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| 1 | Viral effector protein manipulates host hormone signaling to attract insect vectors显示文摘 | Dewei Wu Tiancong Qi Wan-Xiang Li Haixia Tian Hua Gao Jiaojiao Wang Jin Ge Ruifeng Yao Chunmei Ren Xian-Bing Wang Yule Liu Le Kang Shou-Wei Ding Daoxin Xie | 2017 | Cell Research2017，27，3： | 20 |
| 2 | Role of pre-vertical compression in deformation behavior of Mg alloy AZ31B during super-high reduction hot rolling process显示文摘Mg alloy AZ31 B plates were processed by hot rolling with different thickness reductions per pass and prevertical compression followed by super-high reduction hot rolling(PVCR), respectively. Microstructure evolution, rolling formability variation and mechanical responses were investigated. As reduction per pass increased, the number of shear bands deflecting toward rolling direction increased, resulting in easy crack initiation in and around the bands. With increasing reduction per pass up to 80%, twinning and twinning-induced dynamic recrystallization(DRX) dominated the deformation of the edge material at350?C, resulting in local recrystallization with coarse grains and further largest edge-crack degree. Preinduced {10ī12} tensile twins by pre-vertical compression(PVC) increased number density of nucleation sites for dynamic recrystallization during the subsequent severe rolling, which enhanced the dominant role of continuous dynamic recrystallization. Designed PVCR-b was proved to be a relatively effective method to improve rolling formability of rolled Mg alloy AZ31 B plates. With this method, mean grain size of AZ31 B plate was significantly refined from ~600 mm to ~14.1 mm and more homogeneous grain size distribution along transverse direction(TD) was achieved. In addition, basal texture intensity was greatly weakened. As a result, tensile anisotropy was distinctly decreased and fracture elongation increased dramatically. | Weitao Jia Qichi Le Yan Tang Yunpeng Ding Fangkun Ning Jianzhong Cui | 2018 | Journal of Materials Science & Technology2018，34，11： | 8 |
| 3 | Three new phenanthrenes from Monomeria barbata Lindl.显示文摘Three new monophenanthrene compounds were isolated from an acetone extract of the tubers of Monomeria barbata Lindl. (Orchidaceae).Using spectroscopic methods,the structures of compounds 1-3 were determined as 1,4,7-trihydroxy-2-methoxy- 9,10-dihydrophenanthrene(1),1-(p-hydroxybenzoyl)-2-methoxy-4,7-dihydroxy-9,10-dihydrophenanthrene(2),1,3,8-tri(p-hydroxybenzyl) -4-methoxy-phenanthrene-4,7-diol(3).These compounds showed cytotoxicities on four tumor cell lines(HepG2, HL-60,Skov-3,A431). | Yang, Ming Hui Cai, Le Li, Mei Hong Zeng, Xiang Hui Yang, Ya Bin Ding, Zhong Tao | 2010 | Chinese Chemical Letters2010，21，3： | 5 |
| 4 | Correlation of Deactivation of Ni-Mo-W/Al2O3 during Ultra-Low-Sulfur Diesel Production with Surface Carbon Species显示文摘The deactivation of a Ni-Mo-W/Al_2O_3 catalyst during ultra-low-sulfur diesel production was investigated in a pilot plant. The reasons of catalyst deactivation were analyzed by the methods of elemental analysis, BET and TG-MS. The results showed that the catalyst deactivation rate was notable at the beginning of run, and then gradually reached a steady state after 448 h. In the initial period the catalyst deactivation may mainly be caused by the formation of the carbon deposits. The carbon deposits blocked the catalyst pores and the accessibility of active center decreased. The TG-MS analysis identified three types of carbon species deposited on the catalysts, viz.: the low temperature carbon deposit with high H/C atomic ratio, the medium temperature carbon deposit, and the high temperature carbon with low H/C atomic ratio. The amount of high temperature carbon deposits on the catalyst determined the overall activity and, therefore the high temperature carbon was a major contributor to the deactivation of Ni-Mo-W catalyst. | Ge Panzhu Zhang Le Ding Shi Li Dadong Nie Hong | 2017 | China Petroleum Processing & Petrochemical Technology2017，19，2： | 5 |
