2 |
| 15 | IMPULSIVE BOUNDARY VALUE PROBLEMS FOR STURM-LIOUVILLE TYPE DIFFERENTIAL INCLUSIONS显示文摘在这篇论文,作者调查 Sturm-Liouville 类型的冲动的边界价值问题的答案的存在在右手上承认 non-convex-valued 多功能的微分包括站在一起。在更弱的条件下面的二结果被介绍。方法为收缩依靠一条固定的点定理多珍视的地图由于 Covitz;Nadler;Schaefer 的固定的点定理与 decomposable 价值与更低的半连续的多珍视的操作员结合了。 | Yicheng LIU Jun WU Zhixiang LI | 2007 | Journal of Systems Science & Complexity2007，20，3： | 2 |
| 16 | Transcriptional regulation of the waaAE-coaD operon by PhoP and RcsAB in Yersinia pestis biovar Microtus显示文摘亲爱的编辑, | Lei Liu Nan Fang Yicheng Sun Huiying Yang Yiquan Zhang Yanping Han Dongsheng Zhou Ruifu Yang | 2014 | Protein & Cell2014，5，12： | 2 |
| 17 | The first discovery of eclogite and Palaeoproterozoic granitoids in the Beishan area,northwestern Gansu Province,China显示文摘The eclogite, discovered in Liuyuan, occurs as lenticular enclave within granitic gneiss. It has typical features of eclogite in petrology and mineralogy. The eclogite provides an important wirdow to reconstruct the tectonic border of the Tarim block. The granitoids, located in Baihu area, yield U-Pb zircon ages of 1 660—2 000 Ma (Palaeoproterozoic), which irrplies an early Precambrian basement in the area. | Hualin Mei Haifeng Yu Quan Li Songnian Lu Huimin Li Yicheng Zuo Guochao Zuo Dejin Ye Jincheng Liu | 1999 | Chinese Science Bulletin1999，44，4： | 1 |
| 18 | 显示文摘 | Liu Yicheng Qiu Xinping Huang Yuqing | 2002 | Carbon2002，40，13： | 1 |
| 19 | Analysis of the flow field of cartier-based aircraft exhaust jets im- pact on the flight deck显示文摘 | YUE KUIZHI SUN YICHENG LIU HU | 2015 | International Journal of Aero- nautical and Space Sciences2015，16，1： | 1 |
| 20 | Upregulated expression of ubiquitin-conjugating enzyme E2Q1 (UBE2Q1) is associated with enhanced cell proliferation and poor prognosis in human hapatocellular carcinoma显示文摘 | Renan Chang Lixian Wei Yuhua Lu Xiaopeng Cui Cuihua Lu Luoliang Liu Dawei Jiang YiCheng Xiong Gang Wang Chunhua Wan Haixin Qian | 2015 | Journal of Molecular Histology2015，，1： | 1 |
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