| 5 | A Bunyavirus-Inducible Ubiquitin Ligase Targets RNA Polymerase IV for Degradation during Viral Pathogenesis in Rice显示文摘The ubiquitin-proteasome system(UPS)is an important post-translational regulatory mechanism that controls many cellular functions in eukaryotes.Here,we show that stable expression of P3 protein encoded by Rice grassy stunt virus(RGSV),a negative-strand RNA virus in the Bunyavirales,causes developmental abnormities similar to the disease symptoms caused by RGSV,such as dwarfing and excess tillering,in transgenic rice plants.We found that both transgenic expression of P3 and RGSV infection induce ubiquitination and UPS-dependent degradation of rice NUCLEAR RNA POLYMERASE D1a(OsNRPD1a),one of two orthologs of the largest subunit of plant-specific RNA polymerase IV(Pol IV),which is required for RNA-directed DNA methylation(RdDM).Furthermore,we identified a P3-inducible U-box type E3 ubiquitin ligase,designated as P3-inducible protein 1(P3IP1),which interacts with OsNRPD1a and mediates its ubiquitination and UPS-dependent degradation in vitro and in vivo.Notably,both knockdown of OsNRPD1 and overexpression of P3IP1 in rice plants induced developmental phenotypes similar to RGSV disease symptomss.Taken together,our findings reveal a novel virulence mechanism whereby plant pathogens target host RNA Pol IV for UPS-dependent degradation to induce disease symptoms.Our study also identified an E3 ubiquitin ligase,which targets the RdDM compotent NRPD1 for UPS-mediated degradation in rice. | Chao Zhang Ying Wei Le Xu Kang-Cheng Wu Liang Yang Chao-Nan Shi Guo-Yi Yang Dong Chen Fei-Fei Yu Qi Xie Shou-Wei Ding Jian-Guo Wu | 2020 | Molecular Plant2020，13，6： | 5 |
| 6 | Threading dislocation density comparison between GaN grown on the patterned and conventional sapphire substrate by high resolution X-ray diffraction显示文摘GaN epifilms are grown on the patterned sapphire substrates (PSS) (0001) and the conventional sapphire substrates (CSS) (0001) by metal-organic chemical vapor deposition (MOCVD) using a novel two-step growth. High resolution X-ray diffraction (HR-XRD) is used to investigate the threading dislocation (TD) density of the GaN epifilms. The TD density is calculated from the ω-scans full width at half maximum (FWHM) results of HR-XRD. The edge dislocation destiny of GaN grown on the PSS is 2.7×108 cm-2, which is less than on the CSS. This is confirmed by the results of atomic force microscopy (AFM) measurement. The lower TD destiny indicates that the crystalline quality of the GaN epifilms grown on the PSS is improved compared to GaN epifilms grown on the CSS. The residual strains of GaN grown on the PSS and CSS are compared by Raman Scattering spectra. It is clearly seen that the residual strain in the GaN grown on PSS is lower than on the CSS. | ZHANG YuChao1, XING ZhiGang2, MA ZiGuang2, CHEN Yao2, DING GuoJian2, XU PeiQiang2, DONG ChenMing3, CHEN Hong2 & LE XiaoYun1 1 School of Physics and Nuclear Energy Engineering, Beihang University, Beijing 100190, China 2 Renewable Energy Laboratory, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China 3 School of Information and Communication, Tianjin Polytechnic University, Tianjin 300160, China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，3： | 5 |
| 7 | Geomyces luteus发酵丹参实现抗氧化活性的增加和丹酚酸的富集(英文)显示文摘目的:研究真菌固态发酵对丹参抗氧化活性的影响及探索丹酚酸富集的途径。创新点:该研究发现真菌G.luteus固态发酵可增加丹参的抗氧化活性及有效地富集丹酚酸B,为丹参更有效的开发利用提供了新思路。方法:采用20种真菌对丹参进行固态发酵,以两种抗氧化模型(二苯代苦味酰基自由基(DPPH·)和2,2'-联氮基双(3-乙基苯并噻唑啉-6-磺酸)二铵盐自由基(ABTS^+·))测定发酵物的抗氧化活性;采用Folin-Ciocaltea比色法测定发酵物的总酚含量;以多种波谱学方法(紫外光谱(UV)、红外光谱(IR)和核磁共振波谱(NMR))和高效液相色谱法(HPLC)表征发酵前后丹参化学成分的变化。结论:抗氧化活性测试和总酚测定结果表明,G.luteus发酵可有效地增加丹参的抗氧化活性和总酚含量。UV、IR及NMR等波谱表征发现,在丹参经G.luteus发酵后,丹酚酸类化合物的含量提高了;同时HPLC测定也发现,丹酚酸B含量显著增加。这些结果表明,G.luteus发酵可实现丹酚酸B的富集。 | Yun XING Le CAI Tian-peng YIN Yang CHEN Jing YU Ya-rong WANG Zhong-tao DING | 2016 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2016，17，5： | 4 |
| 8 | Study on Seepage Characteristics of Composite Bucket Foundation Under Eccentric Load显示文摘Under the effect of eccentric loads,when the suction pressure of the composite bucket foundation is leveled,the seepage failure is very easy to occur.The seepage failure occurrence causes the foundation to settle unevenly and impairs the bearing performance.This study uses ABAQUS finite element software to establish a composite bucket foundation model for finite element analysis.The model simulates the seepage of the foundation penetrating process under eccentric load to reveal the induced seepage characteristics of the bucket foundation.The most vulnerable position of seepage failure under the eccentric loading is elucidated.Critical suction formulas for different offset eccentric moment strategies are derived and compared with existing literature formulas.Then the derived formula is supplemented and corrected according to the pressure difference between adjacent cabins.Conclusions can be drawn:(1)Under eccentric loads,the critical suction decreases about 7%−10%.(2)The pressure difference between adjacent cabins impacts significantly on the seepage field,and the critical suction,at most,can be reduced by 17.56%.(3)the offset strategies have little effect on the seepage field.Efficient and appropriate strategies can be selected to meet the requirement of leveling in engineering project. | CHEN Qing-shan ZHANG Pu-yang DING Hong-yan LE Cong-huan XU Yun-long | 2021 | China Ocean Engineering2021，35，1： | 4 |
| 9 | Reduced grain chalkiness and its possible physiological mechanism in transgenic rice overexpressing L-GalLDH显示文摘Chalkiness is one of the key factors determining rice quality and price. Ascorbic acid(Asc) is a major plant antioxidant that performs many functions in plants. L-Galactono-1,4-lactone dehydrogenase(L-Gal LDH, EC1.3.2.3) is an enzyme that catalyzes the final step of Asc biosynthesis in plants. Here we show that the L-Gal LDH-overexpressing transgenic rice, GO-2,which has constitutively higher leaf Asc content than wild-type(WT) plants, exhibits significantly reduced grain chalkiness. Higher foliar ascorbate/dehydroascorbate(Asc/DHA)ratios at 40, 60, 80, and 100 days of plant age were observed in GO-2. Further investigation showed that the enhanced level of Asc resulted in a significantly higher ribulose-1,5-bisphosphate(Ru BP) carboxylase/oxygenase(Rubisco) protein level in GO-2 at 80 days. In addition, levels of abscisic acid(ABA) and jasmonic acid(JA) were lower in GO-2 at 60, 80, and100 days. The results we present here indicate that the enhanced level of Asc is likely responsible for changing redox homeostasis in key developmental stages associated with grain filling and alters grain chalkiness in the L-Gal LDH-overexpressing transgenic by maintaining photosynthetic function and affecting phytohormones associated with grain filling. | Le Yu Yonghai Liu Jianhua Tong Junhui Ding Ruozhong Wang Changlian Peng Langtao Xiao | 2015 | The Crop Journal2015，3，2： | 4 |
| 10 | Expansion of PmBEAT genes in the Prunus mume genome induces characteristic floral scent production显示文摘Prunus mume is the only plant in the genus Prunus of the Rosaceae family with a characteristic floral scent,and the main component of this scent is benzyl acetate.By contrast,benzyl acetate is not synthesized in Prunus persica flowers.Here,we searched for benzyl alcohol acetyltransferase(BEAT)genes based on genomic data from P.mume and P.persica and found 44 unique PmBEATs in P.mume.These genes,which were mainly detected in clusters on chromosomes,originated from gene duplication events during the species evolution of P.mume,and retroduplication and tandem duplication were the two dominant duplication patterns.The genes PmBEAT34,PmBEAT36 and PmBEAT37,which were generated by tandem duplication,were highly expressed in flowers,and their highest levels were detected during the blooming stage.In vitro,PmBEAT34,PmBEAT3,and PmBEAT37 all had benzyl alcohol acetyltransferase activity that was localized in the cytoplasm.Overexpression of the PmBEAT36 or PmBEAT37 genes increased benzyl acetate production in the petal protoplasts of P.mume,and interference in the expression of these genes slightly decreased the benzyl acetate content.In addition,light and temperature regulated the expression of the PmBEAT34,PmBEAT36 and PmBEAT37 genes.According to these results,we hypothesize that the expansion of the PmBEAT genes in the genome induce the characteristic floral scent of P.mume. | Fei Bao Anqi Ding Tengxun Zhang Le Luo Jia Wang Tangren Cheng Qixiang Zhang | 2019 | Horticulture Research2019，6，1： | 4 |
| 11 | Design and experiment of electro hydraulic active suspension for controlling the rolling motion of spray boom显示文摘Boom sprayer is one of the most commonly used plant protection machinery for spraying pesticide.Studies have shown that the efficiency of chemicals is highly correlated with the uniformity of spray distribution patterns.As the boom is a large and flexible structure,boom rolling leads to overlapping and leakage of the pesticides.In order to improve spray uniformity,the boom attitude should be kept parallel to the ground slope or to the crop canopy beneath the boom.Passive suspension can attenuate frequencies above its resonance frequency,but nothing can be done to align the boom to the sloping ground.Therefore,an active suspension system is designed,which includes DSP-based controller,a servo valve,a hydraulic cylinder,two ultrasonic sensors,one inertial attitude sensor,and the developed control procedures.In order to prevent the wrong response of the control system caused by the high frequency component due to uneven crop canopy or rough ground.A special signal processing algorithm was proposed,including the limiting filter,smoothing algorithm and data fusion algorithm based on optimal weight.The transient and steady-state performances of the boom control system using velocity feedforward PID algorithm were tested on a six DOF motion simulator.It can be seen that the low-frequency tracking performance of the boom was greatly improved after the electro-hydraulic active suspension was added.At the resonance frequency,the peak angle of active suspension and passive suspensions are 0.72°and 1.29°respectively,and the resonance peak is greatly reduced.The controller was implemented on a self-propelled boom sprayer and validated under field conditions,the standard deviation of the roll angle of the boom with active suspension is 0.40°,compared with 1.04°of the sprayer chassis.Experimental results show that the active suspension control system can effectively reduce the effect of ground excitation disturbance on the application process,and has good tracking performance for low frequency terrain change. | Longfei Cui Xinyu Xue Feixiang Le Hanping Mao Suming Ding | 2019 | International Journal of Agricultural and Biological Engineering2019，12，4： | 3 |
| 12 | Integrated Towing Transportation Technique for Offshore Wind Turbine with Composite Bucket Foundation显示文摘Composite bucket foundation and one-step installation technology for offshore wind turbine are the integration of foundation construction,transportation and whole installation at sea.The cost of offshore wind turbine construction and installation has been largely reduced.Foundation stability is the key technology in the process of towing transportation.Field observation data can reflect the real state of the foundation.In this paper,the influence of water depth and towing speed on liquid level,the compartment pressure,and the pitch angles during towing of composite bucket foundation are studied.These data are analyzed based on the field measurements data from a 3.3 MW offshore wind power project in China.The results show that with varied water depths and towing speeds,the compartment pressure changes are small during the bucket foundation towing process.The offshore wind turbine composite bucket foundation is stable while being towed in the ocean. | DING Hong-yan FENG Zun-tao ZHANG Pu-yang LE Cong-huan | 2022 | China Ocean Engineering2022，36，1： | 3 |
| 13 | Two new glucosides from the pellicle of the walnut (Juglans regia)显示文摘A newα-tetralonyl glucoside,6'-O-acetyl-juglanoside E(1),and a new dihydrophaseic acid glucoside,dihydrophaseic acid 1-O-(6-O-acetyl)-glucopyranoside(2),together with two known ones,juglanoside E(3)and dihydrophaseic acid(4),were isolated from the pellicle of the walnut(Juglans regia).The structures of the new compounds were elucidated by comprehensive spectroscopic analysis,including IR,HRESIMS,1D and 2D NMR data. | Le CAI Chuan-Shui LIU Xiao-Wei FU Xiao-Jing SHEN Tian-Peng YIN Ya-Bin YANG Zhong-Tao DING | 2012 | Natural Products and Bioprospecting2012，2，4： | 2 |
| 14 | Evaluation of triage strategies for high-risk human papillomavirus-positive women in cervical cancer screening:A multicenter randomized controlled trial in different resource settings in China显示文摘Objective:We aimed to evaluate the effectiveness of different triage strategies for high-risk human papillomavirus(hrHPV)-positive women in primary healthcare settings in China.Methods:This study was undertaken in 11 rural and 9 urban sites.Women aged 35-64 years old were enrolled.HrHPV-positive women were randomly allocated to liquid-based cytology(LBC),visual inspection with acetic acid and Lugol’s iodine(VIA/VILI)(rural only)triage,or directly referred to colposcopy(direct COLP).At 24 months,hrHPV testing,LBC and VIA/VILI were conducted for combined screening.Results:In rural sites,1,949 hrHPV-positive women were analyzed.A total of 852,218 and 480 women were randomly assigned to direct COLP,LBC and VIA/VILI.At baseline,colposcopy referral rates of LBC or VIA/VILI triage could be reduced by 70%-80%.LBC(n=3 and n=7)or VIA/VILI(n=8 and n=26)could significantly decrease the number of colposcopies needed to detect one cervical intraepithelial neoplasia(CIN)2 or worse and CIN3+compared with direct COLP(n=14 and n=23).For the 24-month cumulative detection rate of CIN2+,VIA/VILI triage was 0.50-fold compared with LBC triage and 0.46-fold with the direct COLP.When stratified by age,baseline LBC triage+performed best(P<0.001),peaking among women aged 35-44 years(Ptrend=0.002).In urban sites,1,728 women were hrHPV genotyping test positive.A total of 408,571 and 568women were randomly assigned to direct COLP for HPV16/18+,direct COLP for other hrHPV subtypes+,and LBC triage for other hrHPV subtypes+.LBC(n=12 and n=31)significantly decreased the number of colposcopies needed to detect one CIN2+and CIN3+compared with direct COLP(n=14 and n=44).HPV16/18+increased the 24-month cumulative detection rate of CIN2+(17.89%,P<0.001).Conclusions:LBC triage for hrHPV-positive women in rural settings and direct COLP for HPV16/18+women and LBC triage for other hrHPV subtype+women in urban settings might be feasible strategies. | Le Dang Linghua Kong Yuqian Zhao Yi Dai Li Ma Lihui Wei Shulan Zhang Jihong Liu Mingrong Xi Long Chen Xianzhi Duan Qing Xiao Guzhalinuer Abulizi Guonan Zhang Ying Hong Qi Zhou Xing Xie Li Li Mayinuer Niyazi Zhifen Zhang Jiyu Tuo Yiling Ding Youlin Qiao Jinghe Lang | 2022 | Chinese Journal of Cancer Research2022，34，5： | 2 |
| 15 | Shaking Table Tests of Four-Bucket Jacket Foundation for Offshore Wind Turbines显示文摘As the offshore wind turbine foundation,the four-bucket jacket foundation has a large stiffness and the structure is difficult to be damaged under seismic load.Nevertheless,the saturated subsoil of the four-bucket jacket foundation tends to be liquefied under earthquake,which greatly affects the safety of offshore wind turbine.Therefore,the seismic performance of four-bucket jacket foundation is mainly reflected in the anti-liquefaction capacity of foundation soil.In this paper,the liquefaction resistance of sandy soil of four-bucket jacket foundation for offshore wind turbine is studied.The liquefaction and dynamic response of sandy soil foundation of four-bucket jacket foundation under seismic load are obtained by carrying out the shaking table test,and the influence mechanism of four-bucket jacket foundation on the liquefaction resistance of sandy soil foundation is analyzed. | DING Hong-yan LI Jing-yi LE Cong-huan PAN Chen ZHANG Pu-yang | 2022 | China Ocean Engineering2022，36，6： | 2 |
| 16 | MEMS inductor fabrication and emerging applications in power electronics and neurotechnologies显示文摘MEMS inductors are used in a wide range of applications in micro-and nanotechnology,including RF MEMS,sensors,power electronics,and Bio-MEMS.Fabrication technologies set the boundary conditions for inductor design and their electrical and mechanical performance.This review provides a comprehensive overview of state-of-the-art MEMS technologies for inductor fabrication,presents recent advances in 3D additive fabrication technologies,and discusses the challenges and opportunities of MEMS inductors for two emerging applications,namely,integrated power electronics and neurotechnologies.Among the four top-down MEMS fabrication approaches,3D surface micromachining and through-substrate-via(TSV)fabrication technology have been intensively studied to fabricate 3D inductors such as solenoid and toroid in-substrate TSV inductors.While 3D inductors are preferred for their high-quality factor,high power density,and low parasitic capacitance,in-substrate TSV inductors offer an additional unique advantage for 3D system integration and efficient thermal dissipation.These features make in-substrate TSV inductors promising to achieve the ultimate goal of monolithically integrated power converters.From another perspective,3D bottom-up additive techniques such as ice lithography have great potential for fabricating inductors with geometries and specifications that are very challenging to achieve with established MEMS technologies.Finally,we discuss inspiring and emerging research opportunities for MEMS inductors. | Hoa Thanh Le Rubaiyet I.Haque Ziwei Ouyang Seung Woo Lee Shelley I.Fried Ding Zhao Min Qiu Anpan Han | 2021 | Microsystems & Nanoengineering2021，7，4： | 2 |
| 17 | Three new diterpenoid alkaloids isolated from Aconitum brevicalcaratum显示文摘In the present study, three new aconitine-type diterpenoid alkaloids brochyponines A–C(1–3) were isolated from the roots of Aconitum brevicalcaratum. Their structures were established on the basis of extensive spectroscopic analyses(IR, HR-ESI-MS, and 1D and 2D NMR). The NMR data of salt form for compound 1 in CDCl_3 were also measured. | SHU Yan YIN Tian-Peng WANG Jia-Peng GAN Dong ZHANG Qin-Yan CAI Le DING Zhong-Tao | 2018 | Chinese Journal of Natural Medicines2018，16，11： | 2 |
| 18 | Developing hierarchical CdS/NiO hollow heterogeneous architectures for boosting photocatalytic hydrogen generation显示文摘The hierarchical binary CdS/NiO hollow heterogeneous architectures(HHAs)with p–n heterojunction are constructed by a facile microwave-assisted wet chemical process for high-efficient photocatalytic hydrogen evolution reaction(HER)from water.The as-designed CdS/NiO HHAs are composed of hexagonal n-type CdS nanoparticles with a size in the range of 20–40 nm attaching to cubic p-type NiO hollow microspheres(HMSs)which are aggregates of porous nanoplates with a thickness of about 20 nm.The photocatalytic water splitting over CdS/NiO HHAs is significantly increased under simulated solar irradiation,among which the most active sample of CdS/NiO-3(the mass ratio of CdS to NiO is 1:3)exhibits the fastest photocatalytic HER rate of 1.77 mmol∙g^(−1)∙h^(−1),being 16.2 times than that of pure CdS.The boosted photocatalytic HER could be attributed to the synergistic effect on the proportional p–n heterojunction with special hierarchical hollow and porous morphology,an enhancement of visible light absorption,and an improvement of photoinduced charge separation as well as the photo-stability given by the composite heterojunction.This work shows a viable strategy to design the heterojunction with special morphology for the efficient hydrogen generation by water splitting utilizing solar energy. | Chonghai Deng Fan Ye Tao Wang Xiaohui Ling Lulu Peng Hong Yu Kangzhe Ding Hanmei Hu Qiang Dong Huirong Le Yongsheng Han | 2022 | Nano Research2022，15，3： | 2 |
| 19 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 20 | Shaking Table Tests and Seismic Response of Three-Bucket Jacket Foundations for Offshore Wind Turbines显示文摘The seismic response characteristics of three-bucket jacket foundations for offshore wind turbines(OWTs)and the liquefaction of the surrounding soil are particularly important for the development and application of this type of structure for offshore use.Using the shaking table test and three-dimensional finite element analysis,different magnitudes of simulated earthquake waves were used as inputs to the shaking table to model seismic excitations.The resulting changes in the excess pore water pressure and acceleration response of the soil under horizontal earthquake are compared in this paper.Calculations of the anti-liquefaction shear stress and equivalent shearing stress during the earthquake,determination of the areas prone to liquefaction,and identification of the effect of the three-bucket jacket foundation on the soil liquefaction resistance were conducted by developing a soil-structure finite element model.The development law of the soil’s amplification effect on seismic acceleration and the seismic response of the foundation soil under various magnitude earthquake waves were also discussed.Results indicate that liquefying the soil inside the bucket of the foundation is more difficult than that outside the bucket during the excitation of seismic waves due to the large upper load and the restraint of the surrounding hoop.This finding confirms the advantages of the three-bucket jacket foundations in improving the liquefaction resistance of the soil inside the bucket.However,the confinement has a barely noticeable impact on the nearby soil outside the skirt.The phenomenon of soil liquefaction at the bottom of the skirt occurred earlier than that in other positions during the seismic excitation,and the excess pore water pressure slowly dissipated.The acceleration amplification coefficient of the sand outside the bucket increases with depth,but that of the sand inside the bucket is substantially inhibited in the height range of the bucket foundation.This result proves the inhibition effects of the three-bucket jacket foundations on the seismic responses of soils.The liquefied soil layer has a significant effect in absorbing a certain amount of seismic wave energy and reducing the amplification effect.The numerical simulation results are consistent with the phenomenon and data measured during the shaking table test.The current study also verifies the feasibility of the excess pore water pressure ratio and the anti-liquefaction shear stress method for judging soil liquefaction. | DING Hongyan PAN Chen ZHANG Puyang WANG Le XU Yunlong | 2022 | Journal of Ocean University of China2022，21，3： | 1 |
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